Biochemicals and Reagents

<p>Peptide H-FGESEQIIVTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VDPVNFK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-SYSMEHFRWGKPV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-EILDAFDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>ApoB antibody was raised in goat using human apolipoprotein B as the immunogen.</p>

<p>RC-3095 is a guanine nucleotide-binding protein (G protein) antagonist that inhibits the activation of Toll-like receptor 4 (TLR4). It has been shown to reduce oxidative injury and improve locomotor activity in an experimental model. RC-3095 also has anti-inflammatory effects, which may be due to its ability to inhibit the activity of matrix metalloproteinase 9, as well as its ability to modulate toll-like receptor signaling. RC-3095 also binds to polymerase chain reaction amplicons, allowing for the development of a new analytical method for screening and confirming the presence of mutations in genes associated with chronic arthritis.</p>

<p>H-Trp(Boc)-2-ClTrt-Resin (200-400 mesh) is a resin that contains amines and thiols. It can be used as a building block of peptides and proteins. H-Trp(Boc)-2-ClTrt-Resin (200-400 mesh) can also be used in the synthesis of alcohols, which are important chemicals for industry.</p>

<p>M02493 - Salicylaldoxime</p>

<p>Applications Ethyl 2-Methyl-4-pentenoate, can be used as flavoring and fragrant agent. It can also be used for the synthesis of Phthalazines and Pyridazino-aromatics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Luan, F., et al.: Flavour and Fragrance J., 23, 232 (2008); Kessler, S., et al.: Org. Lett., 14, 3268 (2012);<br></p>

<p>Applications A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 10.6 Angstroms<br>References Weltman, J.K., et al.: Biotechniques, 1, 148 (1983)<br></p>

<p>Applications 1-(2-Naphthyl) 2-Trifluroacetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside-d7 is a reagent in the synthesis of 2-Amino-2-Deoxy-1-α-(2-Naphthyl-1,3,4,5,6,7,8-d7)-Glucopyranoside (A605651) which is 13C labeled version of 2-Amino-2-Deoxy-1-Alpha-(2-Naphthyl)-Glucopyranoside (A605650)<br></p>

<p>Applications A cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts.<br>References Hayden, P.J., et al.: J. Biol. Chem., 266, 18415 (1991),<br></p>

<p>Applications 2,4,6-Tritert-butylpyridine is used in the synthesis of acceptors in organic solar cells.<br>References Morgan, M., et al.: Chem. Comm., 55, 11095-11098 (2019)<br></p>

<p>Applications Boc-L-His(Tos)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications 1,3-Bis(diphenylphosphino)propane is a ligand that binds to a central metal ion (e.g. Gold) to create a coordination complex. One of its complexes, bis[chlorogold(I)] [DPPP(Au2Cl3)], displays cytotoxic activity against mice leukemia cells in vitro.<br>References Caruso, F., et al.: J. Med. Chem., 46, 1737 (2003); Snyder, R., et al.: Cancer Res., 46, 5054 (1986)<br></p>

<p>Applications 5-Methyl-2-(phenylsulfonyl)thiazole is an intermediate used in the synthesis of Deschloro-2-phenylsulfonyl-thiamethoxam (D290790), which is an impurity of thiamethoxam (T344180), which is a neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications N-Benzyloxycarbonyl-L-alanine is an intermediate in the synthesis of Perindopril (P287500), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Lees, K.R., et al.: Brit. J. Clin. Pharmacol., 23, 159 (1987); Morgan, T., et al.: J. Cardiovasc. Pharmacol., 10, Supp. 7, S116, (1987)<br></p>

<p>Stability Hygroscopic<br>Applications 3-O-(α-D-Galactopyranosyl)-D-galactose (cas# 13168-24-6) is a compound useful in organic synthesis.<br>References Abramenko, I.V., et al.: Tsitologiya, 35 (5), 91 (1993), Kelly, R.F., et al.: Mol. Microbiol., 10 (3), 615 (1993), Stortz, C.A., et al.: J. Carbohydr. Chem., 13 (2), 235 (1994), Neethling, F.A., et al.: Transplantation, 57 (6), 959 (1994)<br></p>

<p>Applications 5-Bromo-2',3',5'-tri-O-acetyluridine (cas# 105659-32-3) is a compound useful in organic synthesis.<br></p>

<p>Impurity Atorvastatin EP Impurity E<br>Stability Hygroscopic<br>Applications (3S,5S)-Atorvastatin Sodium Salt (Atorvastatin EP Impurity E) is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18. 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>

<p>Applications 4-Benzyl N-Carbobenzoxy-L-aspartate (cas# 3479-47-8) is a useful research chemical.<br></p>

<p>Applications (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) (cas# 19249-03-7) is a useful research chemical.<br></p>

<p>Applications A analogue of tamoxifen with anti-estrogenic properties.<br>References Ruenitz, P.C., et al.: J. Med. Chem., 25, 1056 (1982)<br></p>

<p>Applications 1-Palmito-2-stearin is a diacylglycerol used to increase the activity of the ARF1 GTPase-activating protein on membrane-bound ARF1GTP.<br>References Antonny, B., et al.: J. Biol. Chem., 272, 30848 (1997)<br></p>

<p>Applications α-Methyl-1-naphthaleneacetic Acid-d3 Ethyl Ester, is a labeled building block used in various chemical synthesis.<br></p>

<p>Applications An intermediate of Ticlopidine (T438325). Thieno[3,2-c]pyridine derivatives are used for treatment of inflammatory disorders.<br>References Malicorne, G., et al.: Eur. J. Med. Chem., 26, 3 (1991), Wagner, G., et al.: Pharmazie, 48, 95 (1993), El-Abadelah, M., et al.: Eur. J. Med. Chem., 33, 33 (1998),<br></p>

<p>Applications Boc-α-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids.<br>References Lu, Y. et al.: Chem. Sci., 2, 967 (2011); Engle, K. et al.: JK. Am. Chem. Soc., 133, 18183 (2011);<br></p>

<p>Applications 5-Methyl-d3-amino-4-nitro-2,1,3-benzoselenadiazole (cas# 1246815-24-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications Pinacol is used in the synthesis of organic reagents such as alkenylphenylphosphonates and alkenylboronates.<br>References Peng, A. et al.: J. Fluor. Chem., 151, 58 (2013); Mazzacano, T. et al.: J. Am. Chem. Soc., 135, 17258 (2013);<br></p>

<p>Applications Permanent Orange (cas# 3468-63-1) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications A fluorescent reagent with a terminal amine for derivatization.<br>References Hudson, E.N. and Weber, G.: Biochem, 12(21), 4154-4161 (1973)<br></p>

<p>Applications L-Cysteine Ethyl Ester Hydrochloride is the hydrochloride form of ethyl ester of L-Cysteine (C995000) which is a non-essential amino acid commonly used as a precursor in the food and pharmaceutical industries. L-Cysteine Ethyl Ester Hydrochloride is used in the synthesis of several organic compounds including that of diastereoisomers and analogues of tubulysin-U which is a potent anti-mitotic compound.<br>References Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010); Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Shankar, P., et al.: Tetrahedron Lett., 54, 6137 (2013);<br></p>

<p>Applications DL-Proline-2,5,5-d3 (CAS# 784086-28-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-Fucose is a hexose deoxy sugar found on N-linked glycans that appears on the cell surface of mammalian and plant cells. D-Fucose is also the building block of fucoidan polysaccharide, an sulfated polysaccharide found in various species of brown algae.<br>References Becker, D.J., et al.: Glycobiol., 13, 41 (2003); Denkova, R., et al.: Food. Environ. Safe., 11, 5 (2012); Janathan, M.C., et al.: Carb. Poly., 93, 232 (2013);<br></p>

<p>Applications (+)-Betulonic Acid shows potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines.<br>References Liu, M., et. al.: Molecules, 17, 6156 (2012)<br></p>

<p>Applications N-Benzyloxycarbonyl-D-serine is D-serine (S270975) with amine protected from eletrophiles by carboxybenzyl group in organic synthesis. N-Benzyloxycarbonyl-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>

<p>Applications S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.<br>References Mougenot, P., et la.: Bioorg. Med. Chem. Lett., 22, 2497 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Itaconic acid is an unsaturated dicarbonic acid that is used as a comonomer in resins, synthetic fibers, and rubbers. Itaconic acid is naturally biosynthesized by Aspergillus terreus, but is also synthesized in a macroscale basis from sugars.<br>References Okabe, M., et al.: Appl. Microbiol. Biot., 84, 597 (2009); Wilke, T., et al.: Appl. Microbiol. Biot., 56, 289 (2001)<br></p>

<p>Applications Used in the crosslinking of intracellular proteins prior to cell lysis.<br></p>

<p>Applications (2S)-2-[[(phenylmethoxy)carbonyl]amino]-4-Pentenoic acid is a useful building block, and has been used in the regioselective preparation of nonracemic silylated amino acids.<br>References Marchand, D.; et al.: Eur. J. Org. Chem., 18, 3107 (2008).<br></p>

<p>Applications Used for the synthesis of carboxyalkyl peptides as inhibitors of angiotensin-converting enzyme of human blood serum.<br>References Anderson, A., et al.: Chem. Biol., 8, 445 (2001), Claussen, H., et al.: J. Mol. Biol., 308, 377 (2001), Sherman, W., et al.: J. Med. Chem., 49, 534 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications 1-Myristoyl-3-chloropropanediol is a MCPD fatty acid ester found in a variety of vegetable oils.<br>References Velisek, J., et al.: J. Agric. Food Chem., 28, 1142 (1980), Zelinkova, Z., et al.: Food Addit. Contam., 23, 1290 (2006), Weisshaar, R., et al.: Eur. J. Lipid Sci. Technol., 110, 183 (2008),<br></p>

<p>Applications Glyceryl derivative.<br></p>

<p>Applications 3-Aminobenzoic-d4 Acid (A591492) derivative. It increases attractiveness when combines with sex pheromones.<br>References Maekawa, M. et al.: Appl. Entomol. Zool., 34, 9 (1999)<br></p>

<p>Applications 3-Nitro-1,8-naphthalic anhydride is a reagent used to synthesize a monoboronic acid fluorescent sensor that exhibits emission suitable for ratiometric testing and also displays sensitivity for glucose relative to fructose and galactose. 3-Nitro-1,8-naphthalic anhydride is also used as a starting reagent in the synthesis of 5-substituted naphthalimide derivatives which exhibit high anti-cancer activity.<br>References Haishi, C., et al.: Org. Lett., 4, 1503 (2002); Ingrassia, L., et al.: Curr. Med. Chem., 16, 1192 (2009);<br></p>

<p>Applications 8-Bromoguanosine (cas# 4016-63-1) is a compound useful in organic synthesis.<br>References Hu, H., et al.: Mol. Pharmacol., 69, 1542 (2006), Mallett, D., et al.: J. Pharm. Biomed. Anal., 49, 100 (2009),<br></p>

<p>Applications Leccinine A analogue. Used in the preparation of pyridine derivatives as peptidomimetic inhibitors and antiviral agents.<br>References Klossowski, S. et al.; J. Med. Chem. 55, 55 (2012); Choi, J. et al.; Tetrahedron 67, 6649 (2011)<br></p>

<p>Applications GLUTARONITRILE (cas# 544-13-8) is a useful research chemical.<br></p>

<p>Applications Triglyme could be a useful component for absorption refrigeration based on better environmental, health, and safety properties.<br>References Papadopoulos, A. I., et al.: Energy Convers. Manag., 223, 113262 (2020)<br></p>

<p>Applications Bradykinin Acetate elicits vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane.<br>References Wiegershausen, B., Klausch, B.: Experientia, 23, 29 (1967)<br></p>

<p>Applications L-Thyronine is a type of thyroid hormone. Thyroid hormones are important regulators of growth and maturation before birth in mammals.<br>References Harris, Shelley E., et al.: J. Physiol., 595, 3331 (2017);<br></p>

<p>Applications 3-Nitro-4-toluidine (cas# 119-32-4) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing<br></p>

<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.<br>References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)<br></p>

<p>Applications Acetyl-L-phenylalanine ethyl ester is a derivative of L-Phenylalanine (P319415), a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. Acetyl-L-phenylalanine ethyl ester is also used to inhibit pepsin-catalyzed reactions.<br>References Auer, H. &amp; Doty, P.: Biochemistry, 5, 1708 (1966); Birkmayer, W., et al.: J. Neural Transm., 59, 81 (1984); Borison, R., et al.: Res. Commun. Chem. Path., 21, 363 (1978); Kitson, T., et al.: Biochem. J., 122, 241 (1971)<br></p>

<p>Applications Intermediate in the preparation of Ximelagatran.<br>References Thorstensson, F., et al.: Bioorg. Med. Chem., 15, 827 (2007), Nilsson, M., et al.: J. Med. Chem., 52, 2708 (2009),<br></p>

<p>Applications Used in the synthesis of peptides containing histidine and lysine.<br>References Bizzozero, S., et al.: Eur. J. Biochem., 122, 251 (1982), Schellenberger, V., et al.: Biochim. Biophys Acta., 869, 54 (1986), Jakubke, H., et al.: Biol. Chem., 377, 455 (1996),<br></p>

<p>Applications Amberlites IRA-402 Chloride is used in purifying organic compounds using ion exchange resin. Also, used in preparation method of Cyclic Polyethylene Glycol.<br>References Paiocchi, M., et al.: Ital. Appl., (1995); Yan, Z., et al.: Faming Zhuanli Shenqing, (2018);<br></p>

<p>Applications A hydrophobic fluoresent probe that shows intramolecular excimer fluorescence (intensity IE) in competition with fluorescence from locally excited pyrene chromophore (monomer emission, intensity IM). Has been used to investigate the fluidity and micropolarity of the polymeric micelles that exist in aqueous solutions of copolymers of N-isopropylacrylamide and other acrylamides. A useful tool for studying hydrophobic microenvironments.Fluorescence: max. Abs. l = 345, max. Em. l = 490 (in aqueous poly(N-isopropylacrylamide PNIPAM)<br>References Winnik, F.M., et al.: J. Phys. Chem., 95, 2583 (1991), Nivaggioli, T., et al.: Langmuir, 11, 119 (1995)<br></p>

<p>Applications 4-CHLORO-2-NITRODIPHENYLAMINE (cas# 16611-15-7) is a useful research chemical.<br></p>

<p>Applications (all-Z)-2-(6,9,12,15,18-Heneicosapentaenyl)-4,5-dihydro-4,4-dimethyl-oxazole is a useful starting material for organic synthesis.<br></p>

<p>Applications 1-[(4-methylphenyl)sulfonyl]proline (cas# 51077-01-1) is a useful research chemical.<br></p>

<p>Applications Biuret is used as a source of non-protein nitrogen in feed for ruminant. It is an impurity of urea based fertilizers as it has a poisonous effect on plants if present in high concentrations. Like peptide bonds, biuret forms violet-colored complexes with copper(II) ion in alkaline solution. This color change response is used to identify and quantify protein concentration (due to peptides present) and is known as biuret test.<br>References Li, J., et al.: Siliao Yanjiu, 1, 53 (2008); Kaasenbrood, P., et al.: J. Agr. Food. Chem.., 11, 39 (1963); Jayle, M., et al.: B. Soc. Chim. Biol., 33, 881 (1951);<br></p>

<p>Stability Light Sensitive<br>Applications Linolenic Acid Ethyl Ester is the ethyl ester derivative of Linolenic Acid (L467650); an essential fatty acid that occurs mostly as the glyceride in most drying oils. Also a nutrient.<br>References Folch, J., et al.: J. Biol. Chem., 226, 497 (1957); Orban, E., et al.: J. Food Sci., 68, 128 (2003); Tritt, K., et al.: J. Agric. Food Chem., 53, 5304 (2005)<br></p>

<p>Applications Phenylsuccinic Acid (cas# 635-51-8) is a useful research chemical.<br></p>

<p>Impurity Capecitabine 3-O-BDR Impurity (USP)<br>Applications Capecitabine (C175650) impurity. Capecitabine 3-O-BDR Impurity (USP).<br></p>

<p>Applications N-Fmoc-L-alanine-d4 is the isotope labelled analog of N-Fmoc-L-alanine (F619945); the Fmoc-protected form of L-Alanine (A481500). L-Alanine is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development and is one of the 20 amino acids encoded by the genetic code.<br>References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)<br></p>

<p>Applications A sulfhydryl and carbohydrate reactive, heterobifunctional crosslinking reagent.<br></p>

<p>Applications N-[(1,1-Dimethylethoxy)carbonyl]glycine-2,2-d2 is a reagent in the identification of a ERα17p, a peptide reproducing the hinge region of the estrogen receptor α, which exerts pharmacological efffects in breast cancer cells.<br>References Byrne, C., et al.: Steroids, 77, 979-987 (2012)<br></p>

<p>Applications Protected 2-Thiouridine.<br>References El-Tayeb, A., et al.: J. Med. Chem., 49, 7076 (2006),<br></p>

<p>Applications A metabolite of Thymidine (T412000). Also, a Thymidine (T412000) analogue as phosphate donor.<br>References Lyu, B., et al.: Anal. Biochem., 220, 410 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications Nonanoyl Coenzyme A Sodium Salt, plays a key role as an acyl-CoA enzyme that metabolizes fatty acids, participating in their dehydrogenation.<br>References Ensenauer, R. et al.: J. Biol. Chem., 280, 32309 (2005); Hu, L. et al.: PLoS One, 6, e29491 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Guanosine-5'-triphosphate Disodium Salt is one the substances used in GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity for the study of GTP-binding proteins.<br>References George C., et al.: J. Am. Chem. Soc., 135, 4676 (2013)<br></p>

<p>Applications D-Glutamic Acid 1,5-Dimethyl Ester Hydrochloride, is a diester analogue of D-Glutamic Acid (G596965), a non-essential amino acid. It can also be used for the synthesis of more complex pharmaceutical compounds.<br>References McEntee, W. et al.: Psychopharmacology, 111, 391 (1993); Manev, H. et al.: Mol. Pharmacol., 36, 106 (1989);<br></p>

<p>Stability Air Sensitive<br>Applications N-Acetyl-D-cysteine is an isomer of N-Acetyl Cysteine which can act as a radioprotectant against many aspects of oxidative damage due to high dose irradiation.<br>References Neal, R., et al.: Free Radic. Biol. Med, 34, 689-695 (2003)<br></p>

<p>Stability Hygroscopic<br>Applications Stavudine Triphosphate Trisodium Salt has a free acid of Stavudine Triphosphate. Stavudine Triphosphate inhibits HIV-1 RT (reverse transcriptase). Stavudine Triphosphate Trisodium Salt is a metabolite of Stavudine.<br>References Vaccaro, J.A., Parnell K.M., Terezakis S.A., Anderson, K.S.: Antimicrob. Agents Ch., 44, 217 (2000)<br></p>