Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

BMS-986165 is a P-glycoprotein (P-gp) inhibitor that has been shown to reduce the absorption of ciclosporin, tacrolimus, and everolimus in vitro. BMS-986165 has an activity index of 100% and inhibits the inflammatory response by inhibiting the production of cytokines. It has been found to be effective for treating bowel diseases, such as ulcerative colitis and Crohn's disease. The drug also may be used for the treatment of autoimmune diseases, such as psoriasis or rheumatoid arthritis. BMS-986165 is administered orally and is rapidly absorbed. It is metabolized by CYP3A4 and excreted in urine as metabolites. END>> END>>

<p>3,6-Dichloropicolinonitrile is a peroxide that is used in the synthesis of organic compounds. It is produced by the reaction of sodium carbonate and hydrochloric acid with nitric acid as a catalyst. 3,6-Dichloropicolinonitrile has been shown to be more selective than other oxidizing agents such as hydrogen peroxide and potassium permanganate. The product can then be purified by adding diacetate, which selectively reacts with the chlorine to form acetyl chloride and glycolic acid. The resulting mixture can then be distilled to produce 3,6-dichloropicolinonitrile in high purity. 3,6-Dichloropicolinonitrile can also be used in electrochemical methods for the synthesis of cyanides or biochemically for virulent products such as pesticides and organic solvents.</p>

<p>Nerol oxide is a natural compound and fragrance ingredient that has been shown to have anti-aging effects. Nerol oxide is an ester of citronellal, nerolic acid and ethyl decanoate. It is found naturally in orange blossoms and other citrus plants, as well as in lavender oil. Nerol oxide can be extracted from the plant material using solid phase microextraction. The chemical analyses of this extract reveal the presence of various fatty acids, including ethyl esters, fatty acids and their corresponding alcohols. These compounds are used to produce nerol oxide by polymerization with an initiator such as potassium hydroxide or sodium hydroxide at a neutral pH.</p>

<p>Dimethyl pyridine-3,4-dicarboxylate is an organic compound that is used as a precursor to make other chemicals. It is a pyridinedicarboxylic acid and it can be synthesized from the reduction of pyridine with sodium borohydride in ethanol. Dimethyl pyridine-3,4-dicarboxylate is also used in the production of acetaldehyde by way of hydrosilylation with chloride and chloroform. This chemical has been found to be useful for the synthesis of various drugs such as antiepileptics, antihistamines, antipsychotics, and antidepressants.</p>

<p>Versatile small molecule scaffold</p>

<p>Chromane-2-carboxylic acid is an amide with a hydroxy group that has inhibitory effects on alkoxyphenols. It has been shown to have the ability to inhibit the growth of cancer cells in mammalian tissue and has been used in synthesizing nitro compounds. Chromane-2-carboxylic acid also inhibits matrix metalloproteinases, which are enzymes that break down proteins in the extracellular matrix and are associated with tumor invasion and metastasis. This compound also has radical scavenging activities, which may be due to its ability to form hydrogen bonds or intramolecular hydrogen bonds with aromatic hydrocarbons or fatty acids.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromophenyl-2-hydroxyacetic acid is a ligand that binds to the ethylene receptor in plants and can be used as a monomer for the polymerization of polyethylene. It has been shown that 2-bromophenyl-2-hydroxyacetic acid can also be used as an initiator for the polymerization of β-cyclodextrin. This compound has also been shown to be an analyte in gas chromatography, which is used to separate compounds based on their chemical properties. The use of this compound as a tethering agent has also been investigated with copolymerization reactions in order to create more stable polymers. 2-Bromophenyl-2-hydroxyacetic acid has been found to inhibit nonsteroidal antiinflammatory drugs and may have potential applications for chiral synthesis, such as mandelic acid production.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 5-hexynoate is a synthetic product that can be synthesized from soybean lipoxygenase and hydrogenation reduction. This product has been shown to be a useful synthon for the synthesis of monoclonal antibodies with high binding affinity. The synthetic pathway, which involves cross-coupling and asymmetric synthesis, is outlined in the diagram below. The following are the steps involved in the production of methyl 5-hexynoate: 1) Addition of ethyl bromide to terminal alkynes 2) Addition of hydrochloric acid 3) Reaction with potassium tert-butoxide 4) Hydrogenation reduction 5) Cross-coupling reaction 6) Asymmetric synthesis</p>

<p>Ferrocenylmethyl methacrylate is a reactive, irreversible oxidation agent. It is used in the synthesis of hydroxylated polymers and redox-active biological sensors. Ferrocenylmethyl methacrylate has been used as a component in polymerization reactions to produce polymers with recording potential. It has also been used for the detection of cancer cells and for the diagnosis of prostate cancer.</p>

<p>4-Bromo-2,5-dimethoxybenzaldehyde is a nucleophilic compound that can act as an iminium. It is used in the synthesis of chalcones, which are aromatic compounds that have been found to have anticancer properties. 4-Bromo-2,5-dimethoxybenzaldehyde has two isomers: 2,4-dimethoxybenzaldehyde and 2,5-dimethoxybenzaldehyde. The separation of these compounds can be achieved using chromatography with a silica gel column. This process can be done on both the mixture of the two isomers or on one specific isomer. The synthetic pathway for this product begins with benzylpiperazine and piperazine. These two molecules react to form 3,4-dichlorobenzylpiperazine, which reacts with dimethoxybenzyl chloride to form 4-bromo-2,5-dim</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Dimethoxyisonicotinic acid is a cytotoxic agent that is structurally related to colchicine and combretastatin A-4. It has been shown to induce apoptosis in cancer cells by inhibiting the polymerization of tubulin. This drug also inhibits the proliferation of cancer cells by binding to DNA and disrupting the synthesis of proteins necessary for cell division. The inhibitory effect on protein synthesis may be due to its ability to inhibit the activity of RNA polymerase II and III, which are essential for transcription. 2,6-Dimethoxyisonicotinic acid also induces an anticancer effect through its ability to bind to phenolic moieties and inhibit the growth of cancer cells.</p>

<p>8-Quinolinesulfonyl chloride (8QSC) is a quinoline derivative that has been shown to have anticancer activity. 8QSC binds to the receptor site of cells and inhibits the production of amines, which are important for cell growth and proliferation. It also binds to hydrogen bonds, which may be involved in the cytotoxicity observed in pancreatic cancer cells. 8QSC shows significant cytotoxicity against Panc-1 cells, but not against NIH 3T3 cells. This may be due to its ability to form supramolecular aggregates with copper ions and quinoline derivatives.</p>

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<p>Polycarbosilane is a cross-linking agent that can be used to modify the surface properties of polymers. It reacts with the hydroxyl groups on the polymer to form carbosilane bonds, which lead to a change in the viscosity and other physical properties of the material. Polycarbosilane is insoluble in water and has an absorption peak at 350 nm. When reacted with argon gas, polycarbosilane reacts with oxygen or nitrogen to produce carbonyls or amines, respectively. Polycarbosilane can react with x-rays or magnetic resonance spectroscopy to produce elemental analysis data for a variety of elements. This chemical also has optical properties that make it useful as an organic solution for optical devices such as lenses and mirrors. Polycarbosilane is stable under most conditions and can be used as an efficient method for environmental pollution control by removing heavy metals from wastewater streams.</p>

<p>Pyrazin-2-ylboronic acid is a white crystalline solid that is soluble in water. It is an efficient and economical selenium source for use in the synthesis of selenides and other selenium compounds. Pyrazin-2-ylboronic acid can be produced by the reaction of aniline with borohydride, or by the reaction of pyrazine with borane. This synthetic process also provides a convenient way to produce diaryl compounds.</p>

Bioavailable form of vitamin B6; coenzyme; food supplement

<p>2,2-Paracyclophane is a high-sensitivity c-reactive protein (hsCRP) that has been isolated from the fungus Cryptococcus neoformans. This compound has shown to have anti-cancer properties in animal studies. 2,2-Paracyclophane binds to fatty acids and is soluble in water, which may be due to its hydrogen bonding with the hydroxyl group at C1. The crystal structure of this compound reveals that it has a cyclohexane ring and two fatty acids. The thermal expansion coefficient of this molecule is also high, which suggests that it may be suitable for use as a solid lubricant.</p>

<p>Pyridine-2-aldehyde is a stable complex that can be synthesized using the asymmetric synthesis of ethylene diamine and picolinic acid. The solid catalyst is the copper chloride, which coordinates to two nitrogen atoms in the pyridine ring. The coordination geometry is octahedral. Pyridine-2-aldehyde has been shown to react with copper complexes to form stable complexes, as well as undergoing kinetic reactions with metal carbonyls. Pyridine-2-aldehyde has also demonstrated analytical chemistry properties by reacting with picolinic acid to form a picolinic acid derivative.</p>

<p>Pyridine-2-aldoxime is a chemical compound that is used as a pesticide. It is an inhibitor of acetylcholinesterase, and it can be toxic at low doses. Pyridine-2-aldoxime binds to the active site of acetylcholinesterase and prevents the breakdown of acetylcholine by this enzyme, leading to paralysis of the respiratory muscles. Pyridine-2-aldoxime has been shown to be effective against chronic oral exposure to sarin gas, with lethal dose (LD) values ranging from 0.5–1 mg/kg in rats.</p>

<p>(Oc-6-21)-(4-Bromophenyl)Pentafluoro-Sulfur is the chemical compound with the formula BrSbF5. It is a yellow solid that is soluble in organic solvents. The molecule consists of a pentafluorothiophenium cation and a bromine anion. It has two regioisomers, one with the sulfur atom in the 4 position and one with it in the 6 position. The compound has been studied as a precursor to polythiophene, which can be synthesized by heating BrSbF5 with sulfur dichloride.</p>

<p>4-Methylenepiperidine hydrochloride is a synthetic, ethylene oxide derivative that is used as an antifungal drug. It is also used in the synthesis of other compounds and as a reagent in organic chemistry. 4-Methylenepiperidine hydrochloride can be synthesized by reacting ethylene with an alkoxide, followed by adding a metal halide such as organolithium reagents to form the desired product. The yield rate of this reaction is high and it is easy to perform on a large scale.</p>

<p>2-Mercapto-N-methylbenzamide is a synthetic compound that has been shown to have inhibitory activities against activated brain cells and cell lines. This drug has been used in the synthesis of axitinib, a cancer drug that inhibits cellular growth. 2-Mercapto-N-methylbenzamide is also used as a preservative in cosmetics and can be found in carbonated drinks and foods. It has been shown to inhibit the production of serotonin in microbicidal reactions by inhibiting the enzyme hydroxymethyl transferase, which catalyzes the conversion of 5-hydroxytryptophan to serotonin. It also prevents the reaction products from being formed by reacting with hypoxanthine, xanthine, and phosphoribosyl pyrophosphate (PRPP). 2-Mercapto-N-methylbenzamide also reacts with plasma samples to form ethylmercaptoacetate, which is then oxidized to merc</p>

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<p>Please enquire for more information about Methyl 2-Bromo-5-iodobenzoate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Methanesulfonato(diadamantyl-n-butylphosphino)-2'-amino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Mercaptopyridine is a quinone that has been used as an inhibitor of the HIV reverse transcriptase enzyme. It binds to the active site of the enzyme and inhibits its activity by forming a stable covalent bond with two cysteine residues in the enzyme. The molecule is stabilized by two adjacent sulfide bonds, which form a six-membered ring with three nitrogen atoms and one oxygen atom. This ring coordinates to the zinc ion in the active site of the enzyme. 2-Mercaptopyridine has also been found to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. 2-Mercaptopyridine binds to DNA at positions where it is complementary to guanine or adenine nucleotides, thus preventing RNA synthesis and replication.</p>

<p>8-Chlorotetrazolo[1,5-A]pyrazine is a chlorine-containing compound. It is a heterocyclic aromatic organic compound and an important intermediate in the synthesis of other compounds. 8-Chlorotetrazolo[1,5-A]pyrazine is not found in nature. The elimination of chlorine from 8-chlorotetrazolo[1,5-A]pyrazine produces benzotriazole and the molecule tetrazole. 8-Chlorotetrazolo[1,5-A]pyrazine is used as a raw material for many organic syntheses.</p>

<p>Cbznh-PEG3-OH is a pegylation product that belongs to the family of PEG products. It is a derivative of Cbz-NH-PEG5-OH and Cbz-N-PEG5-OH, which are carboxybenzyl amido PEG compounds. Pegylation is the process of attaching polyethylene glycol (PEG) chains to molecules, such as proteins or drugs, to enhance their stability, solubility, and bioavailability. Cbznh-PEG3-OH can be used in various applications, including drug delivery systems, diagnostics, and biotechnology. Its unique chemical structure allows for precise control over the size and properties of the PEG chains, making it a versatile tool in the field of biomedical research.</p>

<p>(S)-2-Methylpiperidine hydrochloride is a synthetic reagent that can be used in asymmetric synthesis. It is a homochiral amide that can be used as a reagent for the efficient preparation of β-unsaturated piperidines. (S)-2-Methylpiperidine hydrochloride can be synthesized from a Grignard reaction with an aldehyde, which is an important chemical reaction in organic chemistry.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Indol-2-ylmethanol is a model compound for the synthesis of bioactive molecules. It is used in biological studies as an inhibitor of chronic lymphocytic leukemia, heart disease, and inflammatory pain. The nitro group on 1H-Indol-2-ylmethanol has been shown to activate various enzymes involved in the inflammatory response. The hydroxy group on 1H-Indol-2-ylmethanol has been shown to inhibit cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins that cause inflammation.</p>

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<p>Isononyl alcohol is a polycarboxylic acid that has been used in the treatment of skin conditions, such as atopic dermatitis and psoriasis. It has been shown to penetrate the skin and stimulate the production of sebum. Isononyl alcohol is also used as a plasticizer for polyvinyl chloride (PVC) and other plastics, which increases their flexibility. This chemical also has a hydrophobic effect, which may be due to its hydroxyl group. The unsaturated alkyl chain on this chemical also makes it susceptible to oxidation by ozone in air and water vapor in air. Isononyl alcohol is metabolized by humans through conjugation with glucuronic acid or sulfate esters.</p>

<p>3-Bromofuran-2-carbaldehyde is a chemical compound that belongs to the group of carbonyl compounds. It is an acetylated form of 3-bromofuran and its molecular formula is C6H5BrO. This chemical contains a carbonyl group, which reacts with the hydroxyl group in epidermal growth factor (EGF) to produce epidermal growth. 3-Bromofuran-2-carbaldehyde has been shown to be an adrenergic receptor agonist and can be used as a structural formula blocker or hydrochloric acid. The chemical can also be synthesized in acidic conditions using methods such as fluorination, chlorination, and acetylation.</p>

<p>2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine is an alkaloid compound that has various applications in research and chemical studies. It has been found to interact with dopamine receptors and exhibit photothermal properties. This compound has been studied in the context of G. lucidum (also known as Reishi mushroom) and its potential therapeutic effects. Additionally, it has shown interactions with quinpirole, lithium, ergovaline, efrotomycin, and other compounds. The photocatalytic and fatty acid properties of 2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine make it a versatile compound for various research purposes.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Please enquire for more information about 8-Methylnonan-1-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl acetate is a reactive intermediate that can be used as a starting material for the synthesis of other organic compounds. It is synthesized by the reaction of an acid with an aldehyde or ketone in the presence of a base. The rate of this reaction depends on the functional groups present in both reactants and their relative concentrations. This intermediate can be converted to another chemical compound through various reactions, including hydroxymethylation, decarboxylation and oxidation. This chemical has been used as a cocatalyst for the production of 5-hydroxymethylfurfural (HMF).</p>

<p>6-Chloro-2-methyl-4-pyrimidinol is an aldehyde that reacts with hydrazine to form a monoxide, which reacts with carbon monoxide to form a hydrazide.</p>

<p>3,3-Diethoxypropan-1-amine is a synthetic drug that reversibly inhibits the growth of bacteria. It has been shown to be effective against methicillin resistant strains of Staphylococcus aureus and Clostridium perfringens, with no detectable activity against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. 3,3-Diethoxypropan-1-amine is a heterobifunctional compound that binds to epidermal growth factor with high affinity. 3,3-Diethoxypropan-1-amine can also bind to collagen and liposomal formulations, which may be useful for the treatment of wounds. This drug has been shown to inhibit δ opioid receptors in mice and rats, which is thought to contribute to its analgesic effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl N-(4-methylphenyl)carbamate is a reusable, efficient method for the synthesis of tert-butyl carbamates from amines and carbon dioxide. This reaction is an example of a C–H bond activation that proceeds through an anion intermediate. The reaction time can be reduced by irradiation to increase the efficiency. Electrons are unpaired during this process, which is modeled with quantum mechanics software. Chloride is used as a catalyst to activate the electron and generate a reactive intermediate. Amine functionalities are added to the molecule in order to give it desired properties. The chloride group can be replaced with other anions such as bromide or iodide, which will also introduce different reactivity patterns.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethanol is a congener that belongs to the class of monoclonal antibodies. It is a degradable and photophysical agent that enhances ionotropic gelation and proton exchange in an acidic environment. This agent has been shown to react with nucleophilic groups, such as amines and thiols, and has fluorescence properties that are sensitive to pH changes. The reactive nature of this compound makes it useful for the localization of model proteins in analytical chemistry experiments.</p>

<p>Versatile small molecule scaffold</p>

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is an environmental and industrial chemical that is used as a formate, benzoate, and methyl benzoate intermediate. It reacts with nitric acid to form N-(4-aminophenyl)-N-methyl-2-(4-nitrophenoxy)acetamide (NPA). NPA has been shown to have antiangiogenic properties. NPA inhibits the proliferation of endothelial cells by interfering with the cell cycle and inducing apoptosis.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Bis(trifluoromethyl)-1H-pyrazole-4-carboxylic acid is a chiral compound that has been shown to be an active building block for coordination frameworks. It is prepared from the reaction of 3,5-bis(trifluoromethyl)-1H-pyrazole with a carboxylic acid and can be used in the synthesis of metalloporphyrins. 3,5-Bis(trifluoromethyl)-1H-pyrazole-4-carboxylic acid has been shown to form stable coordination complexes with ligands such as bidentate or tridentate phosphoramidites and dimethylammonium chloride. This compound undergoes thermal treatment during the preparation process and reacts with various solvents and reagents.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(4-(tert-Butoxy)phenyl)methanamine (BPMT) is a ligand that binds to the alpha-2 receptor and acts as an antagonist. This compound has been shown to be a molecular target for positron emission tomography imaging, which is used in the diagnosis of tumours. BPMT is also used in the treatment of neuropeptide-associated disorders such as Parkinson's disease. The chiral nature of this compound makes it useful for the production of radiopharmaceuticals and other diagnostic agents with different physical properties.</p>

<p>Trans-3-(Benzyloxy)cyclobutanol is a radiolabeled compound that is used as a model system for understanding the metabolism of drugs in humans. It has been shown to be metabolized by the liver to produce metabolites that are excreted in urine. Trans-3-(Benzyloxy)cyclobutanol has also been shown to have tumor cell line stability, which may be due to its ability to inhibit DNA synthesis and protein synthesis in vitro and reduce tumor cells in vivo. Trans-3-(Benzyloxy)cyclobutanol has been shown to have no effect on normal rat plasma and lung carcinoma cells, but does affect prosthetic group activity.</p>

<p>Benzyl N,N,N',N'-tetraisopropylphosphorodiamidite is a reagent that reacts with hydroxybenzyl amine to form an ester. This product is used for the synthesis of phosphoramidites and benzyl esters. It is also used as a catalyst for the synthesis of diesters.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>IR-780 iodide is a water-soluble drug that has been shown to have significant cytotoxicity against prostate cancer cells. It binds to the mitochondrial membrane potential, which is involved in energy production and the regulation of the cell cycle. IR-780 iodide is taken up by tumor cells, where it inhibits adriamycin uptake and induces apoptosis. In vitro assays have shown that IR-780 iodide can be used as a diagnostic tool for detecting bladder cancer by binding to the mitochondria of cells from patients with bladder cancer. In vivo studies have been done in mice to determine the effectiveness of IR-780 iodide in treating cervical cancer. These studies showed that IR-780 iodide was not significantly effective in vivo, due to its low bioavailability and lack of specificity for cervical cancer cells. Histological analysis showed that IR-780 iodide did not inhibit tumor growth or induce apoptosis in vivo.</p>

<p>Versatile small molecule scaffold</p>

<p>Di(1-adamantyl)chlorophosphine is a bifunctional ligand that can be used for the palladium-catalyzed coupling of aryl chlorides and amines. Di(1-adamantyl)chlorophosphine is synthesized from adamantane, phosphorous pentachloride, and anhydrous ammonia in the presence of catalytic amounts of palladium. Di(1-adamantyl)chlorophosphine is immobilized on silica gel to prevent hydrolysis. This ligand reacts with primary amines to form iminophosphoranes, which can then be reacted with aryl chlorides to form aryl chloroamines.</p>