Acids and Synthetic Reagents

<p>Applications AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.<br>References Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007), Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications 9-Mesityl-10-methylacridinium Tetrafluoroborate can be used for the synthesis of γ-butyrolactones, γ-lactams and pyrrolidines. 9-Mesityl-10-methylacridinium Tetrafluoroborate has been reported by Nicewicz et al. to mediate myriad transformations through Photoredox Catalysis. The applications include the anti-Markovnikov hydroamination of alkenes and addition of carboxylic acids to alkenes and the hydrotrifluoromethylation of styrenes using the Langlois reagent S673690.<br>References Gesmundo, N. J. et al.: Org. Lett. 17, 1316 (2015); Zeller, M. A., et al.: Org. Lett. 16, 4810 (2014); Nicewicz et al., J. Am. Chem. Soc., 135 (26), 9588–9591(2013)<br></p>

<p>Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.<br>References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);<br></p>

<p>Applications Lithium Trifluoromethylsulfonate has been shown to improve the cycling performance of lithium-oxygen batteries.<br>References Nasybulin, E., et. al.: J. Phys. Chem. C, 117, 2635 (2013)<br></p>

<p>Applications Zinc Acetate is used in biological studies and pharmacological activity of motexafin gadolinium disruptions of zinc metabolism in human cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Magda, D., et al.: Cancer Res., 65, 3837 (2005);<br></p>

<p>Applications 4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2'-deoxyinosine-containing oligodeoxyribonucleotide duplexes.<br>References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012); Acedo, M., et al.: J. Org. Chem., 60, 6262 (1995)<br></p>

<p>Applications Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.<br>References Duska, L. et al.: Gynecol. Oncol., 135, 44 (2014); Deeken, J. et al.: Cancer Chemother. Pharmacol., 73, 1071 (2014);<br></p>

<p>Impurity Atomoxetine EP Impurity C<br>Applications p-Methyl Atomoxetine Hydrochloride (Atomoxetine EP Impurity C) is an impurity of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications Synthetic pentasaccharide corresponding to the anti-thrombin binding site of heparin. Anti-thrombotic.<br>References Herbert, J.M., et al.: Cardiovasc. Drug Rev., 15, 1 (1997), Turpie, A.G.G., et al.: Expert Opin. Drug Saf., 4, 707 (2005),<br></p>

<p>Applications 4-Bromophenylhydrazine Hydrochloride is a reactant in the synthesis of fluoro substituted novel pyrazolylpyrazolines scaffold with antibacterial activity, antituberculosis activity against Mycobacterium tuberculosis H37Rv and antimalarial activity against Plasmodium falciparum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Karad, S.C., et. al.: Eur. J. Med. Chem., 84, 51 (2014)<br></p>

<p>Applications Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.<br>References Rosen, L., et al.: J. Clin. Oncol., 25, 2369 (2007), Sherman, S., et al.: New Engl. J. Med., 359, 31 (2008),<br></p>

<p>Applications Thromboxane A2-receptor antagonist. Antiasthmatic.<br>References Hussein, Z., et al.: Clin. Pharmacol. Ther., 55, 441 (1994),<br></p>

<p>Applications A 5-HT3 receptor antagonist and used as an antiemetic (1,2).<br>References (1) Sato, N., et al.: Japan J. Pharmacol., 59, 443 (1992) (2) Haga, K., et al.: Japan J. Pharmacol., 63, 377 (1993)<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications 3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, S. et al.: Bioorg. Med, Chem., 12, 3017 (2004); Balderamos, M. et al.: Exp. Biol. Med., 233, 1395 (2008);<br></p>

<p>Applications Chiral ligand for metal mediated asymmetric catalysis.<br>References Inui, Y., et al.: Chem. Pharm. Bull., 57, 1158 (2009), Lam, K., et al.: Eur. J. Med. Chem., 45, 5527 (2010),<br></p>

<p>Applications 2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metzner, J. et al.: Pharmazie, 36, 368 (1981); Galal, S.A&gt; et al.: Eur. J. Med. Chem., 46, 327 (2011);<br></p>

<p>Applications 2,6-Dichloro-1,4-benzoquinone is a disinfection byproduct in drinking water and a halobenzoquinone (HBQ) that has been reported to be cytotoxic to T24 bladder cancer cells.<br>References Huang, H., et al.: Huanjing Yu Jiankang Zazhi, 31, 471 (2014); Du, H., et al.: Environ. Sci. Technol., 47, 2823 (2013)<br></p>

<p>Applications Phosphorothioic Acid Trisodium Salt Hydrate can be involved in reactions of alkali hexafluoroaluminates.<br>References Bukhalova, G. A., et al.: Issled. v Obl. Khim. i Technol. Mineral'n. Solei i Okislov, Akad. Nauk SSSR, Sb. Statei, 124 (1965)<br></p>

<p>Applications 4-​Methoxy-​6-​methyl-​2H-​pyran-​2-​one acts as a potential selective agonist for the ghrelin receptor (GHS-​R1a), a receptor which plays in a role in appetite.<br>References Pastor-Cavada, E., et al.: Sci. Rep., 6, 36456 (2016);<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications 3'-Bromoacetophenone is a chemical reagent used in the synthesis of chalcone derivatives as anti-cancer agents. Also used in the preparation of biphenyl pyridazinone deriatives as PDE4 inhibitors in anti-inflammatory treatments.<br>References Madhavi, S. et al.: Lett. Org. 13, 682 (2016); Gracia, J. et al.: J. Med. Chem., 59, 10479 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Niperoditine is a H2 antagonists used in the treatment intestinal disorders.<br>References Mannino, S. et al.: Pharmacoepidemiol. Drug Safety, 7, 233 (1998); Miyaji, Y. et al.: Bioanalysis., 4, 263 (2012);<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications 1,1,3,3-Tetramethyldisiloxane is an organosilane reducing agent and can be used in several reduction reactions including reductive formation of sulfides and reductive etherification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesti, J., et al.: Org. Process Res. Dev., pages ahead of print (2016);<br></p>

<p>Applications 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)-β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and TGF-β2-induced endothelial cell differentiation in iPSCs (1,2).<br>References (1) Jinnin, M., et al. Mol.Pharmacol. 69 597 (2006). (2) Di Bernardini, M., et al.: J.Biol.Chem. 289 3383 (2014).<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications is an (2S)-2-(Methoxydiphenylmethyl)pyrrolidine intermediate in the synthesis of α-Zingiberene which is a sesquiterpine found in leaf glandular trichomes that is currently being evaluated for its cytotoxicity towards human tumour cell lines.<br>References Bou, D., et al.: Molecules, 18, 9477 (2013); Freitas, J., et al.: Euphytica, 127, 275 (2002)<br></p>

<p>Stability Light Sensitive<br>Applications GFT-505 is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.<br>References Carious, B., et al.: Diabetes Care 36, 2923 (2013); Carious, B., et al.: Diabetes Care 34, 2008 (2011)<br></p>

<p>Applications An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.<br>References Schweppe, R., et al.: J. Clin. Endocrinol., Metab., 94, 2199 (2009), Chen, Y., et al.: Clin. Canc. Res., 15, 3396 (2009), McDermott, U., et al.: Cancer Res., 70, 1625 (2010),<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Applications Di-p-toluoyl-d-tartaric Acid Monohydrate is a useful intermediate in the preparation of chiral rivastigmine hydrogen tartrate.<br>References Feng, J., et al.; Nanfang Yike Daxue Xuebao, 27, 177 (2007)<br></p>

<p>Applications N-Carbobenzyloxy-D-serine-beta-lactone (cas# 98632-91-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Vasodilator (cerebral and peripheral). Neuroprotective agent.<br>References Carron, C., et al.: Arzneim.-Forsch., 21, 1992 (1971),<br></p>

<p>Applications tert-Butyl 4-Hydroxybutanoate is used as a reagent in the synthesis of theranostic vitamin-linker-taxoid conjugates. tert-Butyl 4-Hydroxybutanoate is also used as a reagent in the synthesis of teroxazoles as α-helix mimetics.<br>References Vineberg, J.G., et al.: J. Med. Chem., 58, 2406 (2015); Pinto Gomes, C., et al.: Eur. J. Org. Chem., 2012, 3270 (2012)<br></p>

<p>Applications Dirhodium tetracaprolactamate is an organometallic complex used as a catalyst in the regioselective azidation of arenes.<br>References Wang, Y.; et al.: Org. Lett., 20, 5732 (2018).<br></p>

<p>Applications Magnesium Bromide Hexahydrate is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Applications 2-Acetamido-5-fluorophenylboronic acid, pinacol ester<br></p>

<p>Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.<br>References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;<br></p>

<p>Applications 4-Aminoresorcinol Hydrochloride is a reactant in the preparation of diethers with antiviral activity against group A and B human Rhinoviruses.<br>References Bernard, A.M., et. al.: Bioorg. Med. Chem., 22, 4061 (2014)<br></p>

<p>Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.<br>References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications 1-Bromooctadecane is a reagent in the preparation of branched glycosyl phosphatidyl inositol (GPI) anchors of rat brain Thy-1.<br>References Pekari, K., et al.: J. Org. Chem., 68, 1295 (2003);<br></p>

<p>Stability Light Sensitive<br>Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.<br>References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);<br></p>

<p>Applications (R)-(+)-3-Methylcyclopentanone (cas# 6672-30-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Derivatives of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.<br>References Ji, X., et al.: Drug Dev. Res., 33, 51 (1994), Poulsen, S., et al.: Bioorg. Med. Chem., 6, 619 (1998), Fredholm, B., et al.: Pharmacol. Rev., 53, 527 (2001), Gessi, S., et al.: Clin. Cancer Res., 10, 5895 (2004), Moro, S., et al.: Med. Chem. Res., 26, 131 (2006), Tafi, A., et al.: J. Med. Chem., 49, 4085 (2006),<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Applications Batyl Alcohol is used to synthesize amphiphilic alkylglycerolipids with antitumor activities. It is also used in cosmetic compounds for prevention or treatment of erythema or dermatitis or promotion of wound healing.<br>References Ukawa, K., et al.: Chem. Pharma. Bull., 37, 3277 (1989); Schoenrock, U., et al.: Ger. (1995), DE 4420625 C1 19951102.<br></p>

<p>Applications 1,4-Diazabicyclo[2.2.2]octane is an aliphatic amine that is used as a catalyst in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baghernejad, B.: Eur. J. Chem., 1, No pp. given (2010); Guzonas, D., et al.: Langmuir, 6, 11002 (1990)<br></p>

<p>Applications Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1. Also used in the synthesis of benzobisoxazoles used in the preparation of organic semiconductors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kazmierski, W. et al.: J. Med. Chem., 54, 3756 (2011); Mike, J. et al.: Org. Lett., 10, 4915 (2008);<br></p>

<p>Applications trans-2,5-Dimethylpiperazine is a C-alkyl substituted piperazine used in the preparation of opioid receptor ligands as well as other biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janetka, J.W. et al.: J. Org, Chem., 68, 3976 (2003);<br></p>

<p>Applications Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012) (2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.<br>References Salvadori, S., et al.: Bioorg. Med. Chem., 15, 6876-6881 (2007);<br></p>

<p>Applications 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents.<br>References Gangjee, A. et al.: J. Med. Chem., 52, 4892 (2009); Gangjee, A. et al.: Biiorg. Med. Chem., 18, 953 (2010);<br></p>

<p>Applications (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a bicyclic monoterpene diols that has been shown to induce differentiation of S91 melanoma and PC12 pheochromocytoma cells and thus provide possible therapeutic and sunless tanning use. (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a microbial oxidation product of (-)-β-pinene, a flavor and fragrance monoterpene.<br>References Farooq, A. et al.: Zeitsch. Naturforsch. C J. Biosci., 57, 686 (2002); Brown, D.A. et al.: Pigment Cell Res., 12, 36 (1999);<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>