Acids and Synthetic Reagents

<p>Stability Moisture Sensitive<br>Applications N,N-Dimethylphosphoramidodichloridate functions as a reagent used in the inhibition of acetylcholinestrase and butyryl cholinestrase by nerve agent surrogates. Also, the are used as reagents in the synthesis and in the antitumor activity of nonsymmetric phosphoric acid triamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meek, E. C., et al.: Toxicol. Sci., 126, 525 (2012); Kosykhova, L., et al.: Pharm. Chem., 34, 525 (2000)<br></p>

<p>Applications Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Potent PI3K/mTOR Dual Inhibitor.<br>References Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009), Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009), Pollizzi, K., et al.: Mol. Cancer, 8 (2009),<br></p>

<p>Applications Rhenium Carbonyl, is used as a catalyst and in material science. iIt is also a key starting material used for the synthesis of other rhenium carbonyl complexes. It plays an important role in metathesis, reforming and hydrogenation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kremlev, K. V., et al.: J. Surf. Ingestig.-X-Ray Synchro. 2015, 9 (4), 694-698.; Di, X., et al.: Catal. Sci. Technol. 2015, 5 (4), 2441-2448.;<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications Triphenylsilylamine is used as a reagent to produce 2-Amino-3-hydroxy-indoles with potent in vivo antimalarial activity. Triphenylsilylamine is also used to modify Mo/HZSM-5 catalysts and is predicted to have effects on selectivity in the methane-to-benzene (MTB) reaction.<br>References Kikuchi, S., et al.: J. Catal., 242, 349 (2006); Urgaonkar, S., et al.: Org. Lett., 12, 3998 (2010);<br></p>

<p>Applications BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.<br>References Ouyang, Liang., et al.: J. Med. Chem., 61, 2776 (2018),<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications ML141 is a potent selective reversible non-competitive inhibitor of Rho family GTPase use in the treatment of bacterial infections.<br>References Hong, L. et al.: J. Biol. Chem., 288, 8531 (2013)<br></p>

<p>Applications Ammonium Bromide is used as a bromide activated chloramine biocide for effective control of volatile fatty acids and catalase and biofilm elimination in paper making industry. Also applied in biopharmaceuticals and dosage form designs.<br>References Bharati, S., et al.: Appita J., 56, 426 92003); Torosian, G., et al.: Am. J. Hosp. Pharm., 30, 716 (1973)<br></p>

<p>Stability Hygroscopic<br>Applications Rhodium (II) Acetate Dimer is used in the preparation of molybdenum triisopropylbenzoate isonicotinate which maintains ambivalent properties.<br>References Chisholm, M. et al: Inorg. Chem., 47, 9248 (2008);<br></p>

<p>Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.<br>References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),<br></p>

<p>Applications 1,4,7-triazonane (cas# 4730-54-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Hydrohchloride Salt of α-Aminoacetophenone, used in the preparation og pseudopeptidic inhibitors of human sirtuins1-3. This action effectually displays antiproliferative protperties in cancer cells. Also used in the preparation of dual δ/μopiod receptor agonists in th<br>References Mellini, P. et al.: J. Med. Chem., 56, 6681 (2013); Breslin, H. et al.: Bioorg. Med. Chem. Lett., 22, 4869 (2013);<br></p>

<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Applications Inhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.<br>References Shimomura, K., et al.: J. Biochem., 78, 269 (1975), Ambler, J., et al.: Bioorg. Med. Chem. Lett., 9, 737 (1999),<br></p>

<p>Applications Main metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Harvilchuck, J., et al.: Toxicol. Lett., 183, 28 (2008), Harvilchuck, J., et al.: Toxicol., 264, 171 (2009), Woo, J., et al.: App. Microbiol., Biotechnol., 82, 873 (2009),<br></p>

<p>Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.<br>References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications LE 300 is a potent and selective dopamine receptor antagonist.<br>References Hefnawy, M., et al.: Luminescence, 31, 63-66 (2016)<br></p>

<p>Applications 3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetragedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002);<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications Trifluoromethanesulfonic Acid Magnesium Salt is a strong acid that is used as a catalyst for esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. D., et al.: Chemical Rev., 77, 69 (1977);<br></p>

<p>Applications Bismuth Subnitrate is a compound used in the synthesis of anti-inflammatory and anti-microbial pharmaceuticals for use in mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parker, K.. et al.: J. Dairy, Sci., 91, 169 (2008); Lougheed, K. et al.: Tuberculo., 89, 364 (2009);<br></p>

<p>Applications (S)-(-)-1-(2-Naphthyl)ethanol is a useful biochemical for proteomics research.<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications (R)-Trolox is used in synthesis of vitamin E analogs.<br>References Dong, L., et al.: J. Biol. Chem., 286, 3717 (2011);<br></p>

<p>Applications Rhodium Carbonyl Chloride is a reagent for rhodium-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and carbon monoxide to produce [4+2+1] cycloadducts<br>References Tian, Z.Y., et al.: Angewandte Chemie Int. Ed.’ 57, 15544 (2018)<br></p>

<p>Applications AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).<br>References Zarrinkar, P., et al.: Blood, 114, 2984 (2009); Sato, T., et al.: Blood, 117, 3286 (2011)<br></p>

<p>Applications ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.<br>References Liang, Y., et al.: Sci. Translational Med., 5, 167ra5 (2013)<br></p>

<p>Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);<br></p>

<p>Applications N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.<br>References Obreque, B., et al.: Eur. J. Med. Chem., 109, 124 (2016); Rodriguez-Hernandez, D., et al.: Eur. J. Med. Chem., 105, 57 (2015);<br></p>

<p>Applications Sodium Cyanide is used in the synthesis of antihypertensive agents, such as 2-amino-4-aryl-2-imidazolines. Also used in the synthesis of nonpeptidic cyanamides as potent reversible inhibitors of human cathespins K and L.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matier, W. et al.: J. Med. Chem., 16, 901 (1974); Falgueyret, J. et al.: J. Med. Chem., 44, 94 (2001);<br></p>

<p>Applications SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.<br>References Morris, E. J., et. al.: Cancer Discovery, 3, 742 (2013)<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.<br>References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);<br></p>

<p>Applications (S)-(−)-α,4-Dimethylbenzylamine was used in the study of heterogeneous Raney nickel and cobalt catalysts for racemization and dynamic kinetic resolution of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parvulescu, A., et al.: Adv. Synth. Catal., 350, 113 (2008);<br></p>

<p>Applications Sodium Carbonate, has wide rang of applications. It can be used as a food additive acting as an acidity regulator, anti-caking agent, raising agent, and stabilizer. It is also used widely in the manufacture of glass. Sodium carbonate is also used as a relatively strong base in various settings.<br>References Karaca, H. et al.: Int. J. Food Microbio., 58, 1230 (2014); Merten, G. et al.: J. Am. Med. Addoc., 291, 2328 (2004); Robey, I. et al.: Canc. Res., 69, 2260 (2009);<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications Thromboxane A2-receptor antagonist. Antiasthmatic.<br>References Hussein, Z., et al.: Clin. Pharmacol. Ther., 55, 441 (1994),<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Stability Moisture Sensitive<br>Applications O-Acetylsalicyloyl chloride is used in the derivatisation of amines, and also improve electrochemical detection of these amines when they are run through high-performance liquid chromatography. O-Acetylsalicyloyl chloride is also used as a reagent to synthesize benzimidazole derivatives, compounds that inhibit leukotriene synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banoglu, E., et al.: Bioorg. Med. Chem., 20, 3728 (2012); Smith, R., et al.: J. Chromatogr. A, 455, 349 (1988)<br></p>

<p>Applications A 5-HT3 receptor antagonist and used as an antiemetic (1,2).<br>References (1) Sato, N., et al.: Japan J. Pharmacol., 59, 443 (1992) (2) Haga, K., et al.: Japan J. Pharmacol., 63, 377 (1993)<br></p>

<p>Applications A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Misumi, Y., et al.: J. Biol. Chem., 261 (1986), Mordente, J.A., et al.: J. Urol., 159, 275 (1998), Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999), Nojiri, H., et al.: FEBS Letters, 453, 140 (1999),<br></p>

<p>Applications 1,2-Diformylhydrazine as a bidentate ligand forms 1:1 metal to ligand complexes with transition metals Mn, Zn and Ni. It combines with iron (II) and iron(III) in alkaline conditions to a complex of an intense red-purple color making it a useful reagent in spectrophotometric analysis of iron(II) and iron(III). It was observed that mice were more likely to develop lung tumor when administered 1,2-Diformylhydrazine as a 2% solution.<br>References Nagabhushana, B., et al.: Anal. Bioanal. Chem., 373, 299 (2002); Bhargavi, G., et al.: P. Indian As-chem. Sci., 115, 23 (2003); Toth, B., Z. Krebsforsch. Klin. O., 92, 11 (1978);<br></p>

<p>Applications tert-Butylethyne, is an organic building block used for the synthesis of various pharmaceutical compounds, such as Terbinafine Hydrochloride (T107500), which is a synthetic allylamine antifungal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hadi, V., et al.: Tetrahedron Letters, 50, 2370 (2009); Petranyi, G., et al.: Science, 224, 1239 (1984);<br></p>

<p>Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.<br>References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)<br></p>

<p>Applications Pentadecanoic acid is a saturated fatty acid. Pentadecanoic acid was utilized as a biomarker to examine for the intake of milk fat in relation to its metabolic risk factors. Pentadecanoic Acid that is also produced by certain plant species and acts as an toxic essential oil, which is known to exhibits potential anxiolytic, antinociceptive and antimicrobial properties.<br>References Smedman, A.EM., et al.: Am. J. Clin. Nutr., 69, 22 (1999); Radulovic, N.S., et al.: Food. Chem. Toxiol., 50, 2016 (2012);<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications (2-Bromoethyl)trimethylammonium Bromide (cas# 2758-06-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paetzel, M., et al.: J. Biol. Chem., 272, 9994 (1997), Francavilla, C., et al.: Bioorg. Med. Chem. Lett., 19, 2731 (2009),<br></p>

<p>Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.<br>References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);<br></p>

<p>Applications Brincidofovir is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells. Cytostatic, cytotoxic agent.<br>References Tylden, G. et al.: Antimicrob. Agent. Chemother., 59, 3306 (2015); Cardile, A. et al.: Recent Patents Anti-Infect. Drug DIscov., 9, 97 (2014)<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications 2-(Tributylstannyl)oxazole is a useful reactant in preparation of potent, selective and efficacious reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boger, D., et al.: J. Med. Chem., 48, 1849 (2005);<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.<br>References Guagnano, V., et al.: J. Med. Chem., 54, 7066 (2011); Konecny, G., et al.: Mol. Cancer Ther., 12, 632 (2013)<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.<br>References Stark, H. et al.: J. Med. Chem., 43, 3987 (2000); Mahmood, D. et al.: Pharmacolol. Rep., 64, 191 (2012); Passani, M. et al.: Trends Pharmacol. Sci., 25, 618 (2004);<br></p>

<p>Applications meso-Tetra (N-methyl-4-pyridyl) porphine tetrachloride is a synthetic porphyrin for research use.<br></p>