Lignans

<p>Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal</p>

<p>Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.</p>

Ether phenol

Oxygen-heterocyclic compound

Oxygen-heterocyclic compound

Ether alcohol phenol

Polyphenol

Ether alcohol phenol

Natural glycoside

Natural glycoside

Oxygen-heterocyclic compound

Natural glycoside

Natural glycoside

Ether phenol

Oxygen-heterocyclic compound

Ether phenol

Lactone

Oxygen-heterocyclic compound

Ether alcohol phenol

Oxygen-heterocyclic compound

Natural glycoside

Lactone

Carboxylic acid with additional oxygen functions

Oxygen-heterocyclic compound

Ether alcohol phenol

Oxygen-heterocyclic compound

Lactone

Natural glycoside

Oxygen-heterocyclic compound

Lactone

Natural glycoside

Polyphenol

Compound with non-condensed furan ring

Oxygen-heterocyclic compound

Lactone

Natural glycoside

Oxygen-heterocyclic compound

Ether phenol

Oxygen-heterocyclic compound

Oxygen-heterocyclic compound

Polyphenol

Compound with non-condensed furan ring

Ether phenol

Lactone

Carboxylic acid with additional oxygen functions

Lactone

Carboxylic acid with additional oxygen functions

Natural glycoside

<p>Oxygen-heterocyclic compound</p>

Polyphenol

Natural glycoside

<p>Fargesin is a naturally occurring compound that is a bioactive constituent of Magnolia flowers. It is derived from the dried buds of Magnolia fargesii, a plant traditionally used in herbal medicine. The compound exhibits a mode of action that involves anti-inflammatory and anti-allergic properties. It operates through the inhibition of the release of pro-inflammatory mediators, thereby reducing inflammation and allergic responses.</p>

<p>Honokiol - 98% is a high-purity bioactive compound derived from the bark of Magnolia species. This natural lignan is obtained through advanced extraction and purification techniques to achieve a concentration of 98%, ensuring its efficacy for research and potential therapeutic applications.</p>

<p>Styraxlignolide F is a bioactive compound, which is a sesquiterpene lactone derived from plants of the Styrax genus. These compounds are naturally occurring metabolites known for their structural complexity and diverse biological activities. Styraxlignolide F, in particular, has shown promising potential in the realm of pharmacology.</p>

<p>Magnolol is a bioactive compound, which is a type of lignan extracted from the bark of the magnolia tree, primarily Magnolia officinalis. It exhibits a diverse range of pharmacological activities, primarily attributed to its anti-inflammatory and antioxidant properties. Through the modulation of various signaling pathways, including the NF-κB pathway, magnolol effectively inhibits the activation of inflammatory mediators and scavenges free radicals.</p>

<p>(+)-Syringaresinol, 98% is a lignan compound, which is a type of phenolic compound found in a variety of plant sources. It is primarily derived from the wood and bark of specific plant species, most notably those within the Syringa genus. The mode of action of (+)-Syringaresinol involves its function as an antioxidant, where it can scavenge free radicals and inhibit oxidative stress within biological systems.</p>

<p>Salvadoraside is a glycosylated natural compound, which is derived from the plant Salvadora persica, commonly known as the toothbrush tree. This compound is primarily extracted from the stems and roots of the plant. Its mode of action involves a variety of biochemical pathways, including potential antioxidative, antimicrobial, and anti-inflammatory activities. Salvadoraside interacts with cellular pathways by modulating the expression of specific enzymes and receptors, offering promising avenues in medicinal chemistry.</p>

<p>(-)-Asarinin is a naturally occurring lignan, which is an organic compound extracted primarily from the bark and roots of plants in the family Lauraceae, notably Asarum species. This compound is widespread in several traditional medicinal plants used in East Asia.</p>

<p>Pinoresinol dimethyl ether is a lignan compound, which is a type of polyphenolic substance. It is naturally sourced from various plant materials, prominently found in seeds, bark, and roots of certain plant species. The compound exhibits significant antioxidant activity, which is attributed to its ability to scavenge free radicals and protect cells from oxidative stress.</p>

<p>Dehydropodophyllotoxin is a lignan compound, which is derived from the roots and rhizomes of the plant genus Podophyllum. It exhibits its activity primarily as an inhibitor of microtubule assembly. Microtubules are essential components of the cell cytoskeleton, playing a critical role in cell division and intracellular transport. By interfering with microtubule dynamics, dehydropodophyllotoxin disrupts mitosis, leading to cell cycle arrest and potential apoptosis in rapidly dividing cancer cells.</p>

<p>Epi-podophyllotoxin is a lignan that is primarily derived from the rhizomes and roots of the plant species Podophyllum, commonly known as mayapple. This compound exhibits significant pharmacological activity, primarily due to its ability to disrupt the mitotic process. As an antimitotic agent, epi-podophyllotoxin exerts its effects by inhibiting microtubule assembly, which is crucial for cell division. This action leads to the arrest of the cell cycle in the metaphase, ultimately causing apoptosis in rapidly dividing cancer cells.</p>

<p>Arctiin is a lignan compound, which is a naturally occurring polyphenolic substance. It is extracted primarily from the seeds of plants in the Asteraceae family, such as Arctium lappa, commonly known as burdock. Arctiin acts as a bioactive compound that interacts with various biological pathways, exhibiting antioxidant, anti-inflammatory, and anti-carcinogenic properties.</p>

<p>Syringaresinol-di-O-glucoside is a lignan-derived glucoside, which is a naturally occurring compound found predominantly in the Syringa plant, part of the Oleaceae family. This compound is classified as a plant lignan glycoside, which is obtained through extraction from natural botanical sources, specifically those of the Syringa genus. Its mode of action primarily involves antioxidant activity, where it scours and neutralizes free radicals, protecting cellular structures from oxidative stress. This mechanism is vital in mitigating the damage caused by reactive oxygen species within biological systems.</p>

<p>(+)-Lariciresinol is a lignan, a type of polyphenolic compound, which is primarily derived from plant sources such as flaxseeds, sesame seeds, and whole grains. As a naturally occurring compound in these plants, it plays a role in their defense mechanisms against pathogens.</p>

<p>Enterodiol is a phytoestrogenic compound, specifically classified as a plant-derived lignan metabolite, which originates from the consumption and subsequent gut microbial transformation of lignans found in dietary fiber-rich foods such as flaxseeds, whole grains, and certain vegetables. The mode of action involves its conversion by intestinal microbiota into enterodiol from precursors such as secoisolariciresinol diglucoside. Once absorbed, enterodiol can interact with estrogen receptors, exhibiting weak estrogenic activity, which contributes to its role as a selective estrogen receptor modulator.</p>

<p>4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies.</p>

<p>(+)-Pinoresinol is a chiral lignan compound, which is primarily found in various plant sources such as flaxseed, sesame seeds, and olive oil. It plays a significant role in the plant's defense mechanisms by contributing to the formation of the plant cell wall and acting as an antioxidant.</p>

<p>Schizantherin B is a natural diterpenoid compound, which is isolated from the traditional Chinese medicinal plant Schizandra chinensis. It exhibits numerous biological activities due to its complex molecular structure. The primary mode of action of Schizantherin B involves modulation of multiple signaling pathways, which contributes to its anti-inflammatory, antioxidant, and neuroprotective effects. Researchers have also identified its role in inhibiting cell proliferation and inducing apoptosis in various cancer cell lines.</p>

<p>(+/-)-Secoisolariciresinol is a lignan compound, a type of polyphenolic phytonutrient, primarily found in plant-based sources. It is abundantly obtained from flaxseeds, but also present in other seeds and whole grains. The compound undergoes metabolism by gut microflora to produce enterolignans, such as enterodiol and enterolactone, which exhibit weak estrogenic and antioxidant properties.</p>

<p>Secoisolariciresinol diglucoside is a plant lignan, which is primarily sourced from flaxseed. As a type of phytoestrogen, SDG is known for its antioxidant properties and ability to influence estrogen metabolism. The mode of action involves the conversion of SDG into mammalian lignans such as enterolactone and enterodiol by intestinal microflora, which then exhibit biological activity. These metabolites can bind to estrogen receptors, thereby exerting weak estrogenic or antiestrogenic effects depending on endogenous estrogen levels.</p>

<p>Phillyrin is a lignan compound, which is a bioactive chemical derived from the seeds and fruits of the plant Forsythia suspensa, a traditional medicinal herb. This compound is recognized for its multifaceted mode of action, primarily through its anti-inflammatory, antioxidant, and antimicrobial properties. Phillyrin functions by modulating signaling pathways, inhibiting oxidative stress, and suppressing pro-inflammatory cytokine production, making it significant in the field of pharmacology.</p>

<p>(-)-Arctigenin is a lignan compound, which is naturally derived from certain plant species, primarily found in the seeds of Arctium lappa, commonly known as burdock. The compound exhibits a diverse mode of action, primarily noted for its ability to inhibit the proliferation of cancer cells through apoptosis induction, cell cycle arrest, and modulation of various signaling pathways. Additionally, it exerts antiviral effects by targeting viral replication processes and exhibits anti-inflammatory properties by downregulating pro-inflammatory cytokines.</p>

<p>4'-Demethylepipodophyllotoxin is a semisynthetic lignan, derived from the toxin podophyllotoxin, which is extracted from the roots and rhizomes of Podophyllum species, such as Podophyllum peltatum. The compound acts primarily as a topoisomerase II inhibitor. By binding to and stabilizing the enzyme-DNA complex, it prevents the re-ligation of DNA strands, which ultimately leads to breaks in the DNA and triggers apoptosis in rapidly dividing cancer cells.</p>

<p>(+/-)-Matairesinol is a lignan compound, which is a type of phytoestrogen. It is primarily sourced from various plant species, such as flaxseeds, sesame seeds, and whole grains. This compound is an important constituent of the plant's defense mechanisms and contributes to their overall health properties.</p>

<p>(+/-)-Syringaresinol is a type of lignan, which is a category of polyphenolic compounds. It is primarily sourced from various plant materials, including seeds, roots, and barks of certain tree species. These naturally occurring compounds are integral to the plant's defense mechanisms and provide various ecological benefits.</p>

<p>(+)-Sylvatesmin is a type of arylnaphthalene lignan, which is a naturally occurring organic compound. It is derived from certain coniferous trees and is typically found as a secondary metabolite within these plants. These lignans are known for their complex polyphenolic structures, which are biosynthesized from phenylpropanoid precursors.</p>

<p>(+/-)-Pinoresinol is a plant-derived lignan, which is primarily sourced from various plant species, including olives, sesame seeds, and other lignan-rich plants. As an emerging compound in the field of natural products, it is extracted through processes targeting its abundant presence in lignin-containing materials. The mode of action of (+/-)-Pinoresinol involves its participation in the antioxidant defense system, where it can effectively scavenge free radicals and modulate oxidative stress. This activity is mediated by its ability to influence cellular pathways associated with oxidative systems and signal transduction mechanisms.</p>

<p>(-)-Matairesinol is a polyphenolic lignan compound, which is primarily sourced from various plants, including flaxseeds, sesame seeds, and whole grains. This compound belongs to a group of plant-derived molecules known as phytoestrogens, which exhibit structural similarity to estrogen hormones.</p>