Nucleotides

<p>5-Methoxycarbonylmethyluridine is a nucleoside that is a precursor in the synthesis of other nucleotides. It has been shown to have potential as a biomarker for various diseases, such as metabolic disorders and hepatic steatosis. 5-Methoxycarbonylmethyluridine also inhibits the activity of methyltransferases, which are enzymes that catalyze the transfer of methyl groups from S-adenosylmethionine to substrates. It is also used as a model system for polymerase chain reaction in cancer research, because it has been shown to inhibit DNA replication by blocking the incorporation of uracil into DNA.<br>5-Methoxycarbonylmethyluridine has been found at high levels in fetal bovine serum and eukaryotic cells, but not in prokaryotes or cancerous tissues.</p>

<p>1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-ethyluracil is a nucleoside analog with modifications to alter its biological activity. It contains a β-D-arabinofuranose sugar instead of the standard β-D-deoxyribose in natural nucleosides and<br>the fluorine (F) at the 2'-position increases resistance to enzymatic degradation and alters its biological activity. The 5-ethyl modification on the uracil ring enhances its interaction with viral polymerases.</p>

<p>Cyclopentenyl cytosine is a cytotoxic drug that inhibits the synthesis of DNA, RNA, and proteins. It is a nucleoside analogue that inhibits the enzyme activity of ribonucleotide reductase. Cyclopentenyl cytosine has significant cytotoxicity against hl-60 cells, as well as squamous carcinoma and MDA-MB-231 breast cancer cells. It also has significant activity against cyclopentenyl, dextran sulfate, and mitochondrial functions in vivo in human cells. Cyclopentenyl cytosine binds to the response element on the DNA strand, preventing transcription of genes for protein synthesis and cell division.</p>

<p>2'-Deoxy-5'-O-DMT-2'-fluorouridine is a medicament that belongs to the group of antineoplastic agents and is used in cancer treatment. It inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase, which is required for the formation of thymine nucleotides. This drug has been shown to be effective against some cancer cells in vitro and in vivo, but not all. 2'-Deoxy-5'-O-DMT-2'-fluorouridine can also inhibit terminal growth phases and induce programmed cell death. Solid phase synthesis has been used to synthesize this molecule as a phosphoramidite.</p>

<p>2'-Deoxyadenosine-5'-monophosphate disodium salt (DAP) is a white crystalline powder. It is soluble in water and insoluble in ethanol. DAP can be neutralised by aqueous solutions of hydroxide, such as sodium hydroxide or ammonium hydroxide. DAP is also reactive with aluminium oxide, which can be used for drying the compound to form anhydrous particles. DAP reacts with chloride ions to form 2',3'-diacetylpyridine-5'-diphosphate dibasic chloride, which has been shown to inhibit bacterial growth and act as an antibacterial agent. Autoclaving may be required for preparation of this drug due to its sensitivity to heat energy.</p>

<p>9-(b-D-Arabinofuranosyl)adenine is a nucleoside that is used as an antiviral agent. It binds to viral RNA and inhibits viral replication. 9-(b-D-Arabinofuranosyl)adenine has been shown to have potent side-effect profiles, including myocardial infarct, neuronal death, and immunological reactions. These effects are due to its ability to inhibit the synthesis of guanine nucleotides in the heart and brain cells, which are essential for energy production and neurotransmitter release respectively. 9-(b-D-Arabinofuranosyl)adenine also binds to toll-like receptors (TLRs), which are proteins found on the surface of cells that recognize invading microbes or foreign substances. This binding leads to activation of immune response pathways.</p>

<p>2'-O-Methyluridine-5'-triphosphate sodium salt is a nucleoside containing a 2'-O-methyl group at the 5' position. It is a novel antiviral and anticancer agent that can inhibit viral replication and induce cell apoptosis. This drug has been shown to be effective against herpes simplex virus type 1 (HSV1) and Epstein-Barr virus (EBV) in vitro, as well as some tumor cells in vivo. 2'-O-Methyluridine-5'-triphosphate sodium salt has also been shown to have high purity and high quality, with less than 0.01% impurities by HPLC, NMR, and elemental analysis analyses.</p>

<p>Anti-viral; anti-neoplastic</p>

<p>2'-Deoxycytidine HCl is a nucleoside analogue that is used as a radiation sensitizer in the treatment of tumors. It is converted into 2'-deoxycytidine-5'-triphosphate by incorporation into DNA during replication and inhibits DNA synthesis. This compound has been shown to have anti-leukemic activity against murine leukemia virus (MLV) and murine sarcoma virus (MSV) in mice, although it does not inhibit the proliferation of Swiss-Webster mice. The protonated form of 2'-deoxycytidine HCl has been observed using nuclear magnetic resonance spectroscopy, with a cyclohexane ring as the proton acceptor. The monosodium salt also forms a stable complex with amino groups, which may be due to its acidic ph.</p>

<p>N2-Phenoxyacetylguanosine is a nucleoside that contains an uridine, phenoxyacetyl, and ribose moiety. N2-Phenoxyacetylguanosine is synthesized from the corresponding 2′-deoxyribonucleoside by coupling to an activated phosphoramidite derivative of phenoxyacetyl. It can be used as a building block for oligonucleotides.</p>

<p>5-Azacytidine 5'-monophosphate (5-Aza-CMP) is a modified nucleoside that inhibits DNA synthesis by competitively inhibiting the incorporation of deoxycytidine 5'-triphosphate into DNA. It is used as an antiviral and anticancer agent. 5-Aza-CMP has been shown to inhibit the proliferation of human cancer cells in vitro, including T cell leukemia, lymphoma, breast cancer, and melanoma.</p>

<p>5-Iodocytidine is a nucleoside analogue that has been shown to possess potent antitumor activity. It is also used as a fluorescent probe for detection of uridine in biological samples. 5-Iodocytidine is structurally similar to uridine, which allows it to be taken up by cells and incorporated into RNA. This analog can also be detected with antibody response, as well as with the use of a fluorescence microscope. 5-Iodocytidine may have the potential to treat infectious diseases and autoimmune diseases because it binds to response elements on DNA and activates gene transcription.</p>

<p>S-adenosyl-L-methionine chloride dihydrochloride is a form of S-adenosyl-L-methionine. It is used as a nutritional supplement and has been shown to increase the production of antibodies in the body. This drug is also used for the treatment of inflammatory diseases, such as rheumatoid arthritis and osteoarthritis, because it inhibits cyclooxygenase enzymes. S-adenosyl-L-methionine chloride dihydrochloride binds to the response element on DNA that regulates gene expression and inhibits polymerase chain reactions by blocking the binding of nucleic acids to their complementary strands. The mechanism of action of this drug has not been established but may be related to its ability to inhibit nuclear DNA transcription or cell proliferation by affecting camp concentration.</p>

<p>Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond. Inosine derives from a hypoxanthine and a ribofuranose. Inosine plays a key role as a metabolite in bacteria, fungi, humans, and other animals. There is preliminary evidence that inosine may have neurorestorative, anti-inflammatory, immunomodulatory, and cardioprotective effects.</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>2'-Deoxy-5-propynyluridine is a nucleoside that is naturally synthesized in the body. It is an intermediate in the synthesis of pyrimidine nucleotides and has been shown to be useful for the treatment of cardiac arrhythmias. 2'-Deoxy-5-propynyluridine has also been found to have a stabilizing effect on RNA, enhancing its biological relevance. This compound can be used as a fluorescent probe and can be used to study transcriptional regulation mechanisms.</p>

<p>3'-Azido-3'-deoxyuridine is a nucleoside analog that is used as a substrate for DNA synthesis in the cell. 3'-Azido-3'-deoxyuridine is transported across the blood-brain barrier by a sodium-independent transporter and accumulates in the carotid artery, where it is converted to uridine. This drug has been shown to be activated at the site of infection and may have regiospecific activity against bacteria. 3'-Azido-3'-deoxyuridine has an imidazole ring and dinucleoside structure, which are important for its activity as a terminal half-life enhancer and anticancer agent. 3'-Azido-3'-deoxyuridine has also been used in liquid chromatography to purify nucleic acids research products.</p>

<p>2'-Deoxy-N6-methyladenosine (2DMA) is a nucleoside that has been found to inhibit the phosphorylation of p2y receptors in rat kidney cells. 2DMA inhibits the production of collagen, which may have a matrix effect on cells. Studies have shown that 2DMA can be used as a sample preparation reagent for nuclear DNA. It has also been shown to be effective at inhibiting transcription and replication of human mitochondrial DNA.</p>

<p>Uridine-2',3'-cyclic monophosphate sodium salt (CAS No. 15718-50-0) is a novel anticancer agent that has been shown to inhibit the growth of cancer cells in vitro and in vivo. It is a nucleoside analog that inhibits the synthesis of DNA by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase, two enzymes involved in the production of DNA. Uridine-2',3'-cyclic monophosphate sodium salt is also an antiviral agent used to treat herpesvirus infections, such as herpes simplex type 1 and 2. This drug binds to viral RNA polymerase, which prevents viral replication by preventing mRNA synthesis.</p>

<p>4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analogue that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labelling. 4-SU is typically used to modify RNA oligonucleotides, or in structure studies of RNA-protein complexes. The crosslinking thiol moiety is attached directly to the nucleotide base, thus 4-SU differs from the nucleoside uridine only by a single sulfur substitution. This means it can be incorporated into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will significantly impair RNA interactions or activities.</p>

<p>An intermediate for the preparation of modified oligonucleotides and other uridine derivatives containing a 2',2'-difluoro modification.</p>

<p>5-Iodouridine is a pyrimidine nucleoside that is found in the human body. It is used as a starting material for the synthesis of 5-iodo-2'-deoxyuridine, which has been shown to have biological properties. 5-Iodouridine binds to the dna template and prevents radiation from altering it's conformation. This binding has been shown to be specific for ultraviolet (UV) radiation, with little absorption at visible wavelengths. The biological effects of 5-iodouridine are dependent on its acidic pH and hydrogen bonding ability. In vitro assays have demonstrated that this compound can inhibit prostate cancer cells from proliferating and may be useful in treating cervical cancer.</p>

<p>2'-C-Methylguanosine 5'-diphosphate triethylammonium salt is a synthetic nucleotide analog for use in research</p>

<p>E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine is a nucleoside that is a modified form of uridine. It is a nucleotide analog that inhibits the synthesis of DNA and RNA and can be used to treat cancer. E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine is an activator that activates the phosphoramidites in the synthesis of DNA and RNA. This drug can also be used as antiviral therapy for herpes simplex virus type 1, influenza virus, and HIV. E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine has been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis.</p>

<p>5-O-[[[(1S)-1-Methyl-2-(1-methylethoxy)-2-oxoethyl]amino]-phenoxyphosphinyl]-cytidine is a modified nucleoside analog that inhibits the synthesis of DNA and RNA. It has been shown to have antiviral, anticancer, and antiinflammatory activities. 5-O-[[[(1S)-1-Methyl-2-(1-methylethoxy)-2-oxoethyl]amino]-phenoxyphosphinyl]-cytidine is a ribonucleoside that can be used as a building block for the production of deoxyribonucleosides (i.e., as an activator). This product also has high purity and quality, as well as being novel in structure.</p>

<p>N2-Diboc-7/9-(2,3,4,6-tetra-O-acetyl-D-mannopyranosyl)-6-chloro-2-aminopurine is a nucleoside that is modified with a chlorine group. The modification of the nucleoside may enhance its anticancer activity. N2-Diboc-7/9-(2,3,4,6-tetra-O-acetyl-D-mannopyranosyl)-6-chloro-2 aminopurine has been shown to inhibit the growth of virus and cancer cells by inhibiting DNA synthesis. It has also been shown to induce apoptosis in human leukemia cells.</p>

<p>Cytidine-2'-monophosphate sodium (CMP) is a nucleotide that is used as a monophosphate or diphosphate. It can be used to synthesize DNA and RNA. CMP also has antiviral, anticancer, and high purity properties. CMP is an activator of DNA polymerases and helps in the synthesis of DNA. It has novel properties that make it different from other nucleotides, such as its modified sugar moiety.</p>

<p>5'-O-DMT-2'-O-methyl-N6-phenylacetyladenosine is a synthetic nucleoside with anticancer properties. It is modified to be more resistant to phosphodiesterase which blocks the synthesis of DNA and RNA. This drug has been shown to activate the immune system, inhibit tumor growth, and inhibit viral replication. It has been shown to be effective in animal models against leukemia and lymphoma. The high quality pure chemical will be used for use in research purposes only.</p>

<p>6-O-Methylinosine is a modified nucleoside that is used in the synthesis of recombinant proteins. It is synthesized from the reaction of methylphosphate and 6-O-methylguanosine. The phosphate group of the 6-O-methylguanosine molecule reacts with methylphosphate in an acid or neutral environment, while it reacts with phosphoric acid in a basic environment. This reaction can be monitored by measuring the amount of free phosphate groups present after the reaction. The rate of this reaction can be increased by increasing temperature and pH. 6-O-Methylinosine has been shown to have anticancer activity, which may be due to its ability to inhibit enzyme catalysis and modify DNA structure.</p>

<p>7-Deaza-2'-deoxyguanosine is an analog of guanosine that has been shown to inhibit the activity of telomerase. This enzyme synthesizes a sequence of DNA called a telomere, which protects the ends of chromosomes from deterioration and prevents chromosomal end-to-end fusion. 7-Deaza-2'-deoxyguanosine has an inhibitory effect on the polymerase chain reaction (PCR) in mammalian cells and inhibits the transcription-polymerase chain reaction (PCR) in vitro. It has also been shown to be potent against cancer cells. 7-Deaza-2'-deoxyguanosine is synthesized by solid phase synthesis, which is a chemical process that involves attaching one molecule to another molecule with similar structure, using organic solvents as intermediates.</p>

<p>2'-Deoxy-2'-fluoro-L-uridine is a synthetic nucleoside analog of uridine where the sugar is both fluorinated at the 2' position and in the L-configuration, which is the mirror image of naturally occurring D-nucleosides. This modification makes it structurally distinct and biologically significant for certain applications in drug development and biochemical research.</p>

<p>2-Amino-6-chloro-9-(2'-deoxy-b-D-ribofuranosyl)purine is a purine nucleoside where the purine base has a 2-amino group at position 2 and a chlorine at position 6. The sugar is 2'-deoxy, meaning it is like the sugar found in DNA, lacking the 2'-hydroxyl group that is present in RNA. The amino and chloro groups on the purine base modify how this molecule behaves in biological systems making it useful in research applications.</p>

<p>5-Methyluridine is a nucleoside that is used to inhibit the replication of cells. It is also used for the treatment of cancer, infectious diseases, and other conditions. 5-Methyluridine inhibits cellular replication by binding to ribothymidine and uridine in the nucleus. The inhibition of cellular proliferation is due to a lack of dna synthesis and RNA synthesis. This nucleoside has been shown to have inhibitory properties against mouse tumor cells grown in vitro, as well as the wild-type strain grown in vivo. 5-Methyluridine may be useful for the treatment of cancer tissues because it can suppress the growth of tumors by inhibiting their ability to replicate.</p>

<p>Treats herpes-associated keratitis and keratoconjunctivitis; antineoplastic</p>

<p>Cytidine-5'-diphosphate trisodium (CDP-Tris) is a copolymerization agent that contains a formamide molecule, which is used to increase the viscosity of the polymer. It is also used as a hydrogen bond donor and acceptor in the synthesis of polymers. CDP-Tris can be used for DNA replication and repairs damaged DNA by binding to 7-methylguanine, one of the most common lesions found in DNA. This agent has been shown to be effective in diluting crude cell extracts from E. coli bacteria. CDP-Tris is also used to synthesize polymers with 3-methylcytidine monomers that contain nitrogen atoms. These polymers are then used as substitutes for natural polymers such as cellulose and starch, which can be difficult to process because they are hydrophobic.</p>

<p>2',3'-Di-O-acetyl-D-uridine is a nucleoside for use in research applications</p>

<p>2'-Deoxy-6-methylthioguanosine is a novel nucleoside and nucleotide analog with antiviral and anticancer activities. It has been shown to inhibit the replication of DNA by inhibiting the activity of DNA polymerase. The target of this drug is not related to any virus or bacterial species, but it inhibits the growth of cancer cells in vitro. The synthesis of 2'-deoxy-6-methylthioguanosine can be achieved by modifying commercially available phosphoramidites.</p>

<p>2'-O-Benzoyl-5'-O-DMT-4-thiouridine is a phosphoramidite monophosphate nucleoside analog. It has antiviral and anticancer properties, and has been shown to activate the immune system in mice. 2'-O-Benzoyl-5'-O-DMT-4-thiouridine is also novel because it is structurally different from all other nucleosides that have been studied for antiviral and anticancer activity. This drug can be used as an activator of DNA synthesis in vitro.</p>

<p>Used as a protected 2'-ketouridine nucleoside in the synthesis of modified RNA oligonucleotides. The 1,1,3,3-tetraisopropyldisiloxane-1,3-diyl (TIPDS or TBDPSi2) group protects the 3' and 5' hydroxyl groups, while the 2'-keto (or 2'-oxo) modification introduces a specific functional group at the 2' position of the ribose sugar.</p>

<p>2'-O-Methyladenosine (2'-OMeA) is a nucleoside that is a low-energy analog of adenosine. It has been shown to be an effective inhibitor of protein synthesis in vitro, by inhibiting RNA polymerase in the process of transcription. 2'-OMeA has also been shown to inhibit virus replication in vitro and to have potent inhibitory activity against human immunodeficiency virus type 1 (HIV-1). 2'-OMeA inhibits viral replication by binding to the viral ribonucleotide reductase enzyme and blocking the conversion of ribonucleotides into deoxyribonucleotides. The chemical structures of 2'-OMeA are similar to those found in fatty acids and can be detected using chemical ionization mass spectroscopy. The sequence for 2'-OMeA was determined through sequencing methods including NMR spectroscopy and nuclear magnetic resonance data analysis.</p>

<p>5-Fluorouridine-5'-triphosphate triethylammonium salt - aqueous solution is an activated nucleoside that is synthesized from the triethylamine salt of 5-fluorouridine. This product has antiviral and anticancer activities, and can be used as a DNA-synthesizing agent in the synthesis of deoxyribonucleosides. It has been shown to inhibit replication of human immunodeficiency virus (HIV) by inhibiting viral reverse transcriptase, as well as cytomegalovirus (CMV) by inhibiting viral DNA polymerase.</p>

<p>2'-Deoxy-a-cytidine is a nucleoside analog that inhibits the growth of bacteria by competitively binding to the 5' position of the ribose sugar in RNA. This prevents the enzyme from adding a new linkage to the ribose, which results in an irreversible blockage of RNA synthesis. 2'-Deoxy-a-cytidine has been shown to be bacteriostatic against Escherichia coli and other bacterial species. It is also able to inhibit adenosine production, although it does not show any activity against DNA synthesis.<br>2'-Deoxy-a-cytidine has been shown to be effective against E. coli and other bacterial species, but does not show any activity against DNA synthesis</p>

<p>Inosine-5'-diphosphate disodium salt (IDPS) is a nitro compound that is used in the synthesis of antibacterial drugs. It is also used in the production of polymers and as a precursor to other organic compounds. IDPS has been shown to have antibacterial activity against halogeno bacteria, such as buprestidae, and many Gram-positive bacteria, including encapsulated strains. IDPS has been shown to be effective against both damaged cells and healthy cells in culture. The mechanism of action may involve inhibition of protein synthesis by blocking the ribosomes or by interfering with DNA replication. This drug also inhibits growth rate of japonica rice and heterocycles.</p>

<p>Protein kinase A inhibitor; cAMP agonist</p>

<p>5-Hydroxymethylcytidine is a nucleoside that has been shown to inhibit the activity of RNA polymerase by forming hydrogen bonds with the enzyme. It is used in vitro to study the role of messenger RNA in regulating gene expression, and also as a probe for transcriptase activity. 5-Hydroxymethylcytidine has also been shown to have a biological function in solid tumours and may be an analytical method for detecting cancer.</p>

<p>5-Fluorocytidine (5FC) is an antiviral drug that inhibits the synthesis of DNA. 5FC is a prodrug that is converted to cytosine in vivo, and then incorporated into viral DNA by polymerase chain reactions. The incorporation of 5FC into viral DNA prevents replication and transcription, which can lead to the death of cells infected with HIV. In addition, 5FC has been shown to be effective in treating chronic viral hepatitis and bowel diseases such as Crohn's disease. It also has potential use as a drug target for cancer treatments.<br>5FC has been shown to inhibit transcription activators in murine hepatoma cells and inhibit the growth of tumors in transfection experiments using human colon cancer cells. This antiviral agent has also been shown to have antimicrobial activity against Gram-positive bacteria, including Clostridium difficile, Staphylococcus aureus, Streptococcus pyogenes and Enterococcus faec</p>

<p>Orotidine is a decarboxylase inhibitor. It inhibits the enzyme that converts orotate to uridine and the enzyme that converts orotate to decarboxylase. Orotidine has been shown to inhibit the growth of opportunistic fungal organisms and may be useful in treating infections caused by these pathogens. Orotidine is an analytical method for measuring the activity of orotidase, which catalyzes conversion of orotate to uridine. The enzyme form of orotidase found in human erythrocytes is very sensitive to inhibition by picolinic acid, which is used as a substrate for this reaction.</p>

<p>2'-Deoxyinosine is an antimicrobial peptide that has been shown to have potent activity against Gram-positive bacteria, including Staphylococcus aureus. 2'-Deoxyinosine binds to the 3′-hydroxyl group of nucleic acid, preventing DNA replication and transcription. This binding also prevents ribosomal RNA from binding to the ribosome, inhibiting protein synthesis. 2'-Deoxyinosine has been detected using a highly sensitive optical sensor and can be used as a model system for studying the interaction between dsDNA duplexes and other biomolecules. The pharmacokinetic properties of this molecule have been determined in rats by measuring its concentration in serum over time after injection. These data were then used to determine the amount of 2'-deoxyinosine that was needed to inhibit bacterial growth in water samples.</p>

<p>2'-Deoxypseudoisocytidine is a synthetic nucleoside that is structurally similar to pseudoisocytidine. It is used as an anti-cancer agent in labeling studies. The compound exhibits cytotoxic activity against tumor cells and inhibits the growth of cultured human cancer cell lines. 2'-Deoxypseudoisocytidine has been shown to be effective in preventing the growth of brain tumors in mice by targeting DNA synthesis, which may be due to its ability to act as an analog of cytosine and bind to DNA. This drug also has potential for use as a chemotherapeutic agent for leukemia and other cancers.</p>

<p>2'-Chloro-2'-deoxycytidine is a synthetic nucleoside analog. It is a modified deoxycytidine with a chlorine atom at the 2'-position of the deoxyribose sugar. This molecule can be used in research applications</p>

<p>5'-O-DMT-5-iodo-2'-O-methyluridine is an activator and antitumor agent that is used in the synthesis of 5'-O-DMT-5-iodo-2'-O-(2,4,6-trimethoxybenzoyl)uridine for cancer research. This chemical is a novel synthetic nucleoside with a high purity and quality that can be used to synthesize deoxyribonucleosides, nucleosides, and phosphoramidites. It has a CAS number of 588691-24-1. 5'-O-DMT-5-iodo-2'-O-(2,4,6 trimethoxybenzoyl)uridine can be used as an antiviral agent against HIV and other retroviruses.</p>

<p>a-Thymidine is a thymidylate analog that is used as an anti-HIV drug. It is the L-enantiomer of thymidine, which is a nucleoside base in DNA. The biological effects of a-thymidine are due to its ability to be incorporated into DNA and act as a competitive inhibitor of the enzyme protein synthesis. It also has been shown to have antiviral properties against herpes simplex virus type 1 and hepatitis B virus.</p>

<p>2′,3′-Dideoxy-2′,3′-didehydroadenosine, abbreviated to d4A, is a synthetic purine nucleoside analog. Possible applications are its use to study antiviral activity.</p>

<p>Also known as AMT, this is a catabolite of the nucleoside analog zidovudine (AZT), a drug used to treat HIV infection.</p>

<p>Adenosine-3'-monophosphate is a nucleotide that is an important precursor in the synthesis of proteins. The ribosome, which is a large macromolecular complex that catalyzes protein synthesis, binds to the 3' end of the mRNA and adds adenosine-3'-monophosphate to the growing polypeptide chain. Adenosine-3'-monophosphate plays an important role in bacterial ribosomal RNA termination and protein synthesis. It also has sequence analysis capabilities and helps determine the sequence of subunits in the ribosome by providing a terminal nucleotide.</p>

<p>5'-(N-Cyclopropyl)carboxamidoadenosine (5' CAPA) is a cyclic nucleotide analog. It has been shown to have photochemical properties and can be used as a fluorescent probe for the detection of DNA. 5' CAPA binds to the α subunit of RNA polymerase and inhibits transcription, which may result in reduced expression of proteins involved in growth control. Structural analysis has revealed that 5' CAPA binds to the catalytic site of the enzyme, sterically interfering with ATP binding. The inhibitory effect is reversible by removal of 5' CAPA from the reaction solution or by addition of cytosolic calcium chelators. 5' CAPA was found to have no effect on phycocyanin production by phytoplankton when added at concentrations up to 1 mM and did not affect transcription-polymerase chain reactions or regulatory processes in bacterial cells.<br>5'-(N-Cy</p>

<p>5'-O-DMT-5-methyluridine is a mesylate that is used as a chemical building block in the synthesis of unmodified, modified, and conjugate nucleosides. 5'-O-DMT-5-methyluridine can be used to modify ribonucleotides and derivates. It has been shown to be useful for labeling DNA probes with fluorescein and rhodamine dyes. 5'-O-DMT-5-methyluridine also has affinity for nucleophile groups such as phosphate, hydroxyl and amino groups. This compound is used in the incorporation of labeled polypeptides into proteins by ligation.</p>

<p>Stavudine 5'-triphosphate sodium salt is a modified nucleoside analog with antiviral and anticancer properties. It is a phosphoramidate of stavudine, which has been modified by the replacement of the L-cysteine moiety with a 2-thiophenecarboxamide group. The novel chemical structure of stavudine 5'-triphosphate sodium salt leads to higher solubility in water than other analogues and improved pharmacokinetics. Stavudine 5'-triphosphate sodium salt is an activator for the synthesis of DNA, RNA, and protein. It also inhibits viral replication by interfering with viral DNA polymerase and ribonucleotide reductase, which are essential enzymes for viral replication.</p>

<p>5-Chloro-2'-deoxyuridine is a nucleoside analog that inhibits DNA synthesis by inhibiting the enzyme thymidylate synthetase. It has been used for the treatment of bladder cancer and may also be beneficial in treating other cancers such as colon cancer. 5-Chloro-2'-deoxyuridine is taken up from the intestine by cells, where it is converted to thymidine monophosphate and then to thymidine diphosphate, which inhibits DNA synthesis by interfering with cell division. The mechanism of action is similar to that of cytosine arabinoside, but it does not require activation by intracellular enzymes. 5-Chloro-2'-deoxyuridine can cause cell lysis and can inhibit protease activity during cell culture, which makes it a useful tool for purifying proteins or peptides. The drug has been shown to be an analog of cytosine arabinos</p>

<p>AMP plays a crucial role in cellular metabolic processes, including the synthesis of RNA and the regulation of enzymes like AMP-activated protein kinase (AMPK)</p>

<p>5-Azidouridine is used for nucleotide labelling and promptly reacts via a click reaction with a terminal alkyne or cyclooctyne conjugated to a reporter (fluorophore or biotine). The formed labelled nucleotide has a stable triazole linker. 5-Azidouridine has been used in living cell fluorescent imaging of cancer cells.</p>

<p>Thionicotinamide adenine dinucleotide is a cofactor in the production of ATP, and is also used as a reagent for determining the activity of dehydrogenases. It is produced by the oxidation of thionocinamide ribonucleotide, which is synthesized from dihydroxyacetone phosphate and phosphoric acid.<br>Thionicotinamide adenine dinucleotide binds to NADP+, which acts as a hydrogen acceptor, and transfers two electrons to it. The nadph then donates an electron to the dehydrogenase, which converts a substrate into its product in a redox reaction.</p>

<p>N4-Methylcytidine is a member of the group P2. Its chemical structure consists of two nitrogen atoms, one carbon atom, and four hydrogen atoms. It is a nucleoside analogue that inhibits synthesis of human mitochondrial DNA by inhibiting bacterial enzyme uridine-cytidine kinase, which converts uridine to cytidine in the mitochondria. N4-Methylcytidine has been shown to be potent against viruses such as HIV and herpes simplex virus type 1 (HSV-1) in cell culture studies. This antiviral effect is due to the interference with viral dna replication and protein synthesis by preventing incorporation of uracil into dna and ribosomal RNA.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>2'-Deoxy-L-cytidine 3'-O-L-valinyl ester 2HCl is a nucleoside analog that is converted to its active form by intracellular dephosphorylation. It inhibits viral DNA polymerase, thereby preventing the replication of the virus. This drug has been shown to be effective against hepatitis B virus and influenza A virus. The triphosphate form of 2'-deoxy-3'-O-L-valinyl cytidine 2HCl is used as an antiviral agent in the treatment of chronic hepatitis and for prophylaxis against influenza A.</p>

<p>8-Benzyloxy-2'-deoxyguanosine is a dinucleoside that is synthesised from uracil and hydrogenated 8-hydroxyquinoline. The synthesis of 8-benzyloxy-2'-deoxyguanosine was achieved by cyclic photocyclization of 2,4,6-trichlorobenzaldehyde with 2,4,6-trimethoxyphenylacetone in the presence of sodium nitrite. This compound has been used for the quantification of DNA damage caused by irradiation or sodium chloride. 8-Benzyloxy-2'-deoxyguanosine has also been shown to inhibit the polymerase chain reaction (PCR) amplification of oligodeoxynucleotides.</p>

<p>8-Chloroadenosine-5'-monophosphate triethylammonium is a novel phosphoramidite that is used in the synthesis of DNA. 8-Chloroadenosine-5'-monophosphate triethylammonium has been shown to activate antiviral and anticancer drugs with high specificity. It is also used as a reagent for the synthesis of deoxyribonucleosides and nucleosides. 8-Chloroadenosine-5'-monophosphate triethylammonium has high purity and can be used in the synthesis of DNA, RNA, and other nucleosides.</p>

<p>3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro-5-methyluridine is a synthetic nucleoside that has antiviral activity. It is a modified nucleoside that contains a monophosphate group, which makes it an activator of DNA polymerase. 3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro-5-methyluridine is novel because it contains an acetyl group at the 3' position and a silyl ether on the 2' oxygen atom. 3'-O-Acetyl-5'-tert-butyldiphenylsilyl-2'-deoxy-2'-fluoro -5 -methyluridine has CAS No. 62768‑36‑3 and is available in high purity.</p>

<p>2'-Deoxy-5'-O-DMT-N2-isobutyryl-a-guanosine is a nucleoside that is synthesized from 2'-deoxyribonucleosides and activated with diphosphate. It is an antiviral and anticancer agent that inhibits viral DNA polymerases, leading to the inhibition of viral replication. 2'-Deoxy-5'-O-DMT-N2-isobutyryl-a-guanosine has also been shown to inhibit cancer cell growth in vitro by inhibiting the synthesis of cellular DNA. This nucleoside has high purity and quality as it is made synthetically and has novel properties because it contains modified groups.</p>

<p>2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is a novel phosphoramidite nucleoside that is an antiviral and anticancer agent. It can be used as a monophosphate or diphosphate. 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine has been shown to inhibit the replication of DNA, RNA, and protein synthesis. This compound also has an activating effect on the immune system by inducing lymphocyte proliferation and increasing NK activity. It inhibits the growth of viruses such as HIV and influenza A virus. The purity of 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is high, with a CAS number of 11052282-2.</p>

<p>3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine is a synthetic nucleoside with antiviral properties. It is a monophosphate that can be used to activate other nucleosides. This product has been shown to inhibit human immunodeficiency virus (HIV) reverse transcriptase in vitro and in vivo, as well as the replication of other viruses such as herpes simplex virus (HSV).</p>

<p>Please enquire for more information about 3',5'-Di-O-acetyl-5-bromo-2'-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,3'-Anhydro-5'-O-tert-butyldiphenylsilylthymidine is a synthetically modified thymidine analog for use in research</p>

<p>1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine is a nucleoside analog with a modified ribofuranosyl sugar, which includes a 2'-O-4'-C-methylene bridge that constrains the sugar conformation.</p>

<p>2-Azidoadenosine is a nucleoside analog of adenosine, where the 2'-hydroxyl group of the ribose sugar is replaced with an azido group (–N₃). This substitution imparts unique chemical properties, notably enabling molecules to undergo bioorthogonal reactions, such as click chemistry, which involves the cycloaddition of the azide group with alkynes.</p>

<p>6-Methylmercapto-9-(b-D-ribofuranosyl)purine (6MMPR) is a nucleotide analog that is synthesized through the process of ribosylation. It has been shown to be reactive and inflammatory in the colon, which may be due to its role as an enzyme inhibitor. 6MMPR inhibits target enzymes such as 2-methylthio-6-chloropurine riboside, which are involved in DNA synthesis and repair. This drug also has anti-inflammatory properties, which may be due to its ability to inhibit the production of inflammatory cytokines by activated immune cells. 6MMPR is used for the treatment of bowel diseases such as Crohn's disease and ulcerative colitis.</p>

<p>6-Aza-2-thiouridine is a molecule that has been shown to inhibit human immunodeficiency virus (HIV). The compound is cytotoxic to leukemia cells and selectively inhibits the function of cytidine deaminase, which is an enzyme required for DNA synthesis. 6-Aza-2-thiouridine also inhibits the production of viruses by interfering with the activity of their nucleic acid polymerases. This inhibition may be due to its ability to hydrolyze extracellular hydroxyl groups on the viral nucleotide. 6-Aza-2-thiouridine has also been shown to have anti-cancer properties in mammalian cells.</p>

<p>7-Deaza-2'-C-methyladenosine (7DMA) is an antiviral agent that has shown anti-Hepatitis C virus activity in vitro. 7DMA inhibits the binding of a number of compounds to the viral RNA polymerase and blocks mRNA synthesis, leading to inhibition of viral replication. This drug also binds to the Toll-like receptor 3, which is involved in the immune response against hepatitis. 7DMA has been shown to have a pharmacokinetic profile suitable for use as an antiviral agent. However, it does not show any significant pharmacokinetic properties in vivo and needs further study.</p>

<p>2'-Deoxy-5-propargyloxyuridine is a synthetic compound that inhibits the herpes simplex virus by inhibiting thymidylate synthase, an enzyme in the synthesis of DNA. It is used to study the growth rate of herpes virus and has been shown to inhibit murine leukemia L1210 and human l1210 cells at concentrations of 10-20 μg/mL. 2'-Deoxy-5-propargyloxyuridine has also been shown to have inhibitory activities against other viruses, such as polio virus and influenza virus. 2'-Deoxy-5-propargyloxyuridine inhibits biosynthesis by binding to enzymes involved in the synthesis of nucleic acids. The inhibitory dose for this compound is not yet known, but it has been shown to have an inhibitory effect on cell culture when preincubated with cells before infection with herpes simplex virus.</p>

<p>6-(4-Morpholino)-9-(β-D-ribofuranosyl)-9H-purine is a modified monophosphate analog of adenosine. It is an antiviral agent that inhibits the synthesis of nucleic acids in virus-infected cells, preventing viral replication and spread. 6-(4-Morpholino)-9-(β-D-ribofuranosyl)-9H-purine is also used as a radiosensitizer to treat cancer. This drug is synthesized by high purity, high quality and reliable suppliers.</p>