Others

Applications Dehydro Silodosin is an impurity of Silodosin (S465000).
References Moriyama., et al.: Eur. J. Pharmacol., 331, 39 (1997), Zhu, J., et al.: Br. J. Pharmacol., 131, 546 (2000),

Applications 3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-amine (cas# 20529-23-1) is a useful research chemical.

Applications Labelled Bimatoprost (B386800). Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.
References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),

Applications (E)-Isomer of labelled Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.
References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);

M06199 - BOC-SER(TBU)-OH DCHA

Applications 1,1,1-Tris(hydroxymethyl)propane is a building block often used to make polymers. 1,1,1-Tris(hydroxymethyl)propane has been used as a precursor to prepatre alkyd resins for linseed oil based paint.
References Wang, X., et. al.: J. Polym. Res., 18, 721 (2011); Isiri-Caglar, D., et. al.: Rog. Org. Coat., 77, 81 (2014); Heiskanen,N., et. al.: J. Appl. Polym. Sci., 119, 209 (2011)

Applications 5,6-Dimethylbenzimidazole (cas# 582-60-5) is a useful research chemical.

Applications Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Applications 6-Amino-1,3-dimethyluracil is used as a reagent in the synthesis of new pyrimidine and caffeine derivatives that display highly potential antitumor activity. It is also used as a starting material in the synthesis of fused pyrido-pyrimidines.
References Abu-Hashem, A., et al.: Lett. Drug. Des. Discov., 12, 471 (2015); Azev, Y., et al.: Mendeleev Commun., 25, 310 (2015)

Impurity Diazepam EP Impurity B
Applications N-(2-Benzoyl-4-chlorophenyl)-2-chloro-N-methylacetamide (Diazepam EP Impurity B) is the impurity of Temazepam (T017200), which is a pharmacologically active metabolite of Diazepam. It is used as a sedative and hypnotic drug.
References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)

Impurity Atenolol USP Related Compound D; Atenolol EP Impurity F
Applications 4,4'-[[(1-methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide (Atenolol USP Related Compound D; Atenolol EP Impurity F) is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Caplar, V., et al.: Acta. Pharma. Jugoslavica., 33, 71 (1983);

Applications Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),

Applications N-Nitrosoatenolol is an N-nitroso derivative of Atenolol (A790075), which is a cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II). N-Nitrosoatenolol can be used for its genotoxic effect in rat and human hepatocytes.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Robbiano, L., et.al., Cancer Res., 51, 2273-2279, (1991);

Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.

Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);

Impurity Atenolol EP Impurity C
Applications 4-(2,3-Epoxypropoxy)phenylacetamide (Atenolol EP Impurity C) is an impurity of Atenolol, a cardioselective β-adrenergic blocker.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)

Stability Moisture Sensitive
Applications 4-​Amino-​2-​fluoro-​N-​methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors
References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)

Impurity Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol)
Applications 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).
References England, P., et al.: Biochemistry, 43, 11623 (2004), Schousboe, A., et al.: Eur. J. Pharmacol., 500, 281 (2004), Horvat, S., et al.: J. Med. Chem., 49, 3136 (2006),

Applications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);

Applications Desmethyl 5-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Applications An impurity of Nintedanib, which is an antifibrotic drug.
References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)

Applications Labelled (S)-Atenolol (A790080). Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),

Applications Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),

Applications Lindane is an insecticide that is used as a treatment for scabies and lice. Lindane has been used as a broad-spectrum insecticide for seed and soil treatment, foliar applications, tree and wood treatment and against ectoparasites in both veterinary and human applications. Lindane is persistent, bioaccumulates easily in the food chain and bioconcentrates rapidly. There is evidence for long-range transport and toxic effects (immunotoxic, reproductive and developmental effects) in laboratory animals and aquatic organisms. One of the new POPs under the Stockholm Convention.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);

Applications An intermediate in the production of Bimatoprost (B386800).

Applications N-Desmethyl Zopiclone-d8 is a labelled metabolite of Zopiclone (Z700500), which is Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Fernandez, C., et al.: Clin. Pharmacokinet., 29, 431 (1995), Nordgren, H., et al.: Ther. Drug Monit., 24, 410 (2002)

Stability Unstable in Methanol
Applications Used in the synthesis of cyanogen glycoside. A component contains in antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),

Applications N-Acetyl Memantine is an intermediate used for preparation of Memantine (M218000).
References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963), Reddy, J., et al.: Org. Process Res. Dev., 11, 268 (2007),

Applications Fulvestrant (F862500) impurity D.

Applications Perfluorophenol is used in the synthesis of PGA-films as biodegradable polymers. It also participates in the synthesis of tripod macrocyclic Gd(III) chelates for cancer molecular MRI.
References Lee, K. et al.: Langmuir., 20, 2531 (2004); Zhou, Z. et al.: Biomater., 34, 7683 (2013);

Applications Hexabromocyclododecane diasteomeric mixture, which is derived from 1,2,5,6,9,10-Hexabromocyclododecane (H290740) a flame retardant used in foamed polystyrene. One of the new POPs under the Stockholm Convention.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Larsen, E.R. et al.: J. Fire Sci., 4, 261 (1986); Chen, D. et al.: Env. Sci. Tech., 45, 8254 (2011);

Applications Ethyl Ethanesulfonate is used as a reactant in stereoselective Friedel-Crafts alkylation reactions. Also used in the preparation of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids.
References Stadler, D., Bach, T.: Chem. Asian J., 3, 272 (2008); Blesic, M., et al.: Phys. Chem. Chem. Phys., 11, 8939 (2009);

Applications A labelled metabolite of Zopiclone.

Impurity Diazepam EP Impurity E
Applications 6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (Diazepam EP Impurity E) is an impurity of Temazepam (T017200), which is a pharmacologically active metabolite. It is used as a sedative and hypnotic drug.
References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)

Applications Diazepam is an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a controlled substance (depressant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);

Impurity Abiraterone Impurity 5
Applications 17-Iodo-androsta-5,16-diene-3β-ol is an analog of Abiraterone (A108490) and is used as a reagent in the synthesis of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens which exhibit antitumor activity. Abiraterone Impurity 5
References Handratta, V.D., et al.: J. Med. Chem., 48, 2972 (2005)

Impurity Fulvestrant EP Impurity A
Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.
References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),

Applications Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Applications A metabolite of Eszopiclone (E889150).
References Mannaert, E., et al.: J. Pharm. Biomed. Anal., 14, 1367 (1996), Gebauer, M., et al.: Biomed. Chromatogr., 16, 241 (2002),

Applications Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);

Impurity Memantine Related Compound A (1,3-Dimethyladamantane)
Applications 1,3-Dimethyladamantane is a dimethylated adamantane derivative. Memantine impurity A. Memantine Related Compound A (1,3-Dimethyladamantane).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);

Impurity Atenolol EP Impurity A
Applications 4-(Hydroxyphenyl)acetamide (Atenolol EP Impurity A) is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075)
References Inkum, R., et al.: Maejo Int. J. Sci. Tech., 6, 372 (2012); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012); Moon, J.T., et al.: Bio-org. Medn. Chem., 20, 734 (2012);

Impurity Lorazepam USP Related Compound A
Stability hygroscopic
Applications Lorazepam is an anxiolytic compound that potentiates GABAergic synaptic transmission by binding at the benzodiazepine site on the GABAA receptor.1,2 This product is intended for forensic and research applications. Lorazepam acts as ananticonvulsant. Lorazepam USP Related Compound A.Controlled substance (depressant).
References Rutgers, G., et al.: Anal. Profiles Drug Subs., 9, 397 (1980), Korkmaz, S., et al.: Eur. Neuropsychopharmacol., 8, 175 (1998), D’Onofrio, G., et al.: N. Engl. J. Med., 340, 915 (1999),

Applications Selective non-benzodiazepine GABAA receptor agonist.
References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)

Applications Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);

Applications Fulvestrant 17-Ketone, is an impurity of Fulvestrant (F862500), a novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).
References Wakeling, A.E., et al.: Cancer Res., 51, 3867 (1991), Howell, A., et al.: Br. J. Cancer, 74, 300 (1996), Robertson, J.F., et al.: Cancer Res., 61, 6739 (2001),

Applications Methyl Ethanesulfonate is a sulfonic acid ester that is transparent at around 157 nm region, and is used in DFT calculations of vacuum-UV spectra in order to design the vinyl alkylsulfonate polymers for vacuum-UV photoresist applications.
References Fujigaya, T., et al.: J. Photopolym. Sci. Tec., 15, 643 (2002);

Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).
References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),