Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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4-Desmethoxypropoxyl-4-chloro Rabeprazole
CAS:Controlled Product<p>Impurity Rabeprazole EP Impurity H (Lansoprazole EP Impurity F)<br>Applications 4-Desmethoxypropoxyl-4-chloro Rabeprazole (Rabeprazole EP Impurity H (Lansoprazole EP Impurity F)) is a process impurity of Rabeprazole (R070500).<br></p>Formula:C14H12ClN3OSColor and Shape:NeatMolecular weight:305.78(2R,4R)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol 4-(4-Methylbenzenesulfonate)
CAS:Controlled ProductFormula:C21H20Cl2N2O5SColor and Shape:NeatMolecular weight:483.3652,6-Dimethylaniline-d6
CAS:Controlled Product<p>Applications Labelled Bupivacaine (B689560) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lepage, F., et al.: Eur. J. Med. Chem., 27, 581 (1992), Thummel, K.E., et al.: Drug Metab. Dispos., 21, 350 (1993)<br></p>Formula:C82H6H5NColor and Shape:BrownMolecular weight:127.22rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid
CAS:Controlled Product<p>Applications rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid is a potent peptidic renin inhibitor. Pramipexole Related Compound<br></p>Formula:C10H15N3O2Color and Shape:NeatMolecular weight:209.24Lansoprazole-d4
CAS:Controlled ProductFormula:C162H4H10F3N3O2SColor and Shape:NeatMolecular weight:373.39Dipyridamole Tri(diethanolamine)
CAS:Controlled Product<p>Impurity Dipyridamole EP Impurity B<br>Applications Dipyridamole Tri(diethanolamine) (Dipyridamole EP Impurity B) Dipyridamole (D492625) impurity.<br>References Gerlach, E., et al.: Arzneim.-Forsch., 15, 558 (1965),<br></p>Formula:C23H40N8O6Color and Shape:NeatMolecular weight:524.61Sulindac Sulfide
CAS:<p>Stability Hygroscopic<br>Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.<br>References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),<br></p>Formula:C20H17FO2SColor and Shape:Yellow-OrangeMolecular weight:340.41(Z)-Flunarizine
CAS:Controlled Product<p>Impurity Flunarizine EP Impurity D<br>Applications (Z)-Flunarizine is Z-isomer of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). EP Impurity C<br>References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984),<br></p>Formula:C26H26F2N2Color and Shape:NeatMolecular weight:404.49N-Desmethyl Riociguat
CAS:Controlled Product<p>Applications N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem., 4, 853 (2009)<br></p>Formula:C19H17FN8O2Color and Shape:NeatMolecular weight:408.39N-Formyl Amlodipine
CAS:Controlled Product<p>Applications N-Fomyl Amlodipine acts as a reagent for the synthesis of dihydropyridine anti-ischemic and antihypertensive agents.<br>References Alker, D., et al.: Pat. Appl. (1984), EP 119050 A2 19840919<br></p>Formula:C21H25ClN2O6Color and Shape:White To Off-WhiteMolecular weight:436.886Astemizole
CAS:Controlled Product<p>Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>Formula:C28H31FN4OColor and Shape:White To Off-WhiteMolecular weight:458.57Deschloro Aripiprazole
CAS:Controlled Product<p>Impurity Aripiprazole EP Impurity C<br>Applications Deschloroaripiprazole (Aripiprazole EP Impurity C) is a derivative of Aripiprazole (A771000), a dopamine D2 receptor agonist. Antipsychotic.<br>References Chen, X. et al.: J. Med. Chem., 55, 7141 (2012); Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C23H28ClN3O2Color and Shape:Off-WhiteMolecular weight:413.94Sertindole
CAS:Controlled Product<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>Formula:C24H26ClFN4OColor and Shape:NeatMolecular weight:440.94Carprofen Glucuronide
CAS:<p>Stability Hygroscopic<br>Applications Carprofen Glucuronide is a derivative of Carprofen (C184350), a non steroidal anti-inflammatory that is used by veterinarians for the relief of arthritic systems in dogs. It can be used for joint pain or post operative inflammation. Carprofen, is also used for the relief from pain and inflammation associated with osteoarthritis, hip dysplasia and other joint issues.<br>References Randall, L.O., et al.: Arch. Int. Pharmacodyn., 220, 94 (1976), Yu, T.F., et al.: J. Clin. Pharmacol., 20, 347 (1980), O’Brien, W.M., et al.: Pharmacotherapy, 7, 16 (1987),<br></p>Formula:C21H20ClNO8Color and Shape:Light BrownMolecular weight:449.843-Cyclohexyl-6,8-dibromo-3-methyl-1,2,3,4-tetrahydroquinazolinium Chloride
CAS:<p>Impurity Bromhexine EP Impurity E Chloride<br>Applications 3-Cyclohexyl-6,8-dibromo-3-methyl-1,2,3,4-tetrahydroquinazolinium Chloride is an impurity of Bromhexine Hydrochloride (B678600). Bromhexine Hydrochloride impurity E Chloride. Bromhexine is an expectorant; mucolytic.<br>References Goicoechea, H., et al.: Talanta, 49, 793 (1999), Ribone, M., et al.: J. Pharm. Biomed. Anal., 23, 591 (2000),<br></p>Formula:C15H21Br2N2·ClColor and Shape:NeatMolecular weight:424.61Tianeptine
CAS:<p>Applications Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),<br></p>Formula:C21H25ClN2O4SColor and Shape:White To Off-WhiteMolecular weight:436.95Deoxy Epinephrine Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Andregenic and dopamine receptor agonist; active metabolite of Ibopramine (I123500). Also, it is used as internal standard in chromatographic analysis of catecholamines.<br>References Kindler, P., et al.: Arch. Pharm., 270, 340 (1932), Bridgers, W.F., et al.: J. Biol. Chem., 237, 526 (1962),<br></p>Formula:C9H13NO2·ClHColor and Shape:Light Brown To PurpleMolecular weight:203.67Empagliflozin (Tetrahydrofuranyl-d4)
CAS:Controlled Product<p>Applications Empagliflozin-d4 is a labelled analog of Empagliflozin (E521510); a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>Formula:C23D4H23ClO7Color and Shape:NeatMolecular weight:454.934Empagliflozin α-Anomer
CAS:Controlled ProductFormula:C23H27ClO7Color and Shape:White To Off-WhiteMolecular weight:450.9092-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid
CAS:Controlled Product<p>Applications 2-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid is an impurity of Nitrofurantoin (N493850), a nitrofuran antibiotic with low resistance potential that is rapidly metabolized by mammals.<br>References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976); Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004);<br></p>Formula:C7H7N3O5Color and Shape:NeatMolecular weight:213.1483-Hydroxyagomelatine
CAS:<p>Impurity Agomelatine Impurity 11/ Agomelatine 3-Hydroxy Impurity<br>Applications 3-Hydroxyagomelatine is an intermediate in the synthesis of 1-(aminoethyl)naphthalene derivative with potential binding affinity for melatonin receptors. Agomelatine Impurity 11<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simonin, G., et al.: J. Pharma. Biomed. Anal., 21, 591 (1999)<br></p>Formula:C15H17NO3Color and Shape:NeatMolecular weight:259.3(S)-5-Iodo Naproxen
CAS:Controlled ProductFormula:C14H13IO3Color and Shape:NeatMolecular weight:356.16Mavoglurant
CAS:Controlled Product<p>Applications Mavoglurant is a non-competitive metabotropic glutamate receptor 5 (mGlu5) receptor antagonist.<br>References Vranesic, I., et al.; Bioorg. Med. Chem., 22, 5790 (2014); Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23, 6370 (2013)<br></p>Formula:C19H23NO3Color and Shape:NeatMolecular weight:313.39Ebastine
CAS:<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),<br></p>Formula:C32H39NO2Color and Shape:White To Off-WhiteMolecular weight:469.6642-O-tert-Butyldimethylsilyloxyethyl Rapamycin
CAS:<p>Stability Hygroscopic<br>Applications 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012<br></p>Formula:C59H97NO14SiColor and Shape:NeatMolecular weight:1072.48Hydroxydehydro Nifedipine Carboxylate
CAS:Controlled ProductFormula:C16H14N2O7Color and Shape:NeatMolecular weight:346.29Desfluoro Risperidone
CAS:Controlled Product<p>Impurity Risperidone EP Impurity K<br>Applications Desfluoro Risperidone (Risperidone EP Impurity K) is a Risperidone (R525000) impurity, as antipsychotics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C23H28N4O2Color and Shape:NeatMolecular weight:392.49(Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications (Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid is a stereoisomer of Epalrestat (E565300), an aldose reductase inhibitor. Used in the treatment of diabetic neuropathy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985), Qi, M. et al.: J. Beij, Inst. Tech., 13, 445 (2004);<br></p>Formula:C15H13NO3S2Color and Shape:Yellow-Red SolidMolecular weight:319.42-Amino-4-thiazoleacetic Acid
CAS:Controlled ProductFormula:C5H6N2O2SColor and Shape:NeatMolecular weight:158.18Levomepromazine EP Impurity D
Controlled ProductFormula:C32H33N3O2S2Color and Shape:NeatMolecular weight:555.8N-Acetyldesloratadine
CAS:Controlled Product<p>Applications N-Acetyldesloratadine is an impurity in the synthesis of Desloratadine (D290250), Nonsedating-type histamine H1-receptor antagonist.<br>References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000); Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000); Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001);<br></p>Formula:C21H21ClN2OColor and Shape:NeatMolecular weight:352.86Dasatinib Carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Protected Dasatinib Carboxylic Acid (D193605). An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C24H28ClN7O3SColor and Shape:NeatMolecular weight:530.04Perphenazine Sulfoxide
CAS:Controlled Product<p>Impurity Perphenazine EP Impurity A<br>Applications Perphenazine Sulfoxide (Perphenazine EP Impurity A) acts as a D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.<br>References Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975), O Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formula:C21H26ClN3O2SColor and Shape:NeatMolecular weight:419.97Ezetimibe-d4 β-D-Glucuronide, >85%
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Phase-II labelled metabolite of Ezetimibe, an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C30H25D4F2NO9Purity:>85%Color and Shape:NeatMolecular weight:589.57cis Lacidipine
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Z-Isomer of Lacidipine; a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),<br></p>Formula:C26H33NO6Color and Shape:NeatMolecular weight:455.54Ezetimibe Diol Impurity
CAS:Controlled ProductFormula:C24H25F2NO3Color and Shape:NeatMolecular weight:413.466-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline
CAS:Controlled Product<p>Impurity Efavirenz USP Related Compound C/ Efavirenz Quinoline Impurity<br>Applications 6-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Jiang, B., et al.: Euro. J. Org. Chem., 16, 2693 (2008); Ribeiro, J.A., et al.: J. Pharma. Biomed. Anal., 43, 298 (2007);<br></p>Formula:C13H9ClF3NColor and Shape:NeatMolecular weight:271.67Piperazin-1-yl(quinoxalin-6-yl)methanone hydrochloride
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:278.739990234375(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid
CAS:Controlled Product<p>Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.<br>References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)<br></p>Formula:C15H18F3NO4Color and Shape:NeatMolecular weight:333.30Aripiprazole N4-Oxide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 9<br>Applications Aripiprazole N4-Oxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000). Aripiprazole Impurity 9<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Formula:C23H27Cl2N3O3Color and Shape:NeatMolecular weight:464.38Stiripentol-d9
CAS:Controlled Product<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Formula:C14H9D9O3Color and Shape:White SolidMolecular weight:243.35Macitentan
CAS:Controlled Product<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formula:C19H20Br2N6O4SColor and Shape:White To Off-WhiteMolecular weight:588.278-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 12<br>Applications 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide is an intermediate used in the preparation of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Antipsychotic. Aripiprazole Impurity 12<br>References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C14H19Cl2N2·BrColor and Shape:NeatMolecular weight:366.122-Amino-2-[2-(4-hexylphenyl)ethyl]-1,3-propanediol
CAS:Controlled ProductFormula:C17H29NO2Color and Shape:NeatMolecular weight:279.421,1-Cyclohexanediacetic Acid Monoamide
CAS:Controlled Product<p>Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C10H17NO3Color and Shape:White To Off-WhiteMolecular weight:199.247N-Ethoxycarbonyl Norfloxacin
CAS:Formula:C19H22FN3O5Color and Shape:White To Off-WhiteMolecular weight:391.39(Z)-Methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS:Formula:C17H13NO4Color and Shape:NeatMolecular weight:295.292-Hydroxymethyl Olanzapine-d3 (Major)
CAS:Controlled Product<p>Applications A minor labelled metabolite of Olanzapine.<br>References Moore, N., et al.: J. Pharmacol. Exper. Ther., 262, 545 (1992), Chiu, J., et al.: J. Pharmaceut. Biomed. Anal., 14, 609 (1996), Kassahun, K., et al.: Drug Metab. Dispos., 25, 81 (1997),<br></p>Formula:C17H17D3N4OSColor and Shape:NeatMolecular weight:331.452-(Chloromethyl)-4-methylquinazoline
CAS:Controlled Product<p>Impurity Linagliptin 2-Chloromethyl Impurity<br>Applications 2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Formula:C10H9ClN2Color and Shape:NeatMolecular weight:192.64Oxaprozin-d10
CAS:Controlled Product<p>Applications Oxaprozin-d10 is the labeled analogue of Oxaprozin (O845400), an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).<br>References Whitehouse, M.W., et al.: Biochem. Pharmacol., 20, 2309 (1971); Janssen, F.W., et al.: Drug Metab. Dispos., 6, 465 (1978); Shriver, D.A., et al.: Toxicol. Appl. Pharmacol., 42, 75 (1977)<br></p>Formula:C18H5D10NO3Color and Shape:NeatMolecular weight:303.38Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Controlled Product<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Formula:C22H22N4O4Color and Shape:NeatMolecular weight:406.43rac Sulpiride
CAS:Controlled Product<p>Applications An antipsychotic drug used in the treatment of Schozophrenia and depression.<br>References Kramer, P., et al.: J. Neurosci., 31, 126 (2011), Alelyunas, Y., et al.: Bioorg. Med. Chem. Lett., 20, 7312, (2010),<br></p>Formula:C15H23N3O4SColor and Shape:Off-WhiteMolecular weight:341.43Famotidine Sulfoxide
CAS:Controlled Product<p>Applications An intermediate in the synthesis of the metabolite of the drug Famotidine (F102250(P)), which is a histamine H2-receptor antagonist and an antiulcerative.<br>References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982), Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984), Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985),<br></p>Formula:C8H15N7O3S3Color and Shape:NeatMolecular weight:353.44Ticagrelor
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O4SColor and Shape:WhiteMolecular weight:522.57Pomalidomide
CAS:<p>Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.<br>References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)<br></p>Formula:C13H11N3O4Color and Shape:YellowMolecular weight:273.243-Hydroxy Phenytoin
CAS:Controlled Product<p>Applications A major metabolite of Phenytoin, an anticonvulsant.<br>References Bowmer, C., et al.: Biochem. Pharmacol., 27, 937 (1978), Kober, A., et al.: Mol. Pharmacol., 18, 237 (1980), Dasgupta, A., et al.: Ther. Drug Monit., 21, 625 (1999),<br></p>Formula:C15H12N2O3Color and Shape:NeatMolecular weight:268.27trans-Hydroxy Praziquantel
CAS:Controlled Product<p>Applications The main trans-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Formula:C19H24N2O3Color and Shape:NeatMolecular weight:328.412-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one (>90%)
CAS:<p>Impurity Timolol EP Impurity H<br>Applications 2-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one is a impurity of Timolol (T443710), an antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Lacroix, P.M., et. al.: Chirality, 6, 484 (1994); Wasson, et al.: J. Med. Chem., 15, 651 (1972); Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972); Heel, R.C., et al.: Drugs, 17, 38 (1979); Rofman, B.A., et al.: Hypertension, 2, 643 (1980); Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987)<br></p>Formula:C13H24N4O3SPurity:>90%Color and Shape:NeatMolecular weight:316.42Desmethyl Atomoxetine Hydrochloride
CAS:Controlled ProductFormula:C16H20ClNOColor and Shape:Off-WhiteMolecular weight:277.79(Z)-Sulindac Sulfone
CAS:<p>Stability Hygroscopic<br>Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.<br>References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)<br></p>Formula:C20H17FO4SColor and Shape:NeatMolecular weight:372.41N-Nitroso Silodosin
Controlled ProductFormula:C25H31F3N4O5Color and Shape:NeatMolecular weight:524.5334,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine Impurity)
CAS:Controlled Product<p>Impurity Loratadine USP Related Compound E<br>Applications Loratadine impurity. Loratidine impurity E. Loratadine USP Related Compound E.<br>References Villani, et al.: J. Med. Chem., 15, 750 (1972), Zhong, D., et al.: Pharmazie, 49, 736 (1994), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),<br></p>Formula:C14H9Cl2NOColor and Shape:NeatMolecular weight:278.136,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine
CAS:Controlled ProductFormula:C12H16N4O2Color and Shape:NeatMolecular weight:248.281Brivaracetam
CAS:Controlled Product<p>Applications Brivaracetam, is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H20N2O2Color and Shape:Off-WhiteMolecular weight:212.29trans-Amorolfine
CAS:Controlled Product<p>Applications trans-Amorolfine is an analog / impurity of Amorolfine (A634170, HCl); a morpholine antifungal drug and topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Formula:C21H35NOColor and Shape:NeatMolecular weight:317.51A 77-1726
CAS:<p>Impurity Leflunomide EP Impurity B<br>Applications A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formula:C12H9F3N2O2Color and Shape:White To Off-WhiteMolecular weight:270.21Deschloro Dasatinib
CAS:Controlled ProductFormula:C22H27N7O2SColor and Shape:BrownMolecular weight:453.56rac Metanephrine-d3 Hydrochloride Salt
CAS:Controlled Product<p>Applications A labelled metabolite of Epinephrine (E588585). A naturraly occurring derivative of Epinephrine, found in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Formula:C102H3H12NO3·ClHColor and Shape:BeigeMolecular weight:236.71Ticagrelor Acetonide
CAS:<p>Stability Hygroscopic<br>Applications 2-[[(3aS,4R,6S,6aa)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol is an intermediate in the synthesis of Ticagrelor (T437700) which is an anticoagulant.<br>References Qiao, D., et al.: Preparation of anticoagulant Ticagrelor, China Patent 104592237, May 6, 2015;<br></p>Formula:C26H32F2N6O4SColor and Shape:NeatMolecular weight:562.63Tezacaftor-D4
CAS:Controlled ProductFormula:C26D4H23F3N2O6Color and Shape:NeatMolecular weight:524.52(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications (2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.<br>References Karancsi, T., et al.: Acta Pharm. Hung., 66, 21 (1996); Poetter, H., et al.: J. Pharmaceut. Biomed., 6, 115 (1988); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)<br></p>Formula:C19H18N4O6Color and Shape:NeatMolecular weight:398.37Gabapentin-d4 (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C9D4H13NO2Color and Shape:Single SolutionMolecular weight:175.26Cabozantinib N-oxide
CAS:Controlled Product<p>Applications Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.<br>References Jaeger, S., et al.: Cancer Res, 77, 459-469 (2017)<br></p>Formula:C28H24FN3O6Color and Shape:Off-WhiteMolecular weight:517.51Dimepranol-d6
CAS:Controlled Product<p>Stability Volatile<br>Applications Labelled analiogue of Dimepranol, a component of Inosine pranobex (I822350) that produces a small but significant inhibition of the histamine release from human mast cells. Dimepranol is one of the compounds used to identify the illegal manufacture of methadone.<br>References Gielsdorf, W. et al.: Arch. Kriminol., 164, 83 (1979); Schmutzler, W. et al.: Int. Arch. Allergy Appl. Immunol., 88, 244 (1989);<br></p>Formula:C5H7D6NOColor and Shape:NeatMolecular weight:109.2Marbofloxacin
CAS:<p>Applications Fluorinated quinolone antibacterial.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977), Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998),<br></p>Formula:C17H19FN4O4Color and Shape:Off-WhiteMolecular weight:362.36N,N’-Desethylene Ofloxacin Hydrochloride
CAS:Controlled Product<p>Impurity Ofloxacin Desethylene Impurity<br>Applications N,N’-Desethylene Ofloxacin Hydrochloride is an Ofloxacin (O245750) derivative.<br></p>Formula:C16H19ClFN3O4Color and Shape:NeatMolecular weight:371.79Desmethyl Fondenafil
CAS:<p>Applications Desmethyl Fondenafil is an impurity of the drug Fondenafil/Carbodenafil (F685400) a Sildenafil (S435000) related compound found in health foods.<br>References Hamilton, et al.: J. Med. Chem., 30, 91 (1987),<br></p>Formula:C23H30N6O3Color and Shape:White To Light BeigeMolecular weight:438.52ent-Valsartan
CAS:<p>Impurity Valsartan USP Related Compound A<br>Applications ent-Valsartan (Valsartan USP Related Compound A) is the (R)-enantiomer of Valsartan (V095750).<br>References Corea, L., et al.: Clin. Pharmacol. Ther., 60, 341 (1996), Satana, E;., et al.: J. Pharm. Biomed. Anal., 25, 1009 (2001), Sironi, L., et al.: Hypertension, 37, 961 (2001),<br></p>Formula:C24H29N5O3Color and Shape:WhiteMolecular weight:435.523-Isopropylamino-1,2-propanediol
CAS:<p>Impurity Metoprolol EP Impurity N<br>Applications 3-Isopropylamino-1,2-propanediol (Metoprolol EP Impurity N) is a versatile organic building block, used in different chemical synthesis. It is used in the preparation of heterocyclic propanolamines, which are shown to have β-adrenergic antagonist activity.<br>References Dean, V. et al.: Drug Design and Discovery,10, 89 (1993);<br></p>Formula:C6H15NO2Color and Shape:ColourlessMolecular weight:133.191,4-bis[3,4-dihydro-2(1H)-quinolinon-7-oxy]butane
CAS:Controlled Product<p>Impurity Aripiprazole Diquinoline Butanediol Impurity (USP)<br>Applications An impurity found in the process for the preparation of Aripiprazole (A771000). Aripiprazole Diquinoline Butanediol Impurity (USP).<br>References Burris, K., et al.: J. Pharmacol. Exp. Ther., 302, 381 (2002), Harrison, T., et al.: Drugs, 64, 1715 (2004),<br></p>Formula:C22H24N2O4Color and Shape:Off-WhiteMolecular weight:380.44(-)-trans-Phenothrin
CAS:<p>Applications (-)-trans-Phenothrin is used in exhaustive parallel conformational search of pyrethroids and structural similarity study. Also used as an active compound combination having insecticidal properties, a synthetic reagent in the preparation and optical purity of benzylic ester pyrethroid enantiomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bertok, B., et al.: J. Environ. Sci. Health, Part B., 31, 495 (1996); Chuman, H., et al.: Journal of Chemical Software, 4, 143 (1998); Thielert, W., et al.: PCT Int. Appl. (2015), WO 2015132140 A1 20150911;<br></p>Formula:C23H26O3Color and Shape:Colourless To YellowMolecular weight:350.45Decloxizine Dihydrochloride
CAS:Controlled Product<p>Impurity Hydroxyzine EP Impurity B<br>Applications Decloxizine Dihydrochloride (Hydroxyzine EP Impurity B) is a Hydroxyzine (H996500) impurity.<br>References Lulling, J., et al.: Medicina Pharmacol. Exp., 16 48 (1967),<br></p>Formula:C21H28N2O2·2ClHColor and Shape:NeatMolecular weight:413.38Oxyphenbutazone-d9
CAS:Controlled ProductFormula:C192H9H11N2O3Color and Shape:BeigeMolecular weight:333.43Mirtazapine-d4
CAS:Controlled Product<p>Applications Mirtazapine-d4 is the labeled analogue of Mirtazapine (M365000), which is an α2-Adrenergic blocker, analogue of Mianserin, and antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990);<br></p>Formula:C17H15D4N3Color and Shape:White To Light YellowMolecular weight:269.386-Hydroxy-2-mercaptobenzimidazole
CAS:Controlled ProductFormula:C7H6N2OSColor and Shape:NeatMolecular weight:166.20Tolcapone
CAS:Controlled Product<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>Formula:C14H11NO5Color and Shape:ColourlessMolecular weight:273.24Sitagliptin Monohydrochloride Monohydrate
CAS:<p>Applications Sitagliptin Monohydrochloride Monohydrate has therapeutic applications and is used in pharmaceutical compositions in the form of immediate release tablets.<br>References Arroyo Hidalgo, S., & Pladevall Roses, M.: PCT Int. Appl. (2015), WO 2015114152 A1<br></p>Formula:C16H15F6N5O·HCl·H2OColor and Shape:NeatMolecular weight:407.31 + 36.46 + 18.023,4-Dihydro-7-hydroxyquinoline-2(1H)-one
CAS:Formula:C9H9NO2Color and Shape:NeatMolecular weight:163.175-Hydroxy Omeprazole Sodium Salt
CAS:<p>Stability Hygroscopic<br>Applications The main metabolite of Omeprazole.<br>References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),<br></p>Formula:C17H18N3NaO4SColor and Shape:White To Light YellowMolecular weight:383.40(R)-Lisinopril Sodium Salt
CAS:<p>Applications R,S,S-Isomer of Lisinopril (L468985).<br>References Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)<br></p>Formula:C21H31N3NaO5Color and Shape:NeatMolecular weight:428.48
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