Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5593 products of "Apoptosis"
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Thalidomide-O-C4-COOH
CAS:<p>Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.</p>Formula:C18H18N2O7Color and Shape:SolidMolecular weight:374.3447Kdo2-Lipid A ammonium
CAS:<p>Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.</p>Formula:C110H214N6O39P2Purity:98%Color and Shape:SolidMolecular weight:2306.84Anticancer agent 268
<p>Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.</p>Color and Shape:Odour SolidDapirolizumab
<p>Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.</p>Purity:>95%Color and Shape:LiquidMolecular weight:145.5 kDa(-)-Mcl-1 inhibitor 21
CAS:<p>(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Formula:C32H33N3O4Color and Shape:SolidMolecular weight:523.622STM3006
CAS:<p>STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).</p>Formula:C25H27BrN8Purity:97.16%Color and Shape:SoildMolecular weight:519.44ZX782
<p>ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.</p>Formula:C39H48ClN5O8Color and Shape:SolidMolecular weight:750.28Didocosahexaenoin
CAS:<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Formula:C25H40O5Color and Shape:SolidMolecular weight:420.58Macrophage-activating lipopeptide 2 TFA
<p>Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,</p>Formula:C99H167N19O30S·xC2HF3O2Purity:97.56%Color and Shape:SolidMolecular weight:2135.56 (free base)SBP-0636457
CAS:<p>SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.</p>Formula:C25H36N4O4Color and Shape:SolidMolecular weight:456.587Thalidomide-NH-C6-NH-Boc
CAS:<p>Thalidomide-based E3 ligase ligand for PROTAC degrader MI-389 synthesis, linked to cereblon and Boc.</p>Formula:C24H32N4O6Color and Shape:SolidMolecular weight:472.542Thalidomide-5-propargyne-NH2 hydrochloride
CAS:<p>Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.</p>Formula:C16H14ClN3O4Color and Shape:SolidMolecular weight:347.753Pantinin-1
CAS:<p>Pantinin-1 is an antimicrobial peptide found in the venom of the emperor scorpion (Pandinus imperator). This compound exhibits strong antibacterial activity against Gram-positive bacteria and fungi, but has weaker effects on Gram-negative bacteria. Additionally, Pantinin-1 demonstrates very low hemolytic activity on human red blood cells and possesses anticancer properties, specifically inducing apoptosis in tumor cells.</p>Formula:C75H119N17O18Color and Shape:SolidMolecular weight:1546.85c-Met/HDAC-IN-4
<p>c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.</p>Formula:C37H36N8OColor and Shape:SolidMolecular weight:608.73Caspase-3 activator 3
<p>Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic</p>Purity:98%Color and Shape:Odour SolidKRN 5500
CAS:<p>KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.</p>Formula:C28H43N7O7Purity:98%Color and Shape:SolidMolecular weight:589.68Methyl-4-oxoretinoate
CAS:<p>Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.</p>Formula:C21H28O3Purity:98.07%Color and Shape:SolidMolecular weight:328.45CAY10678
CAS:<p>CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS</p>Formula:C23H34N4OPurity:99.66%Color and Shape:SolidMolecular weight:382.54Canfosfamide
CAS:<p>Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.</p>Formula:C26H40Cl4N5O10PSColor and Shape:SolidMolecular weight:787.47sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Formula:C28H28F3N3O4Color and Shape:SolidMolecular weight:527.535Milademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Formula:C37H44Cl2FN5O8SColor and Shape:SolidMolecular weight:808.74eIF4A3-IN-5
CAS:<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Formula:C26H22N2O7Color and Shape:SolidMolecular weight:474.469Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98Eciskafusp alfa
CAS:<p>Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific</p>Purity:98%Color and Shape:SolidAnti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
<p>Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.</p>Color and Shape:Odour LiquidFGFR1/VEGFR2-IN-3
<p>FGFR1/VEGFR2-IN-3 (Compound 8m) acts as a dual inhibitor of FGFR1 and VEGFR2. This compound exhibits both anti-cancer cell proliferation and anti-migration activities, and it also has the capability to induce cell apoptosis (apoptosis).</p>Formula:C27H18N4O4Color and Shape:SolidMolecular weight:462.46IRAK4-IN-27
<p>IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.</p>Formula:C23H22N6O3Purity:98%Color and Shape:SolidMolecular weight:430.46CDK-TCIP1
CAS:<p>CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.</p>Formula:C48H62ClN11O8S2Color and Shape:SolidMolecular weight:1020.66CYP51/PD-L1-IN-4
<p>CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.</p>Formula:C27H28N4O3Color and Shape:SolidMolecular weight:456.54EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Formula:C24H27Cl2N7Purity:98%Color and Shape:SolidMolecular weight:484.42ROS inducer 5
<p>ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.</p>Formula:C20H15ClN4O2S3Color and Shape:SolidMolecular weight:475.01Besufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Color and Shape:LiquidChoKα inhibitor-3
<p>ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to</p>Formula:C50H54Br2Cl2N4S2Color and Shape:SolidMolecular weight:1005.8315-Acetoxyscirpenol
CAS:<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>Formula:C17H24O6Purity:98%Color and Shape:SolidMolecular weight:324.373Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Formula:C21H30O5Color and Shape:SolidMolecular weight:362.47PKM2-IN-8
<p>PKM2-IN-8 (Compound 9b) is an inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.31 μM. It exhibits potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 induces early apoptosis and reduces lactate levels. This compound is useful for research in glioblastoma.</p>Formula:C19H13N7OColor and Shape:SolidMolecular weight:355.353NF-κB-IN-19
<p>NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. It effectively induces DNA damage in tumor cells through the NF-κB signaling pathway and promotes the production of reactive oxygen species (ROS), as well as induces autophagy and apoptosis. Additionally, NF-κB-IN-19 inhibits levels of VEGF and HIF-1α, exerting antiproliferative effects in tumor cells through the PI3K/AKT and STAT-3 pathways. It is also effective in overcoming cisplatin resistance and exhibits antitumor activity.</p>Formula:C24H26Cl3F2N3O4PtColor and Shape:SolidMolecular weight:759.92Antiproliferative agent-59
<p>Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.</p>Formula:C26H22N2O3Color and Shape:SolidMolecular weight:410.46ADPM06
CAS:<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Formula:C34H24BBr2F2N3O2Color and Shape:SolidMolecular weight:715.195α-dihydro Levonorgestrel
CAS:<p>5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .</p>Formula:C21H30O2Color and Shape:SolidMolecular weight:314.469Schisandronic acid
CAS:<p>Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.</p>Formula:C30H46O3Color and Shape:SolidMolecular weight:454.68S-Adenosyl-L-methionine iodide
CAS:<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Formula:C15H23IN6O5SColor and Shape:SolidMolecular weight:526.35Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Formula:C80H113N25O27Color and Shape:SolidMolecular weight:1856.932ATPase-IN-3
CAS:<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Formula:C10H6N2O3S2Purity:97.76%Color and Shape:SoildMolecular weight:266.3PROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Formula:C32H29IN4O4S2Color and Shape:SolidMolecular weight:724.63BLU-222
CAS:<p>BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.</p>Formula:C15H17F2N7O2Purity:99.17% - 99.92%Color and Shape:SoildMolecular weight:365.34LSD1-IN-36
<p>LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.</p>Formula:C22H25N3O6SColor and Shape:SolidMolecular weight:459.52Bcl-xL antagonist 2
CAS:<p>Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.</p>Formula:C21H16N4O3S2Purity:99.81%Color and Shape:SolidMolecular weight:436.51Kurzipene D
CAS:<p>Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.</p>Formula:C26H36O8Color and Shape:SolidMolecular weight:476.56RA-XII
CAS:<p>RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.</p>Formula:C46H58N6O14Color and Shape:SolidMolecular weight:918.998
