Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(114 products)
- CDK(546 products)
- Cell Cycle Arrest(5 products)
- Chk(48 products)
- DYRK(47 products)
- Dynamin(27 products)
- Ferroptosis(227 products)
- HSP(179 products)
- Integrin(263 products)
- Kinesin(87 products)
- LIM Kinase(20 products)
- Microtubule Associated(274 products)
- PKC(126 products)
- PLK(25 products)
- ROCK(62 products)
- Rho(6 products)
- Wee1(14 products)
- c-Myc(76 products)
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Found 3891 products of "Cell Cycle/Checkpoint"
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2′-OMe-ADP
CAS:2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.Formula:C11H17N5O10P2Color and Shape:SolidMolecular weight:441.232′-F-UDP
CAS:2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C9H13FN2O11P2Color and Shape:SolidMolecular weight:406.15CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Formula:C25H31FN8Purity:98%Color and Shape:SolidMolecular weight:462.57LIMK1 inhibitor 1
CAS:LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.Formula:C12H15N3S2Color and Shape:SolidMolecular weight:265.398LNA-UTP
CAS:LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C10H15N2O15P3Color and Shape:SolidMolecular weight:496.15CDK1-IN-3
CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.Formula:C28H25ClF3N5O2Color and Shape:SolidMolecular weight:555.98CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Formula:C20H18N4O4Color and Shape:SolidMolecular weight:378.38WRN inhibitor 11
CAS:WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formula:C34H35ClF3N9O5Color and Shape:SolidMolecular weight:742.15c-Myc inhibitor 4
Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.Formula:C26H33FN6O3Color and Shape:SolidMolecular weight:496.58UM-C162
CAS:UM-C162, a benzimidazole derivative, offers protection to nematodes from Staphylococcus aureus infections. It inhibits biofilm formation without impairing bacterial viability. Additionally, UM-C162 disrupts the production of Staphylococcus aureus hemolysins, proteases, and coagulases. This compound holds potential as an antivirulence agent for managing Staphylococcus aureus infections.Formula:C30H25N3O4Color and Shape:SolidMolecular weight:491.54CDK7-IN-26
CAS:CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.Formula:C22H22FN6OPSMolecular weight:468.49Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formula:C14H13F3N6Color and Shape:SolidMolecular weight:322.29Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Formula:C20H21N5O3SColor and Shape:SolidMolecular weight:411.48Adafosbuvir
CAS:Adafosbuvir has antiviral activity.Formula:C22H29FN3O10PColor and Shape:SolidMolecular weight:545.457CDK8-IN-5
CAS:CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Formula:C26H22N2O4Color and Shape:SolidMolecular weight:426.46PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Color and Shape:SolidPolθ-IN-7
CAS:Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.Formula:C28H35F3N6O2Color and Shape:SolidMolecular weight:544.6123'-Deoxy-GTP
CAS:3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.Formula:C10H16N5O13P3Color and Shape:SolidMolecular weight:507.181Zorubicin
CAS:Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.Formula:C34H35N3O10Color and Shape:SolidMolecular weight:645.66RAD51-IN-5
CAS:RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)Formula:C26H38N4O5S2Color and Shape:SolidMolecular weight:550.73MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Formula:C21H23N5O2Color and Shape:SolidMolecular weight:377.44EFdA-TP tetrasodium
CAS:EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Formula:C12H11FN5Na4O12P3Purity:98%Color and Shape:SolidMolecular weight:621.12CDK7-IN-18
CAS:CDK7-IN-18 (Compound 15) is a pyrimidine-derived CDK7 inhibitor suitable for studying cancers with transcriptional dysregulation.Formula:C22H24F3N7OSPurity:99.28% - 99.54%Color and Shape:SolidMolecular weight:491.53ATIC-IN-2
CAS:ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.Formula:C4H4N4O3SColor and Shape:SolidMolecular weight:188.165CTX-712
CAS:CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.Formula:C19H17FN8O2Color and Shape:SolidMolecular weight:408.39PAIR2
CAS:PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.Formula:C27H26F4N6O3SColor and Shape:SolidMolecular weight:590.595-Methylcytosine hydrochloride
CAS:5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Formula:C5H8ClN3OColor and Shape:SolidMolecular weight:161.59MTH1 activator-1
CAS:MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.Formula:C29H23F3N4O2Color and Shape:SolidMolecular weight:516.514DNA Gyrase-IN-13
CAS:DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.Formula:C15H21N3O3SColor and Shape:SolidMolecular weight:323.41Ascofuranone
CAS:Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODHFormula:C23H29ClO5Color and Shape:SolidMolecular weight:420.933'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
CAS:3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.Formula:C41H50N9O3PColor and Shape:SolidMolecular weight:747.87LZ9
CAS:LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.Formula:C17H11F3N4O2Color and Shape:SolidMolecular weight:360.29CDK2 degrader 4
CAS:CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Formula:C23H26ClN3O5Color and Shape:SolidMolecular weight:459.923Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Formula:C22H16FN3O2SColor and Shape:SolidMolecular weight:405.445NRTT-IN-1
CAS:NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.Formula:C28H24FN5O5Color and Shape:SolidMolecular weight:529.519Uridine 3',5'-diphosphate
CAS:Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].Formula:C9H14N2O12P2Color and Shape:SolidMolecular weight:404.16CDK2-IN-18
CAS:CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].Formula:C21H23N7O2SColor and Shape:SolidMolecular weight:437.52Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C15H25ClN4O6Color and Shape:SolidMolecular weight:392.84PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formula:C22H19N5O2Color and Shape:SolidMolecular weight:385.42DB18
CAS:DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Formula:C24H18ClN7O3Color and Shape:SolidMolecular weight:487.9WRN inhibitor 7
CAS:WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].Formula:C27H23N3O6Color and Shape:SolidMolecular weight:485.49CDK2 degrader 6
CAS:CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formula:C23H22F5N5O3Color and Shape:SolidMolecular weight:511.447-Methylguanosine 5′-monophosphate
CAS:7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.Formula:C11H16N5O8PColor and Shape:SolidMolecular weight:377.258-Azakinetin riboside
CAS:8-Azakinetin riboside, a structural analog of kinetin riboside, exhibits cytotoxic activity [1].Formula:C14H16N6O5Color and Shape:SolidMolecular weight:348.31GSK_WRN4
CAS:GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFormula:C16H20N2O4SPurity:99.95%Color and Shape:SolidMolecular weight:336.41p38α inhibitor 9
CAS:p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.Formula:C27H24FN3O3Color and Shape:SolidMolecular weight:457.496INX-315
CAS:INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.Formula:C19H21N7O3SPurity:99.88%Color and Shape:SolidMolecular weight:427.482'-F-CDP
CAS:2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.Formula:C9H14FN3O10P2Color and Shape:SolidMolecular weight:405.17Anti-neuroinflammation agent 3
CAS:Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Formula:C22H23FN6O2Molecular weight:422.455Dmf-dg
CAS:Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.Formula:C13H18N6O4Color and Shape:SolidMolecular weight:322.326-N-Hydroxylaminopurine
CAS:6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Formula:C5H5N5OMolecular weight:151.13DHX9-IN-9
CAS:DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].Formula:C21H21ClFN5O3S2Color and Shape:SolidMolecular weight:510CDK8-IN-14
CAS:CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].Formula:C18H13N3O2Color and Shape:SolidMolecular weight:303.31PLK1-IN-5
CAS:PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].Formula:C28H39N7O3Color and Shape:SolidMolecular weight:521.65Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formula:C17H21N3OColor and Shape:SolidMolecular weight:283.37KI-CDK9d-32
CAS:KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.Formula:C39H45N9O4Color and Shape:SolidMolecular weight:703.83CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Color and Shape:SolidMolecular weight:406.44CD 10899
CAS:CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].Formula:C34H50N8O4Color and Shape:SolidMolecular weight:634.81iPAF1C
CAS:iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].
Formula:C27H26BrFN4OColor and Shape:SolidMolecular weight:521.42L-Tyrosyl-L-glutamic acid
CAS:L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Formula:C14H18N2O6Color and Shape:SolidMolecular weight:310.3CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.Formula:C22H25N5O3Color and Shape:SolidMolecular weight:407.47Mps1-IN-8
CAS:Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formula:C35H47N8O6PColor and Shape:SolidMolecular weight:706.77LIMK-IN-2
CAS:LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].Formula:C28H27N5O2Color and Shape:SolidMolecular weight:465.55PLK1-IN-11
CAS:PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.Formula:C12H11N5OColor and Shape:SolidMolecular weight:241.249Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formula:C12H8N4O2SColor and Shape:SolidMolecular weight:272.28SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formula:C20H25N5O4SPurity:98%Color and Shape:SolidMolecular weight:431.51Antitumor agent-75
Antitumor agent-75 is a novel and potent antitumor agent.Formula:C26H23FN6Color and Shape:SolidMolecular weight:438.5CDK1-IN-4
CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.Formula:C26H24ClN5SColor and Shape:SolidMolecular weight:474.02RAD51-IN-6
CAS:RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)Formula:C27H40N3O5PSColor and Shape:SolidMolecular weight:549.66CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formula:C19H15F3N4O2Purity:99.74%Color and Shape:SolidMolecular weight:388.34Ref: TM-T61742
1mg54.00€5mg114.00€10mg178.00€25mg409.00€50mg708.00€100mg982.00€1mL*10mM (DMSO)126.00€Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Formula:C23H25N9SPurity:98%Color and Shape:SolidMolecular weight:459.57RNase L ligand 3
CAS:RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Formula:C27H27N3OSColor and Shape:SolidMolecular weight:441.59AGH-107
CAS:AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.Formula:C13H12IN3Color and Shape:SolidMolecular weight:337.16CDK9-IN-34
CAS:CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.Formula:C18H20N4Color and Shape:SolidMolecular weight:292.38DENV-IN-6
CAS:DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.Formula:C23H26ClFN4OSColor and Shape:SolidMolecular weight:461BBI-355
CAS:BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.40Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFormula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45L-2'-Fd4C
CAS:L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Formula:C9H10FN3O3Color and Shape:SolidMolecular weight:227.193-IN-PP1
CAS:3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.Formula:C17H18N6Color and Shape:SolidMolecular weight:306.362'-F-UMP
CAS:2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.
Formula:C9H12FN2O8PMolecular weight:326.17Aurora A inhibitor 1
CAS:Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Formula:C25H28ClF2N5O2Color and Shape:SolidMolecular weight:503.9712(S)-HETE
CAS:Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.
Formula:C20H32O3Color and Shape:SolidMolecular weight:320.472′-O-MOE-AMP
CAS:2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C13H20N5O8PColor and Shape:SolidMolecular weight:405.30LN-439A
CAS:LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.Formula:C24H26FN3O4Color and Shape:SolidMolecular weight:439.48CB 30900
CAS:CB30900 is a novel and effective thymidylate synthase inhibitor.Formula:C31H32FN5O9Color and Shape:SolidMolecular weight:637.61RECTAS-2.0
CAS:RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.
Formula:C18H17ClN4O4Color and Shape:SolidMolecular weight:388.805ddCTP trisodium
ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.Formula:C9H13N3Na3O12P3Color and Shape:SolidMolecular weight:517.1Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Formula:C23H23F5N8OColor and Shape:SolidMolecular weight:522.47Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formula:C23H18ClF2N7O3SColor and Shape:SolidMolecular weight:545.95Z4P
CAS:Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Formula:C19H24N2O2Purity:98.99%Color and Shape:SolidMolecular weight:312.41Ref: TM-T87658
1mg77.00€5mg167.00€10mg268.00€25mg537.00€50mg858.00€100mg1,333.00€200mg1,783.00€1mL*10mM (DMSO)178.00€Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Color and Shape:SolidMolecular weight:437.612-Amino-2'-fluoro-2'-deoxyadenosine
CAS:2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.Formula:C10H13FN6O3Color and Shape:SolidMolecular weight:284.253′-Amino-2′,3′-dideoxy-CTP
CAS:3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.Formula:C9H17N4O12P3Color and Shape:SolidMolecular weight:466.17CDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Formula:C19H16ClF3N4O2Color and Shape:SolidMolecular weight:424.8And1 degrader 1
CAS:And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.Formula:C26H27Cl2N3OColor and Shape:SolidMolecular weight:468.42DNA Gyrase-IN-1
DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.Formula:C24H24FN7O6Color and Shape:SolidMolecular weight:525.49Norharmine
CAS:Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.Formula:C12H10N2OColor and Shape:SolidMolecular weight:198.2215-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Formula:C9H12FN2O9PColor and Shape:SolidMolecular weight:342.172CDK7-IN-33
CAS:CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Formula:C29H36N6O4SColor and Shape:SolidMolecular weight:564.699IIP0943
CAS:IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.Formula:C26H28N6O3SColor and Shape:SolidMolecular weight:504.604
