Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(109 products)
- CDK(522 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(222 products)
- HSP(179 products)
- Integrin(256 products)
- Kinesin(83 products)
- LIM Kinase(19 products)
- Microtubule Associated(284 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(67 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(74 products)
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Found 3726 products of "Cell Cycle/Checkpoint"
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GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Formula:C93H134N22O25Purity:99.92%Color and Shape:SolidMolecular weight:1960.19RI-2
CAS:<p>RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.</p>Formula:C21H18Cl2N2O4Purity:99.63% - 99.86%Color and Shape:SolidMolecular weight:433.28SBC-115337
CAS:SBC-115337 is a PCSK9 inhibitor.Formula:C29H19N3O4Purity:99.41%Color and Shape:SolidMolecular weight:473.48NSC 617145
CAS:<p>NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent</p>Formula:C13H10Cl4N2O4Purity:99.72%Color and Shape:SolidMolecular weight:400.04T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purity:98.39% - 99.57%Color and Shape:SolidMolecular weight:389.33Acelarin
CAS:<p>Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.</p>Formula:C25H27F2N4O8PPurity:99.26%Color and Shape:SolidMolecular weight:580.47CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurity:97.36% - 97.59%Color and Shape:SolidMolecular weight:368.46kb-NB77-78
CAS:<p>kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).</p>Formula:C18H25NO3SiPurity:99.54%Color and Shape:SolidMolecular weight:331.48EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Formula:C25H29Cl2F3N2O4SPurity:98.39% - 99.42%Color and Shape:SolidMolecular weight:581.47Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Formula:C38H47N5O7S2Purity:99.45% - 99.92%Color and Shape:SolidMolecular weight:749.94IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Dalpiciclib
CAS:<p>Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.</p>Formula:C25H30N6O2Purity:99.69%Color and Shape:SolidMolecular weight:446.54N1-Methylpseudouridine
CAS:N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms byFormula:C10H14N2O6Purity:98.95% - 99.88%Color and Shape:SolidMolecular weight:258.23LJI308
CAS:LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Formula:C21H18F2N2O2Purity:99.73% - 99.87%Color and Shape:SolidMolecular weight:368.38Trifluridine/tipiracil hydrochloride mixture
CAS:Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormula:C29H34Cl2F6N8O12Purity:98% - 99.79%Color and Shape:SolidMolecular weight:871.53Mitonafide
CAS:<p>Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.</p>Formula:C16H15N3O4Purity:99.89%Color and Shape:SolidMolecular weight:313.31Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43PFM01
CAS:PFM01 inhibits MRE11 enzyme, steering DSBR towards NHEJ over HR.Formula:C14H15NO2S2Purity:98.68%Color and Shape:SolidMolecular weight:293.4HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formula:C22H20N2O5SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:424.47TAK-960
CAS:<p>TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.</p>Formula:C27H34F3N7O3Purity:97.06%Color and Shape:SolidMolecular weight:561.6Carotegrast methyl HCl
CAS:Carotegrast methyl (AJM300/PTC-100) is an oral α4 integrin blocker reducing inflammation and experimental colitis.Formula:C25H20Cl3N3O5Color and Shape:SolidMolecular weight:548.8015-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Formula:C5H3FN2O4Purity:99.7% - >99.99%Color and Shape:White To Pale Yellow PowderMolecular weight:174.09CHR-6494 TFA
CAS:CHR-6494 TFA: potent haspin inhibitor (IC50=2 nM), blocks H3T3 phosphorylation, triggers apoptosis in cancer cells. Used for cancer research.Formula:C18H17F3N6O2Purity:99.50%Color and Shape:SolidMolecular weight:406.36Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purity:98.99% - 99.54%Color and Shape:SolidMolecular weight:717.69Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFormula:C24H26N4O5SPurity:99.00% - 99.86%Color and Shape:SolidMolecular weight:482.55Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Formula:C11H10Cl2N4Purity:98.42%Color and Shape:SolidMolecular weight:269.13Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formula:C5H7N6NaO5SPurity:99.55%Color and Shape:SolidMolecular weight:286.2Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Formula:C24H30N8OPurity:99.624%Color and Shape:SolidMolecular weight:446.55CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Formula:C9H6N2O4Purity:98.27% - 98.98%Color and Shape:Brown PowderMolecular weight:206.15Methotrexate metabolite
CAS:DAMPA, active metabolite of Methotrexate, is a chemotherapeutic and immunosuppressive folic acid antagonist.Formula:C15H15N7O2Purity:95.60% - 97.59%Color and Shape:SolidMolecular weight:325.33Nemorubicin
CAS:<p>Nemorubicin (PNU 152243) is a unique doxorubicin variant with varied antitumor action, metabolism, and toxicity, effective against resistant tumors.</p>Formula:C32H37NO13Purity:97.4%Color and Shape:SolidMolecular weight:643.64SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormula:C15H19Br2ClN4Purity:98.13% - 98.47%Color and Shape:SolidMolecular weight:450.6NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formula:C18H14N2O3Purity:99.27%Color and Shape:SolidMolecular weight:306.32Apcin-A
CAS:Apcin-A is an anaphase-promoting complex (APC) inhibitor.Formula:C10H14Cl3N5O2Color and Shape:SolidMolecular weight:342.61MLS000532223
CAS:<p>MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).</p>Formula:C15H9NO3Purity:98.6%Color and Shape:SolidMolecular weight:251.24Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormula:C23H20F2N2O4·CH4O3S·H2OPurity:99.56%Color and Shape:SolidMolecular weight:540.53TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurity:98.23%Color and Shape:SolidMolecular weight:422.54BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formula:C22H32N6·HClPurity:99.21%Color and Shape:SolidMolecular weight:416.99NSC23005 Sodium
CAS:<p>NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.</p>Formula:C13H16NNaO4SPurity:99.64%Color and Shape:SolidMolecular weight:305.32TAK-960 monohydrochloride
CAS:<p>TAK-960 monohydrochloride, an oral compound, inhibits PLK1 (IC50=0.8 nM), PLK2, PLK3, stunts cancer cell growth, and is effective in tumor models.</p>Formula:C27H35ClF3N7O3Color and Shape:SolidMolecular weight:598.07ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormula:C38H43N3O6Purity:99.16% - 99.27%Color and Shape:SolidMolecular weight:637.76FEN1-IN-SC13
CAS:<p>FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)</p>Formula:C24H23N3O3SPurity:98.02%Color and Shape:SolidMolecular weight:433.52DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:<p>DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.</p>Formula:C41H49N4O9PPurity:98.28%Color and Shape:SolidMolecular weight:772.82THZ1
CAS:<p>THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.</p>Formula:C31H28ClN7O2Purity:95.09% - 99.27%Color and Shape:SolidMolecular weight:566.05Palbociclib dihydrochloride
<p>Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.</p>Formula:C24H31Cl2N7O2Color and Shape:SolidMolecular weight:520.45SBC-110736
CAS:SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitorFormula:C26H27N3O2Purity:99.44%Color and Shape:SolidMolecular weight:413.51MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formula:C25H15ClF2N4O2Purity:98.07% - 98.26%Color and Shape:SolidMolecular weight:476.86(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formula:C29H30Cl2N6O2Purity:97.08%Color and Shape:SolidMolecular weight:565.5
