Sirtuin

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism …

Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary …

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).

5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can …

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a …

SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.

Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).

UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that …

lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of …

SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent …

AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease …

SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent …

SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold …

EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold …

Tenovin-6 is a p53 transcriptional activity agonist.

Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: …

Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally …

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a …

Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes …

AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 …

SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).

YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells …

N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 …

MC2184 is the inhibitor of human recombinant SIRT1.

Selisistat R-enantiomer is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat …

SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.

SRT1460 is a SIRT1 activator.

Tenovin-3 acts as a p53 activator.

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin …

Selisistat S-enantiomer is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows …

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin …

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 …

4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)

Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: …

OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma …

Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.

3-TYP is a selective SIRT3 inhibitor.