Neuroscience

<p>Ogerin: GPR68 modulator, blocks mice fear recall, A2A inverse agonist/antagonist (Ki 220 nM), weak 5-HT2B antagonist (Ki 736 nM).</p>

<p>LY2389575 hydrochloride is a selective mGlu3 NAM with 190 nM IC50, increases Mrc1, and aids Alzheimer's research.</p>

<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>

<p>Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of end</p>

<p>Fluxametamide, an isoxazoline insecticide, targets insect chloride channels with IC50s of 1.95 nM (GABA) and 225 nM (glutamate).</p>

<p>Pamicogrel (KBT3022) is an inhibitor of COX.</p>

<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>

<p>Tegaserod (SDZ-HTF-919), a 5-HT4 agonist for irritable bowel syndrome, was withdrawn by FDA on March 30, 2007, due to heart risk concerns.</p>

<p>Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.</p>

<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>

<p>4-Hydroxyisophthalic acid is used as medical intermediate</p>

<p>Ipratropium bromide, safer than atropine, treats bronchial disorders, rhinitis, and irregular heartbeat via inhalation.</p>

<p>Quetiapine treats schizophrenia and bipolar I, targeting serotonin, dopamine, and adrenoreceptor subtypes, plus H1 histamine receptor.</p>

<p>Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.</p>

<p>Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.</p>

<p>Desbenzyl Donepezil Hydrochloride is an impurity of Donepezil.</p>

<p>Mirtazapine is a unique tetracyclic antidepressant, may cause temporary liver enzyme elevation, and is linked to rare liver injury.</p>

<p>S-(+)-Ketoprofen, an NSAID, blocks cyclo-oxygenase to reduce pain and inflammation. Sold as Keral, Miracox, Enantyum, and Dolmen in various regions.</p>

<p>Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.</p>

<p>Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.</p>

<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>

<p>Luzindole (N-0774) is a selective melatonin receptor antagonist.</p>

<p>Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and</p>

<p>Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.</p>

<p>BF-1 blocks 5-HT2B, may prevent migraines by hindering BW723C86/mCPP in guinea pigs.</p>

<p>Doxepin hydrochloride, a dibenzoxepin tricyclic, blocks monoamine reuptake and has anticholinergic and antihistaminic effects. Mechanism partly unknown.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human NEFL protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NEFL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NEFL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human NRGN protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NRGN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NRGN in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).</p>

<p>Sarizotan 2HCl is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinsonian movement disorders.</p>

<p>Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.</p>

<p>LJP-1586 HCl: selective VAP-1 inhibitor, reduces inflammation and immune cell infiltration post-ICH.</p>

<p>YKP 10811 (Relenopride) is a novel 5-HT4 receptor partial agonist, which can be used to study irritable bowel syndrome with constipation.</p>

<p>SSR 180 is a potent and subtype-selective α7 agonist with applications in the study of Alzheimer;s disease and schizophrenia.</p>

<p>Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.</p>

<p>JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.</p>

<p>Tropisetron hydrochloride (Tropisetron HCl) is a selective, competitive serotonin 5-HT3 receptor antagonist, with antinauseant and antiemetic activities.</p>

<p>Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy</p>

<p>Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties.</p>

<p>LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)</p>

<p>Org-26576 is a positive allosteric modulator of the AMPA receptor.</p>

<p>Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous</p>

<p>Chlorprothixene hydrochloride, a typical antipsychotic, blocks 5-HT2, D1-D3, H1, muscarinic, and alpha1 receptors.</p>

<p>9-Cyclopentyladenine (NSC-19486) is an adenylate cyclase inhibitor that blocks cellular morphological differentiation and phosphorylation of specific signaling</p>

<p>JNJ-61432059 is an oral active and selective negative modulator of TARP γ‑8 Selective AMPAR(pIC50: 9.7).</p>

<p>PF-04995274: potent, selective partial 5-HT4R agonist; EC50 0.26-0.47 nM; brain penetrant; may treat Alzheimer's cognitive issues.</p>

<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>