Neuroscience
Neuroscience inhibitors are compounds designed to modulate the activity of specific proteins, enzymes, or receptors within the nervous system. These inhibitors are crucial for studying the molecular mechanisms underlying neural function, synaptic transmission, and neurodegenerative diseases. By targeting neurotransmitter receptors, ion channels, and signaling pathways, neuroscience inhibitors aid in the exploration of brain function and the development of therapeutic strategies for neurological disorders such as Alzheimer's, Parkinson's, and epilepsy. At CymitQuimica, we offer a comprehensive range of high-quality neuroscience inhibitors to support your research in neurobiology, neuropharmacology, and cognitive sciences.
Subcategories of "Neuroscience"
- 5-HT Receptor(940 products)
- ACK(1 products)
- AChR(574 products)
- ATP Citrate Lyase(16 products)
- Adrenergic Receptor(2,939 products)
- BACE(36 products)
- Beta Amyloid(204 products)
- CaMK(68 products)
- Cyclooxygenase (COX) Inhibitors(562 products)
- Dopamine Receptor(407 products)
- GABA Receptor(336 products)
- Gamma-secretase(59 products)
- GluR(255 products)
- GlyT(24 products)
- Histamine Receptor(358 products)
- LRRK2(33 products)
- Melatonin Receptor(24 products)
- NMDAR(28 products)
- OX Receptor(40 products)
- Opioid Receptor(296 products)
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Found 5400 products of "Neuroscience"
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BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formula:C26H46BrN5O10P2Color and Shape:SolidMolecular weight:730.52L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Formula:C4H10NO5PPurity:98%Color and Shape:White To Off-White Crystalline PowderMolecular weight:183.14-Chloro-L-phenylalanine
CAS:<p>4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).</p>Formula:C9H10ClNO2Purity:99.76% - 99.96%Color and Shape:SolidMolecular weight:199.63SB 258719
CAS:<p>SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.</p>Formula:C18H30N2O2SPurity:99.73%Color and Shape:SolidMolecular weight:338.51GR 125487 sulfamate
CAS:<p>GR 125487 sulfamate is a 5-HT4 receptor antagonist.</p>Formula:C19H29FN4O8S2Purity:98%Color and Shape:SolidMolecular weight:524.58L 663581
CAS:<p>L 663581 is the benzodiazepine receptor partial agonist.</p>Formula:C17H16ClN5O2Purity:98%Color and Shape:SolidMolecular weight:357.79Piperidine-4-sulfonic acid
CAS:<p>Piperidine-4-sulfonic acid is a potent GABA agonist, demonstrating an IC50 value of 0.034 μM for the inhibition of H-GABA binding [1].</p>Formula:C5H11NO3SPurity:98%Color and Shape:SolidMolecular weight:165.21BACE-1 inhibitor 1
CAS:<p>BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).</p>Formula:C17H14BrF3N4O2Purity:98%Color and Shape:SolidMolecular weight:443.22UNC9994
CAS:<p>UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.</p>Formula:C21H22Cl2N2OSColor and Shape:SolidMolecular weight:421.38mAChR antagonist 1
CAS:<p>Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes,</p>Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39VU0029251
CAS:<p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>Formula:C10H11N3S2Color and Shape:SolidMolecular weight:237.34JM-1232
CAS:<p>JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.</p>Formula:C24H27N3O2Color and Shape:SolidMolecular weight:389.49CGP-54626 free base
CAS:<p>CGP-54626 is a selective antagonist of the GABAB receptor (IC50 = 4 nM ).</p>Formula:C18H28Cl2NO3PPurity:98%Color and Shape:SolidMolecular weight:408.3PHP 501 trifluoroacetate
CAS:<p>GABAA antagonist</p>Formula:C20H21N3OPurity:98%Color and Shape:SolidMolecular weight:319.4AAK1-IN-3
CAS:<p>AAK1-IN-3: Brain-penetrant AAK1 inhibitor for neuropathic pain research; IC50=11 nM.</p>Formula:C20H20N4Color and Shape:SolidMolecular weight:316.4AChE-IN-31
CAS:<p>AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer's disease research [1].</p>Formula:C27H44Na2O9S2Color and Shape:SolidMolecular weight:622.74RAGE/SERT-IN-1
CAS:<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Formula:C38H41ClN4OSColor and Shape:SolidMolecular weight:637.28AAK1-IN-4
CAS:<p>AAK1-IN-4 selectively inhibits AAK1 with IC50 of 4.6 nM; penetrates CNS, oral bioactive, potential for studying neuropathic pain.</p>Formula:C20H28N4O3Color and Shape:SolidMolecular weight:372.46GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Formula:C26H31ClF3NO2Color and Shape:SolidMolecular weight:481.98AZ10606120 dihydrochloride
CAS:<p>AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors,</p>Formula:C25H36Cl2N4O2Purity:99.49%Color and Shape:SolidMolecular weight:495.48GR 127935 hydrochloride
CAS:<p>5-HT1B/1D receptor antagonist</p>Formula:C29H32ClN5O3Purity:98%Color and Shape:SolidMolecular weight:534.05AAK1-IN-5
CAS:<p>AAK1-IN-5: Potent, selective AAK1 inhibitor; CNS-penetrant; oral; IC50: 1.2 nM; Ki: 0.05 nM; cell IC50: 0.5 nM. Useful in neuropathic pain research.</p>Formula:C19H23F4N3OColor and Shape:SolidMolecular weight:385.4Indeloxazine hydrochloride
CAS:<p>Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.</p>Formula:C14H18ClNO2Purity:98%Color and Shape:SolidMolecular weight:267.75Quinolactacin A1
CAS:<p>Quinolactacin A1, a strong AChE inhibitor from Penicillium citrinum, aids Alzheimer's research.</p>Formula:C16H18N2O2Color and Shape:SolidMolecular weight:270.33AMG-8718
CAS:<p>AMG-8718, an oral BACE1 blocker (IC50: 0.0007 μM), also inhibits BACE2 (IC50: 0.005 μM), lowering CSF and Aβ40 brain levels.</p>Formula:C25H19FN4O3Color and Shape:SolidMolecular weight:442.44ABT-418 hydrochloride
CAS:<p>ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.</p>Formula:C9H15ClN2OColor and Shape:SolidMolecular weight:202.68L-772,405
CAS:<p>L-772,405 is a highly selective agonists of h5-HT(1D) receptor.</p>Formula:C26H31FN6OPurity:98%Color and Shape:SolidMolecular weight:462.56Adenylyl cyclase-IN-1
CAS:<p>Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].</p>Formula:C9H8N2S3Color and Shape:SolidMolecular weight:240.37MAO-B-IN-13
CAS:<p>MAO-B-IN-13: a potent, reversible MAO-B inhibitor with BBB penetration, neuroprotective effects; used in Parkinson’s research (IC50=10nM).</p>Formula:C18H19NO3Color and Shape:SolidMolecular weight:297.35Brasofensine
CAS:<p>Brasofensine, a benztoalkane MA reuptake inhibitor, shows promise for Parkinson's and Alzheimer's.</p>Formula:C16H20Cl2N2OColor and Shape:SolidMolecular weight:327.25Velusetrag
CAS:<p>Velusetrag(TD-5108), a potent 5-HT4 agonist, is in development for gastroparesis, constipation, and IBS.</p>Formula:C25H36N4O5SColor and Shape:SolidMolecular weight:504.64mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Formula:C23H18N4O2Color and Shape:SolidMolecular weight:382.41Dothiepin
CAS:<p>Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing</p>Formula:C19H21NSPurity:98%Color and Shape:SolidMolecular weight:295.44R-96544
CAS:<p>R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].</p>Formula:C22H30ClNO3Color and Shape:SolidMolecular weight:391.93Physostigmine hemisulfate
CAS:<p>cholinesterase inhibitor</p>Formula:C15H21N302H204SPurity:98%Color and Shape:SolidMolecular weight:324.395-HT3 antagonist 1
CAS:<p>5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.</p>Formula:C22H27N5OPurity:98%Color and Shape:SolidMolecular weight:377.48AMPA receptor modulator-5
CAS:<p>AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1].</p>Formula:C20H12F4N6Purity:98%Color and Shape:SolidMolecular weight:412.34CGP 54626 hydrochloride
CAS:<p>CGP 54626 hydrochloride is a GABAB receptor antagonist.</p>Formula:C18H29Cl3NO3PPurity:98%Color and Shape:SolidMolecular weight:444.76β-Secretase Inhibitor IV
CAS:<p>β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).</p>Formula:C31H38N4O5SPurity:98%Color and Shape:SolidMolecular weight:578.72Wf-516
CAS:<p>Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant</p>Formula:C25H25Cl2N3O4Purity:98%Color and Shape:SolidMolecular weight:502.39LY 53857
CAS:<p>LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.</p>Formula:C27H36N2O7Color and Shape:SolidMolecular weight:500.592FPPQ
CAS:<p>FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.</p>Formula:C21H19FN4O2SColor and Shape:SolidMolecular weight:410.465-HT2A antagonist 1
CAS:<p>5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.</p>Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Formula:C19H14F4N4O2SColor and Shape:SolidMolecular weight:438.4DU-125530
CAS:<p>DU-125530 is a 5-HT1A receptor antagonist.</p>Formula:C23H26ClN3O5SColor and Shape:SolidMolecular weight:491.99Yhhu-3792 hydrochloride
CAS:<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Formula:C24H25ClN4O2Color and Shape:SolidMolecular weight:436.93LY320954
CAS:<p>LY320954 is an antagonist of 5-HT2A receptor.</p>Formula:C21H26N4O3Purity:98%Color and Shape:SolidMolecular weight:382.46P2X3-IN-1
CAS:<p>P2X3-IN-1 (example 7) is a P2X3 receptor inhibitor suitable for research on neurogenic diseases [1].</p>Formula:C22H21FN8O3Purity:98%Color and Shape:SolidMolecular weight:464.45PQM130
CAS:<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Formula:C23H27NO4Purity:98.73%Color and Shape:SolidMolecular weight:381.46CGP 64213
CAS:<p>CGP 64213 is a GABAb receptor agonist.</p>Formula:C26H36IN2O7PPurity:98%Color and Shape:SolidMolecular weight:646.45Dalzanemdor
CAS:<p>Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive</p>Formula:C27H43F3O2Purity:98.2% - >99.99%Color and Shape:SolidMolecular weight:456.62VU6004909
CAS:<p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>Formula:C21H15FN2O4Purity:96.68% - 98.44%Color and Shape:SolidMolecular weight:378.35Rislenemdaz
CAS:<p>Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).</p>Formula:C19H23FN4O2Purity:98.18%Color and Shape:SolidMolecular weight:358.41AMPA receptor antagonist-3
CAS:<p>AMPA receptor antagonist-3 is an AMPA receptor antagonist.</p>Formula:C20H19N5O2SPurity:99.79%Color and Shape:SolidMolecular weight:393.46Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formula:C30H26O10Purity:96.66%Color and Shape:SolidMolecular weight:546.52BuChE-IN-TM-10
CAS:<p>TM-10: Potent BuChE inhibitor, IC50 8.9 nM, disaggregates Aβ, antioxidant, BBB penetrant, may treat Alzheimer's.</p>Formula:C32H38N2O3Purity:99.54%Color and Shape:SolidMolecular weight:498.66CGP 78608 hydrochloride
CAS:<p>CGP 78608 hydrochloride: NMDA receptor antagonist (IC50=6 nM), anticonvulsant, enhances GluN1/GluN3A currents (EC50=26.3 nM).</p>Formula:C11H14BrClN3O5PPurity:99.85%Color and Shape:SolidMolecular weight:414.58WAY-607695
CAS:<p>WAY-607695 is a potential 5-HT1A receptor agonist.</p>Formula:C13H12FNO2Purity:99.82%Color and Shape:SolidMolecular weight:233.24SB 216641 hydrochloride
CAS:<p>SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.</p>Formula:C28H31ClN4O4Purity:98.06% - 99.23%Color and Shape:SolidMolecular weight:523.02γ-Secretase-IN-1
CAS:<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Formula:C27H24F2N4O3Purity:99.56%Color and Shape:SolidMolecular weight:490.5R-(+)-EU-1180-453
CAS:<p>R-(+)-EU-1180-453 is a novel GluN2C/D selective NMDAR-positive modulator for the study of neurological disorders.</p>Formula:C22H21FN2O3Purity:99.63%Color and Shape:SolidMolecular weight:380.41Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Formula:C24H44Cl2N4O3Purity:99.75%Color and Shape:SolidMolecular weight:507.54Tematropium
CAS:<p>Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.</p>Formula:C21H31NO8SPurity:99.89%Color and Shape:SolidMolecular weight:457.54Osemozotan HCl
CAS:<p>Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.</p>Formula:C19H22ClNO5Purity:98.87% - 99.63%Color and Shape:SolidMolecular weight:379.84AMPA receptor modulator-1
CAS:<p>AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.</p>Formula:C16H11ClF3NO2Purity:99.93%Color and Shape:SolidMolecular weight:341.71Atabecestat
CAS:<p>Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.</p>Formula:C18H14FN5OSPurity:99.21% - 99.77%Color and Shape:SolidMolecular weight:367.4Didesmethyl cariprazine
CAS:<p>Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.</p>Formula:C19H28Cl2N4OPurity:99.52%Color and Shape:SolidMolecular weight:399.36TZ3O
CAS:<p>TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment in Scopolamine-induced Alzheimer's type model in rats.</p>Formula:C18H13NO4SPurity:99.84%Color and Shape:SolidMolecular weight:339.37JNJ-42253432
CAS:<p>JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels</p>Formula:C28H38N4OPurity:99.98%Color and Shape:SolidMolecular weight:446.63MDR-1339
CAS:<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Formula:C20H22O4Purity:98.57%Color and Shape:SolidMolecular weight:326.39SB-616234-A
CAS:<p>SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.</p>Formula:C32H36ClN5O3Purity:99.72%Color and Shape:SolidMolecular weight:574.11PXS-5120A
CAS:<p>PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.</p>Formula:C22H25ClFN3O4SPurity:97.02%Color and Shape:SolidMolecular weight:481.97PXS-5153A
CAS:<p>PXS-5153A rapidly inhibits lysyl oxidase 2/3 enzymes, blocks activity in 15 mins, and reduces fibrosis.</p>Formula:C20H25Cl2FN4O2SPurity:99.58%Color and Shape:SolidMolecular weight:475.41BMS-986176
CAS:<p>AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).</p>Formula:C19H23F4N3OPurity:98.58% - 98.7%Color and Shape:SolidMolecular weight:385.4Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formula:C24H28FN3OPurity:99.68% - 99.91%Color and Shape:SolidMolecular weight:393.5BACE1-IN-5
CAS:<p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.</p>Formula:C18H16F5N5O2SPurity:98%Color and Shape:SolidMolecular weight:461.41Azotomycin
CAS:<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Formula:C17H23N7O8Purity:98%Color and Shape:SolidMolecular weight:453.41Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formula:C15H11NO2Purity:99.77%Color and Shape:SolidMolecular weight:237.251,9-Dideoxyforskolin
CAS:<p>The compound is an inactive analog of forskolin(an adenylyl cyclase activator).</p>Formula:C22H34O5Purity:98%Color and Shape:SolidMolecular weight:378.5PXS-4787 hydrochloride
CAS:<p>PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.</p>Formula:C10H13ClFNO2SColor and Shape:SolidMolecular weight:265.73AChE/BChE-IN-19
CAS:<p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>Formula:C26H22N4O3Molecular weight:438.48Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formula:C14H16N2O5Color and Shape:SolidMolecular weight:292.287EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formula:C22H26N2O2S2Purity:98%Color and Shape:SolidMolecular weight:414.58SB 243213 hydrochloride
CAS:<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Formula:C22H20ClF3N4O2Purity:98%Color and Shape:SolidMolecular weight:464.87P2X4 antagonist-1
CAS:<p>P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.</p>Formula:C20H15Cl3N2O4SPurity:99.9%Color and Shape:SolidMolecular weight:485.77AGH-107
CAS:<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formula:C13H12IN3Color and Shape:SolidMolecular weight:337.16(S)-Norfluoxetine
CAS:<p>(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.</p>Formula:C16H16F3NOColor and Shape:SolidMolecular weight:295.3BACE1-IN-4
CAS:<p>BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.</p>Formula:C21H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:511.57BACE1-IN-8
<p>BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).</p>Formula:C29H45N5O7Color and Shape:SolidMolecular weight:575.7VU6016235
CAS:<p>VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.</p>Formula:C21H22N4OSColor and Shape:SolidMolecular weight:378.49K203
<p>K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.</p>Formula:C16H18Br2N4O2Color and Shape:SolidMolecular weight:458.15AChE-IN-24
<p>AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.</p>Formula:C22H30N2O4S2Color and Shape:SolidMolecular weight:450.61AChE-IN-63
CAS:<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Formula:C18H19N5OColor and Shape:SolidMolecular weight:321.38Poskine
CAS:<p>Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.</p>Formula:C20H25NO5Color and Shape:SolidMolecular weight:359.42Metoquizine
CAS:<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Formula:C22H27N5OPurity:98%Color and Shape:SolidMolecular weight:377.48VU6007496
CAS:<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formula:C25H27N5O2Color and Shape:SolidMolecular weight:429.51γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.513AChE/Aβ-IN-5
CAS:<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Formula:C25H24N4Color and Shape:SolidMolecular weight:380.48MAO-B-IN-6
<p>MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.</p>Color and Shape:SolidRodatristat ethyl
CAS:<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formula:C29H31ClF3N5O3Purity:98%Color and Shape:SolidMolecular weight:590.04
