CymitQuimica logo
Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

Show 3 more subcategories

Found 1044 products of "Proteases/Proteasome"

Sort by

Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • Cathepsin C-IN-5

    CAS:
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92
  • BI 224436

    CAS:
    <p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>
    Formula:C27H26N2O4
    Color and Shape:Solid
    Molecular weight:442.51
  • SMCypI C31


    <p>SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).</p>
    Formula:C27H30N4O2S
    Color and Shape:Solid
    Molecular weight:474.62
  • TCL1

    CAS:
    <p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762
  • HCV NS5B polymerase-IN-2

    CAS:
    <p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>
    Formula:C26H24N2O4
    Color and Shape:Solid
    Molecular weight:428.48
  • Cathepsin K inhibitor 2

    CAS:
    <p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • M826


    <p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7
  • Dup-714

    CAS:
    <p>Dup-714 is a thrombin inhibitor.</p>
    Formula:C21H33BN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.33
  • Feniralstat

    CAS:
    <p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>
    Formula:C26H25F2N5O4
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:509.51
  • Napsagatran hydrate

    CAS:
    <p>Napsagatran hydrate is a novel and specific inhibitor of thrombin.</p>
    Formula:C26H36N6O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:576.66
  • ZINC09518833

    CAS:
    <p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47
  • Tyrosinase-IN-37

    CAS:
    <p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>
    Formula:C12H12N6S
    Color and Shape:Solid
    Molecular weight:272.33
  • Tyrosinase-IN-29

    CAS:
    <p>Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.</p>
    Formula:C10H9NO2
    Color and Shape:Solid
    Molecular weight:175.18
  • (2S,4R)-Teneligliptin

    CAS:
    <p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578
  • HCV-IN-7

    CAS:
    <p>HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>
    Formula:C40H48N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:768.92
  • Idraparinux Na

    CAS:
    <p>Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor</p>
    Formula:C38H55Na9O49S7
    Color and Shape:Solid
    Molecular weight:1727.14
  • Tyrosinase-IN-20

    CAS:
    <p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>
    Formula:C17H18N2O2S
    Color and Shape:Solid
    Molecular weight:314.4
  • Monosodium 2-sulfoterephthalate

    CAS:
    <p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>
    Formula:C8H5NaO7S
    Color and Shape:Solid
    Molecular weight:268.176
  • BMT-052

    CAS:
    <p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>
    Formula:C30H17D9F4N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.61
  • SSR-182289A (Free)

    CAS:
    <p>SSR-182289A (Free) is a thrombin inhibitor.</p>
    Formula:C30H33F2N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:597.68
  • GLS-1-IN-1


    <p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>
    Formula:C26H25FN4OS
    Color and Shape:Solid
    Molecular weight:460.57
  • Cathepsin C-IN-3


    <p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>
    Formula:C28H21F3N6OS
    Color and Shape:Solid
    Molecular weight:546.57
  • Antiplatelet agent 3

    CAS:
    <p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>
    Formula:C38H32N2O5
    Color and Shape:Solid
    Molecular weight:596.671
  • SCO-792


    <p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>
    Formula:C22H22N4O8·xH2O
    Color and Shape:Solid
  • Kallikrein-IN-1

    CAS:
    <p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54
  • CM-352

    CAS:
    <p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>
    Formula:C24H29N3O6S
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:487.57
  • Immunoproteasome activator 1

    CAS:
    Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.46
  • GSK-2878175

    CAS:
    <p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C27H23BClFN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.81
  • Piceid 6″-O-azelaic acid ester


    <p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54
  • IDX184

    CAS:
    <p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62
  • JTK-109

    CAS:
    <p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>
    Formula:C37H33ClFN3O4
    Purity:98.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:638.13
  • Vaniprevir

    CAS:
    <p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94
  • MIV-247

    CAS:
    <p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39
  • PD 151746

    CAS:
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25
  • Sebetralstat

    CAS:
    <p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>
    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51
  • MMP13-IN-2

    CAS:
    <p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>
    Formula:C24H19FN6O4S
    Color and Shape:Solid
    Molecular weight:506.51

    Ref: TM-T41079

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    <p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product
  • ALLM

    CAS:
    <p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • ABT-072 potassium trihydrate

    CAS:
    <p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • 3-Deazaadenosine

    CAS:
    <p>3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.</p>
    Formula:C11H14N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:266.25

    Ref: TM-T10111L

    5mg
    Discontinued
    Discontinued product
  • Oxindole

    CAS:
    <p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>
    Formula:C8H7NO
    Purity:99.34%
    Color and Shape:Off-White Crystalline Powder
    Molecular weight:133.15

    Ref: TM-FR16741

    1g
    Discontinued
    5g
    Discontinued
    10g
    Discontinued
    Discontinued product
  • Butabindide oxalate

    CAS:
    <p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>
    Formula:C19H27N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T22619

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Davelizomib

    CAS:
    <p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>
    Formula:C21H26BF2N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.25

    Ref: TM-T79842

    ne
    Discontinued
    5mg
    Discontinued
    50mg
    Discontinued
    Discontinued product