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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 992 products of "Proteases/Proteasome"

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  • Zetomipzomib

    CAS:
    KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.
    Formula:C30H42N4O8
    Color and Shape:Solid
    Molecular weight:586.68

    Ref: TM-T37419

    25mg
    7,605.00€
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  • Tyrosinase-IN-20

    CAS:
    Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].
    Formula:C17H18N2O2S
    Color and Shape:Solid
    Molecular weight:314.4

    Ref: TM-T87588

    10mg
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  • Deleobuvir

    CAS:
    Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
    Formula:C34H33BrN6O3
    Color and Shape:Solid
    Molecular weight:653.57

    Ref: TM-T31369

    1mg
    5,878.00€
  • SBI-581


    SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.
    Formula:C24H21N3O2
    Color and Shape:Solid
    Molecular weight:383.44

    Ref: TM-T61663

    25mg
    1,305.00€
    50mg
    2,088.00€
    100mg
    3,357.00€
  • GW311616

    CAS:
    GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53

    Ref: TM-T11525

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  • CatD-IN-1

    CAS:
    CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.
    Formula:C18H18Cl2N4O5
    Color and Shape:Solid
    Molecular weight:441.265

    Ref: TM-T205617

    10mg
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  • Valopicitabine

    CAS:
    Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic
    Formula:C15H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.37

    Ref: TM-T13281

    25mg
    2,547.00€
    50mg
    3,861.00€
    100mg
    4,599.00€
  • Matriptase-IN-2 free base

    CAS:
    Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].
    Formula:C29H33Cl2N5O3S
    Color and Shape:Solid
    Molecular weight:602.58

    Ref: TM-T86863

    10mg
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  • TCL1

    CAS:
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762

    Ref: TM-T206909

    10mg
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  • JBIR-22

    CAS:
    JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.
    Formula:C23H33NO6
    Color and Shape:Solid
    Molecular weight:419.51

    Ref: TM-T71203

    25mg
    2,448.00€
    50mg
    3,222.00€
    100mg
    4,410.00€
  • BI-1942

    CAS:
    BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.488

    Ref: TM-T205535

    10mg
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  • Immunoproteasome activator 1

    CAS:
    Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T200985

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  • Belactin A

    CAS:
    Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.
    Formula:C17H21ClN2O4
    Color and Shape:Solid
    Molecular weight:352.81

    Ref: TM-T207748

    10mg
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  • CE-2072

    CAS:
    CE-2072 is a synthetic host serine proteases inhibitor.
    Formula:C33H41N5O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.71

    Ref: TM-T25218

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  • Monosodium 2-sulfoterephthalate

    CAS:

    Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.

    Formula:C8H5NaO7S
    Color and Shape:Solid
    Molecular weight:268.176

    Ref: TM-T204212

    10mg
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  • Ciluprevir

    CAS:
    Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.
    Formula:C40H50N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.93

    Ref: TM-T19627

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  • Gemigliptin tartrate hydrate

    CAS:
    Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.
    Formula:C22H27F8N5O9
    Color and Shape:Solid
    Molecular weight:657.47

    Ref: TM-T212102

    10mg
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  • MeO-Suc-Ala-Ala-Pro-Ala-CMK

    CAS:
    MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).
    Formula:C20H31ClN4O7
    Color and Shape:Solid
    Molecular weight:474.936

    Ref: TM-T206832

    10mg
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  • PNU-248686A

    CAS:
    PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
    Formula:C22H18ClNaO5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.95

    Ref: TM-T12511

    25mg
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  • Piceid 6″-O-azelaic acid ester


    Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54

    Ref: TM-T63219

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€