Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1499 products of "Autophagy"
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Nitazoxanide
CAS:Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.Formula:C12H9N3O5SPurity:99% - 99.93%Color and Shape:SolidMolecular weight:307.28Colchicine
CAS:Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding toFormula:C22H25NO6Purity:98% - 99.96%Color and Shape:Pale Yellow Scales Or Powder; Pale Yellow Needles When Crystallized From Ethyl Acetate To Light Used To Treat Gouty Arthritis Pseudogout Sarcoidal Arthritis And Calcific Tendinitis (EpaMolecular weight:399.44Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFormula:C24H25FNNaO4Purity:98.54% - 99.56%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45NBDHEX
CAS:NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formula:C12H15N3O4SPurity:97.38%Color and Shape:SolidMolecular weight:297.33Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFormula:C23H30CLN3O·2HClPurity:98.24% - 99.80%Color and Shape:Yellow Crystals Or PowderMolecular weight:472.88Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Formula:C19H11ClN3NaO2Purity:99.49% - 99.62%Color and Shape:SolidMolecular weight:371.75BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purity:97.44% - 99.7%Color and Shape:SolidMolecular weight:458.56Ref: TM-T5428
1mg56.00€2mg79.00€5mg118.00€10mg177.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)145.00€Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Formula:C12H17NO2Purity:97.72% - 99.78%Color and Shape:SolidMolecular weight:207.27Carboplatin
CAS:Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.
Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Ref: TM-T0486L
10mg34.00€25mg49.00€50mg65.00€100mg89.00€200mg129.00€500mg254.00€1mL*10mM (DMSO)71.00€Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Formula:C15H24O5Purity:98% - 99.41%Color and Shape:White SolidMolecular weight:284.35TTNPB
CAS:TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM),Formula:C24H28O2Purity:99.55%Color and Shape:White SolidMolecular weight:348.48Ref: TM-T1288
2mg39.00€5mg57.00€10mg87.00€25mg159.00€50mg264.00€100mg445.00€500mg1,008.00€1mL*10mM (DMSO)59.00€Lycorine hydrochloride
CAS:Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.Formula:C16H18ClNO4Purity:99.45% - 99.49%Color and Shape:Fine Crystal PowderMolecular weight:323.77Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Formula:C22H26ClN7O2SPurity:99.59% - 99.86%Color and Shape:Pale-Yellow SolidMolecular weight:488.01Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.
Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Formula:C15H24N2OPurity:99.77% - >99.99%Color and Shape:SolidMolecular weight:248.36Paclitaxel
CAS:Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.
Formula:C47H51NO14Purity:98% - 99.92%Color and Shape:White PowderMolecular weight:853.91Fendiline hydrochloride
CAS:Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.Formula:C23H26ClNPurity:98.76% - 99.75%Color and Shape:SolidMolecular weight:351.91Xylitol
CAS:Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group.Formula:C5H12O5Purity:99.89% - 99.96%Color and Shape:White Solid PowderMolecular weight:152.15Thalidomide
CAS:Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.Formula:C13H10N2O4Purity:98.88% - 99.88%Color and Shape:White SolidMolecular weight:258.23Pravastatin sodium
CAS:Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.Formula:C23H35NaO7Purity:97.14% - 99.97%Color and Shape:White Crystalline PowderMolecular weight:446.52Sunitinib Malate
CAS:Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.Formula:C26H33FN4O7Purity:98% - 99.26%Color and Shape:SolidMolecular weight:532.56Raloxifene hydrochloride
CAS:Raloxifene HCl treats postmenopausal osteoporosis, acts as estrogen on bone/cholesterol, and blocks it in breast/uterus.Formula:C28H28ClNO4SPurity:98% - 99.97%Color and Shape:Light Yellow SolidMolecular weight:510.044Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formula:C20H18ClNO4Purity:99.47% - 99.93%Color and Shape:Yellow Crystalline PowderMolecular weight:371.80Linagliptin
CAS:Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.Formula:C25H28N8O2Purity:99.15% - >99.99%Color and Shape:SolidMolecular weight:472.54Naringin
CAS:Naringin: flavanone glycoside with blood lipid-reducing, antioxidant, anticancer properties, inhibits cytochrome P450.Formula:C27H32O14Purity:99.23%Color and Shape:Beige Creamish Powder Solid Solid Particulate/PowderMolecular weight:580.53Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purity:96.74% - 99.94%Color and Shape:SolidMolecular weight:685.89Olanzapine
CAS:Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.Formula:C17H20N4SPurity:99.86% - ≥95%Color and Shape:Yellowish Crystalline PowderMolecular weight:312.43Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formula:C26H52N6O11SPurity:94.68% - 99.8%Color and Shape:SolidMolecular weight:656.79Erythromycin ethylsuccinate
CAS:Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.Formula:C43H75NO16Purity:77% - 98%Color and Shape:White Or Slightly Yellow Crystalline Powder White To Yellowish Crystalline SolidMolecular weight:862.05Nitroxoline
CAS:Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found inFormula:C9H6N2O3Purity:97.74% - 99.09%Color and Shape:SolidMolecular weight:190.16Lovastatin
CAS:Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.Formula:C24H36O5Purity:99.66% - 99.92%Color and Shape:The Substance Is A White-Yellowish To Yellow Powder Solid PowderMolecular weight:404.54Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4Purity:98.19% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:393.44Stavudine
CAS:Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Formula:C10H12N2O4Purity:99.01% - 99.88%Color and Shape:White PowderMolecular weight:224.21Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Formula:C17H19NO3Purity:98.41% - 98.51%Color and Shape:SolidMolecular weight:285.34Rhein
CAS:Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.Formula:C15H8O6Purity:99.04%Color and Shape:Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Molecular weight:284.22Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
Formula:C21H18FNO7SPurity:99.34%Color and Shape:SolidMolecular weight:447.43Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formula:C7H5NaO3Purity:99.36% - 99.92%Color and Shape:White Solid AmorphousMolecular weight:160.11Ancitabine hydrochloride
CAS:Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Formula:C9H12ClN3O4Purity:99.02% - 99.37%Color and Shape:White SolidMolecular weight:261.66Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formula:C33H45ClN4O9Purity:98.22% - >99.99%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Pemetrexed
CAS:Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).Formula:C20H21N5O6Purity:98.1% - 99.92%Color and Shape:Similar To White PowderMolecular weight:427.41Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Formula:C8H12ClNO3Purity:98.34% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64Isoliquiritigenin
CAS:Isoliquiritigenin (ISL) is a natural flavonoid that inhibits influenza virus and aldose reductase. Isoliquiritigenin has antitumor effect. Cost-effective and quality-assured.Formula:C15H12O4Purity:97.61% - 99.44%Color and Shape:PowderMolecular weight:256.25Ursolic acid
CAS:Ursolic acid (Prunol) is a natural pentacyclic triterpene carboxylic acid. Ursolic acid has anti-tumor and anti-inflammatory effects. Cost-effective and quality-assured.Formula:C30H48O3Purity:99.7% - 99.81%Color and Shape:Platelets From Alcohol SolidMolecular weight:456.70Carvedilol phosphate hemihydrate
CAS:Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent.Formula:C24H26N2O4·5H2O·H3O4PPurity:99.24% - 99.98%Color and Shape:SolidMolecular weight:513.49Myricetin
CAS:Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic and antioxidant activities. Cost-effective and quality-assured.Formula:C15H10O8Purity:97.92% - 99.85%Color and Shape:Yellow Needles From Dilute Alcohol SolidMolecular weight:318.24Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Formula:C26H29Cl2N5O3Purity:98.98% - 99.9%Color and Shape:Yellowish-Orange Or Pink To Brownish Solid Solid PowderMolecular weight:530.45Sorafenib tosylate
CAS:Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).Formula:C21H16ClF3N4O3·C7H8O3SPurity:99.24% - 99.94%Color and Shape:White To Off-White Crystalline PowderMolecular weight:637.03Monacolin J
CAS:Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.Formula:C19H28O4Purity:98.06%Color and Shape:SolidMolecular weight:320.42Ref: TM-T12092
1mg74.00€5mg152.00€10mg222.00€25mg376.00€50mg537.00€100mg777.00€1mL*10mM (DMSO)161.00€Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Formula:C18H18O2Purity:99.65% - 99.94%Color and Shape:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TasteMolecular weight:266.33Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Formula:C26H34F3N7O4SPurity:98.87% - 99.87%Color and Shape:SolidMolecular weight:597.65Ref: TM-T14935
1mg93.00€2mg130.00€5mg230.00€10mg371.00€25mg730.00€50mg1,018.00€100mg1,369.00€1mL*10mM (DMSO)304.00€Ezetimibe
CAS:Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
Formula:C24H21F2NO3Purity:97.28% - 99.77%Color and Shape:SolidMolecular weight:409.43Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.42Salicylic acid
CAS:Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.Formula:C7H6O3Purity:98.04% - 98.83%Color and Shape:White Solid PowderMolecular weight:138.12Dexamethasone
CAS:Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Formula:C22H29FO5Purity:98% - 99.91%Color and Shape:Crystals From Ether (Ntp 1992)Molecular weight:392.46Dexamethasone acetate
CAS:Dexamethasone acetate (NSC 39471) is a potent anti-inflammatory steroid, blocks NF-kB, and lacks salt-retention.
Formula:C24H31FO6Purity:99.22% - 99.65%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:434.50Taurine
CAS:Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Cost-effective and quality-assured.
Formula:C2H7NO3SPurity:99.81% - 99.87%Color and Shape:White Crystalline PowderMolecular weight:125.15Phenformin hydrochloride
CAS:Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.Formula:C10H16ClN5Purity:97.11% - 99.80%Color and Shape:Lactic AcidosisMolecular weight:241.72Felodipine
CAS:Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.Formula:C18H19Cl2NO4Purity:99.91%Color and Shape:SolidMolecular weight:384.25Ref: TM-T0145
2mg34.00€5mg50.00€10mg67.00€25mg96.00€50mg123.00€100mg168.00€500mg409.00€1mL*10mM (DMSO)54.00€Autophagy/REV-ERB-IN-1 hydrochloride
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.Formula:C24H32Cl2F2N2Molecular weight:456.19106(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C31H41N5O6Molecular weight:579.30568RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Formula:C365H585N105O95S5Molecular weight:8119.27766Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Formula:C24H30F2N2Molecular weight:384.23771(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C29H36N8O6Molecular weight:592.27578(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.
Formula:C30H39N5O6Molecular weight:565.29003CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formula:C107H173N33O30Molecular weight:2400.30261(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C33H42N8O7Molecular weight:662.31765(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.Formula:C27H32N8O5Molecular weight:548.24957Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.Formula:C27H24Br2N4O8Molecular weight:689.99609Autophagy Compound Library
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) andColor and Shape:Odour SolidRef: TM-L3200
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireCCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formula:C13H22N6OSMolecular weight:310.15758CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Formula:C41H42Br2IN7O5Molecular weight:997.06589Deoxy-thalidomide-Pip-C-PIP-boc
CAS:Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.Formula:C28H39N5O5Color and Shape:SolidMolecular weight:525.64Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formula:C51H84O22Purity:98%Color and Shape:SolidMolecular weight:1049.21ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formula:C25H30N2OSColor and Shape:SolidMolecular weight:406.58ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Formula:C15H21N5O4Purity:97.13% - 99.69%Color and Shape:SolidMolecular weight:335.36PBA-1105 TFA
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.Formula:C41H49F3N2O8Color and Shape:SolidMolecular weight:754.832SQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Color and Shape:Odour SolidPBA-1105b
CAS:PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.Formula:C47H64N2O10Color and Shape:SolidMolecular weight:817.02Fumagilin-105
CAS:Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Color and Shape:Odour SolidMicrocolin H
CAS:Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].Formula:C38H63N5O9Color and Shape:SolidMolecular weight:733.93Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Color and Shape:Odour SolidElaiophylin
CAS:Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.Formula:C54H88O18Purity:98%Color and Shape:SolidMolecular weight:1025.27Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFormula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397MRT 67307 dihydrochloride
CAS:MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.
Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Formula:C38H42Cl2N6O2Color and Shape:SolidMolecular weight:685.69
