Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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Nicardipine hydrochloride
CAS:<p>Nicardipine hydrochloride is a potent calcium channel blocker used to dilate cerebral and coronary vessels.</p>Formula:C26H30ClN3O6Purity:99.58% - 99.89%Color and Shape:Yellow SolidMolecular weight:515.99Lapatinib Ditosylate
CAS:<p>Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).</p>Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46Imiquimod
CAS:<p>Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.</p>Formula:C14H16N4Purity:99.62% - >99.99%Color and Shape:White To Off White Crystalline PowderMolecular weight:240.30AICAR
CAS:<p>AICAR (Acadesine) is an AMPK activator, metabolic regulation, muscle function regulation, anti-cancer effect, neuroprotection. High-Quality, Low-Cost!</p>Formula:C9H14N4O5Purity:98.00% - ≥95%Color and Shape:SolidMolecular weight:258.23NBDHEX
CAS:<p>NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).</p>Formula:C12H15N3O4SPurity:97.38%Color and Shape:SolidMolecular weight:297.33Fluvastatin sodium
CAS:<p>Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol</p>Formula:C24H25FNNaO4Purity:98.54% - 99.56%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45Silmitasertib sodium salt
CAS:<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formula:C19H11ClN3NaO2Purity:99.49% - 99.62%Color and Shape:SolidMolecular weight:371.75Reserpine
CAS:<p>Reserpine, an alkaloid from Rauwolfia roots, depletes neurotransmitters, used in treating hypertension and psychosis, but side effects restrict use.</p>Formula:C33H40N2O9Purity:98.85% - 99.81%Color and Shape:White Or Pale Buff To Slightly Yellowish Powder With A Bitter Taste (Ntp 1992)Molecular weight:608.68BIX 02565
CAS:<p>BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).</p>Formula:C26H30N6O2Purity:97.44% - 99.7%Color and Shape:SolidMolecular weight:458.56Carboplatin
CAS:<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Irinotecan Hydrochloride
CAS:<p>Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.</p>Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Ponatinib Hydrochloride
CAS:<p>Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.</p>Formula:C29H28ClF3N6OPurity:99.88%Color and Shape:SolidMolecular weight:569.02Dihydroartemisinin
CAS:<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formula:C15H24O5Purity:98% - 99.41%Color and Shape:White SolidMolecular weight:284.35Clarithromycin
CAS:<p>Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.</p>Formula:C38H69NO13Purity:99.89% - 99.89%Color and Shape:White To Off-White Crystalline PowderMolecular weight:747.95Lycorine hydrochloride
CAS:<p>Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.</p>Formula:C16H18ClNO4Purity:99.45% - 99.49%Color and Shape:Fine Crystal PowderMolecular weight:323.77Oxaliplatin
CAS:<p>Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.</p>Formula:C8H14N2O4PtPurity:97% - 99.93%Color and Shape:SolidMolecular weight:397.29Matrine
CAS:<p>Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.</p>Formula:C15H24N2OPurity:97.16% - >99.99%Color and Shape:SolidMolecular weight:248.36Paclitaxel
CAS:<p>Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.</p>Formula:C47H51NO14Purity:98% - 99.92%Color and Shape:White PowderMolecular weight:853.91Pterostilbene
CAS:<p>Pterostilbene is extracted from Pterocarpus indicus.</p>Formula:C16H16O3Purity:99.20%Color and Shape:Off-White Crystalline PowderMolecular weight:256.3Tepotinib
CAS:<p>Tepotinib (EMD-1214063) is a selective, orally, and ATP-competitive c-MET tyrosine kinase inhibitor. Tepotinib has antitumor effect. Cost-effective and quality-assured.</p>Formula:C29H28N6O2Purity:98% - 99.91%Color and Shape:SolidMolecular weight:492.57Rupatadine Fumarate
CAS:<p>Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.</p>Formula:C26H26ClN3·C4H4O4Purity:99.86%Color and Shape:White Or Almost-White PowderMolecular weight:532.03Pravastatin sodium
CAS:<p>Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.</p>Formula:C23H35NaO7Purity:97.14%Color and Shape:White Crystalline PowderMolecular weight:446.52Raloxifene hydrochloride
CAS:<p>Raloxifene HCl treats postmenopausal osteoporosis, acts as estrogen on bone/cholesterol, and blocks it in breast/uterus.</p>Formula:C28H28ClNO4SPurity:98% - 99.97%Color and Shape:Light Yellow SolidMolecular weight:510.044Ciclopirox
CAS:<p>Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.</p>Formula:C12H17NO2Purity:97.72% - 99.78%Color and Shape:SolidMolecular weight:207.27Fluoxetine
CAS:<p>Fluoxetine (LY-110140), a specific serotonin inhibitor, serves as an antidepressant with fewer side-effects.</p>Formula:C17H18F3NOPurity:99.07% - 99.28%Color and Shape:SolidMolecular weight:309.33Trifluoperazine dihydrochloride
CAS:<p>Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.</p>Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43Naringin
CAS:<p>Naringin: flavanone glycoside with blood lipid-reducing, antioxidant, anticancer properties, inhibits cytochrome P450.</p>Formula:C27H32O14Purity:99.23%Color and Shape:Beige Creamish Powder Solid Solid Particulate/PowderMolecular weight:580.53Bromhexine hydrochloride
CAS:<p>Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.</p>Formula:C14H21Br2ClN2Purity:99.98%Color and Shape:White SolidMolecular weight:412.59Piceatannol
CAS:<p>Piceatannol (Astringenin) is a synthetic anti-inflammatory that blocks p56lck, syk kinases, and NF-κB, made from resveratrol.</p>Formula:C14H12O4Purity:98.66% - 99.73%Color and Shape:Light Tan To Yellow PowderMolecular weight:244.24Deferoxamine Mesylate
CAS:<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formula:C26H52N6O11SPurity:94.68% - 99.8%Color and Shape:SolidMolecular weight:656.79Nitroxoline
CAS:<p>Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in</p>Formula:C9H6N2O3Purity:97.74% - 99.09%Color and Shape:SolidMolecular weight:190.16Sunitinib
CAS:<p>Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM).</p>Formula:C22H27FN4O2Purity:98% - 99.67%Color and Shape:Yellow SolidMolecular weight:398.47Lovastatin
CAS:<p>Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.</p>Formula:C24H36O5Purity:99.66% - 99.92%Color and Shape:The Substance Is A White-Yellowish To Yellow Powder Solid PowderMolecular weight:404.54Sitagliptin
CAS:<p>Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.</p>Formula:C16H15F6N5OPurity:99.33% - 99.83%Color and Shape:Yellow GreaseMolecular weight:407.31Erlotinib
CAS:<p>Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formula:C22H23N3O4Purity:98.19% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:393.44Piperine
CAS:<p>Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.</p>Formula:C17H19NO3Purity:98.41% - 98.51%Color and Shape:SolidMolecular weight:285.34Rhein
CAS:<p>Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.</p>Formula:C15H8O6Purity:99.04%Color and Shape:Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Molecular weight:284.22Perphenazine
CAS:<p>Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.</p>Formula:C21H26ClN3OSPurity:99.3% - 99.99%Color and Shape:SolidMolecular weight:403.97Glucosamine hydrochloride
CAS:<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formula:C7H5NaO3Purity:99.36% - 99.92%Color and Shape:White Solid AmorphousMolecular weight:160.11Ancitabine hydrochloride
CAS:<p>Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.</p>Formula:C9H12ClN3O4Purity:99.02% - 99.37%Color and Shape:White SolidMolecular weight:261.66Irinotecan hydrochloride trihydrate
CAS:<p>Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.</p>Formula:C33H45ClN4O9Purity:98.22% - >99.99%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Pemetrexed
CAS:<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>Formula:C20H21N5O6Purity:98.1% - 99.92%Color and Shape:Similar To White PowderMolecular weight:427.41Sophocarpine monohydrate
CAS:<p>Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35Carvedilol phosphate hemihydrate
CAS:<p>Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent.</p>Formula:C24H26N2O4·5H2O·H3O4PPurity:99.24% - 99.98%Color and Shape:SolidMolecular weight:513.49Isoliquiritigenin
CAS:<p>Isoliquiritigenin (ISL) is a natural flavonoid that inhibits influenza virus and aldose reductase. Isoliquiritigenin has antitumor effect. Cost-effective and quality-assured.</p>Formula:C15H12O4Purity:97.61% - 99.44%Color and Shape:PowderMolecular weight:256.259-ING-41
CAS:<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Formula:C22H13FN2O5Purity:99.32%Color and Shape:SolidMolecular weight:404.35Vitamin B3-d4
CAS:<p>Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is a deuterated substitute for Niacin and can be used to track Niacin metabolism in vivo.</p>Formula:C6HD4NO2Purity:99.86%Color and Shape:SolidMolecular weight:127.13Bosutinib
CAS:<p>Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.</p>Formula:C26H29Cl2N5O3Purity:98.98% - 99.9%Color and Shape:Yellowish-Orange Or Pink To Brownish Solid Solid PowderMolecular weight:530.45Erlotinib hydrochloride
CAS:<p>Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formula:C22H23N3O4·HClPurity:99.78% - 99.85%Color and Shape:White Or Off-White PowderMolecular weight:429.9Monacolin J
CAS:<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>Formula:C19H28O4Purity:98.06%Color and Shape:SolidMolecular weight:320.42Dilmapimod
CAS:<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.42Ezetimibe
CAS:<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Formula:C24H21F2NO3Purity:97.28% - 99.77%Color and Shape:SolidMolecular weight:409.43Honokiol
CAS:<p>Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.</p>Formula:C18H18O2Purity:99.65% - 99.94%Color and Shape:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TasteMolecular weight:266.33Dexamethasone
CAS:<p>Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.</p>Formula:C22H29FO5Purity:98% - 99.91%Color and Shape:Crystals From Ether (Ntp 1992)Molecular weight:392.46Salicylic acid
CAS:<p>Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.</p>Formula:C7H6O3Purity:98.04% - 98.83%Color and Shape:White Solid PowderMolecular weight:138.12(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C31H41N5O6Molecular weight:579.30568(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C33H42N8O7Molecular weight:662.31765RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formula:C365H585N105O95S5Molecular weight:8119.27766CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Formula:C107H173N33O30Molecular weight:2400.30261Autophagy/REV-ERB-IN-1
<p>Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.</p>Formula:C24H30F2N2Molecular weight:384.23771CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Formula:C13H22N6OSMolecular weight:310.15758(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C30H39N5O6Molecular weight:565.29003(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C29H36N8O6Molecular weight:592.27578Autophagy/REV-ERB-IN-1 hydrochloride
<p>Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.</p>Formula:C24H32Cl2F2N2Molecular weight:456.19106Autophagy Compound Library
<p>A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and</p>Color and Shape:Odour SolidAntitumor agent-133
<p>Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.</p>Formula:C27H24Br2N4O8Molecular weight:689.99609(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.</p>Formula:C27H32N8O5Molecular weight:548.24957Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Formula:C51H84O22Purity:98%Color and Shape:SolidMolecular weight:1049.21Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37N6-Isopentenyladenosine
CAS:<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Formula:C15H21N5O4Purity:97.13% - 99.69%Color and Shape:SolidMolecular weight:335.36Deoxy-thalidomide-Pip-C-PIP-boc
CAS:<p>Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.</p>Formula:C28H39N5O5Color and Shape:SolidMolecular weight:525.64ALA-A2 peptide
<p>ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.</p>Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79DB1113
CAS:<p>DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.</p>Formula:C59H68F3N13O6SColor and Shape:SolidMolecular weight:1144.31LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Color and Shape:Odour SolidSQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formula:C38H63N5O9Color and Shape:SolidMolecular weight:733.93Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42PBA-1105b
CAS:<p>PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.</p>Formula:C47H64N2O10Color and Shape:SolidMolecular weight:817.02TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397PHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05Elaiophylin
CAS:<p>Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.</p>Formula:C54H88O18Purity:98%Color and Shape:SolidMolecular weight:1025.27Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Color and Shape:Odour SolidMRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purity:99.25% - 99.84%Color and Shape:SolidMolecular weight:464.6Clionamine B
CAS:<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formula:C56H68ClN9O5S2Color and Shape:SolidMolecular weight:1046.78MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53ML-SA5
CAS:<p>ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.</p>Formula:C19H24ClN3O4S2Purity:99.16% - >99.99%Color and Shape:SoildMolecular weight:457.99Tigecycline mesylate
CAS:<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72SJFα
CAS:<p>SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.</p>Formula:C59H67F2N7O11SPurity:95.25%Color and Shape:SolidMolecular weight:1120.27
