PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(170 products)
- ATM/ATR(72 products)
- DNA-PK(49 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(231 products)
- S6 Kinase(6 products)
- gsk-3(109 products)
- mTOR(163 products)
Show 2 more subcategories
Found 984 products of "PI3K/Akt/mTOR Signaling"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purity:97.17%Color and Shape:SolidMolecular weight:432.88Ref: TM-T16369
1mg52.00€5mg105.00€10mg167.00€25mg324.00€50mg518.00€100mg742.00€1mL*10mM (DMSO)114.00€AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formula:C41H44ClFN6O7S2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:851.41Ref: TM-T10419
1mg42.00€2mg55.00€5mg90.00€10mg137.00€25mg240.00€50mg403.00€100mg582.00€1mL*10mM (DMSO)129.00€Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurity:99.00% - 99.81%Color and Shape:PowderMolecular weight:581.06PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formula:C23H25N3O5S2Purity:97.18%Color and Shape:SolidMolecular weight:487.59Ref: TM-T12469
1mg75.00€5mg178.00€10mg268.00€25mg485.00€50mg677.00€100mg888.00€1mL*10mM (DMSO)197.00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Formula:C24H18N2O3SPurity:99.34%Color and Shape:SolidMolecular weight:414.48Ref: TM-T15789
5mg43.00€10mg71.00€25mg138.00€50mg231.00€100mg344.00€200mg505.00€1mL*10mM (DMSO)47.00€SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Formula:C24H33F2N9O4SPurity:98.06%Color and Shape:SolidMolecular weight:581.64NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purity:98% - ≥98%Color and Shape:SolidMolecular weight:181.18Ref: TM-T12270
1mg89.00€5mg215.00€10mg344.00€25mg737.00€50mg1,169.00€100mg1,691.00€1mL*10mM (DMSO)170.00€Erlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4·HClPurity:99.78% - 99.85%Color and Shape:White Or Off-White PowderMolecular weight:429.9P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formula:C31H40N8O3SPurity:99.75%Color and Shape:SolidMolecular weight:604.77Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.
Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.97 kDaSAR405 R enantiomer
CAS:SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.Formula:C19H21ClF3N5O2Purity:98.04%Color and Shape:SolidMolecular weight:443.85Ref: TM-T12831
1mg46.00€5mg96.00€10mg149.00€25mg248.00€50mg359.00€100mg502.00€200mg683.00€1mL*10mM (DMSO)94.00€Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.889-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Formula:C22H13FN2O5Purity:99.32%Color and Shape:SolidMolecular weight:404.35Ref: TM-T14066
1mg50.00€2mg66.00€5mg94.00€10mg155.00€25mg309.00€50mg447.00€100mg667.00€1mL*10mM (DMSO)110.00€LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formula:C20H22N4O2Purity:99.48%Color and Shape:SolidMolecular weight:350.41Ref: TM-T11826
1mg50.00€5mg103.00€10mg156.00€25mg269.00€50mg403.00€100mg583.00€200mg785.00€1mL*10mM (DMSO)110.00€STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Formula:C22H20FN5O4Purity:99.53% - 99.81%Color and Shape:SolidMolecular weight:437.42Ref: TM-T13017
1mg70.00€5mg150.00€10mg219.00€25mg369.00€50mg550.00€100mg722.00€1mL*10mM (DMSO)170.00€Pyrotinib dimaleate
CAS:Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formula:C40H39ClN6O11Purity:97.27% - 99.52%Color and Shape:SolidMolecular weight:815.22Ref: TM-T12594
1mg155.00€5mg457.00€10mg610.00€25mg947.00€50mg1,301.00€100mg1,758.00€1mL*10mM (DMSO)620.00€PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Ref: TM-T12468
1mg75.00€5mg156.00€10mg241.00€25mg399.00€50mg532.00€100mg750.00€200mg1,009.00€1mL*10mM (DMSO)164.00€Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formula:C23H18FN5O2Purity:99.71%Color and Shape:SolidMolecular weight:415.42Ref: TM-T13119
1mg35.00€2mg50.00€5mg77.00€10mg105.00€25mg178.00€50mg289.00€100mg434.00€1mL*10mM (DMSO)84.00€Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Formula:C7H6N2Purity:99.59% - 99.85%Color and Shape:White Or Beige Crystalline PowderMolecular weight:118.14IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purity:98.00%Color and Shape:SolidMolecular weight:455.51Ref: TM-T15592
1mg44.00€2mg60.00€5mg99.00€10mg166.00€25mg323.00€50mg447.00€100mg610.00€1mL*10mM (DMSO)107.00€Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Purity:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:25.79 kDaAllitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formula:C24H18ClFN4O2Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:448.88Ref: TM-T14336
1mg50.00€5mg105.00€10mg172.00€25mg313.00€50mg467.00€100mg663.00€1mL*10mM (DMSO)128.00€Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.
Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Ref: TM-T10606
1mg94.00€5mg173.00€10mg253.00€25mg374.00€50mg525.00€100mg702.00€1mL*10mM (DMSO)190.00€Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Purity:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.86 kDaMELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Formula:C31H33N5O4Purity:99.84%Color and Shape:SolidMolecular weight:539.62Panitumumab
CAS:Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Purity:95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:147 kDaAZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:99.65%Color and Shape:SolidMolecular weight:522.04Gefitinib
CAS:Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formula:C22H24ClFN4O3Purity:99.92% - >99.99%Color and Shape:Light-Yellow Crystalline PowderMolecular weight:446.90Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Formula:C23H14Na2O11Purity:99.4% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33HyT36
CAS:HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.Formula:C25H44ClNO3Purity:99.02%Color and Shape:SolidMolecular weight:442.07Ref: TM-T72075
1mg56.00€5mg119.00€10mg188.00€25mg393.00€50mg628.00€100mg908.00€1mL*10mM (DMSO)131.00€BLU-945
CAS:BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.Formula:C28H37FN6O3SPurity:99.11% - 99.16%Color and Shape:SolidMolecular weight:556.7Ref: TM-T9754
1mg35.00€5mg75.00€10mg114.00€25mg222.00€50mg356.00€100mg557.00€200mg790.00€1mL*10mM (DMSO)241.00€Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formula:C14H12O5Purity:99.89% - 99.95%Color and Shape:Light Yellow CrystallineMolecular weight:260.24Rociletinib
CAS:Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFormula:C27H28F3N7O3Purity:98.52% - 99.25%Color and Shape:SolidMolecular weight:555.55Epertinib hydrochloride
CAS:Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formula:C30H28Cl2FN5O3Purity:99.14%Color and Shape:SolidMolecular weight:596.48Ref: TM-T11213
1mg87.00€5mg178.00€10mg295.00€25mg505.00€50mg715.00€100mg964.00€500mg1,935.00€1mL*10mM (DMSO)241.00€Mutated EGFR-IN-1
CAS:Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormula:C25H31N7OPurity:98.91%Color and Shape:SolidMolecular weight:445.56Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4Purity:98.19% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:393.44NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Formula:C29H27F2N5O5S2Purity:99.58%Color and Shape:SolidMolecular weight:627.68Ref: TM-T16355
2mg39.00€5mg60.00€10mg87.00€25mg159.00€50mg231.00€100mg355.00€200mg505.00€1mL*10mM (DMSO)84.00€OK2
OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.Formula:C42H62N14O9Purity:98%Color and Shape:SolidMolecular weight:907.03GSK3β/mTOR modulator 1
GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.Formula:C19H28O5Color and Shape:SolidMolecular weight:336.19367MS9427
CAS:MS9427: PROTAC EGFR degrader, 7.1 nM (WT), 4.3 nM (L858R); targets mutant via UPS and autophagy; inhibits NSCLC cell growth; anticancer research.Formula:C48H58ClFN8O12Color and Shape:SolidMolecular weight:993.47PROTAC EGFR degrader 2
Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.Formula:C58H72ClFN12O8SColor and Shape:SolidMolecular weight:1151.78MCX 28
CAS:MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.Formula:C25H19N5O4S3Color and Shape:SolidMolecular weight:549.64HER2-IN-13
CAS:HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with anFormula:C26H23ClF2N8O3Color and Shape:SolidMolecular weight:568.96PI3Kδ-IN-9
CAS:PI3Kδ-IN-9 is a selective PI3Kδ inhibitor with an IC 50 value of 3.8 nM.Formula:C24H26FN9OColor and Shape:SolidMolecular weight:475.532FRATide
CAS:FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.Formula:C55H102N2O2Color and Shape:SolidMolecular weight:823.433PROTAC EGFR degrader 3
CAS:Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Formula:C60H77N13O5SColor and Shape:SolidMolecular weight:1092.4Inetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.Purity:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Color and Shape:Odour LiquidGSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Formula:C14H10N2OPurity:99.40%Color and Shape:SolidMolecular weight:222.24Ref: TM-T11467
1mg60.00€5mg130.00€10mg200.00€25mg356.00€50mg537.00€100mg737.00€200mg973.00€1mL*10mM (DMSO)142.00€CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Formula:C20H16Cl2N8O2Color and Shape:SolidMolecular weight:471.30PI3Kδ-IN-8
CAS:PI3Kδ-IN-8 is a powerful and specific oral inhibitor of PI3Kδ, exhibiting an IC50 of 3.3 nM.Formula:C28H21F2N7OColor and Shape:SolidMolecular weight:509.521FD274
CAS:FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,Formula:C22H14ClFN6O2SPurity:98%Color and Shape:SoildMolecular weight:480.9Multi-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.Color and Shape:Odour SolidGSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.
Formula:C25H30N6O7SPurity:99.52%Color and Shape:SoildMolecular weight:558.61EGFR-IN-162
EGFR-IN-162 (compound 20) is an effective EGFR inhibitor that enhances both early and late apoptosis (EGFR) as well as necrosis (necrosis). It shows potential for use in breast cancer research.Formula:C27H31N3O2Color and Shape:SolidMolecular weight:429.24163RMC-4627
CAS:RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.Formula:C93H141N11O23Color and Shape:SolidMolecular weight:1781.17PI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Color and Shape:Odour SolidDSPE-PEG5000-GE11
DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.Color and Shape:Odour SolidAZ14240475
AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.Formula:C23H15ClF2N6O2Color and Shape:SolidMolecular weight:480.854DSPE-PEG2000-GE11
DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.Color and Shape:Odour SolidHDS 029
CAS:HDS 029 has a wide range of applications in life science related research.Formula:C17H11ClFN5OColor and Shape:SolidMolecular weight:355.76(R)-VX-984
CAS:(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.Formula:C23H21D2N7OPurity:98%Color and Shape:SolidMolecular weight:415.49ARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purity:99.75%Color and Shape:SoildMolecular weight:319.40IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.68%Color and Shape:SolidMolecular weight:221.25Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formula:C22H18Cl2N6OPurity:99.86% - 99.88%Color and Shape:SoildMolecular weight:453.32Ref: TM-T11129L
1mg296.00€5mg718.00€10mg982.00€25mg1,485.00€50mg2,008.00€100mg2,637.00€1mL*10mM (DMSO)895.00€DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour SolidGSK3β Inhibitor XI
CAS:GSK3β Inhibitor XI has GSK3β inhibitory effect.Formula:C18H15N5O3Color and Shape:SolidMolecular weight:349.35BMS-599626 2HCL(714971-09-2 Free base)
CAS:BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative.Formula:C27H29Cl2FN8O3Purity:99.11%Color and Shape:Odour SolidMolecular weight:603.47PI3Kγ inhibitor 5
CAS:PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM.Formula:C28H32F2N6O4Color and Shape:SolidMolecular weight:554.599Simotinib hydrochloride
CAS:Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.Formula:C25H27Cl2FN4O4Color and Shape:SolidMolecular weight:537.41HL-8
CAS:HL-8, a PROTAC targeting PI3K, degrades it fully at 10 μM in 8h, useful in cancer research.Formula:C57H59F2N11O9S2Color and Shape:SolidMolecular weight:1144.276-Me-ATP
CAS:6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.Formula:C11H18N5O13P3Color and Shape:SolidMolecular weight:521.21DP-C-4
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].Color and Shape:LiquidHER2-IN-14
CAS:HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formula:C26H23ClF2N8O3Color and Shape:SolidMolecular weight:568.96PI3-Kinase α Inhibitor 2 (hydrochloride)
CAS:PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor.Formula:C16H17Cl2N3O2SColor and Shape:SolidMolecular weight:386.3GSK-3β inhibitor 23
GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.Formula:C18H13Cl2N5O2SColor and Shape:SolidMolecular weight:434.299WAY-270360
CAS:WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Formula:C22H19N3O3Purity:98.05%Color and Shape:SolidMolecular weight:373.4DSPE-PEG1000-GE11
DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.Color and Shape:Odour SolidGSK-3β inhibitor 24
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.Formula:C26H18N4O3Color and Shape:SolidMolecular weight:434.446mTOR inhibitor WYE-28
CAS:mTOR inhibitor WYE-28, Potent mTOR (IC50=0.08 nM) and PI3Kα (IC50=6 nM) inhibitor, short half-life in mouse microsomes.Formula:C30H34N8O5Color and Shape:SolidMolecular weight:586.65MS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formula:C50H59ClF4N8O14Color and Shape:SolidMolecular weight:1107.5GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.
Formula:C9H6BrNOPurity:99.58%Color and Shape:Off-White To Light Yellow Crystalline PowderMolecular weight:224.05Varlitinib
CAS:Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formula:C22H19ClN6O2SPurity:99.7%Color and Shape:SolidMolecular weight:466.94Pertuzumab
CAS:Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Purity:98.00%Color and Shape:LiquidMolecular weight:145.44 kDaGW 583340
CAS:GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formula:C28H25ClFN5O3S2Purity:98.68%Color and Shape:SoildMolecular weight:598.11QL-IX-55
CAS:QL-IX-55 has a wide range of applications in life science related research.Formula:C24H14F4N4OColor and Shape:SolidMolecular weight:450.39CYH33
CAS:CYH33: Oral PI3Kα inhibitor, IC50=5.9 nMα/598 nMβ/78.7 nMδ/225 nMγ; blocks Akt, ERK; causes G1 arrest in breast/lung cancer; effective on solid tumors.Formula:C24H29F3N8O5SColor and Shape:SolidMolecular weight:598.6EGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formula:C27H37FN8O2Color and Shape:SolidMolecular weight:524.633GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurity:99.8%Color and Shape:SolidMolecular weight:584.71Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formula:C31H24F3N5O3Purity:97.34%Color and Shape:SolidMolecular weight:571.55Ref: TM-T13140
1mg187.00€5mg455.00€10mg655.00€25mg1,169.00€50mg1,510.00€100mg1,882.00€1mL*10mM (DMSO)560.00€EGFR-IN-76
CAS:EGFR-IN-76 is a potent EGFR inhibitor.Formula:C30H30ClFN6O2Purity:97.02% - 97.72%Color and Shape:SolidMolecular weight:561.05EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formula:C17H15N7O5SColor and Shape:SolidMolecular weight:429.41AG-1478 hydrochloride
CAS:AG1478 HCl is an epidermal growth factor receptor protein inhibitor.Formula:C16H15Cl2N3O2Color and Shape:SolidMolecular weight:352.212B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Formula:C71H123N26O29PPurity:98%Color and Shape:SolidMolecular weight:1835.87EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formula:C49H53ClFN5O5Color and Shape:SolidMolecular weight:846.43Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquire740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.Formula:C143H223F3N43O41PS3Purity:99.78%Color and Shape:SolidMolecular weight:3384.73PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formula:C21H19ClN4O4Color and Shape:SolidMolecular weight:426.853
