PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(170 products)
- ATM/ATR(72 products)
- DNA-PK(49 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(231 products)
- S6 Kinase(6 products)
- gsk-3(109 products)
- mTOR(163 products)
Show 2 more subcategories
Found 984 products of "PI3K/Akt/mTOR Signaling"
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Pyrotinib dimaleate
CAS:Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formula:C40H39ClN6O11Purity:97.27% - 99.52%Color and Shape:SolidMolecular weight:815.22Ref: TM-T12594
1mg155.00€5mg457.00€10mg610.00€25mg947.00€50mg1,301.00€100mg1,758.00€1mL*10mM (DMSO)620.00€Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Purity:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:25.79 kDaSAR405 R enantiomer
CAS:SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.Formula:C19H21ClF3N5O2Purity:98.04%Color and Shape:SolidMolecular weight:443.85Ref: TM-T12831
1mg46.00€5mg96.00€10mg149.00€25mg248.00€50mg359.00€100mg502.00€200mg683.00€1mL*10mM (DMSO)94.00€Rociletinib
CAS:Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFormula:C27H28F3N7O3Purity:98.52% - 99.25%Color and Shape:SolidMolecular weight:555.55Epertinib hydrochloride
CAS:Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formula:C30H28Cl2FN5O3Purity:99.14%Color and Shape:SolidMolecular weight:596.48Ref: TM-T11213
1mg87.00€5mg178.00€10mg295.00€25mg505.00€50mg715.00€100mg964.00€500mg1,935.00€1mL*10mM (DMSO)241.00€Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Purity:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.86 kDaGefitinib
CAS:Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formula:C22H24ClFN4O3Purity:99.92% - >99.99%Color and Shape:Light-Yellow Crystalline PowderMolecular weight:446.90LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formula:C20H22N4O2Purity:99.48%Color and Shape:SolidMolecular weight:350.41Ref: TM-T11826
1mg50.00€5mg103.00€10mg156.00€25mg269.00€50mg403.00€100mg583.00€200mg785.00€1mL*10mM (DMSO)110.00€STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Formula:C22H20FN5O4Purity:99.53% - 99.81%Color and Shape:SolidMolecular weight:437.42Ref: TM-T13017
1mg70.00€5mg150.00€10mg219.00€25mg369.00€50mg550.00€100mg722.00€1mL*10mM (DMSO)170.00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formula:C31H40N8O3SPurity:99.75%Color and Shape:SolidMolecular weight:604.77AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:99.65%Color and Shape:SolidMolecular weight:522.04NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purity:98% - ≥98%Color and Shape:SolidMolecular weight:181.18Ref: TM-T12270
1mg89.00€5mg215.00€10mg344.00€25mg737.00€50mg1,169.00€100mg1,691.00€1mL*10mM (DMSO)170.00€Erlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4·HClPurity:99.78% - 99.85%Color and Shape:White Or Off-White PowderMolecular weight:429.9SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Formula:C24H33F2N9O4SPurity:98.06%Color and Shape:SolidMolecular weight:581.64AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formula:C41H44ClFN6O7S2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:851.41Ref: TM-T10419
1mg42.00€2mg55.00€5mg90.00€10mg137.00€25mg240.00€50mg403.00€100mg582.00€1mL*10mM (DMSO)129.00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Ref: TM-T10606
1mg94.00€5mg173.00€10mg253.00€25mg374.00€50mg525.00€100mg702.00€1mL*10mM (DMSO)190.00€Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formula:C24H18ClFN4O2Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:448.88Ref: TM-T14336
1mg50.00€5mg105.00€10mg172.00€25mg313.00€50mg467.00€100mg663.00€1mL*10mM (DMSO)128.00€Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Formula:C23H14Na2O11Purity:99.4% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33HyT36
CAS:HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.Formula:C25H44ClNO3Purity:99.02%Color and Shape:SolidMolecular weight:442.07Ref: TM-T72075
1mg56.00€5mg119.00€10mg188.00€25mg393.00€50mg628.00€100mg908.00€1mL*10mM (DMSO)131.00€BLU-945
CAS:BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.Formula:C28H37FN6O3SPurity:99.11% - 99.16%Color and Shape:SolidMolecular weight:556.7Ref: TM-T9754
1mg35.00€5mg75.00€10mg114.00€25mg222.00€50mg356.00€100mg557.00€200mg790.00€1mL*10mM (DMSO)241.00€Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formula:C14H12O5Purity:99.89% - 99.95%Color and Shape:Light Yellow CrystallineMolecular weight:260.24Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurity:99.00% - 99.81%Color and Shape:PowderMolecular weight:581.06Panitumumab
CAS:Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Purity:95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:147 kDaIPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purity:98.00%Color and Shape:SolidMolecular weight:455.51Ref: TM-T15592
1mg44.00€2mg60.00€5mg99.00€10mg166.00€25mg323.00€50mg447.00€100mg610.00€1mL*10mM (DMSO)107.00€Mutated EGFR-IN-1
CAS:Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormula:C25H31N7OPurity:98.91%Color and Shape:SolidMolecular weight:445.56PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Ref: TM-T12468
1mg75.00€5mg156.00€10mg241.00€25mg399.00€50mg532.00€100mg750.00€200mg1,009.00€1mL*10mM (DMSO)164.00€Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4Purity:98.19% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:393.44LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Formula:C24H18N2O3SPurity:99.34%Color and Shape:SolidMolecular weight:414.48Ref: TM-T15789
5mg43.00€10mg71.00€25mg138.00€50mg231.00€100mg344.00€200mg505.00€1mL*10mM (DMSO)47.00€9-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Formula:C22H13FN2O5Purity:99.32%Color and Shape:SolidMolecular weight:404.35Ref: TM-T14066
1mg50.00€2mg66.00€5mg94.00€10mg155.00€25mg309.00€50mg447.00€100mg667.00€1mL*10mM (DMSO)110.00€Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.
Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formula:C23H18FN5O2Purity:99.71%Color and Shape:SolidMolecular weight:415.42Ref: TM-T13119
1mg35.00€2mg50.00€5mg77.00€10mg105.00€25mg178.00€50mg289.00€100mg434.00€1mL*10mM (DMSO)84.00€Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Formula:C7H6N2Purity:99.59% - 99.85%Color and Shape:White Or Beige Crystalline PowderMolecular weight:118.14Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Formula:C31H33N5O4Purity:99.84%Color and Shape:SolidMolecular weight:539.62NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Formula:C29H27F2N5O5S2Purity:99.58%Color and Shape:SolidMolecular weight:627.68Ref: TM-T16355
2mg39.00€5mg60.00€10mg87.00€25mg159.00€50mg231.00€100mg355.00€200mg505.00€1mL*10mM (DMSO)84.00€Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purity:97.17%Color and Shape:SolidMolecular weight:432.88Ref: TM-T16369
1mg52.00€5mg105.00€10mg167.00€25mg324.00€50mg518.00€100mg742.00€1mL*10mM (DMSO)114.00€Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.
Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.97 kDaPI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formula:C23H25N3O5S2Purity:97.18%Color and Shape:SolidMolecular weight:487.59Ref: TM-T12469
1mg75.00€5mg178.00€10mg268.00€25mg485.00€50mg677.00€100mg888.00€1mL*10mM (DMSO)197.00€RMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Formula:C90H139N13O23Color and Shape:SolidMolecular weight:1771.17Varlitinib Tosylate
CAS:Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).Formula:C36H35ClN6O8S3Purity:98%Color and Shape:SolidMolecular weight:811.34Lyso-Monosialoganglioside GM3
CAS:Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.Formula:C41H74N2O20Color and Shape:SolidMolecular weight:915.028Anticancer agent 271
Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.Color and Shape:Odour SolidMulti-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.Color and Shape:Odour SolidPI3K-IN-22
CAS:PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Formula:C31H35F3N8O3Color and Shape:SolidMolecular weight:624.66PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formula:C21H19ClN4O4Color and Shape:SolidMolecular weight:426.853HER2/neu (654-662) GP2
CAS:Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.Formula:C42H77N9O11Purity:98%Color and Shape:SolidMolecular weight:884.11GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Color and Shape:Odour SolidTephrosin
CAS:Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.Formula:C23H22O7Purity:98%Color and Shape:SolidMolecular weight:410.42
