Toxicology

<p>Stability Hygroscopic<br>Applications Orally active, third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),<br></p>

<p>Applications Lapatinib-d7 Dihydrochloride is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005)<br></p>

<p>Applications An oral anti-diabetic drug.<br>References Choi, S., et al.: J. Med. Chem., 53, 3696 (2010), Fritzson, I., et al.: ChemMedChem, 5, 608 (2010), Lee-Manion, A., et al.: J. Agric. Food Chem., 57, 10619 (2009),<br></p>

<p>Applications Chloroquine used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.<br>References Laufer, M. et al.: PLoS One., 7, e42284 (2012); Hangartner, S. et al.: Drug Test. ANal., 5, 777 (2013)<br></p>

<p>Applications Flumetsulam is a ighly active herbicide of the triazolopyrimidine sulfonanilide class. Flumetsulam act by inhibiting acetolactate synthase. Flumetsulam exhibits broad spectrum activity on broadleaf weed species with selectivity to several major agronomic crops in soil and foliar applications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kleschick, W.A. et al.: J. Agric. Food Chem., 40, 1083 (1992); Frear, D.S. et al.: Pest. Biochem. Physiol., 45, 178 (1993); Webster, E.P. et al.: Weed Sci., 49, 652 (2001);<br></p>

<p>Applications (3R)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid is an intermediate in the synthesis of Ofloxacin (O245750), an fluorinated quinolone based antibacterial agent.<br>References Mitscher, L. A., et la.: J. Med. Chem., 30, 2283 (1987);<br></p>

<p>Stability Hygroscopic<br>Applications rac cis-Moxifloxacin-d4 is a labelled fluorinated quinolone with antibacterial activities.<br>References Woodcock, J.M., et al.: Antimicrob. Ag. Chemother., 41, 101 (1997), Stass, H., et al.: Antimicrob. Ag. Chemother., 42, 2060 (1998)<br></p>

<p>Stability Air Sensitive<br>Applications 4-Amino-2-chlorophenol is a general chemical reagent used in the synthesis of magnetically recyclable polydopamine composites as well as in the preparation of antifungal 1,4-benzothiazine derivatives.<br>References Jain, N. et al.: Am. J. PharmTech. Res., 3, 548 (2013); Bian, S. et al.: J. Mat. Sci., 51, 3643 (2016);<br></p>

<p>Applications 4-Chloro-3,5-dimethylphenoxy)acetic Acid is a synthetic auxin, or a class of plant growth regulators.<br>References Savaldi-Goldstein, S. et al.: Proc. Nat. Acad. Sci. Uni. Am., 105, 15190 (2008); Mahajan, D. et al.: J. App. Chem., 2, 765 (2013);<br></p>

<p>Applications Adamantane derivatives have been used to treat influenza, as well as serve as NMDA receptor channel blockers for a wide range of pharmaceutical application.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, C. et al.: Inorg. Chem. 45, 4769 (2012); Thomas. A. et al.: J. Neurosci., 25, 3312 (2005); Deyde, V. et al.: Exp. Rev. Mol. Diag., 9, 493 (2009);<br></p>

<p>Applications Thiamine hydrochloride phosphate-d3 was used as a reagent in the redn. of cytochrome c in its reaction with thiamine and its structural analogs.<br>References Vovk, A. I, et al.: Russian J. of Gen. Chem. 72(11), 1808-1812. (2002)<br></p>

<p>Applications Bromophos-ethyl is a phenyl organothiophosphate insecticide used in the control of flies, mosquitos and other insects. It is also used as an aracacide to control ticks.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brooke, J.P.: Int. Pest Control, 11, 18 (1969); LaBrecque, G.C. et al.: J. Econ. Entomol., 60, 760 (1967); Rueda H. et al.: Rev. Inst. Col. Agros., 3, 103 (1968)<br></p>

<p>Stability Hygroscopic<br>Applications 25-Deacetyl-23-acetyl Rifampicin is a structural isomer, and impurity, of Rifampicin (R508000), a semisynthetic antibiotic. Antibacerial (tuberculostatic).<br>References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),<br></p>

<p>Impurity USP Azithromycin Related Impurity H /Azithromycin EP Impurity H<br>Stability Hygroscopic<br>Applications 3'-N-[[4-(acetylamino)phenyl]sulfonyl]-3'-N-demethyl Azithromycin is an impurity of Azithromycin (A927000).<br>References Debremaeker, D. et al.: Rap. Comm. Mass. Spec., 17, 342 (2003);<br></p>

<p>Applications Labelled Sulfadoxine (S699070). Used as an antibacterial.<br>References Kapoor, V.K., et al.: Anal. Profiles Drug Subs., 17, 571 (1988)<br></p>

<p>Applications 2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma.<br>References Marino, K. et al.: J. Am. Chem. Soc., 12, 1664, (2002); Tilley, J. et al.: Bioorg. Med. Chem. Lett., 23, 1036 (2013);<br></p>

<p>Applications Labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),<br></p>

<p>Applications A metabolite of Drotaverine (D689700).<br>References Lalla, J.K., et al.: J. Pharma. Biomed. Anal., 11, 385 (1993),<br></p>

<p>Applications An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lopaschuk, G., et al.: Mol. Cell. Biochem., 88, 175 (1989), Reinauer, H., et al.: J. Clin. Chem .Clin. Biochem., 28, 335 (1990),<br></p>

<p>Applications Labelled Dopamine. Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carter, J.E., et al.: Anal. Profiles Drug Subs., 11, 257 (1982), Dasta, J.F., et al.: Pharmacotherapy, 6, 304 (1986),<br></p>

<p>Applications 1-Docosanol-d45 is the labelled form of 1-Docosanol (D678855). 1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis.<br>References Noweck, K., et al.: Ullmann's Encyclopedia of Industrial Chemistry (2006); McKeough, M., et al.: Arch. Dermatol., 137, 1153 (2001)<br></p>

<p>Applications Sodium salt of Penicillin G, an antibacterial, antimicrobial medication. Used in the treatment of pneumococcus and streptococcus bacterial infections.<br>References Tanaka, M. et al.: Antimicrob. Agents Chemother., 49, 88 (2005); Song, J. et al.: Epidemio. Infect., 140, 1267 (2012); Gamella, M. et al.: Analyst, 138, 2013 (2013);<br></p>

<p>Applications rac Fosfomycin-13C3 Benzylamine Salt is an antibiotic.<br>References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);<br></p>

<p>Applications A labelled metabolite of Chloroquine. It is a COVID19-related research product.<br>References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981), Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004),<br></p>

<p>Applications Ribavirin-13C2 is the labeled analogue of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986); Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993); Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994); Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>

<p>Applications L-erythro-Chloramphenicol functions as a potent inhibitor of electron transport in the mitochondria in biological studies. The L-isomer can be identified from the other CAP-isomers through reversed phase and chiral liquid chromatography in combination with tandem mass spectrometric detection.<br>References Berendsen, B., et al.: Anal. Chim. Acta., 700, 78 (2011), Wilson, S.B., et al.: Biochim. Biophys. Acta., 292, 603 (1973)<br></p>

<p>Applications (1S,2R)-2-((Benzyloxy)methyl)cyclopent-3-enol is an intermediate in the synthesis of Entecavir (E558900), an oral antiviral drug used in the treatment of hepatitis B infection.<br>References Gathergood, N., et al.: J. Org. Chem., 66, 1014 (2001);<br></p>

<p>Applications Nandrolone-13C2 Benzoate is the isotope analog of Nandrolone Benzoate. Nandrolone Benzoate is a steroid that has effect on gondatropin and muscles, which is derived from Nandrolone (an anabolic steroid).<br>References Lerner, L.J., et al.: Endocrinology, 64, 1010 (1959); Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990); Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991); Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007); Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008)<br></p>

<p>Applications Fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>

<p>Applications An active metabolite of Glimepiride.<br>References Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),<br></p>

<p>Applications It is a bisbiguanide with bacteriostatic activity. Antiseptic; disinfectant.<br>References Davies, G.E., et al.: Br. J. Pharmacol., 9, 192 (1954), Foulkes, D.M., et al.: J. Periodontal Res., 8, 55 (1973),<br></p>

<p>Applications An antiviral. Labelled HIV protease inhibitor. It is a COVID19-related research product.<br>References Patick, A.K., et al.: Antimicrol Ag. Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000)<br></p>

<p>Applications A deuterated prodrug of Penciclovir (P221500), which is used as an antiviral.<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>

<p>Applications 2-Ethylhexyl Salicylate-d4 is an isotopic analog of 2-Ethylhexyl Salicylate (E918775), a skin penetration enhancer that increases drug diffusivity in the skin that has been used in sunscreen products.<br>References Santos, P., et. al.: Int. J. Pharmaceut., 439, 260 (2012); Rigon, R.B., et. al.: Int. J. Pharm. Pharmaceut. Sci., 5, 306 (2013)<br></p>

<p>Stability Light Sensitive<br>Applications An impurity of Minocycline (M344800). Used in the preparation of calpain inhibitors.<br>References Sokoloski, T.D., et al.: J. Pharm. Sci., 66, 1159 (1977), Naidong, W., et al.: J. Pharm. Biomed. Anal., 13, 905 (1995),<br></p>

<p>Applications Sulfacetamide-d4 is the isotope labelled analog of Sulfacetamide. Sulfacetamide is an antibiotic used for the treatment of skin infections and urinary tract infections. Sulfacetamide is also used to treat acne and seborrheic dermatitis. Sulfacetamide was investigated for potential anti-inflammatory properties<br>References Wittwer, M.B., et al.: J. Med. Chem., 56, 781 (2013); Wang. X., et al.: Afr. J. Micriobiol., 6, 4533 (2012); Yu, B., et al.: Euro. J. Med. Chem., 46, 5833 (2011);<br></p>

<p>Applications Metolachlor ESA Sodium Salt is a salt of Metolachlor ESA (M338860), a synthetic herbicide that belongs to the chloroacetanelide. It is commonly used in agriculture.<br>References Mai, H., et al.: Aquat. Toxicol. 147, 48 (2014); McCarty, G. W., et al.: Sci Total Environ 473-474, 473 (2014);<br></p>

<p>Applications A deuterated metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.This compounds contains Sodium Chloride. Water content not determined.<br></p>

<p>Applications 2,5-Dimethoxy-4-methylamphetamine (DOM, STP) is one of the potent hallucinogenic phenylalkylamines with neurotoxic properties. Hallucinogen.<br>References Monte, A., et al.: J. Med. Chem., 39, 2953 (1996), Pedersen, W., et al.: Addiction, 94, 1695 (1999), Kanamori, T., et al.: J. Anal. Toxicol., 26, 61 (2002),<br></p>

<p>Applications 3-Chloroacetanilide is a major metabolite of chlorpropham. An acetanilide herbicide derivative.<br>References Carrera, G., et al.: Arch. Environ. Cont. Tox., 35, 89 (1998); Freitas, M. R., et al.: Bull. Environ. Contam. Toxicol., 92, 143 (2014)<br></p>

<p>Applications Uniconazole is a plant growth regulator, absorbed by the stems and roots. Uniconazole is used to reduce lodging in rice; to reduce vegetative growth and increase flowering of ornamentals; and to reduce vegetative growth and the need for pruning in trees. Uniconazole is an insecticide.<br>References Khush, G., et al.: Plant Mol Biol., 35, 25 (19970), Qiu, J., et al.: Plant Growth Regul., 47, 75 (2005), Zhang, A., et al.: J. Agric. Food Chem., 59, 4300 (2011),<br></p>

<p>Applications rac Guaifenesin-d3 (cas# 1189924-85-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Deracoxin is a selective cyclooxygenase-2 (COX-2) inhibitor used in the treatment of osteoarthritis in dogs. At low doses, adminsitartion of Deracoxin showed no factors associated with gastrointestinal tract perforation.<br>References Lascelles, B.D.X. et al.: J. Am. Vet. Med. Assoc., 227, 1112 (2005); Anderson, G.D. et al.: Inflam. Res., 58, 109 (2009); Brainard, B.M. et al.: Am. J. Vet. Res., 68, 251 (2007);<br></p>

<p>Applications Triclopyr is a selective post-emergence herbicide.<br>References Coupe, R., et al.: Sci. Total Environ., 248, 227 (2000), Lu, C., et al.: Environ. Res., 84, 290 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications An amino alcohol metabolite of nicotine, and precursor to NNK.<br></p>

<p>Applications Isotope labelled Coumachlor (C745000) an internal standard in the analysis of the rodenticide Warfarin.<br>References Dikshith, T., et al.: J. Exp. Biol., 29, 149 (1991),<br></p>

<p>Applications Naloxegol Oxalate is an oxalate form of Naloxegol (N284470) which is a peripherally-selective opioid antagonist.<br>References Seifert, R., et al.: G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, 227 (2012)<br></p>

<p>Impurity Quetiapine EP Impurity R<br>Applications Fumaric Acid Monoethyl Ester (Quetiapine EP Impurity R) is an anti-psoriatic fumaric acid ester. Fumaric Acid Monoethyl Ester inhibited thymidine-14C incorporation into DNA by cultured human lymphocytes. Fumaric Acid Monoethyl Ester has been shown to evoke transient increase in intracellular free calcium concentration and inhibit proliferation of human keratinocytes.<br>References Hagedorn, M. et al.: Arch. Dermatol. Res., 254, 67 (1975); Thio, H.B. et al.: Br. J. Dermatol., 131, 856 (1994); Rostami-Yazdi, M. Arch. Dermatol. Res., 302, 531 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Itraconazole N,N-Dioxide is a derivative of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications Oxychloroaphine is a simple phenazine with weak antifungal activity.<br></p>

<p>Impurity Ciprofloxacin USP Related Compound A / EP Impurity D<br>Stability Hygroscopic<br>Applications 7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride is an impurity in the synthesis of Ciprofloxacin (C482500), a fluorinated quinolone antibacterial.<br>References Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985), Scully, B.E., et al.: Lancet, 1, 819 (1986)<br></p>

<p>Applications Dimoxystrobin is a pesticide component used for its antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hvezdova, M. et al.: Sci. Total. Env., 613-614, 361 (2018);<br></p>

<p>Applications An antibacterial agent that is effective againts garam negative bacteria such as Pseudomonas Aeruginosa as well as some gram positive bacteria.<br>References Massano, S. et al.: Antimicrob. Agents Chemother., 8, 132 (1975); Falagas, M.E. et al.: J. Antimicrob, Chemother., 65, 1863 (2010);<br></p>

<p>Applications Labelled Clofazimine (C324300). Antibacterial (tuberculostatic, leprostatic).<br>References Doak, A., et al.: J. Med. Chem., 53, 4259 (2010), Rodgers, A., et al.: Chem. Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Azure C Dye Content 40% is a useful antifungal and antibacterial cationic dye for studying E. coli K30 bacterial polysaccharide.<br>References Das, B., et al.: Surface Review and Letters, (2020)<br></p>

<p>Applications Tetraethylthiourea is an impurity of Disulfiram (D493640) which is used as rubber accelerator; vulcanizer; seed disinfectant; fungicide; alcohol deterrent.<br>References Child, C., et al.: Acta Pharmacol. Toxicol., 8, 305 (1952), Nash, N.G., et al.: Anal. Profiles Drug Subs., 4, 168 (1975),<br></p>

<p>Applications Creatine-(methyl-d3) Monohydrate is an isotopic analog of Creatine Monohydrate (6020-87-7), which is a nitrogenous organic acid that occurs naturally in vertebrates. Its main role is to facilitate recycling of Adenosine Triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue.<br>References Barcelos, R.P., et al.: Mini Rev Med Chem., 16, 12-8 (2016)<br></p>

<p>Applications Propoxur-d3 (N-methyl-d3) (CAS# 1219798-56-7) is the labelled version of Propoxur (P830800(P)), which is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by reversibly inactivating the enzyme acetylcholinesterase in insects. It is also used in cannabis testing kits as a component of pesticide mixes (P698235).<br>References Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Fraser, J. et al.: J. Sci. Food. Agric., 8 (1968); Corbel, V. et al.: Neurotoxicology, 27, 508 (2006);<br></p>

<p>Stability Light Sensitive<br>Applications Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Tiropramide is an antispasmodic agent. Studies suggest that Tiropramide has a pure musculotropic smooth muscle relaxant activity. Tiropramide is considered to be useful to inhibit the contractile response of the urinary bladder.<br>References Myung, S.-W. et al.: J. Appl. Pharmacol., 8, 262 (2000); Kwon, O.-S. et al.: Arzneim.-Forsch., 53, 578 (2003); Jhee, O.H. et al.: Clin. Chim. Acta, 366, 179 (2006); Takayanagi, I. et al.: Gen, Pharmacol., 20, 335 (1989);<br></p>

<p>Impurity Cefotaxime Sodium EP Impurity A<br>Stability Hygroscopic<br>Applications Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.<br>References Bryson, H.M., et al.: Drugs., 45, 589 (1993); Sharma, R.K., et al.: Asian. J. Biochem. Pharmaceut. Res., 1, 443 (2011); Waters, N.J., et al.: Drug. Metabolism. Disposit., 38, 1159 (2010);<br></p>

<p>Applications Isotope labelled Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications A metabolite of Testosterone (T155000) in human. Controlled substance.<br>References Seckl, J., et al.: Steroids, 62, 89 (1997), Reynolds, R., et al.: J. Clin. Endocrinol. Metab., 86, 245 (2001), Wolf, C., et al.: Toxicol. Sci. 65, 71 (2002), Borlak, J., et al.: Drug Metab. Dispos., 32, 675 (2004),<br></p>

<p>Applications 2,4,6-Trichlorophen-3,5-d2-ol is an impurity in the synthesis of isotope labelled Triclosan which is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Stability Hygroscopic<br>Applications Fosetyl Aluminum-d15 is a deuterated version of Fosetyl Aluminum (F727450), a fungicide. Fosetyl Aluminum has a potent inhibitory activity against several species of Phytophthora.<br>References Fenn, M., et al.: Phytopathology, 74, 606 (1984); Matheron, M., et al.: Plant Disease, 84, 454 (2000)<br></p>

<p>Applications Metaldehyde<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Suvorexant-d6 is the labeled analog of Suvorexant (S870000), a dual (non-selective) orexin receptor antagonist in development by Merck &amp; Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation.<br>References Cox, C., et al.: J. Med. Chem., 53, 5320 (2010); Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011); Winrow, C., et al.: J. Neurogenet., 25, 52 (2011); Mieda, M., et al.: CNS Drugs, 27, 83 (2013); Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)<br></p>

<p>Applications Labelled Bilirubin (B385300), a principal pigment of bile and constituent of many biliary calculi.<br>References Stenhagen, R., et al.: Biochem. J., 33, 1591 (1939), Gray, et al.: J. Chem. Soc., 2264, 2268 (1961),<br></p>

<p>Applications Dimethoate is an organophosphate insecticide (1). It is an anti-cholinesterase which disables cholinesterase, an enzyme essential for central nervous system function (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Tripathy, N. et al.: Mutat. Res.1988 Nov;206(3):351-60.2. Papp, A. et al.: Pest. Biochem. Physiol. 1998 August:61(1) 21-26<br></p>

<p>Applications Clindamycin (C580000) impurity in bulk drug.<br>References Birkenmeyer, R., et al.: J. Med. Chem., 13, 616 (1970), Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006), Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications Spiroxamine is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: J. Agric. Food Chem., 53, 1857 (2005), Abrahim, A., et al.: J. Pharm. Biomed. Anal., 51, 131 (2010), Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010),<br></p>

<p>Applications Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.<br>References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>

<p>Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.<br>References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>

<p>Applications Sulfadimethoxine-d4 is a isotope labeled version of Sulfadimethoxine (S699060), a sulfonamide antibiotic.<br>References Seki, et al.: Arzneim.-Forsch., 15, 1441 (1965), Bohni, et al.: Chemotherapy, 14, 195 (1969),<br></p>

<p>Applications Gingerenone A is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.<br>References Ali, B., et al.: Food Chem. Toxicol., 46, 409 (2008); Bordia, A., et al.: Prost. Leuk. Ess. Fat. Acids, 56, 379 (1997); Choi, W., et al.: J. Appl. Biomed., 11, 15 (2013); Riaz, T., et al.: Nat. Prod. Res., 24, 1131 (2010); Srivastava, K. &amp; Mustava, T.: Med. Hypoth., 39, 342 (1992)<br></p>

<p>Applications A potent inhibitor of taurine transport.<br>References Guidotti, A., et al.: Pharmacol. Res. Commun., 2, 341 (1970),<br></p>