Acids and Synthetic Reagents

<p>Applications Coordination compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Galanski, M., et al.: J. Med. Chem., 46, 4946 (2003), Cui, K., et al.: Bioorg. Med. Chem. Lett., 16, 2937 (2006),<br></p>

<p>Applications Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic.<br>References Moyer, J.D., et al.: Cancer Res., 57, 4838 (1997), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001), Perez-Soler, R., et al.: J. Clin. Oncol., 22, 3238 (2004), Blackhall, F.H., et al.: Expert Opin. Pharmacother., 6, 995 (2005),<br></p>

<p>Applications Used for preparation of hydrophilic polymers for biomedical devices.<br>References Delbressine, L., et al.: Xenobiotica, 11, 241 (1981), Gerberick, G., et al.: Toxicol. Sci., 97, 417 (2007),<br></p>

<p>Stability Very Hygroscopic<br>Applications Potassium trifluoroacetate (cas# 2923-16-2) is a useful research chemical.<br></p>

<p>Applications Sulbactam Pivoxil is a prodrug of the semi-synthetic β-lactamase inhibitor Sulbactam (S699195).<br>References Foulds, G. et al.: Curr. Chemother. Infect. Dis., Proc. Int. Congr. Chemother., 11, 353 (1980); Pei, Q. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 879, 2000 (2011);<br></p>

<p>Applications Dibutyltin(IV) Oxide is used in studies pertaining to discovering novel antitumor agents. Antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boualam, M. et al.: App. Organometal. Chem., 6, 197 (1992); Hadi, S. et al.: Ori. J. Chem., 26, 775 (2010); Hadi, S. et al.: Modern. App. Sci., 3, 12 (2009);<br></p>

<p>Applications An aromatase inhibitor. Also blocks adrenal steroidogenesis.<br>References Santen, R.J. and Misbin, R.I.: Pharmacotherapy, 1, 95 (1981), Havlin, K.A. and Trump, D.L.: Cancer Threat. Res., 39, 83 (1988)<br></p>

<p>Applications Copper(II) Sulfate Pentahydrate is a chemical reagent used as a fungicide. Used to control fungus growth on various fruits and the spread of aquatic plants primarily.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michaud, J. et al.: J. Insect. Sci., 3, 16 (2003);<br></p>

<p>Applications BARIUM CARBONATE (cas# 513-77-9) is a useful research chemical.<br></p>

<p>Applications tert-Butyl (R)-3-Aminopiperidine-1-carboxylate, is an heterocyclic building block used for the synthesis of more complex pharmaceutical compounds. It is also found to act as a γ-secretase modulators, and a potent structure for lowering Aβ42 production in both in vitro and in vivo.<br>References Kobayashi, T., et al.: Bioorg. Med. Chem. Lett., 24, 378 (2014);<br></p>

<p>Applications L-2-Aminobutanol has potential application as an inhibitor of L-Fucosidases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blaser, A. et al.: Org. Lett., 2, 1733 (2000);<br></p>

<p>Applications Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).<br>References (1) Bitner, M., et al.: Int. J. Clin. Pract., 58, 340 (2004) (2) Packman, E., et al.: Headache, 45, 1163 (2005) (3) Rordorf, C.M., et al.: Clin. Pharmacokinet., 44. 1247 (2005) (4) Schnitzer, T.J., et al.: Curr. Med. Res. Opin., 21, 151 (2005)<br></p>

<p>Applications Iodine is used in ionic liquids in the preparation of dye-sensitized solar cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: J. Phys. Chem. B, 107, 13280 (2003); Kubo, W. et al.: J. Phys. Chem. B. 105, 12809 (2001);<br></p>

<p>Applications Brigatinib is a tyrosine kinase receptor Mer (MERTK) inhibitor and can be used in combination with epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancer.<br>References Yan, D.; et al.: U.S. Pat. Appl. Publ. 48 pp. Patent 2017 CODEN:USXXCO<br></p>

<p>Applications N-(2-Carboxy-2-hydroxycaproyl)hydrazobenzene is an impurity in the synthesis of pheylbutazone (P319570) derivatives.<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>

<p>Applications (R)-(+)-α-Methylbenzylamine (cas# 3886-69-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.<br>References Yamada, Y. et al.: Horm. Metab. Res., 40, 539 (2008); Kopelman, P. et al.: Int. J. Obes., 31, 494 (2007); Kopelman, P. et al.: Obesity, 18, 108 (2010);<br></p>

<p>Applications ABT 199 (&gt;99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. &amp; Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>

<p>Applications 2-Hydroxybutanoic Acid is an analyte used in the diagnoses of colorectal cancer as well as Type II diabetes. It is also used in the purification of the major Vibrio autoinducer and the study of its role in virulence factor production for cholera.<br>References Qiu, Y. et al.: J. Proteome Res., 8, 4844 (2009); Salek, R.. et al.: Phys. Genom., 29, 99, (2007); Higgins, D. et al.: Nature, 450, 883 (2007);<br></p>

<p>Applications L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.<br>References (1) Knabl, J., et al.: Nature. 451, 330 (2008) (2) Johnston, G.A.R., et al.: Curr. Pharm. Design, 11, 1867 (2005)<br></p>

<p>Applications A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.<br>References Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);<br></p>

<p>Applications A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),<br></p>

<p>Applications (±)-trans-9,10-Epoxystearic Acid Methyl Ester is a useful synthetic intermediate. It is an intermediate used to prepare (±)-erythro- and (±)-threo-9,10-difluorostearic acids. It is also used to synthesize monofluorinated fatty acids.<br>References Tavasli, M., et al.: Chem. Commun., 11, 1226 (2002); Buist, P., et al.: J. Chem. Soc., 17, 2617 (1997);<br></p>

<p>Stability Hygroscopic<br>Applications Perindopril L-Arginine, is a complex compound of Perindopril (P287500), having the antihypertensive, cardiovascular protective and antithrombotic properties, and has been shown to exists as a neutral complex.<br>References Remko, M., et al.: Euro. J. Med. Chem., 44, 101 (2009); Morgan, T., et al.: J. Cardiovasc. Pharmacol., 10, Supp. 7, S116, (1987);<br></p>

<p>Applications Foscarnet inhibits viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.<br>References Helgstrand, E., et al.: Science, 201, 819 (1978), Reno, J.M., et al.: Antimicrob. Agents Chemother., 13, 188, (1978), Alenius, S., et al.: Arch. Virol., 60, 197 (1979),<br></p>

<p>Applications 1,3-Diaminopropane is a common chemical reagent, used in the synthesis of 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors applied in the treatment of Alzheimer’s disease. Also used in the synthesis of thrombosis inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spilovska, K. et al.: Molecules, 18, 2397 (2013); Smith, S. et al.: Blood, 120, 5103 (2012);<br></p>

<p>Applications 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE (cas# 1892-57-5) is a useful research chemical.<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Ethyl 3-Phenylpropionate is also used in the synthesis pyrimidine based inhibitors of cyclin-dependant kinases. It is also used to preparation of inhibitor BB-3497.<br>References Markwalder, J. et al.: J. Med. Chem., 47, 5894 (2004); Davies, S. et al.: Bioorg. Med. Chem. Lett., 13, 2709 (2003);<br></p>

<p>Applications Magnesium Sulfate is used in the production of epsom salts, as well as being a potential agent to protect against cerebral palsy and other neurological disorders in preterm infants.<br>References Doyle, L. et al.: Obst. Gyne., 6, 1327 (2009); Mukhopadhyay, C. et al.: J. Hetero. Chem., 47, 136 (2010);<br></p>

<p>Applications Calcium Carbonate is a common chemical reagent used in various organic reactions. It is used in the synthesis of small molecules which disrupt Wnp-dependent signalling in tissue regeneration and cancer. Also used in the preparation of non-cytotoxic, silver nanoparticle-polysaccharide nanocomposites shown to provide antimicrobial activity.<br>References Chen, B. et al.: Nat. Chem. Biol., 5, 100 (2009); Travan, A. et al.: Biomacromol., 10, 1429 (2009);<br></p>

<p>Applications Tetraethylammonium Bromide, can be used as a source of tetraethylammonium ions for various pharmaceutical studies. It has also the ability to block K+ channels in various tissues.<br>References Kevill, D.N., et al.: J. Am. Chem. Soc., 83, 3812 (1961); Armstrong, C.M. et al.: J. Gen. Physiol. 59, 388 (1972);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. &amp; Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)<br></p>

<p>Applications D-(-)-Tartaric Acid the synthetic enantiomer of L-(+)-Tartaric Acid (T007630), used in the preparation of synthetic analgesics.<br>References Van Bever, W. et al.: J. Med. Chem., 17, 1047 (1974);<br></p>

<p>Applications A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>

<p>Applications Used in the one-pot synthesis of 2-aminobenzimidazoles.<br>References Artman, G.D., et al.: Tetrahedron Lett., 51, 5319 (2010),<br></p>

<p>Stability Moisture Sensitive<br>Applications Phenylmethylsulfonyl Fluoride Is a Phospholipase C inhibitor that ameliorates post-ischemic neuronal damage, nonspecific irreversible inhibitor of serine protease and other enzymes, including trypsin, chymotrypsin, thrombin and papain. Protease Inhibitors, detecting and measuring antibodies in human intestinal aspirate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trinchieri, G., et al.: J. immunol., 116, 885 (1976); James G. T.: Anal. biochem., 86, 574 (1978); Kraut, D., et al.: Mol. Pharmacol., 57, 1243 (2000); Raulstron, D. L., et al.: J. Biol. Chem., 256, 7173 (1981); Sekar V., et al.: Biochem. biophys. Res. Commun., 89, 474 (1979); Hohmann, A., et al.: J. immunol. Methods, 64, 199 (1983); Umemura, A., et al.: Stroke, 23, 1163 (1992)<br></p>

<p>Applications N-Cyanocyanamide Sodium Salt is used in the preparation of ionic liquids displaying antimicrobial activity. Also used in the synthesis of palladium nanoparticles used in biomass refining.<br>References Gore, R. et al.: Green Chem., 15, 2727 (2013); Xu, X. et al.: J. Am. Chem. Soc., 134, 16987, (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Used primarily as a reagent in trifluoromethylation reactions.<br>References Fantasia, S. et al.: J. Org. Chem., 75, 1779 (2010);<br></p>

<p>Applications Hydroxymethyl Ivacaftor is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>

<p>Applications An anti-ulcer drug. Potent PDE4 inhibitor<br>References Kishimoto, A., et al.: J. Periodont. Res., 43, 508 (2008), Masuyama, H., et al.: Ther. Res., 29, 415 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications AD-mix-β is a catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates. It is also used in the preparation of ß-hydroxy-γ-lactones from ß,γ-unsaturated esters.<br>References Ahmed, M., et al.: J. Org. Chem., 71, 7741 (2006); Tretyakov, E., et al.: Eur. J. Org. Chem., 12, 2669 (2006)<br></p>

<p>Applications 1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene (cas# 91221-46-4) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications (2R,3S)-rel-2,3-Dihydroxy-2-methylbutanoic Acid Sodium Salt, is a synthetic organic compound used in studying the synthesis of chiral molecules from non-chiral reactants.<br>References Chenchaiah,P., et al.: J. Chem. Soc., Chem. Commun., 8, 436 (1982)<br></p>

<p>Applications MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.<br>References Hao, J. et al.: Bioorg. Med. Chem. Lett., 23, 1249 (2013);<br></p>

<p>Stability Shock Sensitive<br>Applications 2,2-Diphenyl-1-picrylhydrazyl is a stable free radical molecule most commonly used as a tool to monitor chemical reactions involving radicals, most notably in antioxidant assay.<br>References Suzhukim K., et al.: J. Org. Chem., 78, 2301 (2013); Chen, Z., et al.: Food. Chem., 138, 414 (2013); Chatterjee, S ., et al.: Advan. BIo. Res., 3, 109 (2012);<br></p>

<p>Applications DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wrzesien, J. &amp; Graham, D.: Tetrahedron, 68, 1230 (2012); Schlottmann, S. et al.: J. Im. Meth., 309, 75 (2006)<br></p>

<p>Applications 5-Hydroxymethyl-2-furoylglycine can be used as analyte for analytical and biological studies of determination of metabolites of 5-​hydroxymethylfurfural in human urine after oral application.<br>References Hardt-Stremayr, M., et al.: J Sep Sci., 36, 670-676 (2013)<br></p>

<p>Applications Dithiothreitol is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol is also used to reduce the disulfide bonds of proteins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, C.-Y. et al.: Langmuir, 21, 5134 (2005); Lu, B.-Y. et al.: Anal. Biochem., 405, 67 (405);<br></p>

<p>Applications (R)-(+)-2-(4-Hydroxyphenoxy)propionic Acid is a degradation product of Cyhalofop-butyl (C989385); an aryloxyphenoxypropionate compound that is used as a herbicide to eliminate grass weeds in rice fields. Cyhalofop-butyl works by selectively inhibiting acetyl CoA carboxylase, an enzyme that is important for the metabolism of fatty acids.<br>References Jackson, R. and Douglas, M.: Human and Environmental Exposure to Xenobiotics, no vol., 345 (1999); Iwakami, S., et al.: Pest Manag. Sci., 68, 1098 (2012); Ottis, B., et al.: J. Agr. Food Chem., 53, 4064 (2005); Ruiz-Santaella, J., et al.: Planta, 223, 191 (2006)<br></p>

<p>Applications Furyl Hydroxymethyl Ketone is a reagent in the preparation of 3-iodocoumarins. Also used in the preparation of quinoxalines generally used in dyes and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reddy, M. et al.: J. Org. Chem., 78, 5878 (2013); Cho, C. et al.: J. Mol. Catal. A. Chem., 276, 205 (2007);<br></p>

<p>Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.<br>References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)<br></p>

<p>Applications AHR 11652 is a metabolite of Bromfenac sodium (B678550).<br>References Walsh, D.A., et al.: J. Med. Chem., 25, 446 (1982),<br></p>

<p>Stability Hygroscopic and Moisture Sensitive<br>Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Malonyl Chloride is used as a reagent in the synthesis of novel thiadiazoloacrylamide analogs as inhibitors of dengue-2 virus NS2B/NS3 protease. Ethyl Malonyl Chloride is also used as a reagent in the synthesis of quinolone-benzylpiperidine derivatives as acetylcholinesterase inhibitors and antioxidant hybrids for Alzheimer disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Bioorg. Med. Chem., 22, 6344 (2014); Pudlo, M., et al.: Bioorg. Med. Chem., 22, 2496 (2014)<br></p>

<p>Applications Fmoc-L-2-nitrophenylalanine<br></p>

<p>Stability Hygroscopic<br>Applications EDDHA is used as an inorganic fertilizer.<br>References Kalantari, S.et al.: Comm. Soil Sci. Plant Anal., 42, 123 (2011); Albano, J. et al.: HortSci., 47, 269 (2012);<br></p>

<p>Applications A synthetic, quaternary ammonium anticholinergic. Antispasmodic; preanesthetic medicant.<br>References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),<br></p>

<p>Applications Halogenated derivative of Febrifugine. Used as an antiprotozoal (coccidiostat).<br>References McIntosh, L., et al.: Biochem. Cell Biol., 73, 181 (1995), Leshem, Y., et al.: Exp. Cell Res., 274, 288 (2002),<br></p>

<p>Applications Cognition enhancer related to Piracetam. Nootropic.<br>References Foltyn, P., et al.: Arzneim.-Forsch., 33, 865 (1983), Yamada, K., et al.: Pharmacol. Biochem. Behav., 22, 645 (1985), Schlappi, B., et al.: Drug Invest., 5, 50 (1993),<br></p>

<p>Applications A thiadiazole derivative with fungacidal properties. An antitumor agent.<br>References Lu, K. et al.: Cancer Chemother. Pharmacol., 4, 275 (1980); Rauckyte, T. et al.: ECOpole’04, Ksiega Konf./Proc., 139 (2004); Nelson, J.A. et al.: Cancer Res., 36, 1375 (1976);<br></p>

<p>Applications Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).<br>References Anon.: Cancer Discovery, 6, 4 (2016); Passiglia, F., et al.: Expert Opin. Investig. Drugs, 25, 385 (2016)<br></p>

<p>Applications Diclofenac and its combination with Pitofenone and Fenpiverinium shows antispasmodic activity.<br>References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi.,12, 366 (1991),<br></p>

<p>Applications An acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Very Hygroscopic<br>Applications EDTA calcium disodium salt (cas# 62-33-9) is a useful research chemical.<br></p>

<p>Applications (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol is proven to have amphetamine-like effects and is being used for recreational drug use. It is one of a new class of synthetic stimulants known as pipradol derivatives. It inibits neurite growth in PC12 cells which contributes to its neurotoxic effects. It is used as a reagent in the synthesis of (S)-duloxetine which is an antidepressant drug. It is used to prepare chiral Corey-Bakshi-Shibata catalyst which is used in organic synthesis.<br>References Coppola, M., et al.: Toxicol. Lett., 212, 57 (2012); Lee, S., et al.: B. Kor. Chem. Soc., 35, 1894 (2014); Kaizaki, A., J. Toxicol. Sci., 35, 375 (2010); Corey, E., et al.: J. Am Chem. Soc., 109, 5551 (1987);<br></p>

<p>Applications 1-(Bromomethyl)-2-nitrobenzene is a reagent used in the synthesis of 1,3,4-oxadiazole derivatives possessing a benzotriazole moiety leading to anticancer activity. Also used in the preparation of antifungal triazole derivatives.<br>References Zhang, S. et al.: Bioorg. Med. Chem., 21, 3723 (2013); Yu, S. et al.: Arch. Pharm. Res., 36, 1215 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications (R,R)-Labetalol Hydrochloride is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol Hydrochloride is also used as an antihypertensive.<br>References Sybertz, E.J., et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981), Clifton, J.E., et al.: J. Med. Chem., 25, 670 (1982), Goa, K.L., et al.: Drugs, 37, 583 (1989),<br></p>

<p>Applications o-Acetyltoluene can be used as a reagent to prepare diaryl dihydropyrazoles as inhibitors of mitotic kinesin spindle protein (1). It is also used to synthesize aryl- and indolyl-cyanoaminopyridines with anti-inflammatory, analgesic, and antipyretic activities (2).<br>References (1) Cox, C., et al.: Bioorg. Med. Chem. Lett. (2005) 15, 2041 (2) Manna, F., et al.: Eur. J. Med. Chem. (1999) 34, 245-54<br></p>

<p>Applications Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning.<br>References Clayden, J., et al.: Org. Chem., 1st ed. (2001); Zhang, Z. et al.: Org. Lett., 16, 3292 (2014);<br></p>

<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>

<p>Applications 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin. The number of 2-hydroxypropyl ranges from 5 to 14.<br>References Pitha, J. et al.: Int. J. Pharmacol., 29, 73 (1986); Frijink, H.W. et al.: Pharm. Res., 8, 380 (1991);<br></p>

<p>Applications A volatile alkyl compound present in tobacco smoke. It is used as a potential biomarker in breath for prediction of lung cancer.<br>References Phillips, M. et al.: Cancer Biomarkers, 3, 95 (2007); Li, Y. et al.: Yan. Keji, 10, 15 (2005);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.<br>References Kim, H.K., et al.: Plant. Pathol. J., 28, 259 (2012); Nam, S., et al.: J. Agr. Food. Chem., 60, 9097 (2012); Durchschein, K., et al.: Eur. J. Org. Chem., 2012, 4963 (2012);<br></p>

<p>Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.<br>References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)<br></p>