Acids and Synthetic Reagents

<p>Applications 1-Bromopentadecane is a building block that has been used in the preparation of 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromide as antibacterial and antioxidant agents.<br>References Kahriman, N., et. al.: Eur. J. Med. Chem., 69, 348 (2013)<br></p>

<p>Applications 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (cas# 60875-16-3) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications Di-tert-Butyl Disulfide is a general reagent used in the synthesis of a novel neuropeptide Y (NPY) Y5 receptor antagonist Velneperit) used in the treatment of obesity.<br>References Oda, S. et al.: Org. Proc. Res. Dev., 19, 531 (2015);<br></p>

<p>Applications A reagent used in the synthesis of Pitavastatin.<br>References Mukaiyama, H., et al.: Chem. Pharm. Bull., 55, 881 (2007), Paruch, K., et al.: Bioorg. Med. Chem. Lett., 17, 6220 (2007),<br></p>

<p>Applications An antineoplastic. A derivative of Cytarabine.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Akiyama, M., et al.: Chem. Pharm. Bull., 26, 981 (1978),<br></p>

<p>Applications 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.<br>References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)<br></p>

<p>Applications Gilteritinib is an AXL inhibitor in cancer.<br>References Myers, S., et al.: J. Med. Chem. (2015)<br></p>

<p>Applications (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester is a dioxolane derivative used in the preparation of matrix metalloproteinases (MMP) inhibitors.<br>References Wada, C.K. et al.: J. Med. Chem., 45, 219 (2002); Chang, S.-J. et al.: Org. Proc. Res. Dev., 6, 329 (2002);<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Applications 4-Methoxybenzoyl Chloride is used in the synthesis of stilbene and dihydrostilbene derivatives as potential anti-cancer agents. It is also used in the synthesis of coumarin dimers with potential HIV-1 activity.<br>References Cushman, M., et al.: J. Med. Chem., 34, 2579 (1991); Mao, P., et al.: Chem. Pharm. Bull. 50, 1634 (2002);<br></p>

<p>Applications 4-Pyridineacetic Acid Hydrochloride is used in the preparation of a highly tumor-selective organometallic ruthenium(II)-Arene complex.<br>References Clavel, C.M., et. al.: J. Med. Chem., 57, 3546 (2014)<br></p>

<p>Applications L-AP3 is a selective antagonist of the PI-linked metabotropic glutamate response.<br></p>

<p>Applications 6-Methoxy-4-pyrimidinamine is used in the synthesis of carbamothiolacrylamides as selective EP2 antagonists in the treatment of neurodegenerative peripheral diseases. Also used in the preparation of PARP-1 inhibitors.<br>References Ganesh, T. et al.: ACS Med. Chem. Lett., 4, 616 (2013); Rhee, H. et al.: Bioorg, Med. Chem., 17, 7537 (2009);<br></p>

<p>Applications 2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, J., et al.: Science, 272, 101 (1996); Rivera-Nevares, J., et al.: Env. Toxicol. Chem., 14, 251 (1995); Rothweiler, H., et al.: Atm. Env. B: Urb. Atm., 25, 231 (1991)<br></p>

<p>Applications Lithium hydroxide is a reagent that is used in the synthesis of O-Desmethyl Mebeverine Acid O-β-D-Glucuronide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Applications A phopshine ligand used in transition-metal mediated organic synthesis, in particular in wittig reactions to improved (Z) selectivity.<br>References Andersen N.G. et al.: Chem. Rev., 101, 997 (2001); Appel M. et al.: Eur. J. Org. Chem., 1143, (2002);<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.<br>References Liu, J., et. al.: Roc. Natl. Acad. Sci. USA, 110, 20224 (2013)<br></p>

<p>Applications Benzenecarbothioic Acid is used in the preparation of anti-leishmanial activity. Also used in the preparation of agents for the treatment against Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andrews, P. et al.: Aus. J. Chem., 66, 1297 (2013); Linning, P. et al.: Org. Biomol. Chem., 10, 8216 (2012);<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Calcium Sulfate Dihydrate is obtained from gypsum, a naturally occurring compound. Also used in the preparation of calcium sulfate and calcium sulfoaluminate.<br>References Strydom, C. et al.: J. Therm. Anal., 49, 1501 (1997); Winnefeld, F. et al.: DGCh-Monograph., 44, 30 (2011);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, E., et al.: J. Pharmacol. Exp. Ther., 307, 720 (2003), Maggio, S., et al.: Cancer Res., 64, 2590 (2004), Gojo, I., et al.: Blood, 109, 2781 (2007), Xu, W; Oncogene, 26, 5541 (2007),<br></p>

<p>Applications 4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.<br>References Bensaid, S., et al.: Tetrahedron Lett., 52, 1383 (2011); Lagoja, I., et al.: Eur. J. Pharm. Sci., 43, 386 (2011); Matsubara, K., et al.: J. Organom. Chem., 691, 3693 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 1-Acetyl-1H-pyrazole-4-boronic acid, pinacol ester<br></p>

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (R)-Ethyl 4-chloro-3-hydroxybutanoate is used in biological studies for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains.<br>References Liu, Y., et al.: Biotech. Lett., 27, 119 (2005);<br></p>

<p>Applications 4-Bromophenylhydrazine Hydrochloride is a reactant in the synthesis of fluoro substituted novel pyrazolylpyrazolines scaffold with antibacterial activity, antituberculosis activity against Mycobacterium tuberculosis H37Rv and antimalarial activity against Plasmodium falciparum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Karad, S.C., et. al.: Eur. J. Med. Chem., 84, 51 (2014)<br></p>

<p>Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);<br></p>

<p>Stability Very Hygroscopic<br>Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).<br>References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications Tin(II) Oxalate is used in stannous oral care compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Surerus, K., et al.: Biochemistry, 1994, 33, 4980 (1994),<br></p>

<p>Stability Moisture Sensitive<br>Applications Potassium Disulfate is used in the synthesis of novel composite superionic conductors. Also used in the catalytic conversion of diethyl tartrate into pyruvate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bukun, N. et al.: Solid State Ionics, 136, 279 (2000); Sugiyama, S. et al.: Bull. Chem. Soc., 65, 2083 (1992);<br></p>

<p>Applications GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.<br>References Wippich, Frank., et al.: Cell., 152, 791(2013); Corona, John A., et al.: Org. Process Res. Dev., 14, 712 (2010)<br></p>

<p>Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)<br></p>

<p>Applications Tin(II) trifluoromethanesulfonate (cas# 62086-04-8) is a useful research chemical.<br></p>

<p>Applications 3-Pyridinemethanol is a useful synthetic intermediate. It can be used in the synthesis of histone deacetylase inhibitors. It can also be used to prepare (phenyl)(cyanopyrazinyl)urea derivatives as possible kinase-1 (Chk1) inhibitors.<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Li, G., et al.: Bioorg. Med. Chem. Lett., 16, 2293 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koltun, E., et al.: Bioorg. Med. Chem. Lett., 22, 3727 (2012)<br></p>

<p>Applications (S)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is often used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications Rhodium Carbonyl Chloride is a reagent for rhodium-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and carbon monoxide to produce [4+2+1] cycloadducts<br>References Tian, Z.Y., et al.: Angewandte Chemie Int. Ed.’ 57, 15544 (2018)<br></p>

<p>Applications BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.<br>References Guagnano, V., et al.: J. Med. Chem., 54, 7066 (2011); Konecny, G., et al.: Mol. Cancer Ther., 12, 632 (2013)<br></p>

<p>Applications Hydrohchloride Salt of α-Aminoacetophenone, used in the preparation og pseudopeptidic inhibitors of human sirtuins1-3. This action effectually displays antiproliferative protperties in cancer cells. Also used in the preparation of dual δ/μopiod receptor agonists in th<br>References Mellini, P. et al.: J. Med. Chem., 56, 6681 (2013); Breslin, H. et al.: Bioorg. Med. Chem. Lett., 22, 4869 (2013);<br></p>

<p>Applications Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.<br>References Courtney, K. et al. J. Molec. Cell. Cardiol., 12, 1273 (1980); Kwok, D. et al.: Res. Comm. Chem. Path. Pharm., 67, 395 (1990);<br></p>

<p>Applications 2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hwang, S. et al.: J. Med. Chem., 50, 3825 (2007); Ludovici, D. et al.: Bioorg. Med. Chem. Lett., 11, 2229 (2001);<br></p>

<p>Applications (±)-Paraconic Acid is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.<br>References Tonari, K., et al.: J. Oleo Sci., 51, 259 (2002)<br></p>

<p>Applications Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.<br>References Stark, H. et al.: J. Med. Chem., 43, 3987 (2000); Mahmood, D. et al.: Pharmacolol. Rep., 64, 191 (2012); Passani, M. et al.: Trends Pharmacol. Sci., 25, 618 (2004);<br></p>

<p>Applications Trifluoromethanesulfonic Acid Magnesium Salt is a strong acid that is used as a catalyst for esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. D., et al.: Chemical Rev., 77, 69 (1977);<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications 2,3-Pyrazinedicarboxylic Acid has been found to exhibit antifungal and antibacterial acitivity. It has also been used as a reagent in the preparation of transition metal pyrazinedicarboxylate complexes.<br>References Beaula, T.J., et al.: Spectrochim. Acta A, 138, 723 (2015); Premkumar, T., et al.: World J. Microb. Biot., 21, 479 (2005); Gunay, G., et al.: Inorg. Chim. Acta, 399, 19 (2013)<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, H., et al.: J. Med. Chem., 55, 10948 (2012); Kim, H., et al.: Bull. Kor. Chem. Soc., 34, 2311 (2013)<br></p>

<p>Applications A Nicotinic acid (N429250) analogue used as a growth factor in Erwinia amylovora growth (pear and apple blossoms).<br>References Davis, A., et al.: Planta, 205, 305 (1998), Valls, F., et al.: J. Agric. Food Chem., 48, 3392 (2000), Gardener, M., et al.: J. Chem. Ecol., 2001, 27, 2545 (2001),<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(triphenylphosphoranylidene)ammonium chloride is a catalyst that is used in the preparation of 5-Hydroxy-clethodim Sulfoxide (H918380). 5-Hydroxy-clethodim Sulfoxide is an impurity of Clethodim (C573250), a post-emergent herbicide. Bis(triphenylphosphoranylidene)ammonium chloride is also a useful new reagent for the synthesis of nucleoside-5’-di and triphosphates.<br>References Falb, L.N., J. Agric. Food Chem., 38, 875 (1990); Hunter., J.H., et al.: Weed Technol., 9, 432 (1995); Beistein J. of Org. Chem. 11: 469 (2015)<br></p>

<p>Applications Sodium Cyanide is used in the synthesis of antihypertensive agents, such as 2-amino-4-aryl-2-imidazolines. Also used in the synthesis of nonpeptidic cyanamides as potent reversible inhibitors of human cathespins K and L.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matier, W. et al.: J. Med. Chem., 16, 901 (1974); Falgueyret, J. et al.: J. Med. Chem., 44, 94 (2001);<br></p>