Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65580 products of "Quinazoline and Quinoline Derivatives"
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3,5-Bis(chloromethyl)pyridine Hydrochloride
CAS:Controlled Product<p>Stability Unstable in Aqueous Solution<br>Applications 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL (cas# 1210824-61-5) is a useful research chemical.<br></p>Formula:C7H7Cl2N•HClColor and Shape:NeatMolecular weight:212.5(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
CAS:Controlled Product<p>Applications Intermediate in the production of Ramelteon.<br>References Uchikawa, O., et al.: J. Med. Chem., 45, 4222 (2002),<br></p>Formula:C16H23NO3Color and Shape:NeatMolecular weight:277.36(R)-Naproxen
CAS:Controlled ProductFormula:C14H14O3Color and Shape:White To Off-WhiteMolecular weight:230.262-Chloro-1,1,1-trimethoxyethane
CAS:Controlled Product<p>Applications 2-Chloro-1,1,1-trimethoxyethanen is a reactant in the synthesis of α-chloro-β-aminosulfinyl imidates as chiral building blocks<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Col0paert, F., et. al.: J. Org. Chem., 76, 2204 (2011)<br></p>Formula:C5H11ClO3Color and Shape:NeatMolecular weight:154.59Benzil
CAS:<p>Applications Benzil is used in organic synthesis as a building block and in polymer chemistry as a photoinitiator. It has also been found to be an inhibitor of mammalian carboxylesterases.<br>References Encinas, M., et al.: J. Polym. Sci. A1., 22, 2469 (1984); Wadkins, R., et al.: J. Med. Chem., 48, 2906 (2005); Hicks, L., et al.: Bioorgan. Med. Chem., 15, 3801 (2007);<br></p>Formula:C14H10O2Color and Shape:NeatMolecular weight:210.23Hydroxy Atrazine-d5
CAS:Controlled Product<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>Formula:C82H5H10N5OColor and Shape:NeatMolecular weight:202.27Plerixafor-d4
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H50D4N8Color and Shape:Off White SolidMolecular weight:506.81rac Viloxazine Hydrochloride
CAS:Controlled ProductFormula:C13H19NO3·ClHColor and Shape:WhiteMolecular weight:273.76Tianeptine Metabolite MC5-d4 Sodium Salt
CAS:Controlled Product<p>Applications Labelled, primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Formula:C19H16D4ClN2NaO4SColor and Shape:NeatMolecular weight:434.914'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide
CAS:Controlled Product<p>Impurity Telmisartan Bromo Amide Impurity<br>Applications An impurity in the preparation of the angiotensin II receptor antagonist Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Formula:C14H12BrNOColor and Shape:WhiteMolecular weight:290.161-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Formula:C14H10N3NaO3Color and Shape:NeatMolecular weight:291.24Zosuquidar Trihydrochloride
CAS:Controlled Product<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>Formula:C32H31F2N3O2·3ClHColor and Shape:NeatMolecular weight:636.99Levofloxacin Hydroxy Acid
CAS:Controlled Product<p>Applications Levofloxacin Hydroxy Acid is found in the synthesis of Levofloxacin (L360000), S-(-)-form of Ofloxacin. An antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formula:C18H21F2N3O4Color and Shape:Light YellowMolecular weight:381.3738Nintedanib Demethyl-O-glucuronic Acid-d3
CAS:Controlled Product<p>Applications Nintedanib Demethyl-O-glucuronic Acid-d3 is an isotopic analog of Nintedanib Demethyl-O-glucuronic Acid (N478295), a metabolite of the drug Nintedanib (N478290).<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C36H36D3N5O10Color and Shape:NeatMolecular weight:704.749-Acridinecarboxylic acid
CAS:Controlled Product<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Formula:C14H9NO2Color and Shape:YellowMolecular weight:223.233-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride
CAS:Formula:C11H11ClN2O2·ClHColor and Shape:NeatMolecular weight:275.13Solifenacin EP Impurity A Nitroso Impurity
Controlled ProductFormula:C15H14N2OColor and Shape:NeatMolecular weight:238.29N-Benzyl Epinephrine-d3
CAS:Controlled Product<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Formula:C16H16D3NO3Color and Shape:NeatMolecular weight:276.35rac Methotrimeprazine Hydrochloride
CAS:Controlled Product<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>Formula:C19H24N2OS·HClColor and Shape:NeatMolecular weight:364.93Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)
Controlled Product<p>Applications Desmethyl 7-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C30H31N5O4Color and Shape:NeatMolecular weight:525.598(R)-(+)-α-Methylbenzylamine (>85%)
CAS:Controlled ProductFormula:C8H11NPurity:>85%Color and Shape:NeatMolecular weight:121.18Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Formula:C24H29N7O2Color and Shape:NeatMolecular weight:447.53(R)-5-Chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol
CAS:Controlled ProductFormula:C13H11ClF3NOColor and Shape:NeatMolecular weight:289.685-Methyl-5-propyl-2-dioxanone (80%)
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications An intermediate in the synthesis of Carisoprodol.<br></p>Formula:C8H14O3Purity:80%Color and Shape:NeatMolecular weight:158.19Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS:Controlled Product<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Formula:C12H13NO5SColor and Shape:NeatMolecular weight:283.3rac 4-(3-Aminobutyl)phenol
CAS:Controlled Product<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Formula:C10H15NOColor and Shape:NeatMolecular weight:165.235-Dehydro Tolvaptan
CAS:Controlled Product<p>Applications 5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g<br>References Yin, L., et al.: Tetrahedron, Asym., 21, 2390 (2010); Torisawa, Y., et al.: Bioorg. Med. Chem. Lett., 17, 6455 (2007); Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999);<br></p>Formula:C26H23ClN2O3Color and Shape:NeatMolecular weight:446.93Tadalafil Hydroxypiperidone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Tadalafil Hydroxypiperidone, is an impurity of Tadalafil (T004500), a phosphodiesterase 5-inhibitor used for the treatment of erectile dysfunction.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>Formula:C22H19N3O6Color and Shape:NeatMolecular weight:421.42,2’-Methylene Bis[Ranitidine]
CAS:Controlled Product<p>Impurity Ranitidine EP Impurity I<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 2,2’-Methylene Bis[Ranitidine] (Ranitidine EP Impurity I) is an impurity of histamine H2-receptor antagonist Ranitidine (R120000).<br>References Jones, M.D. et al.: J. Sep. Sci., 29, 2409 (2006); Kelly, M.A. et al.: J. Chrom. A, 798, 297 (1998);<br></p>Formula:C27H44N8O6S2Color and Shape:NeatMolecular weight:640.82Nifekalant Hydrochloride
CAS:<p>Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.<br>References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);<br></p>Formula:C19H27N5O5·ClHColor and Shape:Light Yellow SolidMolecular weight:441.9091Nafronyl 2-(Ethyl(nitroso)amino)
CAS:Controlled Product<p>Applications Nafronyl 2-(Ethyl(nitroso)amino) is an impurity of Nafronyl (N215000). Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.<br>References Fontaine, et al.: Chim. Ther., 4, 44 (1969), Bessin, P., et al.: Eur. J. Med. Chem., 10, 291 (1975), Clyne, C.A., et al.: Br. J. Surg., 67, 347 (1980),<br></p>Formula:C22H28N2O4Color and Shape:NeatMolecular weight:384.47(E)-Thiothixene
CAS:Controlled Product<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Formula:C23H29N3O2S2Color and Shape:NeatMolecular weight:443.632-(Chloromethyl)-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Formula:C8H10ClN·ClHColor and Shape:NeatMolecular weight:192.09Ethionamide Sulfoxide-D3
CAS:Controlled ProductFormula:C8D3H7N2OSColor and Shape:NeatMolecular weight:185.263-Deschloro-3,4-difluoro Gefitinib
CAS:<p>Applications 3-Deschloro-3,4-difluoro gefitinib, is an impurity of Gefitinib (G304000), an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),<br></p>Formula:C22H24F2N4O3Color and Shape:Off-White To Light YellowMolecular weight:430.448N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide
CAS:Controlled Product<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide is used as a reagent in the preparation of bicalutamide by coupling with sodium p-fluorobenzenesulfinate.<br>References Thijs, L., et al.: U.S. Pat. Appl. Publ. 23pp. (2004)<br></p>Formula:C12H11F3N2O3Color and Shape:NeatMolecular weight:288.224-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Controlled Product<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C14H12ClN3SColor and Shape:NeatMolecular weight:289.781-(2,5-Dimethylphenyl)ethanol
CAS:Controlled Product<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Formula:C10H14OColor and Shape:NeatMolecular weight:150.22N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS:Controlled Product<p>Applications N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Formula:C22H18N4OSColor and Shape:NeatMolecular weight:386.4695Pamapimod
CAS:Controlled Product<p>Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.<br>References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),<br></p>Formula:C19H20F2N4O4Color and Shape:WhiteMolecular weight:406.3810-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.00Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CAS:Controlled Product<p>Applications Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H21ClN2O2Color and Shape:NeatMolecular weight:380.87Losartan Trityl Ether
CAS:<p>Impurity Losartan EP Impurity I<br>Applications Losartan Trityl Ether (Losartan EP Impurity I) is an impurity of Losartan.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Formula:C41H37ClN6OColor and Shape:NeatMolecular weight:665.23Darunavir N-β-D-Glucuronide Sodium Salt (90%)
CAS:Controlled Product<p>Applications Darunavir N-β-D-Glucuronide Sodium Salt (90%) is a salt analogue of Darunavir N-β-D-Glucuronide (D193510), which is a metabolite of Darunavir (D193500) an inhibitor of human immunodeficiency virus (HIV) protease. It is a COVID19-related research product.<br>References Vermeir, M. et al.: Drug Metab. Disp., 37, 809 (2009); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005);<br></p>Formula:C33H44N3NaO13SPurity:90%Color and Shape:NeatMolecular weight:745.77(R)-Phenylephrine β-D-Glucuronide
Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Phenylephrine (P320640).<br></p>Formula:C15H21NO8Color and Shape:NeatMolecular weight:343.333-O-Methyl Tolcapone-d4
CAS:Controlled Product<p>Applications Isotope labelled 3-O-Methyl Tolcapone is a metabolite of the catechol-O-Methyl transferase inhibitor Tolcapone (T535250).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jorga, K. et al.: Br. J. Clin. Pharmacol., 48, 513 (1999); Funaki, T. et al.: J. Pharm. Pharmacol., 46, 571 (1994); Sun, J. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 877, 2557 (2009); Heizmann, P. et al.: J. Chrom. B Biomed. Sci. Appl., 730, 153 (1999);<br></p>Formula:C15H9D4NO5Color and Shape:NeatMolecular weight:291.29Desthiazolylmethyloxycarbonyl Ritonavir
CAS:Controlled ProductFormula:C32H45N5O3SPurity:>85%Color and Shape:NeatMolecular weight:579.80rac Ambrisentan-d3
CAS:Controlled Product<p>Applications Labeled rac-Ambrisentan (A575860) Nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formula:C222H3H19N2O4Color and Shape:Off White SolidMolecular weight:381.44N-Nitroso-1-(2-methoxyphenyl)piperazine
CAS:Controlled Product<p>Applications N-Nitroso-1-(2-methoxyphenyl)piperazine is a reagent used in the preparation of 9-aminoacridine-based agents that impair bovine viral diarrhea virus replication.<br>References Loddo, R. et al.: Bio. & Med. Chem., 26(4), 855-868, (2018)<br></p>Formula:C11H15N3O2Color and Shape:Off-White To Light BrownMolecular weight:221.266-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS:Controlled Product<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Formula:C9H8N2O3Color and Shape:BeigeMolecular weight:192.174-Chloro Perphenazine
CAS:Controlled Product<p>Applications 4-Chloro Perphenazine is an impurity of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic.<br>References Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formula:C21H26ClN3OSColor and Shape:NeatMolecular weight:403.97Bilastine-d6
CAS:Controlled Product<p>Applications Labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.<br>References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),<br></p>Formula:C28H31D6N3O3Color and Shape:White To Light BrownMolecular weight:469.65cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Formula:C23H26N2O3Color and Shape:NeatMolecular weight:378.46S-(+)-Atomoxetine Hydrochloride
CAS:Controlled Product<p>Impurity Atomoxetine EP Impurity B<br>Applications ent S-(+)-Atomoxetine Hydrochloride (Atomoxetine EP Impurity B) is an enatiomer of Atomoxetine, a Norepinephrine uptake blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robertson, D., et al.: J. Med. Chem., 31, 1412 (1988), Hwamg, et al.: Neurosci. Lett., 265, 151 (1999),<br></p>Formula:C17H21NO·ClHColor and Shape:NeatMolecular weight:291.822-Nitroso Riluzole
Controlled Product<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H3F3N2O2SColor and Shape:Dark GreenMolecular weight:248.1824-Chlorophenothiazine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Prochlorperazine (P755800) and related compound.<br></p>Formula:C12H8ClNSColor and Shape:NeatMolecular weight:233.72(3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester
CAS:Controlled ProductFormula:C24H21N3O3Color and Shape:NeatMolecular weight:399.44p-Nitrophenyl 2-(Furfurylsulfinyl)acetate
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications p-Nitrophenyl 2-(Furfurylsulfinyl)acetate is a furfurylsulfinyl derivative with gastroprotective activity. p-Nitrophenyl 2-(Furfurylsulfinyl)acetate is used in the preparation of histamine H2-receptor antagonist.<br>References Hirakawa, N. et al.: Chem. Pharmac. Bull., 46, 616 (1998); Zhu, R. et al.: Hef. Gong. Dax. Xue. Zir. Kex., 28, 1346 (2005);<br></p>Formula:C13H11NO6SColor and Shape:BeigeMolecular weight:309.292-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
CAS:Formula:C13H9FN2O4Color and Shape:Off White PowderMolecular weight:276.22(R)-Levetiracetam
CAS:Controlled Product<p>Impurity Levetiracetam EP Impurity D<br>Applications (R)-Levetiracetam [REV] (Levetiracetam EP Impurity D), is the enantiomer to Levetiracetam [LEV] (L331500), the antiepileptic drug that is highly enantioselective. It is apparent that [LEV] is more potent than [REV] in terms of antiepileptic potency.<br>References Isoherranen, N. et al.: Epilepsia, 42, 825 (2001); Isoherranen, N. et al.: Epilepsia, 44, 1280 (2003);<br></p>Formula:C8H14N2O2Color and Shape:NeatMolecular weight:170.21N,O-Diacetyl Pseudoephedrine
CAS:Controlled Product<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Formula:C14H19NO3Color and Shape:NeatMolecular weight:249.31Hydroxy Iloperidone-d4
CAS:Controlled Product<p>Applications A hydroxylated labelled metabolite of Iloperidone (I267200).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mutlib, A., et al.: Drug Metab. Dispos., 23, 951 (1995), Westerink, B., et al.: Eur. J. Pharmacol., 412, 127 (2001),<br></p>Formula:C24H25D4FN2O4Color and Shape:Off White SolidMolecular weight:432.522-N-Propyl Pramipexole
CAS:Controlled Product<p>Impurity Pramipexole EP Impurity B; Pramipexole BP Impurity B<br>Applications 2-N-Propyl Pramipexole (Pramipexole EP Impurity B; Pramipexole BP Impurity B) is a Pramipexole derivative.<br></p>Formula:C13H23N3SColor and Shape:NeatMolecular weight:253.41Imatinib (Piperidine)-1-oxide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Imatinib (Piperidine)-1-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity C. It is a COVID19-related research product.<br>References Taruns, C., et al.: Bioorg. Chem., 16, 38 (1988), Cohen, M., et al.: Clin. Cancer Res., 8, 935 (2002), Gschwind, H., et al.: Drug Metab. Dispos., 33, 1503 (2005), Peng, B., et al.: Clin. Pharmacokinet., 44, 879 (2005),<br></p>Formula:C29H31N7O2Color and Shape:Light Yellow To YellowMolecular weight:509.60Afatinib N-Oxide
Controlled Product<p>Applications Afatinib N-Oxide is a derivative of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References Ham, J. et al.: Cancer Cell., 29, 159 (2016);<br></p>Formula:C24H25ClFN5O4Color and Shape:White SolidMolecular weight:501.94Dimethylamine (40% aq.)
CAS:Controlled Product<p>Applications Dimethylamine (40% aq.) is a compound often used in industry as a precursor to Nitrosodimethylamine (N525625), a potent carcinogen that is produced during disinfection of wastewater effluent, and is also present in trace amounts in food and polluted air. Dimethylamine is also present in human urine and can be indicative of certain disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gereke, A. & Sedlak, D.: Env. Sci. Tech., 37, 1331 (2003); Mitch, W., et al.: Env. Eng. Sci., 20, 389 (2003); Tsikas, D., et al.: J. Chromatogr. B, 851, 229 (2007)<br></p>Formula:C2H7NColor and Shape:NeatMolecular weight:45.087,7'-[1,4-Piperazinediylbis(4,1-butanediyloxy)]bis-2(1H)-quinolinone
CAS:Controlled ProductFormula:C30H36N4O4Color and Shape:NeatMolecular weight:516.63rac Dropropizine
CAS:Controlled Product<p>Applications Dropropizine is a cough suppressant and central sedative therapeutic agent.<br>References Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000), Salunkhe, M., et al.: Enz. Microb. Technol., 28, 333 (2001), Atul, B., et al.: J. Pharm. Sci., 91, 2067 (2002),<br></p>Formula:C13H20N2O2Color and Shape:WhiteMolecular weight:236.31Atazanavir-d9
CAS:Controlled Product<p>Applications Atazanavir-d9 is the deuterated analog of Atazanavir (A790051), a azapeptide HIV protease inhibitor derivative. Atazanavir have been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>Formula:C382H15H37N6O7Color and Shape:NeatMolecular weight:719.95Valsartan Decarboxylic Acid
CAS:Controlled ProductFormula:C23H29N5OColor and Shape:NeatMolecular weight:391.5093Plerixafor Hydrochloride (1:8)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H54N8·8ClHColor and Shape:NeatMolecular weight:794.474’-Bromomethylbiphenyl-2-carboxylic Acid, Methyl Ester
CAS:Controlled ProductFormula:C15H13BrO2Color and Shape:NeatMolecular weight:305.17Indomethacin 1-Menthol ester
CAS:Controlled Product<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Formula:C29H34ClNO4Color and Shape:NeatMolecular weight:496.038N-Nitrosomorpholine-13C4
CAS:Controlled ProductFormula:C4H8N2O2Color and Shape:NeatMolecular weight:120.09Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Applications Protected Varenicline metabolite.<br></p>Formula:C15H12F3N3O2Color and Shape:NeatMolecular weight:323.27(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Formula:C14H22N2O2Color and Shape:ColourlessMolecular weight:250.34Pazufloxacin Mesylate
CAS:Controlled Product<p>Applications A fluorinated quinolone antibiotic. Antibacterial.<br>References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>Formula:C16H15FN2O4·CH4O3SColor and Shape:NeatMolecular weight:414.417,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone
CAS:<p>Applications 7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone is an impurity of Brexpiprazole (B677385), which is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Formula:C22H20N2O4Color and Shape:NeatMolecular weight:376.4053,4-Dihydro-1-phenylisoquinoline Hydrochloride
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications 3,4-Dihydro-1-phenylisoquinoline has been shown to have anesthetic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moore, M.B., et. al.: J. Am. Chem. Soc., 76, 3656 (1954)<br></p>Formula:C15H13N·ClHColor and Shape:NeatMolecular weight:243.734-O-Des(difluoromethyl) Roflumilast
CAS:Controlled ProductFormula:C16H14Cl2N2O3Color and Shape:NeatMolecular weight:353.205-Ethenyl-2-pyrrolidinone
CAS:Controlled Product<p>Impurity Vigabatrin USP Related Compound A<br>Applications Vigabatrin (V253000) impurity. Vigabatrin USP Related Compound A.<br>References Durham, S. et al.: Drug Metab. Dispos. 21, 480 (1993).<br></p>Formula:C6H9NOColor and Shape:Colourless To BrownMolecular weight:111.14O-Desbromo-pyrimidinyl Macitentan
CAS:Controlled ProductFormula:C15H19BrN4O4SColor and Shape:NeatMolecular weight:431.3(6R,12aS)-N-Desmethyl ent-Tadalafil
CAS:Controlled Product<p>Impurity Tadalafil EP Impurity A N-Desmethyl Impurity<br>Applications (6R,12aS)-N-Desmethyl Tadalafil (Tadalafil EP Impurity A N-Desmethyl Impurity) is an intermediate in the synthesis of novel potent arylated analogues of tadalafil (T004500).<br>References Beghyn, T., et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007);<br></p>Formula:C21H17N3O4Color and Shape:NeatMolecular weight:375.38Azilsartan Imidazole Carbonyl Dioxolene Ester
CAS:<p>Applications Azilsartan Imidazole Carbonyl Dioxolene Ester is an impurity of Azilsartan (A926900), an analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996), Plomgaard, P., et al.: Diabetes, 54, 2939 (2005), Fenton, C., et al.: Drugs, 2005, 65, 537,<br></p>Formula:C33H28N6O8Color and Shape:NeatMolecular weight:636.61N-Methyl-o-phenylenediamine, Dihydrochloride
CAS:Controlled ProductFormula:C7H10N2·2ClHColor and Shape:NeatMolecular weight:195.09Tadalafil-13C2,d3
CAS:Controlled Product<p>Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>Formula:C2013C2H16D3N3O4Color and Shape:White PowderMolecular weight:394.41Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Formula:C18H16ClFN4O2Color and Shape:NeatMolecular weight:374.8Iproniazid
CAS:Controlled Product<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>Formula:C9H13N3OColor and Shape:White SolidMolecular weight:179.22Ofloxacin N-Oxide Hydrochloride
CAS:Controlled ProductFormula:C18H20FN3O5·ClHColor and Shape:Off-WhiteMolecular weight:413.83N-Hydroxy Pomalidomide
CAS:<p>Applications N-Hydroxy Pomalidomide can be involved in pharmacological activity, biological study, and synthetic preparation and anti-tumor activity of nitrogen-substituted thalidomide analogs.<br>References Shah, J., et al.: PCT Int. Appl., WO 2003014315 A2 20030220 (2003)<br></p>Formula:C13H11N3O5Color and Shape:Light YellowMolecular weight:289.24Haloperidol Decanoate
CAS:Controlled Product<p>Applications Antidyskinetic; antipsychotic.<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formula:C31H41ClFNO3Color and Shape:NeatMolecular weight:530.11Lacidipine Monomethyl Ester
CAS:Controlled Product<p>Applications Lacidipine Monomethyl Ester is an impurity of Lacidipine (L098000); a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Mohan, Arivozhi., et al.: J. AOAC Int., 94(6), 1800-1806 (2011); Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989); Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002); McCormack, A.J., et al.: Drugs, 63, 2327 (2003)<br></p>Formula:C25H31NO6Color and Shape:NeatMolecular weight:441.52(S)-(-)-Felodipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Enantiomer S of Felodipine.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formula:C18H19Cl2NO4Color and Shape:White To Off-WhiteMolecular weight:384.25rac Cinacalcet-d3 Hydrochloride
CAS:Controlled Product<p>Applications Clinical trial in secondary hyperparathyroidism.<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Formula:C222H3H19F3N·ClHColor and Shape:NeatMolecular weight:396.89Thalidomide
CAS:Controlled Product<p>Applications Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Formula:C13H10N2O4Color and Shape:NeatMolecular weight:258.235-Ethoxy-2-pyrrolidone
CAS:Controlled Product<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Formula:C6H11NO2Purity:>90%Color and Shape:NeatMolecular weight:129.164-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one-d4
CAS:Controlled Product<p>Applications Isotope labelled Sitagliptin (S491000) intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H8D4F6N4O2Color and Shape:NeatMolecular weight:410.31S-(+)-Arundic Acid
CAS:Controlled Product<p>Applications The S-enantiomer of Arundic Acid. An astrocyte modulating agent, in acute ischemic stroke. A therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer's disease and Parkinson’s disease.<br>References Uchida, Y., et al.: Brain Res., 481, 190 (1989), Tokunaga, M., et al.: Science, 277, 936 (1997), Sorbera, L., et al.: Drugs Future, 29, 441 (2004),<br></p>Formula:C11H22O2Color and Shape:NeatMolecular weight:186.29N’-Benzylidene-2-ethoxybenzimidohydrazide Hydroiodide
Controlled ProductFormula:C16H17N3O·HIColor and Shape:Off-WhiteMolecular weight:395.2381-Ethyl-2-[(methylamino)methyl]pyrrolidine
CAS:<p>Applications 1-Ethyl-2-[(methylamino)methyl]pyrrolidine is an intermediate of the neuroleptic drug Amisulpride (A633250).<br>References Tahara, T., et al.: Chem. Pharmaceut. Bull., 38, 1609 (1990);<br></p>Formula:C8H18N2Color and Shape:Colourless OilyMolecular weight:142.242Olanzapine Lactam Impurity
CAS:<p>Impurity Olanzapine ketolactam impurity<br>Applications A degradation product of Olanzapine (LY170053) (O253750) in solid oral formulations.<br>References Chakrabarti, J., et al.: J.Med. Chem., 25, 1133 (1982), Chafetz, L., et al.: J. Pharm. Sci., 73, 1186 (1984), Hartauer, K., et al.: Pharm. Dev. Technol., 5, 303 (2000),<br></p>Formula:C17H20N4O2Color and Shape:NeatMolecular weight:312.37(R)-Ofloxacin-d3
CAS:Controlled Product<p>Applications A labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>Formula:C182H3H17FN3O4Color and Shape:NeatMolecular weight:364.39N-(4-Methoxybenzyl)-4-chloro-2-(trifluoroacetyl)aniline
CAS:Controlled ProductFormula:C16H13ClF3NO2Color and Shape:NeatMolecular weight:343.733-Chloro-N-(3-hydroxyphenyl)propanamide
CAS:Controlled Product<p>Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.<br></p>Formula:C9H10NO2ClColor and Shape:NeatMolecular weight:199.635-(2-Fluorophenyl)-5-oxovaleric Acid
CAS:Controlled Product<p>Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.<br>References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);<br></p>Formula:C11H11FO3Color and Shape:NeatMolecular weight:210.24-Desfluoro-3-Fluoro Bicalutamide
CAS:Controlled Product<p>Impurity Bicalutamide USP Related Compound B/ Bicalutamide EP Impurity B<br>Applications 3-Fluorophenyl Bicalutamide (Bicalutamide USP Related Compound B) is a steroisomer of Bicalutamide (B382000), non-steroidal peripherally active anti-androgen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O4SColor and Shape:NeatMolecular weight:430.374-Hydroxy Flecainide
CAS:Controlled Product<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>Formula:C17H20F6N2O4Color and Shape:NeatMolecular weight:430.34N1-Methyl-N2-2-pyridinylethanediamide
CAS:Controlled ProductFormula:C8H9N3O2Color and Shape:NeatMolecular weight:179.183-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:<p>Applications An intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, T., et al.: J. Med. Chem., 33, 527 (1990), Yapi, A., et al.: Chem. Pharm. Bull., 48, 1886 (2000), Yapi, A., et al.: Arch. Pharm., 339, 201 (2006); Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000);<br></p>Formula:C11H11ClN2OColor and Shape:NeatMolecular weight:222.672-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
CAS:Controlled Product<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>Formula:C12H15FN2O3Color and Shape:NeatMolecular weight:254.26Methylphenidate Carboxylic Acid Hydrochloride
CAS:Controlled Product<p>Applications O-Desmethyl Methylphenidate Carboxylic Acid is a derivative of Methylphenidate Hydrochloride (M325880), controlled substance (stimulant). CNS stimulant. Methylphenidate Carboxylic Acid Hydrochloride is a 4:1 Mixture of R533105 (DL-erythro Ritalinic Acid Hydrochloride) and R533110 (DL-threo-Ritalinic Acid Hydrochloride)<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Formula:C13H17NO2·HClColor and Shape:Off-WhiteMolecular weight:255.74Diphenhydramine-d6 N-Oxide
CAS:Controlled Product<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Formula:C17H15D6NO2Color and Shape:NeatMolecular weight:277.39Fenpropimorph
CAS:Controlled Product<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>Formula:C20H33NOColor and Shape:ColourlessMolecular weight:303.483-Ethyl Haloperidol
CAS:Controlled ProductFormula:C23H27ClFNO2Color and Shape:NeatMolecular weight:403.92N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide
CAS:Controlled Product<p>Applications N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide is derived from Diethyl 2-Acetamidomalonate (D443130), which is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors.<br>References Gunaherath, G. M., et al.: Bioorg. Med. Chem., 21, 5118 (2013);<br></p>Formula:C25H39NO5Color and Shape:NeatMolecular weight:433.58Iguratimod
CAS:Controlled Product<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>Formula:C17H14N2O6SColor and Shape:NeatMolecular weight:374.37Dehydroxydehydro Terfenadine
CAS:Controlled ProductFormula:C32H39NOColor and Shape:NeatMolecular weight:453.66Clonidine
CAS:Controlled Product<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Formula:C9H9Cl2N3Color and Shape:NeatMolecular weight:230.092-Amino-3-hydroxypyridine
CAS:Controlled Product<p>Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.<br></p>Formula:C5H6N2OColor and Shape:NeatMolecular weight:110.11Irbesartan N-β-D-Glucuronide
CAS:<p>Applications A metabolite of Irbesartan (M8).<br>References Cazaubon, C., et al.: J. Pharmacol. Exp. Ther., 265, 826 (1993), Eberhardt, R., et al.: J. Clin. Pharmacol., 33, 1023 (1993), Huskey, S., et al.: Drug Metab. Dispos., 21, 792 (1993), van Den Meiracker, A., et al.: Hypertension, 25, 22 (1995),<br></p>Formula:C31H36N6O7Color and Shape:NeatMolecular weight:604.65Hydroxymethyl Dasatinib
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H26ClN7O3SColor and Shape:NeatMolecular weight:504.00(S)-(-)-O-Desmethyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. [α]D= -18.7 (c= 0.1 methanol)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Formula:C23H24N2O4Color and Shape:NeatMolecular weight:392.453-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Controlled Product<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Formula:C15H18ClNO3Color and Shape:NeatMolecular weight:295.76L-Valinol
CAS:Controlled Product<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Formula:C5H13NOColor and Shape:WhiteMolecular weight:103.1633-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Controlled Product<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Formula:C27H24N6O9xNaPurity:>90%Color and Shape:NeatMolecular weight:576.51(free acid)10-Acetyloxy Oxcarbazepine
CAS:Controlled Product<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Formula:C17H14N2O4Color and Shape:NeatMolecular weight:310.30N-Nitroso-(1S,2R)-ephedrine
CAS:Controlled ProductFormula:C10H14N2O2Color and Shape:NeatMolecular weight:194.23N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C5H12N2OColor and Shape:ColourlessMolecular weight:116.1616CP-690550 N-Hydroxyl
CAS:Controlled Product<p>Impurity CP-690550 Impurity<br>Applications CP-690550 N-Hydroxyl is an impurity of CP-690550 (C781350), a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis.<br>References Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979); Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1993); Changelian, P., et al.: Science, 302, 875 (2003); Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (2003); Hutmacher, M., et al.: J. Clin. Pharmacol., 47, 238 (2007)<br></p>Formula:C16H20N6O2Color and Shape:NeatMolecular weight:328.3691-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%)
CAS:<p>Impurity Rabeprazole EP Impurity C<br>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%) (Rabeprazole EP Impurity C) is a Rabeprazole (R070500) impurity. A degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999), Carswel, C., et al.: Drugs, 61, 2327 (2001), Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008),<br></p>Formula:C14H11N3O3Purity:>75%Color and Shape:NeatMolecular weight:269.26Loratadine-d5
CAS:Controlled Product<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H18D5ClN2O2Color and Shape:NeatMolecular weight:387.91Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
CAS:Controlled Product<p>Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>Formula:C17H10OS2Color and Shape:NeatMolecular weight:294.393-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CAS:Controlled Product<p>Stability Air Sensitive<br>Applications 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine is used in the preparation of c-Src and Abl inhibitors based on the scaffold present in Imatinib (G407000), used in the treatment of myelogenic leukemia. It is a COVID19-related research product.<br>References Seeliger, M. et al.: Canc. Res., 69, 2384 (2009); Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formula:C11H10N3F3Color and Shape:NeatMolecular weight:241.21N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers)
CAS:Controlled Product<p>Applications N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers) is an impurity of lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor.<br>References Shinde, V., et. al.: J. Pharm. Biomed. Anal., 43, 381 (2007); Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)<br></p>Formula:C31H41N3O7Color and Shape:NeatMolecular weight:567.67Brivaracetam-d7 (Mixture of Diastereomers)
Controlled Product<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H13D7N2O2Color and Shape:NeatMolecular weight:219.33Ezetimibe Hydroxy β-D-Glucuronide
CAS:Controlled Product<p>Applications A metabolite of Ezetimibe. Antilipemic.<br>References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),<br></p>Formula:C30H29F2NO9Color and Shape:NeatMolecular weight:585.55Ibrutinib Dimer (~90%)
CAS:<p>Applications Ibrutinib Dimer is a dimer impurity of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Formula:C50H48N12O4Purity:~90%Color and Shape:NeatMolecular weight:880.992-Chloromethyl-4-methoxy-3-methylpyridine Hydrochloride
CAS:Controlled Product<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>Formula:C8H10ClNO·ClHColor and Shape:NeatMolecular weight:208.08N-Nitroso Amodiaquine
Controlled ProductFormula:C20H21ClN4O2Color and Shape:NeatMolecular weight:384.859Iso Fluconazole
CAS:Controlled Product<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>Formula:C13H12F2N6OColor and Shape:Off-WhiteMolecular weight:306.27N,N-Bis[2-(2-hydroxyethoxy)ethyl] Quetiapine Chloride
Controlled ProductFormula:C25H34ClN3O4SColor and Shape:NeatMolecular weight:508.07N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
CAS:Controlled Product<p>Applications N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>Formula:C10H18N4O2Color and Shape:White To Off-WhiteMolecular weight:226.285-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications 5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester is used in the synthetic preparation of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996);<br></p>Formula:C11H16N2O3Color and Shape:NeatMolecular weight:224.262-(2,4-Difluorophenyl)-1,2,3-propanetriol
CAS:<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>Formula:C9H10F2O3Color and Shape:NeatMolecular weight:204.17(E,Z)-Tamoxifen-d5 N-β-D-Glucuronide (~90%)
CAS:Controlled Product<p>Applications Α labelled metabolite of Tamoxifen (T006000).<br>References Sun, D., et al.: Breast Cancer Res., 8(4), (2006), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Formula:C32H33D5NO7Purity:~90%Color and Shape:NeatMolecular weight:553.682-(4-(Methylsulfonamido)phenyl)acetic Acid
CAS:Controlled Product<p>Applications 2-(4-(Methylsulfonamido)phenyl)acetic Acid acts as a reagent for resiniferatoxin analogs preparation as metabolically stable TRPV1 agonists and potential analgesics. Preparation and structure-activity relationships of 2,6-diaryl-4-(phenacylamino)pyrimidines as selective adenosine A2A antagonists.<br>References Choi, H., et al.: Bioorg. Med. Chem. , 17, 690 (2009); Moorjani, M., et al.: Bioorg. Med. Chem. Lett., 18, 1269 (2008)<br></p>Formula:C9H11NO4SColor and Shape:NeatMolecular weight:229.25Perphenazine-d8 Dihydrochloride Salt (1.0 mg/mL in Methanol)
CAS:Formula:C21H18D8ClN3OS·2HClColor and Shape:ColourlessMolecular weight:484.931,4,8,11-Tetraazacyclotetradecane
CAS:Controlled Product<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Formula:C10H24N4Color and Shape:NeatMolecular weight:200.325-Sulfosalicylic Acid Dihydrate
CAS:Controlled Product<p>Applications 5-Sulfosalicylic Acid Dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels.<br></p>Formula:C7H6O6S·2H2OColor and Shape:WhiteMolecular weight:254.21N-Nitro-1,2,3,4-tetradehydro Argatroban
CAS:Controlled Product<p>Applications N-Nitro-1,2,3,4-tetradehydro Argatroban is an intermediate in the preparation of Argatroban (A769000).<br></p>Formula:C23H31N7O7SColor and Shape:White To Off-WhiteMolecular weight:549.603-Methoxy Favipiravir
CAS:Controlled ProductFormula:C6H6FN3O2Color and Shape:NeatMolecular weight:171.133-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride
CAS:Controlled Product<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride is an impurity of Doxepin (D550000), which is used clinically to treat anxiety and depression and is classified as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985)<br></p>Formula:C19H23NO•(HCl)Color and Shape:NeatMolecular weight:281.393646N-Denitroso-N’-nitroso Lomustine-d4
CAS:Controlled ProductFormula:C9D4H12ClN3O2Color and Shape:NeatMolecular weight:237.722,5-Bis-(3,4-dihydroxyphenyl)piperazine Dihydrochloride
Controlled ProductFormula:C16H18N2O4•2(HCl)Color and Shape:BrownMolecular weight:302.3323646Deshydroxymethyl Losartan Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Applications Losartan Impurity C.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Formula:C21H21ClN6·C2HF3O2Color and Shape:White To Off-WhiteMolecular weight:506.914-Amino-2-fluoro-N-methylbenzamide
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Formula:C8H9FN2OColor and Shape:NeatMolecular weight:168.17Olanzapine Dimer Impurity
Controlled Product<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formula:C29H28N6S2Color and Shape:NeatMolecular weight:524.703Pimavanserin N-Oxide
CAS:Controlled Product<p>Applications Pimavanserin N-Oxide is an impurity of Pimavanserin (P441800), a drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010); Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010);<br></p>Formula:C25H34FN3O3Color and Shape:NeatMolecular weight:443.554-Hydroxy Propranolol β-D-Glucuronide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A metabolite of 4-Hydroxy propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Walle, T., et al.: Clin. Pharmacol. Ther., 46, 257 (1989), Christ, D.D., et al.: Drug Metab. Dispos., 18, 1 (1990),<br></p>Formula:C22H29NO9Color and Shape:NeatMolecular weight:451.47De(methypiperazinyl) Sildenafil Dimer Impurity
CAS:Controlled Product<p>Applications A related dimeric impurity of Sildenafil (S435000).<br></p>Formula:C34H38N8O6SColor and Shape:NeatMolecular weight:686.78α-Phenyl-2-pyridineacetamide
CAS:Controlled Product<p>Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.<br></p>Formula:C13H12N2OColor and Shape:NeatMolecular weight:212.254-(2-Pyridinyl)benzaldehyde
CAS:Controlled Product<p>Impurity Atazanavir Impurity (Pyridinyl Benzaldehyde)<br>Applications Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity<br>References F. Li et al., Drug Metabolism and Disposition 39, 294 (2011)<br></p>Formula:C12H9NOColor and Shape:NeatMolecular weight:183.21N-Desmethyl N-Nitroso Olopatadine-d3
Controlled ProductFormula:C20D3H17N2O4Color and Shape:NeatMolecular weight:355.402Levofloxacin Hydrochloride
CAS:Formula:C18H20FN3O4·(HCl)Color and Shape:White To Light BeigeMolecular weight:361.37 + (36.46)N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br>References Zimmermann., A., et al.: Bioorg. Med. Chem. Lett., 7, 187 (1997),<br></p>Formula:C16H13N5O2Color and Shape:LightMolecular weight:307.31N-(S)-Glycidylphthalimide
CAS:Controlled Product<p>Applications N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).<br>References Rajesh, T. et al.: Pharm. Chem., 3, 168 (2011);<br></p>Formula:C11H9NO3Color and Shape:WhiteMolecular weight:203.19Varenicline Carbamoyl β-D-Glucuronide
CAS:Controlled Product<p>Applications A metabolite of Varenicline.<br>References Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005), Obach, R., et al.: Drug Metab. Dispos., 33, 262 (2005),<br></p>Formula:C20H21N3O8Color and Shape:NeatMolecular weight:431.4Bicalutamide Sulfoxide
CAS:Controlled Product<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O3SColor and Shape:NeatMolecular weight:414.37Levomepromazine-D3 Sulfoxide
CAS:Controlled ProductFormula:C19D3H21N2O2SColor and Shape:NeatMolecular weight:347.49rac N-Nitroso-N-Desmethyl Dapoxetine-D3
Controlled ProductFormula:C20D3H17N2O2Color and Shape:NeatMolecular weight:323.404N-Nitrososotalol-d6
CAS:Controlled ProductFormula:C12D6H13N3O4SColor and Shape:Off-WhiteMolecular weight:307.399(S)-Carisbamate
CAS:<p>Applications Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.<br>References Novak GP, et al. 2007. Neurotherapeutics. Jan;4(1):106-9Nau C, 2004. J Membr Biol. Sep 1;201(1):1-8Codd EE, 2008. Pain. Feb;134(3):254-62. Epub 2007 May 25<br></p>Formula:C9H10ClNO3Color and Shape:NeatMolecular weight:215.63(7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one)
CAS:Controlled Product<p>Impurity Aripiprazole USP Related Compound H<br>Applications (7-(4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole USP Related Compound H.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Formula:C27H35Cl2N3O3Color and Shape:WhiteMolecular weight:520.49Desalkyl Ebastine-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Ebastine.<br>References Wiseman, L., et al.: Drugs, 51, 260 (1996), Takanori, H., et al.: Drug Metab. Dispos., 26, 566 (1998), Moss, A., et al.: Clin. Exp. Allergy 1999, 29, 200 (1999), Simons, F., et al.: Clin. Pharmacokinet., 36, 329 (1999), Hashizume, T., et al.: J. Pharmacol. Exp. Theor., 300, 298 (2002),<br></p>Formula:C18H16D5NOColor and Shape:NeatMolecular weight:272.4Nintedanib Acetyl Impurity
CAS:Controlled Product<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>Formula:C26H23N3O4Color and Shape:NeatMolecular weight:441.49Ambroxol Cycloimine Impurity
CAS:Controlled Product<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C14H16Br2N2OColor and Shape:NeatMolecular weight:388.0976Oprozomib
CAS:Controlled Product<p>Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.<br>References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);<br></p>Formula:C25H32N4O7SColor and Shape:NeatMolecular weight:532.615-(Chloromethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile
CAS:Controlled ProductFormula:C15H17ClN2Color and Shape:NeatMolecular weight:260.76(R)-9-Hydroxy Risperidone
CAS:Controlled Product<p>Applications The R-enantiomer metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Formula:C23H27FN4O3Color and Shape:NeatMolecular weight:426.48S-(s)-Verapamil-D6
CAS:Controlled Product<p>Applications Labelled S-Verapamil (V124991). Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.<br>References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988), Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990),<br></p>Formula:C27H33D6ClN2O4Color and Shape:NeatMolecular weight:497.15-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Controlled Product<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Formula:C10H10N2O2Color and Shape:NeatMolecular weight:190.202-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Controlled ProductFormula:C9H8BrNO4Color and Shape:Light YellowMolecular weight:274.07Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Controlled ProductFormula:C13H17N5O4Color and Shape:NeatMolecular weight:307.305Nitrofurantoin Monohydrate
CAS:Controlled Product<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Formula:C8H8N4O6Color and Shape:YellowMolecular weight:256.18N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod
CAS:Controlled Product<p>Applications N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod, is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C37H59NO4Color and Shape:NeatMolecular weight:581.871-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS:Controlled ProductFormula:C22H35NO3Color and Shape:NeatMolecular weight:361.523-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Controlled Product<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Formula:C26H23F9N6O2Color and Shape:NeatMolecular weight:622.48542-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications 2-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester (cas# 98475-07-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C9H8BrNO4Color and Shape:Off-White To Light YellowMolecular weight:274.07Eltrombopag Methyl Ester
CAS:<p>Applications Eltrombopag Methyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C26H24N4O4Color and Shape:NeatMolecular weight:456.49N-Sulfamoylethyl Naratriptan Pyridinium Chloride
CAS:Controlled Product<p>Impurity Naratriptan Impurity F<br>Stability Hygroscopic<br>Applications 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride is an impurity of Naratriptan (N378730).<br></p>Formula:C20H27ClN4O4S2Color and Shape:NeatMolecular weight:487.04N-Nitroso-desethyl-Hydroxychloroquine
Controlled ProductFormula:C16H21ClN4O3Color and Shape:NeatMolecular weight:336.817
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