Pharmaceutical and Veterinary Compounds and Metabolites

<p>Neogen, also known as Jadinol PU, is a drug potentially for the restoration of the immune system and hemopoiesis after cytostatics treatment.</p>

<p>Ledelabricin alfa, an isoform A variant of human proteoglycan 4 (PRG4), functions as a lubricant for joints and boundaries.</p>

<p>Glucose 1-dehydrogenase, an enzyme, transforms glucose and NAD(P) into NAD(P)H and gluconic acid.</p>

<p>Estriol 3-β-D-glucuronide is a metabolite of estriol .</p>

<p>Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.</p>

<p>CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite.</p>

<p>Burnettramic acid A aglycone, from A. burnettii, has anticancer properties; cytotoxic to NS-1 cells (IC50 = 8.4 μg/ml), not to fibroblasts (&gt;100 μg/ml).</p>

<p>Ethylenediaminediacetic acid is derived from two molecules of glycine linked by amines.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>Alterporriol B is a biochemical.</p>

<p>Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction.</p>

<p>ATP dipotassium is key for energy storage, metabolism, cellular processes, and as a signaling molecule for immunity and inflammation.</p>

<p>7-Hydroxydichloromethotrexate is a methotrexate metabolite.</p>

<p>Roridin L2 is a natural product for research related to life sciences. The catalog number is T41264 and the CAS number is 85124-22-7.</p>

<p>Neohydroxyaspergillic acid, a fungal product from A. sclerotiorum, combats various bacteria and fungi with MICs ranging from 125-700 μg/ml.</p>

<p>EGCase II is an enzyme breaking down the glycan-ceramide bond in glycosphingolipids.</p>

<p>Lumisterol, a steroid, is anti-UVB and inhibits cell growth; it's a (9β,10α)-stereoisomer of Ergosterol.</p>

<p>N-Acetylgalactosaminyltransferase 4 (GALNT4) is a glycosyltransferase capable of inhibiting the activation of ASK1. It functions by directly binding to ASK1, preventing N-terminal dimerization and subsequent phosphorylation. This interaction leads to significant inactivation of downstream JNK/p38 and NF-κB signaling, thereby improving the prognosis of liver surgery.</p>

<p>Angiotensin pentapeptide is a peptide.</p>

<p>FAHFAs, fats linked with insulin sensitivity, are altered by diet and fasting. Most common in AG4OX mice, 9-PAHSA is key, reduced in insulin-resistant humans.</p>

<p>Endogenous vasoactive compound, found in platelets and brain cells, part of diadenosine polyphosphates (ApnA, n=2–7).</p>

<p>(R)-Citronellol is in herbs, spices, bilberry, black cumin seeds, and Rutaceae plant oils.</p>

<p>Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α.</p>

<p>Ascorbate oxidase, a REDOX enzyme, catalyzes ascorbic acid and oxygen to dehydroascorbic acid, regulating the extracellular matrix.</p>

<p>Decanoyl coenzyme A (Decanoyl CoA) serves as a primer for the fatty acid elongation system in Mycobacterium smegmatis [1].</p>

<p>Avellanin B is a fungal metabolite.</p>

<p>Equilenin (E 400) is a natural estrogen that is an endocrine disruptor and has been used in breast cancer research.</p>

<p>Penicitide A: marine metabolite, moderately cytotoxic to A. brassicae, HepG2 cells.</p>

<p>Angiotensinogen (1-14), human,Liver-synthesized globulin. Precursor to angiotensin I.</p>

<p>Sapropterin aids in amino acid breakdown and neurotransmitter synthesis, including dopamine and serotonin, and supports nitric oxide production.</p>

<p>Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.</p>

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.

<p>Acetoacetyl-CoA sodium is a key metabolite, with a Km of 1.10 mM at pH 7.5, used in PTB and PHB synthesis.</p>

<p>Malonyl CoA: needed for fat creation, stops fat breakdown, reversibly inhibits CPT1 in mitochondria.</p>

<p>Methyl ester of 11(Z),14(Z)-eicosadienoic acid is a ω-6 PUFA, inhibits LTB4 binding and IMP dehydrogenase, and might affect sleep.</p>

<p>L-Mevalonic acid, a cholesterol precursor, is studied in autoimmune, atherosclerosis, and Alzheimer's research.</p>

<p>Hydroxypyruvic acid: a metabolic intermediate for glycine, serine, threonine; used by serine-pyruvate aminotransferase, glyoxylate reductase.</p>

<p>Setosusin, a meroterpenoid from C. setosus, reduces Aβ-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM).</p>

<p>1'-Hydroxy bufuralol is a metabolite of bufuralol, an orally active β-adrenoceptor blocker used in the study of hypertension and cardiac arrhythmias.</p>

<p>Lithium sn-glycerol 3-phosphate made by converting dihydroxyacetone phosphate via NADH from glycolysis.</p>

<p>D-Ribofuranose 1-phosphate is used to synthesize 5-fluorouracil via uridine phosphorylase.</p>

<p>(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile), an enantiomer of (+)-JA-L-Ile [1], is an inactive endogenous hormone.</p>

<p>Fungal metabolite 19,20-Epoxycytochalasin D from Nemania sp. kills P. falciparum; non-toxic to Vero, toxic to BT-549, LLC-PK11, P388 cells.</p>

<p>11-trans LTC4 is a C-11 isomer of LTC4, forms slowly on storage, is less common but similarly potent in contractions, pKis: 6.42 (LTC4), 6.58 (11-trans).</p>

<p>(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.</p>

<p>SPP-037 is an orally active selective inhibitor of ST6GAL1, with an IC50 of 3.59 μM. It exhibits anti-migration activity against MDA-MB-231 cells by inhibiting integrin α2,6-sialylation and the integrin-FAK-paxillin pathway. In MDA-MB-231 xenograft mouse models, SPP-037 demonstrates antitumor properties. This compound is applicable in breast cancer research.</p>

<p>4-Phytase is a phosphohydrolase of inositol hexaphosphate [1] .</p>

<p>Coproporphyrin I, an endogenous metabolite found in urine and blood, is utilized in researching liver disease and porphyria [1] [2] [3] [4].</p>

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Zymosterol—a cholesterol precursor, vital for biosynthesis, mainly in cell membranes.</p>

<p>H-Ser-His-OH, an endogenous metabolite, is a short peptide with hydrolysis cleavage activity.</p>

<p>17α-Hydroxyprogesterone-d8 is a deuterated compound of 17α-Hydroxyprogesterone.</p>

<p>Strombine is an endogenous anaerobic metabolite and dehydrogenase product of imidazole, exhibiting cryoprotective effects.</p>

<p>Myristoyl Ethanolamide is an endogenous cannabinoid analog belonging to the fatty acyl ethanolamine famil，has physiological activity in the nervous system.</p>

<p>L-Valyl-L-phenylalanine has been reported as biocompatible polymer.</p>

<p>β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation</p>

<p>Substance P TFA is a CNS neuropeptide, serving as a neurotransmitter and modulator, targeting NK1R.</p>

<p>DL-Glutamic acid, conjugate acid of Glutamic acid, is a key metabolite with improved stability over L-Glutamic acid's polymorphs.</p>

<p>4-Methyl-1-phenyl-2-pentanone (Benzyl isobutyl ketone) is a volatile flavor that is used as a food additive.</p>

<p>Creatinase breaks down creatine into sarcosine and urea, crucial for measuring creatinine levels.</p>

<p>N6-(m-Methoxybenzyl)adenosine is an adenine nucleoside analog and a cytokinin derivative.</p>

<p>2-Hydroxypalmitic acid is a useful organic compound for research related to life sciences. The catalog number is T124257 and the CAS number is 764-67-0.</p>

<p>SAO catalyzes sarcosine into glycine, H2O2, 5,10-CH2-tetrahydrofolate for biochemical reactions.</p>

<p>1-Palmitoyl-2-oleoyl-sn-glycerol, an endogenous metabolite, serves as a predominant diacylglycerol in the hormogonium-inducing factor (HIF)-1 [1].</p>

<p>L-Thyroxine sodium xhydrate is a synthetic thyroid hormone used in the treatment of hypothyroidism.</p>

<p>2-Furoylglycine is a natural product for research related to life sciences. The catalog number is T38061 and the CAS number is 5657-19-2.</p>

<p>UDP-xylose, natural from Cryptococcus laurentii, aids in synthesizing glycoproteins and polysaccharides.</p>

<p>Neuraminidase, an exosialidase, breaks α-ketosidic bonds in sialic acid, aiding mucosal pathogen virulence in infections.</p>

<p>[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM</p>

<p>Glycerophosphoric acid is one of the main components of teichoic acid in bacterial cell walls and is a common emulsifier.</p>

<p>ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

<p>Phenylpropiolic acid is an endogenous metabolite.</p>

<p>(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission,</p>

<p>L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.</p>

<p>Hemicellulase is a glycoside hydrolase enzyme key in degrading plant fibers and carbon cycling.</p>

<p>3-Oxopentanedioic acid, a simple carboxylic acid, is useful in organic synthesis and a microbial metabolite.</p>

<p>Metronidazole acetic acid, a mutagenic metabolite of an antibiotic, targets protozoa and anaerobic bacteria.</p>

<p>5'-Guanylic acid, involved in AICA-ribosiduria, ADA deficiency, aprt, and 2-hydroxyglutric aciduria pathways.</p>

<p>17β-Estradiol-2,4-d2 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.</p>

<p>VX-548 is a potassium salt of L-aspartic acid that boosts nitrogen oxides, enhances phagocytosis, aids fish survival, and may stimulate antibiotics.</p>

<p>Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.</p>

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>Nucleoside Derivatives –3’-Modified nucleoside</p>

<p>LNnT is a metabolite that reduces IL-8, has anti-inflammatory effects, and aids in wound healing.</p>

<p>21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.</p>

<p>11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of being found in Saccharomyces cerevisiae (KD115).</p>

<p>Sodium 3-methyl-2-oxobutanoate is the precursor of pantothenic acid in Escherichia coli.</p>

<p>(R)-Leucic acid is an metabolite of amino acid.</p>

<p>Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol. ChOx competitively inhibits TLR2 enhance ROS production by macrophages.</p>

<p>N,N'-Dimethylarginine-d6 (SDMA-d6) is the deuterated form of N,N'-Dimethylarginine.</p>

<p>Dehydroaripiprazole (DM-14857), aripiprazole's active metabolite, is formed by CYP3A4 and CYP2D6, with similar antipsychotic effects.</p>

<p>(R)-(-)-1,2-Propanediol, (R)-enantiomer from glucose via E. coli NADH-linked glycerol dehydrogenase.</p>

<p>Crocin IV (Dicrocin), a crocetin glycoside belonging to the carotenoid pigments, exhibits significant antioxidant activity [1].</p>

<p>Taurocholic Acid-d4 Sodium is a deuterium-labelled, which can be used for isotopic tracing.Taurocholic Acid is an immunomodulatory bile acid.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.

<p>p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.</p>

<p>DL-α-tocopherol acetate (Vitamin E acetate) is a vitamin E derivative used as a vitamin E supplement in poultry feed.</p>

<p>3-Phenoxybenzoic acid is a natural product for research related to life sciences. The catalog number is T35359 and the CAS number is 3739-38-6.</p>