Apoptosis

Calycosin modulates estrogen receptors, induces apoptosis in cancers, and shows skin-lightening by inhibiting tyrosinase (IC50: 38.4µM).

PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

UTL-5g is a chemoprotective TNF-α inhibitor reducing cisplatin side effects and toxicity in liver, kidneys, and blood.

Applications 25R-3α,7α,12α-Trihydroxy-5β-cholestanoic acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.
References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)

Applications An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.

Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.
References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)

Applications Santamarine is a sesquiterpene lactone shows anticancer properties by inhibiting proliferation and inducing apoptosis.
References Mehmood, T., et al.: J. Cancer, 8, 1-11 (2017)

Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),

Applications Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embelin also displays contraceptive and pro-apoptotic properties.
References Stasiuk, M. et al.: Glob. J. Biochem., 2, 262 (2011); Brahmeshwari, G. et al.: Adv. Plant Sci., 24, 467 (2011); Hu, R. et al.: Med. Oncol., 28, 1598 (2011);

Applications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.
References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)

Applications β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.
References Renslo, A., et al.: Nat. Chem. Biol., 2, 701 (2006), Hopkins, A., et al.: Nat. Chem. Biol., 4, 682 (2008), Stuart, K., et al.: J. Clin. Invest., 118, 1301 (2008), Martin, R., et al.: Science, 25, 1680 (2009),

Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.
References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)

Applications 8,9-di-O-Methyl-urolithin C is a derivative of Urolithin C and is an intestinal microbial metabolite of ellagitannins. It has shown to have inhibitory effects on cell proliferation and apoptosis effects suggesting the potential for reduced risk of colon cancer development when it is found in considerable amounts via consumption of pomegranate juice.
References Kasimsetty, S., et al.: J. Agr. Food Chem., 58, 2180 (2010);

Applications 4-Benzyloxy-3-methoxybenzoic Acid is used in the synthesis of Hsp90 inhibitors as EGCG analogues. Also used in the preparation of vanillates exhibiting cytostatic properties towards cancel cells resistant to pro-apoptotic stimuli.
References Khandelwal, A. et al.: J. Org. Chem., 78, 7859 (2013); Lamoral-Theys, D. et al.: Bioorg. Med. Chem., 18, 3823 (2010);

Applications trans-1-Cinnamylpiperazine is used in the synthesis of bile acid piperazinyl derivatives which display pro-apoptotic properties on carcinoma human cell lines.
References Brossard, D. et al.: Eur. J. Med. Chem., 45, 2912 (2010);

Applications (R)-Muscone is a chemical compound that protects PC12 cells against glutamate-induced apoptosis. In addition, its a primary contributor to the odour of musk.
References Yu, L., et. al.: Neurochem. Int., 70, 10 (2014)