Apoptosis

Carbaryl is a carbamate insecticide/parasiticide with low dermal toxicity used against head lice.

Dantrolene sodium treats spasticity by disrupting muscle contraction; not central in action, grouped with central relaxants.

Cyclamic acid, a synthetic sweetener (NSC-220327), often used as Na/Ca cyclamate. Banned in USA over disputed cancer risk.

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.

Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.

Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.

GSK2795039 reduces ROS, NADPH use, apoptosis, and inhibits NOX2 (pIC50: 6).

Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.

Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).

IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.

Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.

Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.

AZD4320 inhibits BCL2/BCLxL; IC50: KPUM-MS3=26nM, KPUM-UH1=17nM, STR-428=170nM.

Roxithromycin (RU-28965) is a semi-synthetic derivative of the macrolide antibiotic erythromycin with antibacterial and anti-malarial activities.

Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.

Octocrylene, found in sunscreens and cosmetics, penetrates skin, acting as a photosensitizer to increase free radicals when exposed to light.

BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect

Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes. High-Quality, Low-Cost!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian FASL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian FASL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian FASL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian FASL in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian TNFRSF1B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian TNFRSF1B. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian TNFRSF1B, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian TNFRSF1B in the samples is then determined by comparing the OD of the samples to the standard curve.

AP20187: Cell-permeable ligand dimerizing FKBP fusion proteins for signaling and gene expression control.

Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

TYA-018 is an HDAC6 inhibitor with cardioprotective effects and is used in the study of dilated heart disease and heart failure.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian VEGFA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian VEGFA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian VEGFA, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian VEGFA in the samples is then determined by comparing the OD of the samples to the standard curve.

Durvalumab is a humanized antibody for cancer, inhibiting PD-L1/PD-1 and CD80 interactions at very low concentrations.

Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation

Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.

Penpulimab is a monoclonal antibody targeting PD-1 with antitumor activity, used in studies of pancreatic cancer.

Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to

Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.

STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.

Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50

CITCO, an imidazothiazole, selectively inhibits BTSCs growth with 49 nM EC50 on PXR and is a CAR agonist.

Cl-amidine hydrochloride is an orally available PAD inhibitor that blocks histone 3 deimination.Cost-effective and quality-assured.

Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.

AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition

Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TNFRSF10A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TNFRSF10A. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TNFRSF10A, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TNFRSF10A in the samples is then determined by comparing the OD of the samples to the standard curve.

(E)-Methyl 4-coumarate (OMpCA) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of methyl 3-phenylprop-2-enoate.

Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig sC5b-9. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig sC5b-9. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig sC5b-9, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig sC5b-9 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PYCARD. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PYCARD. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PYCARD, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PYCARD in the samples is then determined by comparing the OD of the samples to the standard curve.