Cell Cycle/Checkpoint

<p>Arabinosylhypoxanthine inhibits Ns5b polymerase in hepatitis C virus and can be used in biochemical experiments and organic synthesis.</p>

<p>Nucleoside Derivatives - Fluoro-modified nucleosides, Arabino-nucleosides, Pyridine nucleosides, 3-Deazauridines, 2’-Modified nucleosides</p>

<p>2'-O-MOE-5MeU-3'-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(pyridine-4-yl)purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, 3'-</p>

<p>Nucleoside Derivatives - Fluoro-modified nucleosides; 2’-Modified nucleosides; Nucleoside Phosphoramidites</p>

<p>5-(1-Hydroxy)(methoxycarbonyl)methyl uridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Naturally modified ribo-nucleoside.</p>

<p>1-O-Acetyl-2-O-benzoyl-3-O-tert-butyldiphenylsilyl-L-threofuranose is a Carbohydrate Derivative.</p>

<p>N1,N3-Bis(cyanomethyl)pseudouridine is a Nucleoside Derivative - C-nucleoside;N-Alkylated nucleoside.</p>

<p>4',5'-Didehydro-5'-deoxy-5-methyluridine is a Nucleoside Derivative - 5'-Modified nucleoside, Didehydro-nucleoside.</p>

<p>3'-beta-C-Methyl-5-trifluoromethyluridine is a Nucleoside Derivative - 3'-Modified nucleoside, 5-Modified pyrimidine nucleoside, Fluoro-modified nucleoside.</p>

<p>N6-(2-Propynyl)adenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>

<p>Nucleoside Derivatives - 2’-Modified nucleosides; Scaffolds and Templates;Bi-Tricyclic nucleosides</p>

<p>Alpha-5-Methyluridine is a useful organic compound for research related to life sciences. The catalog number is TNU1643 and the CAS number is 3258-09-1.</p>

<p>Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside is a useful organic compound for research related to life sciences.</p>

<p>5'-O-TBDMS-dG, a modified nucleoside, is utilized in the synthesis of deoxyribonucleic acid or nucleic acid.</p>

<p>Nucleoside Derivatives - C-nucleosides; Thio-nucleosides</p>

<p>5'-homocytidine is a useful organic compound for research related to life sciences. The catalog number is TNU1672 and the CAS number is 55085-34-2.</p>

<p>2'-O-Methyl-5-methylcytidine is a 2'-O-Methyl nucleoside.</p>

<p>5-Ethyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.</p>

<p>Nucleoside Phosphoramidites; Ready for phosphorylation</p>

<p>2'-Chloro-N6-(4-methoxy)benzyl adenosine is a Nucleoside Derivative - Halo-nucleoside;2-Modified purine nucleoside; 6-Modified purine nucleoside;.</p>

<p>6-Chloropurine -9-beta-D-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro)arabinoriboside is a Fluoro-modified nucleoside; Halo-nucleoside; Arabino-nucleoside.</p>

<p>Nucleoside Derivatives - 7-Deaza-purine nucleosides; Drugs and Inhibitors; Antiviral agent, anti-HCV</p>

<p>2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.</p>

<p>5-(3-Azidopropyl)cytidine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Azido nucleoside.</p>

<p>9-(2,3-Di-O-acetyl-6-O-benzoyl-5-deoxy-D-ribo-exofuranoyl)-6-chloropurine is a useful organic compound for research related to life sciences and the catalog</p>

<p>1-(b-D-Xylofuranosyl)-6-azauracil is a Nucleoside Derivative - Xylo-nucleoside; 6-Aza-uridine.</p>

<p>Nucleoside Derivatives –3’-Deoxy nucleosides；Nucleoside Phosphoramidites</p>

<p>Adenosine-2-carboxamide is a Nucleoside Derivative - 2-Modified purine nucleoside.</p>

<p>5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluoro-uridine is a Nucleoside Derivative - Didehydro-nucleoside; Fluoro-modified nucleoside.</p>

<p>Nucleoside Derivatives - Amino-nucleosides, 2’-Modified nucleosides, 5-Modified pyrimidine nucleosides</p>

<p>Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Amino nucleosides; Naturally modified ribo-nucleosides</p>

<p>5-Amino-2'-deoxyuridine hydrochloride is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Amino nucleoside.</p>

<p>5-Methoxycarbonylmethyl-2-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside;Naturally modified ribo-nucleoside.</p>

<p>5'-O-TBDPS-5-methyl-2,2'-anhydrouridine is a Nucleoside Derivative - Protected nucleoside with NH2/OH open.</p>

<p>1-(b-D-Xylofuranosyl)uracil is a Nucleoside Derivative - Xylo-nucleoside.</p>

<p>2'-Deoxy-isoguanosine is a Nucleoside Derivative - Iso-guanosine Derivative.</p>

<p>Nucleoside Derivatives - Fluoro-modified nucleosides; Azido-nucleosides; 4’-Modified nucleosides</p>

<p>3-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)- α-D-glycero-pent-3-enofuranose is a useful organic compound for research related to life sciences.</p>

<p>Nucleoside Phosphoramidites; Nucleoside Derivatives - 2-Deoxy uridines</p>

<p>Nucleoside Derivatives - 7-Deaza-purine nucleosides; Scaffolds and Templates</p>

<p>Nucleoside Derivatives - Xylo-nucleosides; 4-Deoxy pyrimidine nucleosides</p>

<p>Nucleoside Derivatives –Fluoro-modified nucleosides；</p>

<p>4-Chloro-5-iodo-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - Halo-nucleoside, 7-Deaza-purine nucleoside.</p>

<p>N4-Desmethyl-N5-Methyl wyosine is a Nucleoside Derivative - Bi-/Tri-cyclic nucleoside; naturally modified ribo-nucleoside.</p>

<p>Nucleoside Derivatives - Phosphorus-containing nucleosides; 2’-Modified nucleosides; 5’-Modified nucleosides</p>

<p>1,2'-O-Dimethyl guanosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside.</p>

<p>Nucleosides - isocytidine derivative</p>

<p>2',3',5'-Tri-O-benzoyl-5-methoxyuridine is a 5-Modified Pyrimidine Nucleoside.</p>

<p>Nucleoside Derivatives - 6-De-aminopurine nucleosides, 2-Modified purine nucleosides</p>

<p>Nucleoside Derivatives - 2’-Modified nucleosides, Fluoro-modified nucleosides, N-Methylated /alkylated nucleosides</p>

<p>2'-Chloro-2'-deoxyuridine is a Halo-nucleoside.</p>

<p>2'-Deoxy-N6,N6-dimethyladenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>

<p>Nucleoside Derivatives –5-Modified pyrimidine nucleosides；Xylo-nucleosides</p>

<p>3'-O-Methyl-5-methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.</p>

<p>Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides</p>

<p>6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine is a 2'-C-Methyl nucleoside; Halo-nucleoside.</p>

<p>1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a Nucleoside Derivative - Xylo-nucleoside, Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside.</p>

<p>Nucleoside Derivatives - 2’-Modified purine nucleosides</p>

<p>5-Iodoarabinouridine is a Halo-nucleoside; Arabino-nucleoside.</p>

<p>N1-Ethylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Methylated nucleoside.</p>

<p>2'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>

<p>KS15 is a cryptochrome (CRY) inhibitor that promotes G1 cell cycle arrest, enhances drug sensitivity in MCF-7 cells, antitumour against human breast cancer.</p>

<p>3'-O-DMTr-thymidine 5'-CE phosphoramidite (2'-OMe-U Phosphoramidite) is a purine nucleoside analog and phosphoramidite derivative .</p>

<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>

<p>GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.</p>

<p>Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG). It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.</p>

<p>Napropamide is an acetamide herbicide that inhibits root growth to control annual grasses and broadleaf weeds.</p>

<p>N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.</p>

<p>2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.</p>

<p>(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.</p>

<p>5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.</p>

<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>

<p>2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.</p>

<p>A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and &gt;30-fold selective for Akt1 over PKC.</p>

<p>GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.</p>

<p>Maleic hydrazide is a plant germination inhibitor that participates in nucleic acid metabolism pathways ,inhibiting cell division in the apical meristem.</p>

<p>N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity.</p>

<p>2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.</p>

<p>2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic</p>

<p>NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.</p>

<p>LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.</p>

<p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>

<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>

<p>Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.</p>

<p>Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.</p>

<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>

<p>Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.</p>

<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>

<p>Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).</p>

<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>

<p>Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.</p>

<p>N,N-Dimethyl-2'-O-methylcytidine (N4, N4, 2'-O-Trimethylcytidine) is a purine nucleoside analogue with anti-cancer activity.</p>

<p>8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.</p>

<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>

<p>5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.</p>

<p>8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.</p>

<p>NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.</p>

<p>N2-Isobutyryl-2-deoxyguanosine（iBu-dG） is a nucleoside analog that can be used to synthesize oligonucleotides.</p>

<p>APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cells</p>