Immunology and Inflammation

Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.

Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.

IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).

Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.

Theralizumab (TGN1412) is a monoclonal antibody for treating leukemia and arthritis by stimulating T cells.

Talacotuzumab, an IgG1 monoclonal antibody, blocks IL-3/CD123 and boosts ADCC, targeting AML with high CD123 affinity.

Tildrakizumab (SCH 900222) is a humanized antibody against IL-23, with a 136 pM Kd, used for psoriasis research.

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .

Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.

Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.

Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.

Evatanepag (CP-533536) is a selective EP2 agonist for bone formation with 0.3 nM EC50, promoting fracture healing in rats.

IMD-0560 is a novel inhibitor of IκB kinase β.

GNF351: Full AHR antagonist, inhibits DRE-dependent/independent activity, low toxicity, binds AHR (IC50: 62 nM).

CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).

Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.

4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Spesolimab (BI 655130) is an antibody targeting IL-36 receptor, key in immunity, for systemic pustular psoriasis and dermatitis studies.

Tremelimumab, a CTLA-4 blocker, is used with Durvalumab to treat solid tumors like liver and lung cancer.

Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells.

Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone

Dexamethasone acetate (NSC 39471) is a potent anti-inflammatory steroid, blocks NF-kB, and lacks salt-retention.

Ordesekimab (AMG 714) is a human anti-IL-15 IgG1 κ monoclonal antibody for studying NRCD.

Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation

Antipyrine, an analgesic/antipyretic, used orally or as ear drops, tests liver enzyme response to diseases/drugs.

Amfenac Sodium Hydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.

Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.

Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung

AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.

Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.

Amatuximab is a chimeric humanized IgG1/k antibody targeting MSLN with antitumor effects for solid tumors.

AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes