PDGFR

<p>N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.</p>

<p>Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM).</p>

<p>Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.</p>

<p>Axitinib (AG-013736) is a multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1/2/3 and PDGFRβ. Axitinib has antitumor activity. Cost-effective and quality-assured.</p>

<p>Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.</p>

<p>Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,</p>

<p>Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.</p>

<p>Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be</p>

<p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>

<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>

<p>AG 1295 is a selective PDGFR tyrosine-kinase inhibitor; it blocks PDGFR autophosphorylation without affecting EGF receptor.</p>

<p>JNJ-10198409: selective ATP competitive PDGF-RTK inhibitor; IC50: PDGFR-β 4.2 nM, PDGFR-α 45 nM; antiangiogenic &amp; antiproliferative.</p>

<p>CT52923: selective oral PDGFR blocker, ATP-inhibitor, used in research for various diseases including cancer.</p>

<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>

<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>

<p>IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b.</p>

<p>KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.</p>

<p>Rinucumab (REGN 2176) is an anti-PDGF IgG4-like monoclonal antibody that can be used to study age-related macular degeneration.</p>

<p>KIT/PDGFRA-IN-1 (compound 19) is an inhibitor targeting the stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA). Its IC50 values are 2.3 µM for KIT-wt, 12 µM for KIT-D816H, 492 µM for KIT-T670I, 0.8 µM for PDGFRA-wt, 99.9 µM for PDGFRA-D842V, 42.3 µM for PDGFRA-T674I, and 4.3 µM for PDGFRA-G680R. The GR50 values for GIST-T1, T1-a-D842V, and GIST-48B cell lines (gastrointestinal stromal tumor cell lines with PDGFR and KIT mutations) are 12 nM, 8900 nM, and ≥10,000 nM, respectively.</p>

<p>Anti-PDGFRB Antibody (4H405) is a Mouse antibody targeting PDGFRB. Anti-PDGFRB Antibody (4H405) can be used in ELISA(Det).</p>

<p>Anti-PDGFRB Antibody-PE (1A610) is a PE-conjugated Mouse antibody targeting PDGFRB. Anti-PDGFRB Antibody-PE (1A610) can be used in FCM.</p>

<p>Anti-PDGFRB Antibody (8J167) is an antibody targeting PDGFRB. Anti-PDGFRB Antibody (8J167) can be used in ELISA, IHC.</p>

<p>Anti-PDGFRB Antibody-APC (7C914) is a APC-conjugated Rabbit antibody targeting PDGFRB. Anti-PDGFRB Antibody-APC (7C914) can be used in FCM.</p>

<p>Anti-PDGFRB Antibody (1A610) is a Mouse antibody targeting PDGFRB. Anti-PDGFRB Antibody (1A610) can be used in ELISA,FCM.</p>

<p>Anti-PDGFRB Antibody-FITC (7C914) is a FITC-conjugated Rabbit antibody targeting PDGFRB. Anti-PDGFRB Antibody-FITC (7C914) can be used in FCM.</p>

<p>Anti-PDGFRB Antibody (7W816) is a Mouse antibody targeting PDGFRB. Anti-PDGFRB Antibody (7W816) can be used in ELISA(Cap).</p>

<p>Anti-PDGFRB Antibody-FITC (1A610) is a FITC-conjugated Mouse antibody targeting PDGFRB. Anti-PDGFRB Antibody-FITC (1A610) can be used in FCM.</p>

<p>Anti-PDGFRB Antibody-PE (7C914) is a PE-conjugated Rabbit antibody targeting PDGFRB. Anti-PDGFRB Antibody-PE (7C914) can be used in FCM.</p>

<p>Anti-PDGFRB Antibody (4V910) is a Rabbit antibody targeting PDGFRB. Anti-PDGFRB Antibody (4V910) can be used in ELISA.</p>

<p>Anti-PDGFRB Antibody (7C914) is a Rabbit antibody targeting PDGFRB. Anti-PDGFRB Antibody (7C914) can be used in FCM.</p>

<p>Anti-Phospho-PDGFRB (Tyr740) Antibody (9D509) is an antibody targeting Phospho-PDGFRB (Tyr740). Anti-Phospho-PDGFRB (Tyr740) Antibody (9D509) can be used in ELISA, WB.</p>