GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(251 products)
- Adrenergic Receptor(3,028 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(158 products)
- CaSR(34 products)
- Cannabinoid Receptor(218 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(36 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(195 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(42 products)
- Opioid Receptor(327 products)
- PAFR(14 products)
- PKA(61 products)
- S1P Receptor(18 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 6012 products of "GPCR/G-Protein"
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Butopamine hydrochloride
CAS:Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.Formula:C18H24ClNO3Color and Shape:SolidMolecular weight:337.84H3R antagonist 2
Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]Formula:C24H29NO3Color and Shape:SolidMolecular weight:379.49Merigolix
CAS:Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .Formula:C36H35F7N4O6Color and Shape:SolidMolecular weight:752.68CRHR1 antagonist 1
CAS:CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.Formula:C24H34N4OColor and Shape:SolidMolecular weight:394.553Tebideutorexant
CAS:Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.Formula:C23H16D2F4N4O2Purity:98.89%Color and Shape:SolidMolecular weight:460.42LTD4 antagonist 1
CAS:LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).Formula:C31H32F3N3O5SPurity:98%Color and Shape:SolidMolecular weight:615.66LPA receptor antagonist-1
CAS:LPA receptor antagonist-1 (example 52) serves as an antagonist for the lysophosphatidic acid (LPA) receptor and is applicable in various types of studies [1].Formula:C30H26ClNO5SColor and Shape:SolidMolecular weight:548.05GRK6-IN-4
CAS:GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.Formula:C15H15N5Color and Shape:SolidMolecular weight:265.313RGH-122
CAS:RGH-122 (compound 43), characterized as an orally active, potent, and selective hV1a receptor antagonist, demonstrates significant affinity with a K i value of 0.3 nM and an IC 50 of 0.9 nM. It exhibits microsomal stability, indicated by a CL int value of 13/28/25 μL/min/mg [1].Formula:C24H25ClN4O3Color and Shape:SolidMolecular weight:452.93EP-3945
CAS:EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.Formula:C24H26N4O3Color and Shape:SolidMolecular weight:418.4885β-Cholestane-3α,7α,12α,25-tetrol
CAS:5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 µM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.Formula:C27H48O4Color and Shape:SolidMolecular weight:436.67Monlunabant
CAS:Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].Formula:C26H22ClF3N6O3SPurity:98%Color and Shape:SolidMolecular weight:591.002,3-dinor-11β-Prostaglandin F2α
CAS:2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, whereFormula:C18H30O5Color and Shape:SolidMolecular weight:326.43LT-188A
CAS:LT-188A is a potent TGR5 agonist with an EC50 value of 23 μM. It effectively reduces levels of inflammatory mediators in macrophages.Formula:C28H36O7Color and Shape:SolidMolecular weight:484.58HU-308
CAS:HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.
Formula:C27H42O3Color and Shape:SolidMolecular weight:414.62MRS2179 tetrasodium hydrate
MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.Formula:C11H15N5Na4O10P2Color and Shape:SolidMolecular weight:576.21Org 274179-0
CAS:Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI)-mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD).Formula:C28H27F3N2O2Color and Shape:SolidMolecular weight:480.521MrgprX2 antagonist-6
MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.Formula:C24H23F3N6O3Color and Shape:SolidMolecular weight:500.47Mafoprazine
CAS:Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.Formula:C22H28FN3O3Color and Shape:SolidMolecular weight:401.47MSX-3
CAS:MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.Formula:C21H23N4Na2O7PPurity:98%Color and Shape:SolidMolecular weight:520.389
