GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,030 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(159 products)
- CaSR(34 products)
- Cannabinoid Receptor(217 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(196 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(42 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(55 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5985 products of "GPCR/G-Protein"
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COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Formula:C20H27NO6SPurity:99.29% - 99.32%Color and Shape:SoildMolecular weight:409.5MK-8318
CAS:MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).Formula:C27H26F4N2O5Purity:98%Color and Shape:SolidMolecular weight:534.5CB2R/5-HT1AR agonist 1
CAS:Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].Formula:C24H33NO3Color and Shape:SolidMolecular weight:383.52OP-2507
CAS:OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.Formula:C25H41NO4Purity:98%Color and Shape:SolidMolecular weight:419.6ADORA2A/PDE4D-IN-1
CAS:ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.Formula:C14H11N5Color and Shape:SolidMolecular weight:249.271VA012
CAS:VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formula:C21H19N3Color and Shape:SolidMolecular weight:313.40CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:452.48TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Formula:C9H11NOColor and Shape:SolidMolecular weight:149.195-HT1A antagonist 1
Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.Formula:C23H29ClN6O2Color and Shape:SolidMolecular weight:456.97BRD50837
CAS:BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Formula:C26H32ClN3O6SPurity:98%Color and Shape:SolidMolecular weight:550.07A1AR antagonist 1
Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).Formula:C18H14N4OColor and Shape:SolidMolecular weight:302.33Tipelukast
CAS:Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.Formula:C29H38O7SPurity:>99.99%Color and Shape:SolidMolecular weight:530.675-HT2A/5-HT2C inverse agonist 1
CAS:5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Formula:C24H35N5O2Color and Shape:SolidMolecular weight:425.57K-14585
CAS:K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95Butaprost
CAS:Butaprost: EP2 receptor agonist, EC50=33 nM, Ki=2.4 μM (murine), reduces fibrosis via TGF-β/Smad2.Formula:C24H40O5Purity:98%Color and Shape:SolidMolecular weight:408.57PF-07054894
CAS:PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.Formula:C24H30N6O4Color and Shape:SolidMolecular weight:466.53SB 243213 dihydrochloride
CAS:SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 forFormula:C22H21Cl2F3N4O2Purity:98%Color and Shape:SolidMolecular weight:501.33P2Y14R antagonist 4
CAS:Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.Formula:C27H27F3N2O4SColor and Shape:SolidMolecular weight:532.574Elsovaptan
CAS:Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.Formula:C19H20ClN5O2Color and Shape:SolidMolecular weight:385.847CS-0777
CAS:CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).Formula:C21H31N2O5PColor and Shape:SolidMolecular weight:422.45
