GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,995 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5963 products of "GPCR/G-Protein"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Zovaglutide
CAS:Zovaglutide is a GLP-1 receptor agonist that is utilized in diabetes research.Color and Shape:Solid9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
CAS:Meteneprost is a strong, long-lasting Prostaglandin E2 analog effective in ending early monkey pregnancies without causing fever or GI issues.Formula:C23H38O4Color and Shape:SolidMolecular weight:378.553Methimepip dihydrobromide
CAS:Methimepip dihydrobromide is a selective H3R agonist.Formula:C10H19Br2N3Color and Shape:SolidMolecular weight:341.091Urocortin II, human acetate
Urocortin II, human acetate, is a selective endogenous peptide agonist of type 2 corticotropin-releasing factor (CRF2) receptors, used to study the role of CRF2 receptors in feeding behavior.Color and Shape:Odour SolidNavafenterol saccharinate
CAS:AZD-8871 saccharinate is a dual-acting bronchodilator which may be useful in the treatment of Chronic Obstructive Pulmonary Disease (COPD).Formula:C45H47N7O9S3Color and Shape:SolidMolecular weight:926.09N-0500 HCl
CAS:N-0500 HCl, a potent DA receptor agonist, displaces [3H]DP_x005f_x0002_5,6-ADTN with an IC50 of 3nM.Formula:C15H22ClNO2Purity:98.85% - 99.54%Color and Shape:SolidMolecular weight:283.79[Gly8]-GLP-1(7-37) acetate
[Gly8]-GLP-1(7-37) acetate is a derivative of GLP-1, where glycine at position 8 is replaced with alanine. [Gly8]-GLP-1(7-37) acetate is also a peptide fragment of the GLP-1 receptor (GLP-1R) agonist, Dulaglutide.Color and Shape:Odour SolidSSTR4 agonist-1
CAS:SSTR4agonist-1 (Compound 47) is a selective agonist of the somatostatin receptor 4 (SSTR4), with an EC50 of 4.7 nM. It has a half-life of over 130 minutes in human liver microsomes.Formula:C16H23N3O2Color and Shape:SolidMolecular weight:289.37Urocortin, rat
CAS:Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.Formula:C206H338N62O64Purity:98%Color and Shape:SolidMolecular weight:4707.26Human follicular gonadotropin releasing peptide
CAS:Human Follicular Gonadotropin Releasing Peptide (hF-GRP) is a hormonal peptide that, in vitro, can induce the secretion of pituitary luteinizing hormone (LH)Formula:C68H94N22O27Color and Shape:SolidMolecular weight:1651.61mPGES-1/sEH-IN-1
mPGES-1/sEH-IN-1 (compound 1f) is an sEH inhibitor with an IC50 value of 5 μM. It also exhibits antitumor activity by inhibiting mPGES-1, with an IC50 value of 25 µM.Formula:C20H16F3N3O2Color and Shape:SolidMolecular weight:387.355AKP-11
CAS:AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg/kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decreases peripheral total lymphocyte and specific T cell subsets (CD4+, CD8+, and CD26L+ T cells) counts in both EAE rats and healthy controls at a 1.3 mg/kg dosage.Formula:C22H22ClN3O5Color and Shape:SolidMolecular weight:443.88Nastorazepide hemicalcium
CAS:Nastorazepide (Z-360) hemicalcium is a selective, orally-administered 1,5-benzodiazepine derivative that functions as a receptor antagonist for gastrin/cholecystokinin 2 (CCK-2), exhibiting potential antitumor activity.Formula:C29H36N4O5CaColor and Shape:SolidMolecular weight:540.665-HT1AR agonist 2
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.Formula:C31H31N5O3Color and Shape:SolidMolecular weight:521.61CB1R antagonist 2
CB1R antagonist 2 (Compound 11g) functions as an antagonist of the cannabinoid receptor 1 (CB1R), inhibiting the MAPK/NF-κB signaling pathway and exhibiting anti-inflammatory properties. In RAW264.7 cells, it suppresses LPS-induced expression of IL-6, IL-1β, and TNF-α. In murine models, it improves OVA-induced allergic rhinitis.Formula:C24H26N4OColor and Shape:SolidMolecular weight:386.49CCR6 antagonist 2
CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.Formula:C19H24N4O4Color and Shape:SolidMolecular weight:372.42Luprostiol
CAS:Luprostiol is a prostaglandin analog.Formula:C21H29ClO6SColor and Shape:SolidMolecular weight:444.97PACAP (1-27), human, ovine, rat
CAS:PACAP (1-27) (the N-terminal fragment of PACAP-38) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.Formula:C142H224N40O39SPurity:98%Color and Shape:SolidMolecular weight:3147.66BAY-747
CAS:BAY-747: oral, brain-penetrant sGC stimulator; improves rat memory, cognition, lowers blood pressure, aids Duchenne muscular dystrophy.Formula:C22H26F2N4O2Color and Shape:SolidMolecular weight:416.46Neuropeptide Y (22-36)
CAS:Neuropeptide Y (22-36) is a 15-amino acid fragment of NPY, which is abundant in the mammalian brain and involved in multiple physiological functions.Formula:C85H139N29O21Purity:98%Color and Shape:SolidMolecular weight:1903.19
