GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

Purity (%)

100

products per page.

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Kisspeptin 234 TFA
CAS:
- 1848962-29-7
Kisspeptin 234 TFA is a 10-amino acid peptide analog of Kisspeptin 10 [1] that functions as an antagonist to the kisspeptin receptor (KISS1, GPR54).
Formula:C₆₃H₇₈N₁₈O₁₃·xC₂HF₃O₂
Color and Shape:Solid
Molecular weight:1409.43
Ref: TM-T78106
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Fazamorexant
CAS:
- 1808918-69-5
Fazamorexant (YZJ-1139) is a powerful orexin receptor antagonist effective for insomnia research.
Formula:C₂₅H₂₅FN₄O₂
Color and Shape:Solid
Molecular weight:432.49
Ref: TM-T72954
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ATP-γ-S tetrasodium
CAS:
- 88453-52-5
Collagen, Type I, from bovine achilles tendon is a type I collagen extracted from bovine achilles tendon.
Formula:C₁₀H₁₂N₅Na₄O₁₂P₃S
Color and Shape:Solid
Molecular weight:611.17
Ref: TM-T83827
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2-Linoleoyl Glycerol
CAS:
- 3443-82-1
2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.
Formula:C₂₁H₃₈O₄
Color and Shape:Solid
Molecular weight:354.531
Ref: TM-T84648
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RXFP1 receptor agonist-1
CAS:
- 2924619-64-5
RXFP1 receptor agonist-1 (Example 2), an agonist of the RXFP1 receptor, suppresses cAMP production in HEK293 cells that constitutively express the human RXFP1,
Formula:C₃₁H₂₉F₇N₂O₄
Color and Shape:Solid
Molecular weight:626.56
Ref: TM-T81246
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NAS181
CAS:
- 1217474-40-2
rat 5-HT1B receptor antagonist
Formula:C₂₁H₃₄N₂O₁₀S₂
Purity:98%
Color and Shape:Solid
Molecular weight:538.63
Ref: TM-T23055
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Ro-70-0004
CAS:
- 186386-21-0
Ro-70-0004 is a selective antagonist of alpha1A-adrenoceptor.
Formula:C₂₀H₂₄F₄N₄O₃
Color and Shape:Solid
Molecular weight:444.42
Ref: TM-T28606
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ZINC49534341
CAS:
- 1274013-03-4
ZINC49534341 is a potent MRGPRX2 antagonist, exhibiting a K_i (inhibition constant) of 32 nM [1].
Formula:C₁₂H₉N₃OS₂
Color and Shape:Solid
Molecular weight:275.35
Ref: TM-T80727
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Gastrin/CCK antagonist 1
CAS:
- 162271-52-5
Gastrin/CCK antagonist 1 is a potent gastrin/CCK antagonist for the study of metabolic system-related diseases.
Formula:C₂₈H₃₂FN₅O₄
Purity:98.33%
Color and Shape:Solid
Molecular weight:521.58
Ref: TM-T13260
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(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:
- 857679-55-1
PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human
Formula:C₂₉H₃₁F₃N₆O₃
Color and Shape:Solid
Molecular weight:568.59
Ref: TM-T3430L
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Fiboflapon sodium
CAS:
- 1196070-26-4
Fiboflapon sodium, an oral 5-LOX-activating protein inhibitor, binds FLAP at 2.9 nM, inhibits LTB4 at 76 nM.
Formula:C₃₈H₄₃N₃NaO₄S
Color and Shape:Solid
Molecular weight:660.83
Ref: TM-T11487L
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AR-08
CAS:
- 226081-74-9
AR-08 is a potent α2-adrenergic receptor agonist for the study of ADHD and attention deficit.
Formula:C₁₂H₁₂N₆
Purity:99.7%
Color and Shape:Solid
Molecular weight:240.26
Ref: TM-T10052
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KFM19
CAS:
- 133058-72-7
KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.
Formula:C₁₆H₂₂N₄O₃
Purity:98.62%
Color and Shape:Solid
Molecular weight:318.37
Ref: TM-T15655
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(2R,3S)-E1R
CAS:
- 1424832-60-9
(2R,3S)-E1R, an enantiomer of E1R, is a sigma-1 receptor modulator for treating cognitive disorders.
Formula:C₁₃H₁₆N₂O₂
Purity:98%
Color and Shape:Solid
Molecular weight:232.28
Ref: TM-T10094
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CCG-63802
CAS:
- 620112-78-9
CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.
Formula:C₂₆H₁₈N₄O₂S
Purity:90%
Color and Shape:Solid
Molecular weight:450.51
Ref: TM-T14897
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5-HT3-In-1
CAS:
- 186348-68-5
5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.
Formula:C₁₆H₂₁ClN₄O₃
Purity:98%
Color and Shape:Solid
Molecular weight:352.82
Ref: TM-T10006
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Ro-24-0238
CAS:
- 120555-31-9
Ro-24-0238 blocks PAF, curbing thromboxane creation and inflammation caused by PAF release.
Formula:C₂₇H₃₆N₂O₂
Purity:98%
Color and Shape:Solid
Molecular weight:420.59
Ref: TM-T16767
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PW0464
CAS:
- 1643462-93-4
PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.
Formula:C₁₉H₁₇F₂N₃O₄
Purity:98.78%
Color and Shape:Solid
Molecular weight:389.35
Ref: TM-T36946
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Indeloxazine hydrochloride
CAS:
- 65043-22-3
Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.
Formula:C₁₄H₁₈ClNO₂
Purity:98%
Color and Shape:Solid
Molecular weight:267.75
Ref: TM-T19629
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Crisdesalazine
CAS:
- 927685-43-6
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1).
Formula:C₁₆H₁₄F₃NO₃
Purity:98.96%
Color and Shape:Solid
Molecular weight:325.28
Ref: TM-T27084
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LPA1 receptor antagonist 1
CAS:
- 1396006-71-5
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a lysophosphatidic acid receptor antagonist for the study of idiopathic pulmonary fibrosis.
Formula:C₂₈H₂₆N₄O₄
Purity:99.46% - 99.56%
Color and Shape:Solid
Molecular weight:482.53
Ref: TM-T15785
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CY 208-243
CAS:
- 100999-26-6
CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.
Formula:C₁₉H₁₈N₂
Purity:98%
Color and Shape:Solid
Molecular weight:274.36
Ref: TM-T10908
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SB 649915
CAS:
- 420785-70-2
SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist.
Formula:C₂₆H₂₉N₃O₃
Color and Shape:Solid
Molecular weight:431.53
Ref: TM-T28678
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Bima SA
CAS:
- 1175838-84-2
Bimatoprost Serinol Amide (Bima SA), a prostaglandin analog, shows research potential for glaucoma [1].
Formula:C₂₆H₃₉NO₆
Color and Shape:Solid
Molecular weight:461.59
Ref: TM-T84556
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PD 168368
CAS:
- 204066-82-0
PD 168368 is a mixed neuromodulin B receptor (NMB-R) antagonist and potent FPR1/FPR2/FPR3 agonist that inhibits the gastrin-releasing peptide receptor.
Formula:C₃₁H₃₄N₆O₄
Purity:98.44%
Color and Shape:Solid
Molecular weight:554.64
Ref: TM-T8691
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AGN 210676
CAS:
- 910562-15-1
AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
Formula:C₂₃H₂₉NO₅S
Purity:98%
Color and Shape:Solid
Molecular weight:431.55
Ref: TM-T14146
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JNJ-37822681 dihydrochloride
CAS:
- 2108806-02-4
JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。
Formula:C₁₇H₁₉Cl₂F₅N₄
Purity:99.78%
Color and Shape:Solid
Molecular weight:445.26
Ref: TM-T11722
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Quinpirole dihydrochloride
CAS:
- 73625-62-4
Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.
Formula:C₁₃H₂₃Cl₂N₃
Purity:98%
Color and Shape:Solid
Molecular weight:292.25
Ref: TM-T24696
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CB1 antagonist 1
CAS:
- 890037-68-0
CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and
Formula:C₂₆H₂₂Cl₂N₄
Purity:98%
Color and Shape:Solid
Molecular weight:461.39
Ref: TM-T10510
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PSB-SB1202
CAS:
- 1399049-60-5
PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].
Formula:C₂₃H₂₆O₄
Color and Shape:Solid
Molecular weight:366.45
Ref: TM-T84440
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NBI-35965
CAS:
- 268546-19-6
NBI-35965 is a CRF1 receptor antagonist.
Formula:C₂₁H₂₂Cl₂N₄
Color and Shape:Solid
Molecular weight:401.33
Ref: TM-T69544
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E-6123
CAS:
- 131614-02-3
E-6123 is an antagonist of platelet-activating factor (PAF) receptor.
Formula:C₂₃H₂₂ClN₅OS
Purity:98%
Color and Shape:Solid
Molecular weight:451.97
Ref: TM-T15188
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Apelin agonist 1
CAS:
- 2227512-85-6
Apelin agonist 1 is an orally available APJ receptor agonist with an EC50 value of 3.2 nM. Apelin agonist 1 is used in the study of cardiovascular disease.
Formula:C₂₃H₂₀FN₅O₅S
Purity:97.69% - 99.07%
Color and Shape:Solid
Molecular weight:497.5
Ref: TM-T10346
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LY3154885
CAS:
- 2379422-72-5
LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).
Formula:C₂₃H₂₃Cl₂N₃O₂
Color and Shape:Solid
Molecular weight:444.35
Ref: TM-T62610
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Todralazine hydrochloride
CAS:
- 3778-76-5
Todralazine hydrochloride, a β2AR blocker with antioxidant properties, is used in hypertension studies.
Formula:C₁₁H₁₃ClN₄O₂
Purity:99.91%
Color and Shape:Solid
Molecular weight:268.7
Ref: TM-T17111
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(±)-N-Methylcoclaurine
CAS:
- 1472-62-4
N-Methylcoclaurine (±) acts as a selective antagonist at the α2-adrenoceptor [1].
Formula:C₁₈H₂₁NO₃
Purity:98%
Color and Shape:Solid
Molecular weight:299.36
Ref: TM-T79641
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BU-E 75
CAS:
- 114667-74-2
BU-E 75 is an agonist of the histamine H2.
Formula:C₂₁H₂₄F₂N₆
Color and Shape:Solid
Molecular weight:398.45
Ref: TM-T23835
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Prostaglandin D3
CAS:
- 71902-47-1
Prostaglandin D3 (PGD3) functions as an inhibitor of platelet aggregation and modulates autonomic neurotransmission in humans [1].
Formula:C₂₀H₃₀O₅
Purity:98%
Color and Shape:Solid
Molecular weight:350.45
Ref: TM-T78584
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Pecavaptan
CAS:
- 1914998-56-3
Pecavaptan is a vasopressin receptor antagonist.
Formula:C₂₂H₁₉Cl₂F₃N₆O₃
Color and Shape:Solid
Molecular weight:543.33
Ref: TM-T70066
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BLT2 probe 1
CAS:
- 2893803-05-7
BLT2 Probe 1, based on CAY10583, is a fluorescent tool for studying BLT2 pharmacology, aiding research in diabetes and GI lesion treatment.
Formula:C₅₀H₄₅N₃O₁₁S
Purity:98%
Color and Shape:Solid
Molecular weight:895.97
Ref: TM-T74212
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Nolomirole HCl
CAS:
- 138531-51-8
Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study
Formula:C₁₉H₂₈ClNO₄
Purity:99.03% - >99.99%
Color and Shape:Solid
Molecular weight:369.88
Ref: TM-T33711L
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5-HT2A receptor agonist-3
CAS:
- 1391499-52-7
5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.
Formula:C₂₁H₂₆BrNO₃
Purity:98%
Color and Shape:Solid
Molecular weight:420.34
Ref: TM-T79155
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PF-04634817
CAS:
- 1228111-63-4
PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.
Formula:C₂₅H₃₆F₃N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:511.58
Ref: TM-T12419L
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TCS 2510
CAS:
- 346673-06-1
TCS 2510 (CAY10598) 是一种选择性 PGE2 和 EP4 受体激动剂，可增强细胞内 cAMP 浓度和活性 β-caten 的丰度。TCS 2510 抑制TNF-α 产生，可用于研究代谢紊乱带来的疾病。
Formula:C₂₁H₂₉N₅O₂
Purity:98%
Color and Shape:Solid
Molecular weight:383.49
Ref: TM-T23448
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FR-181157
CAS:
- 171046-15-4
FR-181157, a novel prostaglandin (PG) mimetic, shows high potency and agonist efficacy at the IP receptor and has good bioavailability.
Formula:C₃₀H₂₇NNaO₄
Purity:98%
Color and Shape:Solid
Molecular weight:488.539
Ref: TM-T27373
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MRS3558
CAS:
- 793695-40-6
MRS3558 is an agonist of A3 adenosine receptors.
Formula:C₂₀H₂₀Cl₂N₆O₃
Color and Shape:Solid
Molecular weight:463.32
Ref: TM-T28105
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S1p receptor agonist 2
CAS:
- 1354908-17-0
S1P5-selective agonist; less so for S1P1/S1P3; useful for CNS disorders.
Formula:C₂₄H₂₃ClN₂O₄
Color and Shape:Solid
Molecular weight:438.9
Ref: TM-T62517
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GLP-1R agonist 10
CAS:
- 2762515-25-1
GLP-1R agonist 10 is a GLP-1 agonist (EC50: 0.051 nM).
Formula:C₂₉H₂₉ClFN₅O₄
Color and Shape:Solid
Molecular weight:566.02
Ref: TM-T64007
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Domesticine, (-)-
CAS:
- 54325-07-4
Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.
Formula:C₁₉H₁₉NO₄
Purity:98%
Color and Shape:Solid
Molecular weight:325.36
Ref: TM-T24012
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NKP608
CAS:
- 177707-12-9
NKP608 is a NK-1 receptor antagonist with anticancer and anxiolytic activities.
Formula:C₃₁H₂₄ClF₆N₃O₂
Purity:99.88% - 99.88%
Color and Shape:Solid
Molecular weight:619.99
Ref: TM-TQ0087
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Frovatriptan
CAS:
- 158747-02-5
Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.
Formula:C₁₄H₁₇N₃O
Color and Shape:Solid
Molecular weight:243.3
Ref: TM-T60345
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IPG7236
CAS:
- 2756350-91-9
IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer
Formula:C₂₃H₃₁N₃O₃S
Purity:98%
Color and Shape:Solid
Molecular weight:429.58
Ref: TM-T79096
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SC 34301
CAS:
- 81026-63-3
SC 34301 (Enisoprost), a strong oral PGE1 analog, decreases bacterial translocation and increases burned mice survival.
Formula:C₂₂H₃₆O₅
Color and Shape:Solid
Molecular weight:380.52
Ref: TM-T73346
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Phentolamine Analogue 1
CAS:
- 47142-51-8
Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic.
Formula:C₁₇H₁₉N₃O
Purity:99.96%
Color and Shape:Solid
Molecular weight:281.35
Ref: TM-T12444
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MK 0893
CAS:
- 870823-12-4
MK 0893 is a potent and selective Glucagon Receptor (GR) antagonist competitive, reversible cAMP activity, which attenuates blood glucose elevation.
Formula:C₃₂H₂₇Cl₂N₃O₄
Purity:98.79%
Color and Shape:Solid
Molecular weight:588.48
Ref: TM-T12055
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Gestonorone Capronate
CAS:
- 1253-28-7
Gestonorone Capronate is a progesterone used in benign prostatic hyperplasia and endometrial cancer studies.
Formula:C₂₆H₃₈O₄
Purity:99.19%
Color and Shape:Solid
Molecular weight:414.58
Ref: TM-T13703
+ Info
Ubrogepant
CAS:
- 1374248-77-7
Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.
Formula:C₂₉H₂₆F₃N₅O₃
Purity:99.452% - 99.78%
Color and Shape:Solid
Molecular weight:549.54
Ref: TM-T17194
+ Info
PD 160170
CAS:
- 181468-88-2
neuropeptide Y1 receptor antagonist
Formula:C₁₈H₁₇N₃O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:371.41
Ref: TM-T23126
+ Info
L 659837
CAS:
- 125989-10-8
L 659837 is an antagonist of ANC-2, lactam, and tackykinin.
Formula:C₄₀H₅₂N₈O₇S
Color and Shape:Solid
Molecular weight:788.96
Ref: TM-T24312
+ Info
YM348
CAS:
- 372163-84-3
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
Formula:C₁₄H₁₇N₃O
Purity:98%
Color and Shape:Solid
Molecular weight:243.3
Ref: TM-T17275
+ Info
RS100329 hydrochloride
CAS:
- 1215654-26-4
RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
Formula:C₂₀H₂₆ClF₃N₄O₃
Purity:99.95%
Color and Shape:Solid
Molecular weight:462.89
Ref: TM-T23253
+ Info
2-Chloro-ATP
CAS:
- 49564-60-5
2-Chloro-ATP is a soluble inhibitor of guanylate cyclase (guanylate cyclase) that can increase intracellular calcium ion concentrations at low concentrations through a mechanism independent of inositol phosphate production.
Formula:C₁₀H₁₅ClN₅O₁₃P₃
Color and Shape:Solid
Molecular weight:541.63
Ref: TM-T88624
+ Info
Omidenepag isopropyl
CAS:
- 1187451-19-9
Omidenepag isopropyl (DE-117) is a prostaglandin EP2 receptor agonist used in the study of glaucoma and hypertension.
Formula:C₂₆H₂₈N₆O₄S
Purity:99.86%
Color and Shape:Solid
Molecular weight:520.6
Ref: TM-T16388
+ Info
Pentiapine
CAS:
- 81382-51-6
Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.
Formula:C₁₅H₁₇N₅S
Purity:99.35%
Color and Shape:Solid
Molecular weight:299.39
Ref: TM-T12405
+ Info
PSB-10 hydrochloride
CAS:
- 591771-91-4
PSB-10 hydrochloride is a human adenosine A3 receptor antagonist.
Formula:C₁₆H₁₅Cl₄N₅O
Purity:98%
Color and Shape:Solid
Molecular weight:435.14
Ref: TM-T23198
+ Info
(S)-Bexicaserin
CAS:
- 2035818-21-2
(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].
Formula:C₁₅H₁₉F₂N₃O
Purity:98%
Color and Shape:Solid
Molecular weight:295.33
Ref: TM-T79838
+ Info
Sulmazole
CAS:
- 73384-60-8
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.
Formula:C₁₄H₁₃N₃O₂S
Purity:99.94%
Color and Shape:Solid
Molecular weight:287.34
Ref: TM-T28881
+ Info
5-HT2C agonist-3
CAS:
- 2104810-18-4
5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced
Formula:C₁₉H₂₃ClFNO₂
Purity:98%
Color and Shape:Solid
Molecular weight:351.84
Ref: TM-T79802
+ Info
Wf-516
CAS:
- 310392-94-0
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant
Formula:C₂₅H₂₅Cl₂N₃O₄
Purity:98%
Color and Shape:Solid
Molecular weight:502.39
Ref: TM-T13339
+ Info
mPGES1-IN-3
CAS:
- 1469976-70-2
mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
Formula:C₂₄H₁₆ClF₅N₄O₃
Purity:98%
Color and Shape:Solid
Molecular weight:538.85
Ref: TM-T12100
+ Info
BMS-960
CAS:
- 1265321-86-5
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.
Formula:C₂₆H₂₃F₃N₄O₅
Purity:97.66% - 98.69%
Color and Shape:Solid
Molecular weight:528.48
Ref: TM-T26866
+ Info
NVP-SAA164
CAS:
- 312722-60-4
NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.
Formula:C₃₆H₄₅N₅O₅S
Purity:98%
Color and Shape:Solid
Molecular weight:659.84
Ref: TM-T25895
+ Info
Fiduxosin
CAS:
- 208993-54-8
Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki
Formula:C₃₀H₂₉N₅O₄S
Purity:99.73%
Color and Shape:Solid
Molecular weight:555.65
Ref: TM-T11286
+ Info
PF-02575799
CAS:
- 863491-70-7
PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).
Formula:C₄₂H₃₇FN₄O₄
Purity:98%
Color and Shape:Solid
Molecular weight:680.77
Ref: TM-T16158
+ Info
Uridine 5'-diphosphate
CAS:
- 58-98-0
Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].
Formula:C₉H₁₄N₂O₁₂P₂
Purity:98%
Color and Shape:Solid
Molecular weight:404.16
Ref: TM-T78583
+ Info
H4R antagonist 2
CAS:
- 1148115-99-4
H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoid
Formula:C₁₃H₁₇N₅O
Purity:98%
Color and Shape:Solid
Molecular weight:259.31
Ref: TM-T79786
+ Info
YM44778
CAS:
- 173941-74-7
YM44778 is a NK1-receptor antagonist for treating restless legs syndrome.
Formula:C₃₄H₃₉Cl₂N₃O₅
Color and Shape:Solid
Molecular weight:640.6
Ref: TM-T29184
+ Info
SAG 21k
CAS:
- 946002-48-8
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.
Formula:C₂₉H₂₈ClF₂N₃O₂S
Purity:99.51%
Color and Shape:Solid
Molecular weight:556.07
Ref: TM-T35559
+ Info
Selvigaltin
CAS:
- 1978336-95-6
Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.
Formula:C₁₉H₁₆BrF₃N₄O₄S
Purity:99.49%
Color and Shape:Solid
Molecular weight:533.32
Ref: TM-T63751
+ Info
Adomeglivant
CAS:
- 1488363-78-5
Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.
Formula:C₃₂H₃₆F₃NO₄
Purity:99.91%
Color and Shape:Solid
Molecular weight:555.63
Ref: TM-T14130
+ Info
CCR3 antagonist 1
CAS:
- 879399-82-3
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
Formula:C₁₉H₂₁Cl₂N₃O₄S₂
Purity:98.28%
Color and Shape:Solid
Molecular weight:490.42
Ref: TM-T10156
+ Info
(±)-Prenalterol
CAS:
- 57526-81-5
(±)-Prenalterol (H 80/62) is an agonist of beta-2- and beta-1-adrenergic receptors and is used to study chronic congestive heart failure.
Formula:C₁₂H₁₉NO₃
Purity:99.73%
Color and Shape:Solid
Molecular weight:225.28
Ref: TM-T25984
+ Info
AY 77
CAS:
- 1835734-92-3
AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer cell migration.
Formula:C₂₁H₃₂N₄O₄
Purity:99.7%
Color and Shape:Solid
Molecular weight:404.5
Ref: TM-T41190
+ Info
A2B receptor antagonist 1
CAS:
- 531506-36-2
A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist.
Formula:C₂₁H₂₄N₆O₂
Purity:99.53%
Color and Shape:Solid
Molecular weight:392.45
Ref: TM-T10058
+ Info
ST-1006
CAS:
- 1196994-11-2
ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.
Formula:C₁₆H₂₀Cl₂N₆
Purity:98.87% - 99.96%
Color and Shape:Solid
Molecular weight:367.28
Ref: TM-T34709
+ Info
Osemozotan HCl
CAS:
- 137275-80-0
Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
Formula:C₁₉H₂₂ClNO₅
Purity:98.87% - 99.63%
Color and Shape:Solid
Molecular weight:379.84
Ref: TM-T28270
+ Info
GV150013
CAS:
- 167355-22-8
GV150013 is an antagonist of cholecystokinin-2 (CCK2) receptor.
Formula:C₃₃H₃₄N₄O₃
Purity:99.93%
Color and Shape:Solid
Molecular weight:534.65
Ref: TM-T27503
+ Info
Azelaprag
CAS:
- 2049980-18-7
Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. treat nervous system diseases. High-Quality, Low-Cost!
Formula:C₂₅H₂₉N₇O₄S
Purity:98.04% - >99.99%
Color and Shape:Solid
Molecular weight:523.61
Ref: TM-T14390
+ Info
PAOPA
CAS:
- 114200-31-6
dopamine D2 receptor modulator
Formula:C₁₁H₁₈N₄O₃
Purity:>99.99%
Color and Shape:Solid
Molecular weight:254.29
Ref: TM-T23121
+ Info
Didesmethyl cariprazine
CAS:
- 839712-25-3
Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.
Formula:C₁₉H₂₈Cl₂N₄O
Purity:99.52%
Color and Shape:Solid
Molecular weight:399.36
Ref: TM-T15117
+ Info
Lotiglipron
CAS:
- 2401892-75-7
Lotiglipron (PF-07081532) is a GLP-1R agonist that lowers blood glucose and may be used in the study of type 2 diabetes mellitus (T2DM) and excess obesity.
Formula:C₃₁H₃₁ClN₄O₅
Purity:98.3%
Color and Shape:Solid
Molecular weight:575.05
Ref: TM-T77781
+ Info
0990CL
CAS:
- 511514-03-7
0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP
Formula:C₂₁H₂₁N₅
Purity:98.99%
Color and Shape:Solid
Molecular weight:343.42
Ref: TM-T13983
+ Info
SB 216641 hydrochloride
CAS:
- 193611-67-5
SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.
Formula:C₂₈H₃₁ClN₄O₄
Purity:98.06% - 99.23%
Color and Shape:Solid
Molecular weight:523.02
Ref: TM-T23315
+ Info
Clazosentan
CAS:
- 180384-56-9
Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.
Formula:C₂₅H₂₃N₉O₆S
Purity:95.39% - >99.99%
Color and Shape:Solid
Molecular weight:577.57
Ref: TM-T64084
+ Info
Vidupiprant
CAS:
- 1169483-24-2
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma.
Formula:C₂₈H₂₇Cl₂FN₂O₆S
Purity:98.88%
Color and Shape:Solid
Molecular weight:609.49
Ref: TM-T17232
+ Info
LGD-6972
CAS:
- 1207989-09-0
LGD-6972 is an antagonist of glucagon receptor.
Formula:C₄₃H₄₆N₂O₅S
Purity:98.8% - 99.62%
Color and Shape:Solid
Molecular weight:702.9
Ref: TM-T11845
+ Info
OPC-28326
CAS:
- 167626-17-7
OPC-28326: an α2-adrenergic blocker; dilates blood vessels; inhibits α2A/B/C receptors with Ki 2040/285/55 nM.
Formula:C₂₆H₃₅N₃O₂
Purity:99.79%
Color and Shape:Solid
Molecular weight:421.58
Ref: TM-T13804
+ Info
INT-777
CAS:
- 1199796-29-6
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.
Formula:C₂₇H₄₆O₅
Purity:99.89%
Color and Shape:Solid
Molecular weight:450.65
Ref: TM-T11662L
+ Info
α1 adrenoceptor-MO-1
CAS:
- 161905-64-2
α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action.
Formula:C₂₀H₂₄ClN₅O
Purity:99.20% - 99.29%
Color and Shape:Solid
Molecular weight:385.89
Ref: TM-T10003
+ Info
TAK-441
CAS:
- 1186231-83-3
TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.
Formula:C₂₈H₃₁F₃N₄O₆
Purity:99.82%
Color and Shape:Solid
Molecular weight:576.56
Ref: TM-T21325
+ Info
Deriglidole
CAS:
- 122830-14-2
Deriglidole (SL 86-0715), an alpha2 receptor inhibitor, blocks colistin/Idazoxan but not prazosin/α2-adrenergic receptors.
Formula:C₁₆H₂₁N₃
Purity:97.31% - 98.23%
Color and Shape:Solid
Molecular weight:255.36
Ref: TM-T10998
+ Info
Talibegron hydrochloride
CAS:
- 178600-17-4
Talibegron hydrochloride: β3 adrenoceptor agonist, pD2 3.72, relaxes rat arteries, reduces leptin in mice.
Formula:C₁₈H₂₂ClNO₄
Purity:99.82%
Color and Shape:Solid
Molecular weight:351.83
Ref: TM-T23557
+ Info
Selatogrel
CAS:
- 1159500-34-1
Selatogrel (ACT-246475) is a P2Y12 receptor antagonist with antithrombotic activity and inhibits platelet aggregation.
Formula:C₂₈H₃₉N₆O₈P
Purity:98.43%
Color and Shape:Solid
Molecular weight:618.62
Ref: TM-T71364
+ Info
GI 181771
CAS:
- 305366-98-7
GI 181771 is an agonist of the cholecystokinin 1 receptor. GI 181771 can be used in studies about obesity.
Formula:C₃₄H₃₁N₅O₆
Purity:95.02%
Color and Shape:Solid
Molecular weight:605.64
Ref: TM-T15382
+ Info
PSB-603
CAS:
- 1092351-10-4
PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
Formula:C₂₄H₂₅ClN₆O₄S
Purity:97.13%
Color and Shape:Solid
Molecular weight:529.01
Ref: TM-T23203
+ Info
CGP-20712
CAS:
- 137888-49-4
CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.
Formula:C₂₃H₂₅F₃N₄O₅
Purity:99.40% - 99.58%
Color and Shape:Solid
Molecular weight:494.46
Ref: TM-T30846
+ Info
Anti-inflammatory agent 49
CAS:
- 851471-44-8
Compound SC9, an anti-inflammatory agent, serves as a potent and selective inhibitor of the Drp1-Fis1 interaction, mitigating FIS1-mediated mitochondrial
Formula:C₂₁H₂₂N₈O₃S
Purity:99.56% - 99.74%
Color and Shape:Solid
Molecular weight:466.52
Ref: TM-T83057
+ Info
GW 833972A
CAS:
- 1092502-33-4
GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Formula:C₁₈H₁₄Cl₂F₃N₅O
Purity:99.93%
Color and Shape:Soild
Molecular weight:444.24
Ref: TM-T64394
+ Info
WAY-639889
CAS:
- 432506-24-6
WAY-639889 is a small molecule compound with selective and potent inhibitory effects on neuropeptide Y-5 receptors.
Formula:C₂₅H₂₇N₅O
Purity:99.73%
Color and Shape:Solid
Molecular weight:413.51
Ref: TM-T77783
+ Info
K777
CAS:
- 233277-99-1
K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).
Formula:C₃₂H₃₈N₄O₄S
Purity:98.43% - 99.14%
Color and Shape:Solid
Molecular weight:574.73
Ref: TM-T15641
+ Info
Ertugliflozin L-pyroglutamic acid
CAS:
- 1210344-83-4
Ertugliflozin is a potent oral hSGLT2 inhibitor (IC50: 0.877 nM) for type 2 diabetes treatment studies.
Formula:C₂₇H₃₂ClNO₁₀
Purity:99.88% - 99.94%
Color and Shape:Solid
Molecular weight:566
Ref: TM-T15244
+ Info
WAY-607695
CAS:
- 380469-52-3
WAY-607695 is a potential 5-HT1A receptor agonist.
Formula:C₁₃H₁₂FNO₂
Purity:99.82%
Color and Shape:Solid
Molecular weight:233.24
Ref: TM-T80805
+ Info
Enerisant
CAS:
- 1152747-82-4
Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.
Formula:C₂₂H₃₀N₄O₃
Purity:99.7%
Color and Shape:Soild
Molecular weight:398.50
Ref: TM-T67828
+ Info
Calindol hydrochloride
CAS:
- 729610-18-8
Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.
Formula:C₂₁H₂₁ClN₂
Purity:99.47%
Color and Shape:Solid
Molecular weight:336.86
Ref: TM-T21758
+ Info
AS2717638
CAS:
- 2148339-28-8
AS2717638: oral LPA5 antagonist, IC50 38 nM, reduces PGF2α/PGE2/AMPA allodynia.
Formula:C₂₅H₂₅N₃O₅
Purity:99.23%
Color and Shape:Solid
Molecular weight:447.48
Ref: TM-T10381
+ Info
NMI 8739
CAS:
- 129024-87-9
NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.
Formula:C₃₀H₄₁NO₃
Purity:98.51%
Color and Shape:Solid
Molecular weight:463.65
Ref: TM-T11079
+ Info
Lumateperone
CAS:
- 313368-91-1
Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).
Formula:C₂₄H₂₈FN₃O
Purity:99.68% - 99.91%
Color and Shape:Solid
Molecular weight:393.5
Ref: TM-T21069
+ Info
SB-616234-A
CAS:
- 908601-49-0
SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.
Formula:C₃₂H₃₆ClN₅O₃
Purity:99.72%
Color and Shape:Solid
Molecular weight:574.11
Ref: TM-T12847
+ Info
PSB 1115
CAS:
- 152529-79-8
PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.
Formula:C₁₄H₁₄N₄O₅S
Purity:98.69% - >99.99%
Color and Shape:Solid
Molecular weight:350.35
Ref: TM-T23201
+ Info
SR 142948
CAS:
- 184162-64-9
SR 142948 is a neurotensin (NT) receptor antagonist.
Formula:C₃₉H₅₁N₅O₆
Purity:98%
Color and Shape:Solid
Molecular weight:685.85
Ref: TM-T23386
+ Info
INCB3344
CAS:
- 1262238-11-8
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8
Formula:C₂₉H₃₄F₃N₃O₆
Purity:98% - 98.2%
Color and Shape:Solid
Molecular weight:577.59
Ref: TM-TQ0103
+ Info
ONO-9780307
CAS:
- 856691-44-6
ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).
Formula:C₃₀H₃₅NO₇
Color and Shape:Solid
Molecular weight:521.6
Ref: TM-T63645
+ Info
CP-199330
CAS:
- 158102-92-2
CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.
Formula:C₂₈H₂₄ClF₃N₂O₆S
Color and Shape:Solid
Molecular weight:609.01
Ref: TM-T31043
+ Info
Aplaviroc
CAS:
- 461443-59-4
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
Formula:C₃₃H₄₃N₃O₆
Purity:97.98% - 98.26%
Color and Shape:Solid
Molecular weight:577.71
Ref: TM-T14307
+ Info
Befiradol hydrochloride
CAS:
- 2436760-81-3
Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.
Formula:C₂₀H₂₃Cl₂F₂N₃O
Purity:99.1%
Color and Shape:Solid
Molecular weight:430.32
Ref: TM-T62385
+ Info
PGDM
CAS:
- 133161-96-3
PGD2 is involved in allergy, asthma, sleep, temperature regulation, inhibits clotting, and relaxes blood vessels; PGDM, its metabolite, is a biomarker.
Formula:C₁₆H₂₄O₇
Color and Shape:Solid
Molecular weight:328.36
Ref: TM-T38257
+ Info
APJ receptor agonist 8
CAS:
- 2049973-39-7
APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.
Formula:C₂₄H₂₇N₇O₅S
Purity:98.31% - 99.60%
Color and Shape:Solid
Molecular weight:525.58
Ref: TM-T85710
+ Info
Histamine H3 antagonist-1
CAS:
- 1000392-25-5
Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Formula:C₂₄H₂₈F₃N₃O₂
Color and Shape:Solid
Molecular weight:447.49
Ref: TM-T86579
+ Info
MF-592
CAS:
- 1064195-48-7
MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.
Formula:C₃₄H₃₃Cl₂N₃O₆S
Color and Shape:Solid
Molecular weight:682.61
Ref: TM-T71510
+ Info
5-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.
Formula:C₂₁H₂₆N₆S
Color and Shape:Solid
Molecular weight:394.54
Ref: TM-T61837
+ Info
D4R antagonist-1
Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.
Formula:C₂₁H₂₅F₂NO₂
Color and Shape:Solid
Molecular weight:361.43
Ref: TM-T61347
+ Info
CBR Agonist-2
CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.
Formula:C₂₇H₂₇FN₄O
Color and Shape:Solid
Molecular weight:442.53
Ref: TM-T62584
+ Info
H3R antagonist 2
Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]
Formula:C₂₄H₂₉NO₃
Color and Shape:Solid
Molecular weight:379.49
Ref: TM-T61603
+ Info
(±)-Penbutolol
CAS:
- 36507-48-9
(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.
Formula:C₁₈H₂₉NO₂
Color and Shape:Solid
Molecular weight:291.43
Ref: TM-T201472
+ Info
Butopamine hydrochloride
CAS:
- 74432-68-1
Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.
Formula:C₁₈H₂₄ClNO₃
Color and Shape:Solid
Molecular weight:337.84
Ref: TM-T201508
+ Info
AB-FUBINACA 3-fluorobenzyl isomer
CAS:
- 1185282-19-2
AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.
Formula:C₂₀H₂₁FN₄O₂
Color and Shape:Solid
Molecular weight:368.41
Ref: TM-T201486
+ Info
O-1269
CAS:
- 336615-64-6
O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.
Formula:C₂₂H₂₂Cl₃N₃O
Color and Shape:Solid
Molecular weight:450.79
Ref: TM-T201557
+ Info
(R)-MrgprX2 antagonist-3
CAS:
- 2642174-20-5
(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.
Formula:C₁₆H₂₀FN₃O₂S
Molecular weight:337.41
Ref: TM-T208997
+ Info
YM-31636 free base
CAS:
- 159081-22-8
YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.
Formula:C₁₄H₁₁N₃S
Color and Shape:Solid
Molecular weight:253.32
Ref: TM-T201587
+ Info
Rodatristat ethyl
CAS:
- 1673571-51-1
Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.
Formula:C₂₉H₃₁ClF₃N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:590.04
Ref: TM-T16779
+ Info
RS 12254
CAS:
- 137550-79-9
RS 12254 is a dopamine agonist and antihypertensive agent.
Formula:C₂₈H₄₀N₂O₄
Purity:98%
Color and Shape:Solid
Molecular weight:468.63
Ref: TM-T26131
+ Info
F 14679
CAS:
- 208109-38-0
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Formula:C₂₁H₂₅ClF₂N₄O
Purity:99.09%
Color and Shape:Solid
Molecular weight:422.9
Ref: TM-T62269
+ Info
BAY 38-7271
CAS:
- 212188-60-8
BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).
Formula:C₂₀H₂₁F₃O₅S
Purity:98%
Color and Shape:Solid
Molecular weight:430.44
Ref: TM-T14504
+ Info
RU 52583
CAS:
- 123829-33-4
RU 52583 is an alpha 2-adrenergic receptor antagonist.
Formula:C₁₈H₂₀N₂
Purity:98%
Color and Shape:Solid
Molecular weight:264.36
Ref: TM-T26155
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Arpromidine
CAS:
- 106669-71-0
Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.
Formula:C₂₁H₂₅FN₆
Color and Shape:Solid
Molecular weight:380.462
Ref: TM-T204236
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Nocloprost
CAS:
- 79360-43-3
Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.
Formula:C₂₂H₃₇ClO₄
Color and Shape:Solid
Molecular weight:400.98
Ref: TM-T33710
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Monlunabant
CAS:
- 2712480-46-9
Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].
Formula:C₂₆H₂₂ClF₃N₆O₃S
Purity:98%
Color and Shape:Solid
Molecular weight:591.00
Ref: TM-T79137
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MRT-92
CAS:
- 1428315-82-5
MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.
Formula:C₃₃H₃₄N₄O₅
Color and Shape:Solid
Molecular weight:566.65
Ref: TM-T200033
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GnRH-R antagonist 1
CAS:
- 2826273-90-7
Compound 21a: Oral GnRH-R antagonist, IC50=0.57 nM, potent against prostate cancer/prevents LH surges.
Formula:C₃₁H₂₈F₅N₇O₆S
Purity:98%
Color and Shape:Solid
Molecular weight:721.65
Ref: TM-T72492
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D1R antagonist 1
CAS:
- 2983777-67-7
Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].
Formula:C₂₂H₂₆BrNO₄
Purity:98%
Color and Shape:Solid
Molecular weight:448.35
Ref: TM-T78735
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BIIE-0246 HCl
CAS:
- 246146-31-6
BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.
Formula:C₄₉H₅₉Cl₂N₁₁O₆
Color and Shape:Solid
Molecular weight:968.97
Ref: TM-T69621
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AL 8810
CAS:
- 246246-19-5
AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].
Formula:C₂₄H₃₁FO₄
Color and Shape:Solid
Molecular weight:402.5
Ref: TM-T21752
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MSX-3
CAS:
- 261717-23-1
MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.
Formula:C₂₁H₂₃N₄Na₂O₇P
Purity:98%
Color and Shape:Solid
Molecular weight:520.389
Ref: TM-T25841
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ZK118182 isopropyl ester
CAS:
- 154927-31-8
ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).
Formula:C₂₃H₃₇ClO₅
Purity:98%
Color and Shape:Solid
Molecular weight:428.99
Ref: TM-T29225
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BMS-986104
CAS:
- 1622180-31-7
BMS-986104 is an effective selective modulator of the S1P1 receptor. It demonstrates efficacy in the mouse EAE model, comparable to that of FTY720. Furthermore, BMS-986104 shows promising remyelination properties in three-dimensional brain cell cultures subjected to lysophosphatidylcholine (LPC)-induced demyelination.
Formula:C₂₂H₃₅NO
Color and Shape:Solid
Molecular weight:329.52
Ref: TM-T200882
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D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.
Formula:C₂₁H₂₃ClF₂N₂O₂
Color and Shape:Solid
Molecular weight:408.87
Ref: TM-T62054
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Fosrolapitant
CAS:
- 2573694-38-7
Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.
Formula:C₂₇H₂₉F₆N₂O₈P
Color and Shape:Solid
Molecular weight:654.49
Ref: TM-T201161
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MRS4833
CAS:
- 2801627-78-9
MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.
Formula:C₃₀H₂₄F₃NO₃
Color and Shape:Solid
Molecular weight:503.51
Ref: TM-T200837
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Cicaprost
CAS:
- 94079-80-8
Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.
Formula:C₂₂H₃₀O₅
Color and Shape:Solid
Molecular weight:374.47
Ref: TM-T61526
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A2A receptor antagonist 2
A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).
Formula:C₂₅H₂₈FN₇O₃
Color and Shape:Solid
Molecular weight:493.53
Ref: TM-T63326
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U92016A hydrochloride
CAS:
- 149654-41-1
U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.
Formula:C₁₉H₂₆ClN₃
Color and Shape:Solid
Molecular weight:331.89
Ref: TM-T60990
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Ophiobolin C
CAS:
- 19022-51-6
inhibitor of human CCR5 binding to HIV-1 gp120
Formula:C₂₅H₃₈O₃
Purity:98%
Color and Shape:Solid
Molecular weight:386.57
Ref: TM-T23108
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Elzasonan hydrochloride
CAS:
- 220322-05-4
Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.
Formula:C₂₂H₂₄Cl₃N₃OS
Color and Shape:Solid
Molecular weight:484.87
Ref: TM-T201763
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DA-302168S
CAS:
- 2969158-02-7
DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.
Formula:C₃₃H₂₄ClF₂N₃O₅
Color and Shape:Solid
Molecular weight:616.011
Ref: TM-T206917
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Tipindole
CAS:
- 7489-66-9
Tipindole is a serotonin antagonist utilized in research related to depression.
Formula:C₁₆H₂₀N₂O₂S
Color and Shape:Solid
Molecular weight:304.41
Ref: TM-T201819
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Tofogliflozin
CAS:
- 903565-83-3
Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).
Formula:C₂₂H₂₆O₆
Purity:98%
Color and Shape:Solid
Molecular weight:386.44
Ref: TM-T13179
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Sulfinalol hydrochloride
CAS:
- 63251-39-8
Sulfinalol hydrochloride is an orally active β-adrenoceptor (β-adrenoceptor) antagonist that exhibits direct vasodilatory activity. It is also classified as an antihypertensive agent.
Formula:C₂₀H₂₈ClNO₄S
Color and Shape:Solid
Molecular weight:413.96
Ref: TM-T201759
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H1R ligand-1
CAS:
- 19642-70-7
H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.
Formula:C₁₉H₂₃NO
Color and Shape:Solid
Molecular weight:281.392
Ref: TM-T205504
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OP-2507
CAS:
- 101758-79-6
OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.
Formula:C₂₅H₄₁NO₄
Purity:98%
Color and Shape:Solid
Molecular weight:419.6
Ref: TM-T28254
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Fasitibant
CAS:
- 869939-83-3
Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.
Formula:C₃₆H₄₉Cl₂N₆O₆S
Color and Shape:Solid
Molecular weight:764.78
Ref: TM-T68486
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VA012
CAS:
- 885898-58-8
VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
Formula:C₂₁H₁₉N₃
Color and Shape:Solid
Molecular weight:313.40
Ref: TM-T200241
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hA3AR agonist 1
hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .
Formula:C₁₀H₁₄N₆OS
Color and Shape:Solid
Molecular weight:266.32
Ref: TM-T60444
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PF-06372222
CAS:
- 1407592-99-7
PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.
Formula:C₂₆H₂₈F₃N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:515.53
Ref: TM-T24620
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S1PR1 agonist 1
CAS:
- 2700209-37-4
S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.
Formula:C₂₉H₃₀N₄O₄
Color and Shape:Solid
Molecular weight:498.57
Ref: TM-T63378
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LJ-4517
LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.
Formula:C₁₉H₂₁N₅O₃S
Color and Shape:Solid
Molecular weight:399.47
Ref: TM-T61914
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VGD071
CAS:
- 2826992-31-6
VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.
Formula:C₃₂H₄₁N₃O₄S₂
Color and Shape:Solid
Molecular weight:595.82
Ref: TM-T64206
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EP4 receptor antagonist 2
CAS:
- 1965316-82-8
EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects.
Formula:C₂₇H₂₉N₃O₅
Color and Shape:Solid
Molecular weight:475.54
Ref: TM-T63100
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AA 497 (Free Base)
CAS:
- 59605-49-1
AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.
Formula:C₁₄H₂₁NO₃
Purity:98%
Color and Shape:Solid
Molecular weight:251.32
Ref: TM-T26359
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BIBO3304 diTFA
CAS:
- 2310085-85-7
BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].
Formula:C₃₃H₃₇F₆N₇O₇
Color and Shape:Solid
Molecular weight:757.68
Ref: TM-T84889
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THRX-194556
CAS:
- 886579-13-1
THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.
Formula:C₂₈H₄₁N₅O₅S
Color and Shape:Solid
Molecular weight:559.721
Ref: TM-T205695
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5-IAI hydrochloride
CAS:
- 1782044-60-3
5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.
Formula:C₉H₁₁ClIN
Color and Shape:Solid
Molecular weight:295.548
Ref: TM-T204949
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GPBAR1-IN-3
CAS:
- 2760546-05-0
GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].
Formula:C₂₁H₂₃NO₂
Color and Shape:Solid
Molecular weight:321.41
Ref: TM-T60863
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5-HT1A modulator 4
CAS:
- 145208-86-2
5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.
Formula:C₉H₁₄N₄
Color and Shape:Solid
Molecular weight:178.234
Ref: TM-T205724
+ Info
DM-4111
CAS:
- 926035-36-1
DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.
Formula:C₂₆H₂₅ClN₂O₄
Color and Shape:Solid
Molecular weight:464.94
Ref: TM-T207517
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CCG258208
CAS:
- 2055990-90-2
GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
Formula:C₂₄H₂₅FN₄O₄
Purity:98%
Color and Shape:Solid
Molecular weight:452.48
Ref: TM-T13714
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L-796778 acetate
CAS:
- 2922280-21-3
L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.
Formula:C₃₁H₄₄N₆O₉
Color and Shape:Solid
Molecular weight:644.716
Ref: TM-T206311
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Zafirlukast metabolite M1
CAS:
- 219583-10-5
Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.
Formula:C₂₅H₂₅N₃O₄S
Color and Shape:Solid
Molecular weight:463.549
Ref: TM-T204861
+ Info
GRK6-IN-4
CAS:
- 300731-73-1
GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.
Formula:C₁₅H₁₅N₅
Color and Shape:Solid
Molecular weight:265.313
Ref: TM-T204959
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SEP-363856 mesylate
CAS:
- 2375116-27-9
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
Formula:C₁₀H₁₇NO₄S₂
Color and Shape:Solid
Molecular weight:279.38
Ref: TM-T201258
+ Info
UK-432097
CAS:
- 380221-63-6
UK 432097 is an adenosine A2A agonist.
Formula:C₄₀H₄₇N₁₁O₆
Color and Shape:Solid
Molecular weight:777.87
Ref: TM-T29049
+ Info
CBR Agonist-1
CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.
Formula:C₂₇H₂₇FN₄O
Color and Shape:Solid
Molecular weight:442.53
Ref: TM-T62583
+ Info
Cendifensine
CAS:
- 1034048-49-1
Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).
Formula:C₁₄H₁₇Cl₂NO
Color and Shape:Solid
Molecular weight:286.197
Ref: TM-T206480
+ Info
CS-0777
CAS:
- 840523-39-9
CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).
Formula:C₂₁H₃₁N₂O₅P
Color and Shape:Solid
Molecular weight:422.45
Ref: TM-T31107
+ Info
Aeruginosin 98-B
CAS:
- 167228-01-5
Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.
Formula:C₂₉H₄₆N₆O₉S
Color and Shape:Solid
Molecular weight:654.78
Ref: TM-T72736
+ Info
Protease-Activated Receptor-1 antagonist 2
Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.
Color and Shape:Solid
Ref: TM-T64285
+ Info
Org-6906
CAS:
- 67384-25-2
DCB-3503, a tylophorine analog, may treat cancer and suppress immunity by blocking protein synthesis and modulating HSC70's ATPase activity.
Formula:C₁₃H₁₆ClN
Purity:98%
Color and Shape:Solid
Molecular weight:221.73
Ref: TM-T28266
+ Info
YNT-3708
CAS:
- 2923137-99-7
YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.
Formula:C₃₅H₃₆N₄O₆S
Color and Shape:Solid
Molecular weight:640.749
Ref: TM-T206764
+ Info
Nipradolol
CAS:
- 81486-22-8
Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.
Formula:C₁₅H₂₂N₂O₆
Color and Shape:Solid
Molecular weight:326.35
Ref: TM-T73083
+ Info
Leukotriene F4
CAS:
- 83851-42-7
LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.
Formula:C₂₈H₄₄N₂O₈S
Color and Shape:Solid
Molecular weight:568.72
Ref: TM-T38129
+ Info
Beloxepin
CAS:
- 135928-30-2
Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.
Formula:C₁₉H₂₁NO₂
Purity:98%
Color and Shape:Solid
Molecular weight:295.38
Ref: TM-T26765