GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,030 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(159 products)
- CaSR(34 products)
- Cannabinoid Receptor(217 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(444 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(196 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(42 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(55 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5984 products of "GPCR/G-Protein"
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Angiopeptin
CAS:Angiopeptin is a synthetic octapeptide analog of somatostatin; suppresses accelerated transplant atherosclerosis in rabbit heart arteries.Formula:C54H71N11O10S2Color and Shape:SolidMolecular weight:1098.34Cortistatin 29
Cortistatin 29: neuropeptide, relieves neuropathic pain, binds SS receptors (IC50: 2.8-13.7 nM), anti-fibrotic.Formula:C161H242N46O41S2Color and Shape:SolidMolecular weight:3539.7713,14-dihydro-15-keto Prostaglandin F1α
CAS:<p>13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.</p>Formula:C20H36O5Color and Shape:SolidMolecular weight:356.5Danshenol B
Danshenol B is a natural product that can be used as a reference standard.Formula:C22H26O4Color and Shape:SolidMolecular weight:354.446AC 187 TFA
AC 187 TFA, a potent and orally active amylin receptor antagonist, exhibits an IC50 of 0.48 nM and a Ki of 0.275 nM.Formula:C129H206F3N37O42Color and Shape:SolidMolecular weight:3004.27A6770
CAS:A6770 inhibits S1P lyase, causing [3H]dhS1P build-up in IT-79MTNC3 cells (EC50 <0.01 μM); less effective with vitamin B6 (EC50 <100 μM).Formula:C6H8N2O2Color and Shape:SolidMolecular weight:140.142HAEGT
CAS:<p>HAEGT is the first N-terminal 1-5 residues of GLP-1 peptide.</p>Formula:C20H31N7O9Purity:98%Color and Shape:SolidMolecular weight:513.5GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Formula:C20H16N2O2Purity:99.53%Color and Shape:SoildMolecular weight:316.35Ref: TM-T64351
1mg85.00€5mg170.00€10mg250.00€25mg371.00€50mg522.00€100mg712.00€200mg954.00€1mL*10mM (DMSO)170.00€Kisspeptin-10, rat TFA
<p>Kisspeptin-10, a rat TFA, constricts blood vessels, inhibits vessel growth, and counters Methotrexate reproductive toxicity.</p>Formula:C65H84F3N17O17Color and Shape:SolidMolecular weight:1432.465-HT7R antagonist 1 free base
CAS:5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Formula:C14H17ClN4Color and Shape:SolidMolecular weight:276.77Pasireotide
CAS:Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).Formula:C58H66N10O9Purity:98%Color and Shape:SolidMolecular weight:1047.21Methicillin sodium hydrate
CAS:Methicillin sodium hydrate, a narrow-spectrum antibiotic, combats methicillin-resistant Staphylococcus strains and treats various infections.Formula:C17H21N2NaO7SColor and Shape:SolidMolecular weight:420.41Prolactin Releasing Peptide (1-31), human
CAS:Human Prolactin Releasing Peptide (1-31) is a potent GPR10 agonist; Ki values are 1.03 nM (human) and 0.33 nM (rat).Formula:C160H252N56O42SPurity:98%Color and Shape:SolidMolecular weight:3664.155-HT2A receptor agonist-5
CAS:5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A agonist with a Ki value of 0.017 µM and exhibits antidepressant activity.Formula:C23H29N3OColor and Shape:SolidMolecular weight:363.5TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Formula:C29H50NNaO6SColor and Shape:SolidMolecular weight:563.77LY 293284
CAS:LY 293284 is a potent, selective full agonist of 5-HT1A receptor with anxiogenic effects in animal studies.Formula:C19H26N2OColor and Shape:SolidMolecular weight:298.42Guanylin(human) TFA
Guanylin (human) TFA, a 15-amino acid peptide, activates intestinal guanylate cyclase, regulating electrolyte and water transport via cGMP.Color and Shape:LiquidAR-C126313
CAS:<p>AR-C126313 is a thiouracil derivative.</p>Formula:C28H23N7O3SColor and Shape:SolidMolecular weight:537.59Dexbrompheniramine
CAS:Dexbrompheniramine: oral H1 antagonist, antihistamine for hay fever and urticaria research.Formula:C16H19BrN2Color and Shape:SolidMolecular weight:319.2415(S)-15-methyl Prostaglandin D2
CAS:15(S)-15-methyl PGD2 is a stable PGD2 analog that induces vasoconstriction, raises blood pressure, and shows strong antifertility effects.Formula:C21H34O5Color and Shape:SolidMolecular weight:366.49[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
CAS:Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.Formula:C79H109N19O12Purity:98%Color and Shape:SolidMolecular weight:1516.85Histamine H4 receptor antagonist-1
CAS:Histamine H4 receptor antagonist-1 is a potent antagonist of the histamine H4 receptor.Formula:C30H38N8O2Color and Shape:SolidMolecular weight:542.68MAO-B-IN-3
<p>MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki</p>Formula:C24H25N3O2Purity:98%Color and Shape:SolidMolecular weight:387.47Methdilazine
CAS:Methdilazine: oral antibiotic, histamine antagonist, fights mycobacterium (MIC 5-15 μg/mL) for infectious disease research.Formula:C18H20N2SColor and Shape:SolidMolecular weight:296.43MEN 11270
CAS:B2 bradykinin receptor peptide antagonist, pKi 10.3; improves hypotension, bronchoconstriction; B2-selective over 29 receptors/ion channels.Formula:C60H90N20O11SPurity:98%Color and Shape:SolidMolecular weight:1299.56Benzomalvin B
CAS:Benzomalvin B, a metabolite from Penicillium, blocks 24% NK1 receptor binding at 100 μg/ml.Formula:C24H17N3O2Color and Shape:SolidMolecular weight:379.419Maceneolignan H
CAS:Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Formula:C24H30O7Color and Shape:SolidMolecular weight:430.4911-deoxy Prostaglandin E2
CAS:11-deoxy PGE2 is a synthetic PGE2 analog, a potent bronchoconstrictor, 5-30x stronger than PGF2α on human respiratory muscles.Formula:C20H32O4Color and Shape:SolidMolecular weight:336.47Agaridoxin
CAS:<p>Agaridoxin is a mushroom metabolite.</p>Formula:C11H14N2O5Color and Shape:SolidMolecular weight:254.242Tafluprost acid
CAS:Tafluprost acid is a selective agonist at the prostaglandin F receptor.Formula:C22H28F2O5Color and Shape:SolidMolecular weight:410.46(Phe2,Orn8)-Oxytocin
CAS:(Phe2,Orn8)-Oxytocin: Selective V1 agonist, induces rabbit epididymis contractility, EC50=280 nM.Formula:C42H65N13O11S2Color and Shape:SolidMolecular weight:992.18Orforglipron hemicalcium hydrate
CAS:Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes [1].Formula:C48H48F2N10O5Ca·H2OColor and Shape:SolidMolecular weight:921.02Stressin I
Potent CRF1 agonist; Ki: 1.5 nM (CRF1), 224 nM (CRF2). Boosts ACTH, enhances stool frequency after i.p. administration.Formula:C203H337N57O56Purity:98%Color and Shape:SolidMolecular weight:4472.24Piperulin A
CAS:Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,Formula:C23H28O6Color and Shape:SolidMolecular weight:400.46[Ala11,D-Leu15]-Orexin B(human)
CAS:OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).Formula:C120H206N44O35SPurity:98%Color and Shape:SolidMolecular weight:2857.28CYM5442 hydrochloride
CAS:CYM 5442 HCl: potent, selective S1P1 agonist (EC50 = 1.35 nM), induces MAPK activation & lymphopenia, brain-penetrant.Formula:C23H28ClN3O4Color and Shape:SolidMolecular weight:445.942-Methyl-N,N-dimethyltryptamine
CAS:2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.Formula:C13H18N2Color and Shape:SolidMolecular weight:202.3Phenylethanolamine A
CAS:Phenylethanolamine A is a β-adrenergic agonist and a byproduct of the Ractopamine synthesis process.Formula:C19H24N2O4Color and Shape:SolidMolecular weight:344.40α-CGRP(human)
CAS:Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.Formula:C163H267N51O49S2Purity:98%Color and Shape:SolidMolecular weight:3789.33RF9 acetate
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.Formula:C28H42N6O5Purity:99.77%Color and Shape:SolidMolecular weight:542.67Ref: TM-T16738L
1mg65.00€5mg125.00€10mg182.00€25mg325.00€50mg467.00€100mg645.00€200mg868.00€1mL*10mM (DMSO)167.00€GLP-1R agonist 14
CAS:GLP-1R agonist 14, also known as Compound 14, is a potent agonist of the GLP-1 receptor, demonstrating an EC50 range of 0-20 nM against human GLP-1 [1].Formula:C45H42F2N10O5Color and Shape:SolidMolecular weight:840.88Adrenomedullin (16-31), human TFA
Human adrenomedullin (16-31) TFA, fragment 16-31, binds CGRP1 receptor, raises rat blood pressure, not cats’.Formula:C84H130F3N25O23S2Color and Shape:SolidMolecular weight:1979.21Spns2-IN-2
Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.Formula:C22H30ClN3O2Color and Shape:SolidMolecular weight:403.95APJ receptor agonist 1
CAS:Potent APJ-R agonist 1, biphenyl acid, EC50: 0.093 nM (human), 0.12 nM (rat), targets apelin-13, promising for heart failure study.Formula:C31H26ClN3O3Color and Shape:SolidMolecular weight:524.02GLP-1 receptor agonist 9 citrate
<p>GLP-1 receptor agonist 9 citrate is an agonist of GLP-1.</p>Formula:C38H39ClFN3O12Purity:98.76%Color and Shape:SolidMolecular weight:784.18Angiopeptin TFA
CAS:Angiopeptin TFA: somatostatin analogue, sst2/sst5 partial agonist (IC50: 0.26/6.92 nM), suppresses GH & IGF-1, for atherosclerosis research.Formula:C58H73F6N11O14S2Color and Shape:SolidMolecular weight:1326.39Amylin (8-37), human
CAS:Human-derived Amylin (8-37) is a vasodilator in rat arteries and forms aggregates linked to type II diabetes.Formula:C138H216N42O45Color and Shape:SolidMolecular weight:3183.495RFRP-3(human)
CAS:NPFF1 receptor agonist, IC50 0.7 nM, blocks cAMP by forskolin. A GnIH homolog, it inhibits GnRH neuron activity.Formula:C45H72N14O10Purity:98%Color and Shape:SolidMolecular weight:969.15Semaglutide TFA
Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels and reduces cardiovascular risk in diabetic patientsFormula:C189H290F3N45O61Purity:99.69% - 99.94%Color and Shape:SolidMolecular weight:4225.6482Amylin (IAPP), feline TFA
<p>Amylin (IAPP), feline TFA: 37-amino acid peptide; inhibits insulin/glucagon; secreted by pancreatic β-cells.</p>Formula:C167H271F3N52O56S2Color and Shape:SolidMolecular weight:4024.47
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