GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5745 products of "GPCR/G-Protein"

Purity (%)

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ANQ-11125 TFA
ANQ-11125 TFA is a motilin antagonist with a pKd of 8.24, inhibiting motilide contractions in rabbits.
Formula:C₈₈H₁₂₆F₃N₁₉O₂₃
Color and Shape:Solid
Molecular weight:1875.05
Ref: TM-T75861
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Upidosin
CAS:
- 152735-23-4
Upidosin (SB-216469), a uroselective α1 blocker: Ki α1a=0.34 nM, α1b=3.9 nM, α1d=1.5 nM, α2=33.3 nM.
Formula:C₃₁H₃₃N₃O₄
Purity:99.66%
Color and Shape:Solid
Molecular weight:511.61
Ref: TM-T9762
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BMS-753426
CAS:
- 1004536-52-0
BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formula:C₂₅H₃₃F₃N₆O₂
Color and Shape:Solid
Molecular weight:506.574
Ref: TM-T38397
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MGV354
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
Formula:C₃₅H₃₇N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:575.7
Ref: TM-T12888
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Neuropeptide Y (18-36) (porcine)
CAS:
- 114495-97-5
"Neuropeptide Y (18-36) (porcine) is a NPY heart receptor blocker, halts I-NPY binding, aids in heart failure research."
Formula:C₁₁₂H₁₇₄N₃₆O₂₇
Color and Shape:Solid
Molecular weight:2456.8
Ref: TM-T76357
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AR ligand 40
AR ligand 40 (compound 19c) is an Adenosine A1 Receptor ligand with antagonistic activity. It exhibits antiproliferative effects on SW480, SW48, HCT116, K562, MDA-MB-231, and A549 cells, with EC50 values of 7, 10, 12, 13, 15, and 39 μM, respectively.
Formula:C₂₁H₂₅N₅
Color and Shape:Solid
Molecular weight:347.211
Ref: TM-T207383
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K-(D-1-Nal)-FwLL-NH2 TFA
K-(D-1-Nal)-FwLL-NH2 TFA: potent ghrelin inverse agonist; Ki=4.9 nM (COS7), 31 nM (HEK293T); blocks Gq/G13 signaling.
Formula:C₅₃H₆₈F₃N₉O₈
Color and Shape:Solid
Molecular weight:1016.16
Ref: TM-T75948
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Neurokinin Receptor (393-407), rat
CAS:
- 153607-26-2
Rat NK1R fragment (393-407) binds SP, enabling endocytosis and plasma membrane recycling; key in neurogenic inflammation research.
Formula:C₇₂H₁₁₃N₁₇O₂₆S₂
Color and Shape:Solid
Molecular weight:1696.9
Ref: TM-T76429
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PAR-4 Agonist Peptide, amide
CAS:
- 352017-71-1
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
Formula:C₃₄H₄₈N₈O₇
Purity:98%
Color and Shape:Solid
Molecular weight:680.79
Ref: TM-T7623
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Neuropeptide Y (3-36) (porcine)
CAS:
- 143863-88-1
Neuropeptide Y (3-36) (porcine) is a potent, selective agonist at NPY Y2 receptors, increasing feeding in rats.
Formula:C₁₇₆H₂₇₁N₅₃O₅₄
Color and Shape:Solid
Molecular weight:3993.36
Ref: TM-T76355
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(Ala13)-Apelin-13 TFA
'(Ala13)-Apelin-13 TFA acts as a potent antagonist of the apelin receptors (APJ) and impedes gastric motility via the vagal cholinergic pathway [1].'
Formula:C₆₃H₁₀₇N₂₃O₁₆S·xC₂HF₃O₂
Color and Shape:Solid
Molecular weight:1474.73 (free acid)
Ref: TM-T78109
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Colulintide
CAS:
- 2891912-36-8
Colulintide is an analog of amylin, utilized in obesity research.
Color and Shape:Solid
Ref: TM-TP3252
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8-iso Prostaglandin E2 isopropyl ester
CAS:
- 330589-21-4
8-iso PGE2 isopropyl ester: lipophilic, hydrolyzes to acid in vivo, used as prodrug, less active than parent acid.
Formula:C₂₃H₃₈O₅
Color and Shape:Solid
Molecular weight:394.54
Ref: TM-T36161
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GLP-1 moiety from Dulaglutide
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist.
Formula:C₁₄₉H₂₂₁N₃₇O₄₉
Purity:98%
Color and Shape:Solid
Molecular weight:3314.62
Ref: TM-TP1316
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LH-RH (7-10)
CAS:
- 38482-71-2
LH-RH (7-10), a tetrapeptide, is a key LHRH degradation product found in macrophages and pneumocytes.
Formula:C₁₉H₃₆N₈O₄
Color and Shape:Solid
Molecular weight:440.54
Ref: TM-T76353
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Human growth hormone-releasing factor TFA
Human growth hormone-releasing factor TFA is a hypothalamic peptide that promotes GH secretion by targeting pituitary GHRHR.
Formula:C₂₁₇H₃₅₉F₃N₇₂O₆₈S
Color and Shape:Solid
Molecular weight:5153.67
Ref: TM-T75713
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PF-4348235 HCl
PF-4348235 HCl (β2AR/M-receptor agonist-2 HCl) is a muscarinic M3 receptor antagonist (Ki: 0.73 nM) and β2 adrenergic receptor agonist (MABA, EC50: 3.7 nM). PF-4348235 HCl is also a bronchial BM213 acetate is a bronchodilator used to study cardiovascular and respiratory diseases such as chronic obstructive pulmonary disease (COPD).
Formula:C₃₆H₅₀Cl₂N₄O₇S
Purity:98.81%
Color and Shape:Solid
Molecular weight:753.78
Ref: TM-T72226L
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Tetrahydro-β-carboline
CAS:
- 16502-01-5
Compound Fr12161, with CAS No. 16502-01-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12161 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
Formula:C₁₁H₁₂N₂
Purity:96.31%
Color and Shape:Tan Solid
Molecular weight:172.2264
Ref: TM-Fr12161
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1,2,3-Trilinoelaidoyl-rac-glycerol
CAS:
- 5188-25-0
1,2,3-Trilinoelaidoyl-glycerol is a TAG with linoelaidic acid; reduces rat serum thromboxane B2, PGF2, and PGE.
Formula:C₅₇H₉₈O₆
Color and Shape:Solid
Molecular weight:879.405
Ref: TM-T37383
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MRS 2365
CAS:
- 436847-09-5
Highly potent, selective P2Y1 receptor agonist
Formula:C₁₃H₁₉N₅O₉P₂S
Purity:98%
Color and Shape:Solid
Molecular weight:483.33
Ref: TM-T23022
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Plecanatide acetate
CAS:
- 1075732-84-1
Plecanatide acetate: GC-C receptor agonist, EC50=190 nM (T84 cells), anti-inflammatory in murine colitis.
Formula:C₆₇H₁₀₈N₁₈O₂₈S₄
Purity:98%
Color and Shape:Solid
Molecular weight:1741.94
Ref: TM-T12501
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MCUF-651
CAS:
- 2747162-85-0
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
Formula:C₁₇H₂₂F₂N₄OS
Purity:99.83%
Color and Shape:Soild
Molecular weight:368.44
Ref: TM-T67734
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CH-0076989
CAS:
- 954371-52-9
CH-0076989 is a chemokine receptor CCR3 agonist.
Formula:C₂₄H₂₂Br₂N₂O₂
Color and Shape:Solid
Molecular weight:530.25
Ref: TM-T30865
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U92016A
CAS:
- 136924-88-4
U92016A is a highly potent and selective agonist of 5-HT1A receptor.
Formula:C₁₉H₂₅N₃
Purity:98%
Color and Shape:Solid
Molecular weight:295.42
Ref: TM-T29035
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MrgprX2 antagonist-2
CAS:
- 2642346-30-1
MrgprX2 antagonist-2, from patent WO2021092262A1 E163, is potent for skin inflammation studies.
Formula:C₁₇H₁₆F₅N₃O₃
Color and Shape:Solid
Molecular weight:405.325
Ref: TM-T40273
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12-epi Leukotriene B4
CAS:
- 83709-73-3
LTB4 is made enzymatically (12(R)-specific) and non-enzymatically (6-trans-12-epi mix). 12-epi LTB4 has low receptor activity.
Formula:C₂₀H₃₂O₄
Color and Shape:Solid
Molecular weight:336.472
Ref: TM-T37970
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Ecnoglutide
CAS:
- 2459531-73-6
Ecnoglutide (XW003) is a glucagon-like peptide 1 (GLP-1) receptor agonist [1] .
Formula:C₁₉₄H₃₀₄N₄₈O₆₁
Color and Shape:Solid
Molecular weight:4284.76
Ref: TM-T76234
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Linzagolix choline
CAS:
- 1321816-57-2
Linzagolix choline is a GnRH antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.
Formula:C₂₇H₂₈F₃N₃O₈S
Purity:99.64%
Color and Shape:Solid
Molecular weight:611.59
Ref: TM-T25742
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Ularitide
CAS:
- 118812-69-4
Ularitide is a 32-amino acid peptide from ANP prohormone, resistant to dog kidney cortex peptidase.
Formula:C₁₄₅H₂₃₄N₅₂O₄₄S₃
Purity:98%
Color and Shape:Solid
Molecular weight:3505.97
Ref: TM-TP2357
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A71378
CAS:
- 127902-33-4
A71378 is a high potency, selectivity CCK-A receptors agonist.
Formula:C₄₈H₆₂N₈O₁₃S
Purity:98%
Color and Shape:Solid
Molecular weight:991.12
Ref: TM-T26484
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Physalaemin
CAS:
- 2507-24-6
Physalaemin is a non-mammalian tachykinin.
Formula:C₅₈H₈₄N₁₄O₁₆S
Purity:98%
Color and Shape:Solid
Molecular weight:1265.45
Ref: TM-T19518
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ECPLA
CAS:
- 2349367-50-4
ECPLA is an LSD analog and a potent 5-HT2A agonist (EC50 of 14.6 nM), capable of stimulating Gq-mediated calcium flux. It exhibits high affinity for most serotonin receptors, α2-adrenergic receptors, and D2-like dopamine receptors.
Formula:C₂₁H₂₅N₃O
Color and Shape:Solid
Molecular weight:335.44
Ref: TM-T203569
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Albiglutide Fragment
CAS:
- 782500-75-8
Albiglutide fragment is a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
Formula:C₁₄₈H₂₂₄N₄₀O₄₅
Purity:98%
Color and Shape:Solid
Molecular weight:3283.6
Ref: TM-TQ0004
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Sarafotoxin S6a
CAS:
- 126738-34-9
Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
Formula:C₁₀₅H₁₅₆N₂₈O₃₄S₅
Purity:98%
Color and Shape:Solid
Molecular weight:2514.85
Ref: TM-TP2119
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CCK (26-30) (sulfated)
CAS:
- 89911-69-3
CCK (26-30) is a digestive and satiety-related peptide fragment inhibiting [125I]CCK-33 binding by 10% at 0.1 mM.
Formula:C₃₃H₄₁N₇O₁₂S₂
Color and Shape:Solid
Molecular weight:791.85
Ref: TM-T37203
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L-703606 oxalate hydrate
L-703606 oxalate hydrate is an effective, selective NK1 receptor antagonist. It is utilized in research related to gastric acid secretion.
Ref: TM-T89016
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Prostaglandin F2α Alcohol
CAS:
- 13261-27-3
Prostaglandin F2α Alcohol is a PGF2α (T15133) analogue. Prostaglandin F2α Alcohol is an orally active prostaglandin F receptor (FP receptor) agonist.
Formula:C₂₀H₃₆O₄
Color and Shape:Solid
Molecular weight:340.5
Ref: TM-T38197
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(+)-Oxypeucedanin methanolate
CAS:
- 52939-12-5
(+)-Oxypeucedanin methanolate (compound 9) is a natural compound that inhibits prostaglandin E2 production [1].
Formula:C₁₇H₁₈O₆
Color and Shape:Solid
Molecular weight:318.32
Ref: TM-T75620
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JNJ-40929837 succinate
CAS:
- 1191044-47-9
JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].
Formula:C₂₂H₂₄N₄O₂S·xC₄H₆O₄
Color and Shape:Solid
Ref: TM-T86771
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CMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-
Color and Shape:Odour Solid
Ref: TM-T82703
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BIM-23190 hydrochloride
BIM-23190 hydrochloride, somatostatin analog, SSRT2/5 agonist, Ki: 0.34 nM (SSTR2), 11.1 nM (SSTR5). Used in cancer, acromegaly research.
Color and Shape:Liquid
Ref: TM-T37109
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ALEPH hydrochloride
CAS:
- 61638-08-2
ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.
Formula:C₁₂H₂₀ClNO₂S
Color and Shape:Solid
Molecular weight:277.81
Ref: TM-T203157
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Pasireotide pamoate
CAS:
- 396091-79-5
Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.
Formula:C₈₁H₈₂N₁₀O₁₅
Purity:98%
Color and Shape:Solid
Molecular weight:1435.58
Ref: TM-T12369
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Yohimbic acid, ethyl ester
CAS:
- 73840-32-1
Yohimbic acid, ethyl ester is a biochemical with possible effects on reserpine action.
Formula:C₂₂H₂₈N₂O₃
Color and Shape:Solid
Molecular weight:368.47
Ref: TM-T29193
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EP4 receptor antagonist 3
CAS:
- 1207954-34-4
EP4 receptor antagonist 3 from patent WO2010019796 A1 targets EP4 for research on pain, arthritis, and cancer.
Formula:C₂₆H₂₁F₃N₂O₃S
Color and Shape:Solid
Molecular weight:498.52
Ref: TM-T38595
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L-threo Lysosphingomyelin (d18:1)
CAS:
- 105615-55-2
L-threo Lysosphingomyelin, a natural S1P receptor agonist, has EC50s: 19.3 nM (hS1P1), 131.8 nM (hS1P3), 313.3 nM (hS1P2).
Formula:C₂₃H₄₉N₂O₅P
Color and Shape:Solid
Molecular weight:464.62
Ref: TM-T38452
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HS024 TFA
HS024, a selective MC4 receptor antagonist, exhibits affinity with Ki values of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1 receptors, respectively
Formula:C₆₀H₈₀F₃N₁₉O₁₂S₂
Color and Shape:Solid
Molecular weight:1380.52
Ref: TM-T75852
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GR231118
CAS:
- 158859-98-4
Potent NPY Y1 antagonist & Y4 agonist; inhibits rat appetite; binds to NPFF receptors (Ki: 43-73 nM).
Formula:C₁₁₀H₁₇₀N₃₄O₂₄
Purity:98%
Color and Shape:Lyophilized Powder
Molecular weight:2352.77
Ref: TM-TP2022
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Flunarizine
CAS:
- 52468-60-7
Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.
Formula:C₂₆H₂₆F₂N₂
Purity:99.9%
Color and Shape:Solid
Molecular weight:404.50
Ref: TM-T21392
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Luseogliflozin hydrate
CAS:
- 1152425-66-5
Luseogliflozin hydrate: SGLT2 inhibitor, IC50 2.26 nM, oral, for type 2 diabetes research.
Formula:C₂₃H₃₂O₇S
Color and Shape:Solid
Molecular weight:452.56
Ref: TM-T38539