GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5745 products of "GPCR/G-Protein"

Purity (%)

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VIP36
VIP36 is an agonist of the cannabinoid type 1 receptor (CB1) with analgesic properties. It reduces the recruitment of inhibitory proteins, thereby exerting its pain-relieving effects, and is applicable in research related to chronic pain.
Formula:C₂₇H₃₅FN₆O₄
Color and Shape:Solid
Molecular weight:526.603
Ref: TM-T206705
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Prostaglandin F2α 1,11-lactone
CAS:
- 62410-84-8
Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) is a lipid-soluble prodrug of Prostaglandin F2α and can be used in studies about treating glaucoma.
Formula:C₂₀H₃₂O₄
Purity:98%
Color and Shape:Solid
Molecular weight:336.47
Ref: TM-T37326
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GRL018-21
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].
Color and Shape:Odour Solid
Ref: TM-T82258
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Acetyl neurotensin (8-13)
CAS:
- 74853-69-3
Acetyl neurotensin (8-13), the most concise analog of neurotensin, retains complete binding and pharmacological properties [1].
Formula:C₄₀H₆₆N₁₂O₉
Molecular weight:859.03
Ref: TM-T76572
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INCB 3284 dimesylate
CAS:
- 887401-93-6
INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.
Formula:C₂₈H₃₉F₃N₄O₁₀S₂
Purity:98%
Color and Shape:Solid
Molecular weight:712.76
Ref: TM-T11647
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Imelciment
CAS:
- 2845128-03-0
Imelciment (REGN-9035) is a humanised monoclonal antibody targeting NPR1, which can be used for research into heart failure.
Purity:95%
Color and Shape:Soild
Ref: TM-T9901A-366
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α-MSH acetate
α-MSH acetate is an endogenous neuromodulatory peptide derived from POMC and an agonist of MC4R (melanocortin receptor 4).
Purity:99.71%
Color and Shape:Odour Solid
Ref: TM-T7813L
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Cannabidiolic acid methyl ester
CAS:
- 55658-71-4
Cannabidiolic acid methyl ester (HU-580) is an orally active analogue of cannabidiolic acid. It enhances the activation of 5-HT1A receptors and increases the expression of c-Fos and NeuN in specific hypothalamic nuclei in rats. Cannabidiolic acid methyl ester exhibits anti-nausea, anxiolytic, and anti-nociceptive effects.
Formula:C₂₃H₃₂O₄
Color and Shape:Solid
Molecular weight:372.5
Ref: TM-T203571
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(R)-Zevaquenabant
(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.
Color and Shape:Odour Solid
Ref: TM-TYD-02102
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12(S)-HpEPE
CAS:
- 103239-14-1
12(S)-HpEPE, a fatty acid created by 12-lipoxygenase on EPA, has unclear biological activities but may resemble 12(S)-HpETE.
Formula:C₂₀H₃₀O₄
Color and Shape:Solid
Molecular weight:334.456
Ref: TM-T37968
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Poly-D-lysine hydrobromide (MW 1000-5000)
Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.
Color and Shape:Odour Solid
Ref: TM-TCL-01108
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Linaclotide acetate
CAS:
- 851199-60-5
Linaclotide acetate, an oral guanylate cyclase C agonist with 14 amino acids, treats constipation-predominant IBS and chronic constipation.
Formula:C₆₁H₈₃N₁₅O₂₃S₆
Purity:98%
Color and Shape:Solid
Molecular weight:1586.79
Ref: TM-T11852L
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D5R agonist 1
D5R Agonist 1 (Compound 5j) is a selective, orally active partial agonist of the D5 receptor that can penetrate the blood-brain barrier (EC50: 269.7 nM). It has been demonstrated to enhance cognitive abilities in a scopolamine-induced amnesia model.
Color and Shape:Odour Solid
Ref: TM-T200501
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Efranarelaxin alfa
CAS:
- 2969217-22-7
Efranarelaxin alfa is an agonist of the relaxin receptor. It shows potential for research in cardiovascular diseases and tissue repair.
Color and Shape:Liquid
Ref: TM-T9901A-865
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20-Carboxy-Leukotriene B4
CAS:
- 80434-82-8
20-COOH LTB4, a metabolite of LTB4, binds BLT1 receptor and inhibits LTB4-induced neutrophil responses.
Formula:C₂₀H₃₀O₆
Color and Shape:Solid
Molecular weight:366.45
Ref: TM-T73793
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Poly-D-lysine hydrobromide (MW 150000-300000)
Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.
Color and Shape:Odour Solid
Ref: TM-TCL-01090
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FR 113680
CAS:
- 126088-92-4
FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.
Formula:C₃₅H₃₉N₅O₆
Purity:98%
Color and Shape:Solid
Molecular weight:625.726
Ref: TM-T27360
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4-fluoro MBZP
CAS:
- 144734-44-1
4-fluoro MBZP is a novel psychoactive substance in the phenylpiperazine class, utilized for studies on the 5-HT2 receptors in the central nervous system.
Formula:C₁₂H₁₇FN₂
Color and Shape:Solid
Molecular weight:208.28
Ref: TM-T203276
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Urotensin I
CAS:
- 83930-33-0
Urotensin I, 41-aa neuropeptide, agonist for human/rat CRF receptors, lowers blood pressure in rats, isolated from white suckers.
Formula:C₂₁₀H₃₄₀N₆₂O₆₇S₂
Purity:98%
Color and Shape:Solid
Molecular weight:4869.46
Ref: TM-TP1199
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tBPC
CAS:
- 1942-71-8
Enhances Y4R response to PP, NPY & PYY with EC50 of 0.03, 0.4, 0.5 nM; selective for Y4R over Y1R, Y2R, Y5R.
Formula:C₁₆H₂₄O₂
Color and Shape:Solid
Molecular weight:248.36
Ref: TM-T37528
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GS-2278
CAS:
- 2750508-72-4
GS-2278 is an antagonist of LPAR1 (lysophosphatidic acid receptor 1) with potential applications in the study of idiopathic pulmonary fibrosis (IPF).
Formula:C₂₂H₁₆F₅N₉O₃
Color and Shape:Solid
Molecular weight:549.41
Ref: TM-T203480
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β-MSH, human
CAS:
- 17908-57-5
beta-MSH, human is an endogenous peptide hormone and neurotransmitter by POMC, an agonist of MC4-R (melanocortin 4 receptor).
Formula:C₁₁₈H₁₇₄N₃₄O₃₅S
Purity:98%
Color and Shape:Solid
Molecular weight:2660.92
Ref: TM-TP1004
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Veldoreotide
CAS:
- 252845-37-7
Veldoreotide (Somatoprim): a somatostatin analogue targeting receptors 2, 4, 5, reduces GH in pituitary adenomas.
Formula:C₆₀H₇₄N₁₂O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:1123.3
Ref: TM-TP2420
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ACTH (34-39)
CAS:
- 69454-10-0
ACTH (34-39) is an adrenocorticotropic hormone fragment.
Formula:C₃₇H₅₀N₆O₉
Purity:98%
Color and Shape:Solid
Molecular weight:722.83
Ref: TM-TP1751
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WS 9326A
CAS:
- 125774-71-2
WS 9326A is an antagonist of tachykinin receptor from Streptomyces violaceusniger.
Formula:C₅₄H₆₈N₈O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1037.181
Ref: TM-T26333
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Peptide 401
CAS:
- 32908-73-9
Peptide 401: AMP from bee/wasp venom, triggers histamine release, reduces paw swelling.
Formula:C₁₁₀H₁₉₂N₄₀O₂₄S₄
Purity:98%
Color and Shape:Solid
Molecular weight:2587.22
Ref: TM-TP1408
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Adrenomedullin (11-50), rat
CAS:
- 163648-32-6
Adrenomedullin 11-50 rat is a peptide, stimulates CGRP1 receptor for vasodilation, used in bone growth research.
Formula:C₁₉₄H₃₀₄N₅₈O₅₉S₄
Purity:98%
Color and Shape:Solid
Molecular weight:4521.17
Ref: TM-TP1625
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DOTA-EB-TATE
DOTA-EB-TATE is formed by combining the SST peptide derivative DOTA-octreotate with an Evans blue analog (EB). This peptide drug conjugate (PDC) enhances the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. Additionally, DOTA-EB-TATE serves in the synthesis/research of radiopharmaceutical conjugates (RDC).
Formula:C₁₀₅H₁₃₃N₂₁O₃₀S₅
Molecular weight:2329.63
Ref: TM-TP2996
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PAR-4 Agonist Peptide, amide acetate
PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).
Formula:C₃₆H₅₂N₈O₉
Purity:98%
Color and Shape:Solid
Molecular weight:740.86
Ref: TM-T7623L
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5-Bromoimidazo[1,2-A]Pyrazine
CAS:
- 87597-26-0
5-Bromoimidazo[1,2-a]pyrazine inhibits phosphodiesterase and beta-adrenergic receptors.5-Bromoimidazo[1,2-a]pyrazine shows antibronchospastic activity in vitro.
Formula:C₆H₄BrN₃
Purity:99.92%
Color and Shape:Solid
Molecular weight:198.02
Ref: TM-T77641
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Prolactin-Releasing Peptide (12-31), rat
CAS:
- 222988-10-5
Prolactin-Releasing Peptide (12-31), rat, a fragment of PrRP, exhibits high affinity for GPR10 receptors and stimulates calcium mobilization in CHOK1 cells
Formula:C₁₀₄H₁₅₈N₃₂O₂₆
Molecular weight:2272.57
Ref: TM-T81391
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[Leu31,Pro34]-Neuropeptide Y(human,rat)
CAS:
- 132699-73-1
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.
Formula:C₁₈₉H₂₈₄N₅₄O₅₆S
Purity:98%
Color and Shape:Solid
Molecular weight:4241
Ref: TM-TP1985
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LY83583
CAS:
- 91300-60-6
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
Formula:C₁₅H₁₀N₂O₂
Purity:99.54% - 99.80%
Color and Shape:Solid
Molecular weight:250.25
Ref: TM-T21576
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Anti-TSHR Antibody (M22)
Anti-TSHR Antibody (M22) is a humanized IgG1 monoclonal antibody targeting the thyroid-stimulating hormone receptor (TSHR). This antibody is capable of inhibiting the interaction between TSH and TSHR.
Color and Shape:Odour Liquid
Ref: TM-T9901A-942
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Fabesetron
CAS:
- 129300-27-2
Fabesetron (FK1052): oral dual antagonist for 5-HT3/5-HT4 receptors. Aids in managing acute and delayed chemo-induced emesis.
Formula:C₁₈H₁₉N₃O
Color and Shape:Solid
Molecular weight:293.37
Ref: TM-T38692
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Dipivefrin
CAS:
- 52365-63-6
Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.
Formula:C₁₉H₂₉NO₅
Color and Shape:Solid
Molecular weight:351.44
Ref: TM-T0103L
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Pellotine
CAS:
- 19622-05-0
Pellotine is an alkaloid isolated from Lophophora. It acts as an inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with an EC50 of 291 nM. Pellotine shows strong affinity for the 5-HT1DR and 5-HT6R, with Ki values of 117 nM and 170 nM, respectively. Additionally, Pellotine reduces intracellular cAMP levels, thereby decreasing neuronal excitability and neurotransmitter release.
Formula:C₁₃H₁₉NO₃
Color and Shape:Solid
Molecular weight:237.295
Ref: TM-TN9164
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5-MeO-pyr-T
CAS:
- 3949-14-2
5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) acts as a 5-HT1AR agonist, exhibiting Ki values of 0.577 μM and 373 μM for 5-HT1AR and 5-HT2AR, respectively. It inhibits the reuptake of 5-HT and triggers its release. Additionally, 5-MeO-pyr-T can induce reduced motor activity.
Formula:C₁₅H₂₀N₂O
Color and Shape:Solid
Molecular weight:244.33
Ref: TM-T203568
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CB2R/FAAH modulator-3
CAS:
- 2876918-67-9
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH.
Formula:C₂₂H₃₁NO₂
Purity:99.81%
Color and Shape:Soild
Molecular weight:341.49
Ref: TM-T67747
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JKC363
CAS:
- 436083-30-6
MC4 receptor antagonist; IC50: 0.5 nM (MC4), 44.9 nM (MC3). Blocks α-MSH, reduces TRH, food intake, and pain.
Formula:C₆₉H₉₁N₁₉O₁₆S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1506.72
Ref: TM-TP2011
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Cortistatin-8
CAS:
- 485803-62-1
ghrelin receptor antagonist
Formula:C₄₇H₆₈N₁₂O₉S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1009.25
Ref: TM-TP2236
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NSC380324
NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.
Formula:C₃₁H₂₄N₄O₄
Color and Shape:Solid
Molecular weight:516.55
Ref: TM-T205528
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Cianopramine hydrochloride
CAS:
- 66834-20-6
Cianopramine hydrochloride is a bio-active chemical.
Formula:C₂₀H₂₄ClN₃
Color and Shape:Solid
Molecular weight:341.88
Ref: TM-T30929
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Neuropeptide Y (1-24) (human)
CAS:
- 131448-51-6
Neuropeptide Y (1-24) inhibits rat vas deferens twitch and activates NMDA-induced neurons in rat hippocampus.
Formula:C₁₁₆H₁₇₀N₃₀O₄₀S
Molecular weight:2656.83
Ref: TM-T76358
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PZ-128
CAS:
- 371131-16-7
PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.
Formula:C₅₅H₉₉N₁₃O₉
Purity:98%
Color and Shape:Solid
Molecular weight:1086.46
Ref: TM-T28477
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Bombinakinin M acetate
Bombinakinin M acetate is a potent bradykinin receptor agonist with high selectivity for mammalian arterial smooth muscle bradykinin receptors and is
Formula:C₁₀₂H₁₆₃N₃₁O₂₆
Purity:99.80%
Color and Shape:Solid
Molecular weight:2239.58
Ref: TM-TP2075L
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Oxyntomodulin
CAS:
- 62340-29-8
GLP-1 analog modulates appetite, boosts metabolism, and curbs gastric acid. Increases cAMP, mildly stimulates glucagon receptor.
Formula:C₁₉₂H₂₉₅N₅₉O₆₀S
Purity:98%
Color and Shape:Solid
Molecular weight:4421.86
Ref: TM-TP1976
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4-Chloromethamphetamine hydrochloride
CAS:
- 30572-91-9
4-Chloromethamphetamine hydrochloride is a novel psychoactive substance belonging to the amphetamine class.
Formula:C₁₀H₁₅Cl₂N
Color and Shape:Solid
Molecular weight:220.14
Ref: TM-T203542
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(Rac)-Norcisapride
CAS:
- 84946-16-7
Norcisapride, a 5-HT3 and 5-HT4 agonist, treats GI, orofacial, and ENT disorders.
Formula:C₁₄H₂₀ClN₃O₃
Purity:99.32%
Color and Shape:Soild
Molecular weight:313.78
Ref: TM-T68116L
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S 16474
CAS:
- 149250-10-2
S 16474 is an antagonist of Neurokinin-1 Receptor.
Formula:C₄₄H₄₈N₆NaO₈
Purity:98%
Color and Shape:Solid
Molecular weight:811.892
Ref: TM-T26169