CymitQuimica logo
GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5378 products of "GPCR/G-Protein"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • L-796,778 acetate
    Targetmol
    + Info

    L-796,778 acetate

    <p>L-796,778 acetate is a slective somatostatin receptor agonist with IC50 of 24nM for sst3, for sst1, sst2, sst4 and sst5, IC50 is &gt;1000nM.</p>
    Formula:C31H44N6O9
    Purity:98%
    Color and Shape:Soild
    Molecular weight:644.72

    Ref: TM-T32511L

  • [Nle11]-Substance P
    Targetmol
    + Info

    [Nle11]-Substance P

    CAS:
    <p>'[Nle11]-Substance P is a gut and brain peptide, resisting methionine oxidation and causing excitatory neural effects.'</p>
    Formula:C64H100N18O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1329.59

    Ref: TM-TP1831

  • JNJ-10181457 (hydrochloride)
    Targetmol
    + Info

    JNJ-10181457 (hydrochloride)

    CAS:
    <p>JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations</p>
    Formula:C20H30Cl2N2O
    Color and Shape:Solid
    Molecular weight:385.37

    Ref: TM-T37220

  • Galantide
    Targetmol
    + Info

    Galantide

    CAS:
    <p>Galantide is a reversible and non-specific antagonist of galanin receptor.</p>
    Formula:C104H151N25O26S
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2199.53

    Ref: TM-T15368

  • HAEGTFTSDVS acetate
    Targetmol
    + Info

    HAEGTFTSDVS acetate

    <p>HAEGTFTSDVS acetate is the first N-terminal 1-11 residues of GLP-1 which stimulates insulin secretion from pancreatic β-cells.</p>
    Formula:C50H75N13O22
    Purity:97.47%
    Color and Shape:Solid
    Molecular weight:1210.2

    Ref: TM-TP1382L

  • Latanoprost lactone diol
    Targetmol
    + Info

    Latanoprost lactone diol

    CAS:
    Latanoprost lactone diol, a key intermediate for synthesizing Latanoprost (a prostaglandin F2α analogue), lowers IOP by activating FP receptors.
    Formula:C18H24O4
    Purity:98%
    Color and Shape:White Or Almost White Crystalline Powder
    Molecular weight:304.38

    Ref: TM-T11821

  • Brexpiprazole S-oxide
    Targetmol
    + Info

    Brexpiprazole S-oxide

    CAS:
    <p>Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).</p>
    Formula:C25H27N3O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:449.57

    Ref: TM-T10612

  • [Des-Arg9]-Bradykinin
    Targetmol
    + Info

    [Des-Arg9]-Bradykinin

    CAS:
    <p>[Des-Arg9]-Bradykinin ([Des-Arg9]-Bradykinin(2TFA))(2TFA) is an agonist of Bradykinin (B1) receptor.</p>
    Formula:C44H61N11O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:904.02

    Ref: TM-T7645

  • LH-RH (7-10)
    Targetmol
    + Info

    LH-RH (7-10)

    CAS:
    LH-RH (7-10), a tetrapeptide, is a key LHRH degradation product found in macrophages and pneumocytes.
    Formula:C19H36N8O4
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T76353

  • Pexopiprant
    Targetmol
    + Info

    Pexopiprant

    CAS:
    <p>Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.</p>
    Formula:C21H17Cl2F2NO4
    Color and Shape:Solid
    Molecular weight:456.27

    Ref: TM-T41073

  • CymitQuimica logo
    Targetmol
    + Info

    NSC380324

    <p>NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.</p>
    Formula:C31H24N4O4
    Color and Shape:Solid
    Molecular weight:516.55

    Ref: TM-T205528

  • Eledoisin Related Peptide
    Targetmol
    + Info

    Eledoisin Related Peptide

    CAS:
    <p>Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand.</p>
    Formula:C34H58N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:706.94

    Ref: TM-T7631

  • 5-OMe-UDP trisodium salt
    Targetmol
    + Info

    5-OMe-UDP trisodium salt

    CAS:
    <p>Potent P2Y6 agonist</p>
    Formula:C10H16N2O13P2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.19

    Ref: TM-T22525

  • SR142948A
    Targetmol
    + Info

    SR142948A

    CAS:
    <p>SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.</p>
    Formula:C39H52ClN5O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:722.31

    Ref: TM-T28845

  • CymitQuimica logo
    Targetmol
    + Info

    5-HT1AR/5-HT6R ligand-1

    <p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>
    Formula:C25H29ClN4O2S
    Color and Shape:Solid
    Molecular weight:485.04

    Ref: TM-T205634

  • Tiaprost
    Targetmol
    + Info

    Tiaprost

    CAS:
    Tiaprost is a analog of prostaglandin F2α .
    Formula:C20H28O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:396.5

    Ref: TM-T17092

  • ACT-1016-0707
    Targetmol
    + Info

    ACT-1016-0707

    CAS:
    <p>ACT-1016-0707 is a selective, insurmountable LPA1 antagonist with antifibrotic and anti-inflammatory activity in lung fibrosis models</p>
    Formula:C19H23ClN4O4S
    Purity:99.905%
    Color and Shape:Solid
    Molecular weight:438.93

    Ref: TM-T85589

  • IRL-3630
    Targetmol
    + Info

    IRL-3630

    CAS:
    <p>IRL 3460 is an enantiomer.</p>
    Formula:C31H40N4O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:596.74

    Ref: TM-T25541

  • ELA-21 (human)
    Targetmol
    + Info

    ELA-21 (human)

    CAS:
    <p>Apelin receptor agonist with high affinity for normal/PAH hearts (pKi 9.31/9.46). Blocks cAMP, promotes β-arrestin in vitro. Part of ELA-32.</p>
    Formula:C112H184N40O25S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2587.12

    Ref: TM-TP2096

  • CymitQuimica logo
    Targetmol
    + Info

    (Pro34)-Peptide YY (human)

    CAS:
    <p>(Pro34)-Peptide YY (human) is a highly Y 1 -selective full agonist of Peptide YY /neuropeptide Y receptors [1] .</p>
    Formula:C194H294N54O56
    Color and Shape:Solid
    Molecular weight:4278.73

    Ref: TM-T76441

  • CymitQuimica logo
    Targetmol
    + Info

    P2Y14R antagonist 3

    <p>P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases.</p>
    Formula:C26H25N5O5
    Color and Shape:Solid
    Molecular weight:487.51

    Ref: TM-T205281

  • CymitQuimica logo
    Targetmol
    + Info

    Hemokinin 1, human TFA

    <p>Hemokinin-1 is a human TFA and selective NK1 agonist; also activates NK2 &amp; NK3 and induces opioid-independent analgesia.</p>
    Formula:C56H85F3N14O16S
    Color and Shape:Solid
    Molecular weight:1299.42

    Ref: TM-T75840

  • LE 300
    Targetmol
    + Info

    LE 300

    CAS:
    <p>LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.</p>
    Formula:C20H22N2
    Purity:97.91% - 98.79%
    Color and Shape:Solid
    Molecular weight:290.4

    Ref: TM-T22921

  • DSP-1053
    Targetmol
    + Info

    DSP-1053

    CAS:
    <p>Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity.</p>
    Formula:C26H32BrNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:502.44

    Ref: TM-T11107

  • 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-me…
    Targetmol
    + Info

    4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine

    CAS:
    <p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>
    Formula:C27H28ClFN2OS
    Purity:99.02%
    Color and Shape:Soild
    Molecular weight:483.04

    Ref: TM-T60126

  • CymitQuimica logo
    Targetmol
    + Info

    Orexin B, rat, mouse TFA

    <p>Orexin B, rat/mouse TFA, activates OX1-R &amp; OX2-R receptors, influencing food intake, energy, and sleep regulation.</p>
    Formula:C128H216F3N45O36S
    Color and Shape:Solid
    Molecular weight:3050.42

    Ref: TM-T75925

  • MrgprX2 antagonist-3
    Targetmol
    + Info

    MrgprX2 antagonist-3

    CAS:
    <p>MrgprX2 antagonist-3 (compound E117) is a MrgprX2 antagonist applicable for investigating cutaneous inflammation.</p>
    Formula:C16H20FN3O2S
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:337.41

    Ref: TM-T40271

  • Piperulin A
    Targetmol
    + Info

    Piperulin A

    CAS:
    <p>Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,</p>
    Formula:C23H28O6
    Color and Shape:Solid
    Molecular weight:400.46

    Ref: TM-T79950

  • (+)-Oxypeucedanin methanolate
    Targetmol
    + Info

    (+)-Oxypeucedanin methanolate

    CAS:
    <p>(+)-Oxypeucedanin methanolate (compound 9) is a natural compound that inhibits prostaglandin E2 production [1].</p>
    Formula:C17H18O6
    Color and Shape:Solid
    Molecular weight:318.32

    Ref: TM-T75620

  • Phenylethanolamine A
    Targetmol
    + Info

    Phenylethanolamine A

    CAS:
    <p>Phenylethanolamine A is a β-adrenergic agonist and a byproduct of the Ractopamine synthesis process.</p>
    Formula:C19H24N2O4
    Color and Shape:Solid
    Molecular weight:344.40

    Ref: TM-T38741

  • CCK Octapeptide, non-sulfated acetate
    Targetmol
    + Info

    CCK Octapeptide, non-sulfated acetate

    <p>CCK Octapeptide, non-sulfated acetate is a synthetic desulfated peptide of cholecystokinin.</p>
    Formula:C51H66N10O15S2
    Purity:98.9700%
    Color and Shape:Solid
    Molecular weight:1123.26

    Ref: TM-TP2204L

  • [D-Phe12,Leu14]-Bombesin
    Targetmol
    + Info

    [D-Phe12,Leu14]-Bombesin

    CAS:
    <p>Bombesin receptor blocker; stops binding in rat brain (IC50=2 μM), hinders amylase release (IC50=4 μM), reduces appetite suppression in vivo.</p>
    Formula:C77H113F3N22O20
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1724.9

    Ref: TM-TP1916

  • CymitQuimica logo
    Targetmol
    + Info

    CGRP antagonist 6

    <p>CGRP Antagonist 6 (Compound 23) is a potent CGRP receptor antagonist (Ki: 0.84 nM). It is utilized in the study of migraines.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200460

  • [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
    Targetmol
    + Info

    [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

    CAS:
    <p>Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.</p>
    Formula:C79H109N19O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1516.85

    Ref: TM-TP1931

  • AR-C126313
    Targetmol
    + Info

    AR-C126313

    CAS:
    <p>AR-C126313 is a thiouracil derivative.</p>
    Formula:C28H23N7O3S
    Color and Shape:Solid
    Molecular weight:537.59

    Ref: TM-T30120

  • CymitQuimica logo
    Targetmol
    + Info

    Neuropeptide S(Mouse) TFA

    <p>Neuropeptide S(Mouse) TFA: Endogenous NPSR agonist, EC50 3 nM, boosts Ca2+, activity, wakefulness, and lowers mouse anxiety.</p>
    Formula:C92H157F3N34O29
    Color and Shape:Solid
    Molecular weight:2296.49

    Ref: TM-T75950

  • Serazapine
    Targetmol
    + Info

    Serazapine

    CAS:
    <p>Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders.</p>
    Formula:C22H23N3O2
    Purity:98.71% - 99.57%
    Color and Shape:Solid
    Molecular weight:361.44

    Ref: TM-T68142

  • Maceneolignan H
    Targetmol
    + Info

    Maceneolignan H

    CAS:
    <p>Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.</p>
    Formula:C24H30O7
    Color and Shape:Solid
    Molecular weight:430.49

    Ref: TM-T75499

  • GLP-2(1-33)(human)
    Targetmol
    + Info

    GLP-2(1-33)(human)

    CAS:
    GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.
    Formula:C165H254N44O55S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3766.19

    Ref: TM-TP1157

  • CymitQuimica logo
    Targetmol
    + Info

    Guanylin(human) TFA

    <p>Guanylin (human) TFA, a 15-amino acid peptide, activates intestinal guanylate cyclase, regulating electrolyte and water transport via cGMP.</p>
    Color and Shape:Liquid

    Ref: TM-T37960

  • Kassinin
    Targetmol
    + Info

    Kassinin

    CAS:
    <p>Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.</p>
    Formula:C59H95N15O18S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1334.54

    Ref: TM-TP1738

  • CymitQuimica logo
    Targetmol
    + Info

    MAO-B-IN-3

    <p>MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki</p>
    Formula:C24H25N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.47

    Ref: TM-T78648

  • α1A-AR Degrader 9c
    Targetmol
    + Info

    α1A-AR Degrader 9c

    CAS:
    <p>α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM.</p>
    Formula:C38H43N11O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:829.82

    Ref: TM-T74557

  • 5-HT7R antagonist 1 free base
    Targetmol
    + Info

    5-HT7R antagonist 1 free base

    CAS:
    <p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>
    Formula:C14H17ClN4
    Color and Shape:Solid
    Molecular weight:276.77

    Ref: TM-T39870

  • CymitQuimica logo
    Targetmol
    + Info

    DOTA-LM3 TFA

    <p>DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2.</p>
    Formula:C71H94ClF3N16O21S2
    Color and Shape:Solid
    Molecular weight:1664.18

    Ref: TM-T78110

  • JNJ-40929837 succinate
    Targetmol
    + Info

    JNJ-40929837 succinate

    CAS:
    <p>JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].</p>
    Formula:C22H24N4O2S·xC4H6O4
    Color and Shape:Solid

    Ref: TM-T86771

  • HAEGT
    Targetmol
    + Info

    HAEGT

    CAS:
    <p>HAEGT is the first N-terminal 1-5 residues of GLP-1 peptide.</p>
    Formula:C20H31N7O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:513.5

    Ref: TM-TP1381

  • CymitQuimica logo
    Targetmol
    + Info

    U-46619 serinol amide

    <p>U-46619 serinol amide is a derivative of U-46619, acting as a stable analog of Thromboxane A2 (TXA2). It effectively functions as a TXA2 agonist, capable of inducing platelet shape change and aggregation.</p>
    Formula:C24H41NO5
    Color and Shape:Solid
    Molecular weight:423.29847

    Ref: TM-T207554

  • Triazolomethylindole-3-acetic acid
    Targetmol
    + Info

    Triazolomethylindole-3-acetic acid

    CAS:
    <p>Triazolomethylindole-3-acetic acid is a metabolite of Rizatriptan, which acts as an agonist for the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.</p>
    Formula:C13H12N4O2
    Color and Shape:Solid
    Molecular weight:256.26

    Ref: TM-T203624

  • CymitQuimica logo
    Targetmol
    + Info

    PG106 TFA

    <p>PG106 TFA is a potent hMC3 antagonist (IC50=210 nM), inactive at hMC4 (EC50=9900 nM) and hMC5 receptors.</p>
    Formula:C53H70F3N13O11
    Color and Shape:Solid
    Molecular weight:1122.2

    Ref: TM-T75848