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GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

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  • Danshenol B
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    Danshenol B

    <p>Danshenol B is a natural product that can be used as a reference standard.</p>
    Formula:C22H26O4
    Color and Shape:Solid
    Molecular weight:354.446

    Ref: TM-T125490

  • RXFP3/4 agonist 1
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    RXFP3/4 agonist 1

    CAS:
    <p>RXFP3/4 agonist 1 is a relaxin family peptide 3/4 receptor (RXFP3/4) agonist(EC50s of 82/2 nM, respectivley).</p>
    Formula:C20H22ClN5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.88

    Ref: TM-T12785

  • Neuropeptide W-30 (rat)
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    Neuropeptide W-30 (rat)

    CAS:
    <p>Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].</p>
    Formula:C165H249N49O38S
    Color and Shape:Solid
    Molecular weight:3559.11

    Ref: TM-TP2611

  • Pancreatic Polypeptide, human
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    Pancreatic Polypeptide, human

    CAS:
    <p>Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract.</p>
    Formula:C185H287N53O54S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4181.71

    Ref: TM-TP1137

  • Pasireotide
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    Pasireotide

    CAS:
    Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).
    Formula:C58H66N10O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1047.21

    Ref: TM-T12370

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    MAO-B-IN-3

    <p>MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki</p>
    Formula:C24H25N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.47

    Ref: TM-T78648

  • Relamorelin TFA
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    Relamorelin TFA

    CAS:
    <p>Relamorelin (RM-131) TFA: ghrelin analog, GHSR agonist, 0.42 nM affinity, boosts growth hormone, enhances gastric emptying, potential in motility disorders.</p>
    Formula:C45H51F3N8O7S
    Color and Shape:Solid
    Molecular weight:905

    Ref: TM-T75262

  • Pasireotide ditrifluoroacetate
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    Pasireotide ditrifluoroacetate

    <p>Pasireotide is a stable cyclohexapeptide somatostatin mimic.</p>
    Formula:C62H68F6N10O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1275.25

    Ref: TM-T13811

  • Succinate/succinate receptor antagonist 1
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    Succinate/succinate receptor antagonist 1

    CAS:
    <p>Potent succinate receptor antagonist with IC50 of 20 μM; blocks gingival succinate signaling, may treat periodontal disease.</p>
    Formula:C17H15N3O
    Purity:99.53%
    Color and Shape:Soild
    Molecular weight:277.32

    Ref: TM-T67915

  • 11β-Prostaglandin E2
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    11β-Prostaglandin E2

    CAS:
    <p>11β-PGE2 is the C-11 epimer of PGE2.</p>
    Formula:C20H32O5
    Color and Shape:Solid
    Molecular weight:352.47

    Ref: TM-T36144

  • Fluphenazine free base
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    Fluphenazine free base

    CAS:
    <p>Flufenazine: antipsychotic for schizophrenia, blocks dopamine D2 receptors, reduces hallucinations and delusions.</p>
    Formula:C22H26F3N3OS
    Color and Shape:Solid
    Molecular weight:437.52

    Ref: TM-T0068L2

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    Neuropeptide SF(mouse,rat) TFA

    <p>Neuropeptide SF TFA is a potent agonist for NPFF1 (Ki=48.4 nM) and NPFF2 (Ki=12.1 nM) and enhances ASIC3 current.</p>
    Formula:C42H66F3N13O12
    Color and Shape:Solid
    Molecular weight:1002.05

    Ref: TM-T75865

  • SGLT1/2-IN-2
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    SGLT1/2-IN-2

    CAS:
    <p>SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).</p>
    Formula:C23H26F2O7
    Color and Shape:Solid
    Molecular weight:452.451

    Ref: TM-T39966

  • α-Helical CRF(9-41)
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    α-Helical CRF(9-41)

    CAS:
    <p>Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).</p>
    Formula:C166H274N46O53S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3827

    Ref: TM-TP2048

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    Utreglutide

    CAS:
    <p>Utreglutide is a potent glucagon-like peptide 1 (GLP-1) receptor agonit [1] .</p>
    Formula:C191H298N46O58
    Color and Shape:Solid
    Molecular weight:4166.67

    Ref: TM-T76237

  • (R)-Preclamol hydrochloride
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    (R)-Preclamol hydrochloride

    CAS:
    <p>(R)-Preclamol HCl is a dopamine agonist stimulating both auto and postsynaptic receptors.</p>
    Formula:C14H22ClNO
    Color and Shape:Solid
    Molecular weight:255.78

    Ref: TM-T73685

  • CymitQuimica logo
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    Selepressin acetate

    <p>Selepressin acetate is a useful organic compound for research related to life sciences and the catalog number is T73654.</p>
    Formula:C48H77N13O13S2
    Color and Shape:Solid
    Molecular weight:1108.33

    Ref: TM-T73654

  • CymitQuimica logo
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    Pancreatic polypeptide TFA

    <p>Pancreatic polypeptide TFA acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.</p>
    Color and Shape:Odour Solid

    Ref: TM-TP2887

  • (Iso)-Landipirdine
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    (Iso)-Landipirdine

    CAS:
    <p>(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist.</p>
    Formula:C18H19FN2O3S
    Purity:98.50%
    Color and Shape:Soild
    Molecular weight:362.42

    Ref: TM-T27795L

  • PAMP-12(human, porcine)
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    PAMP-12(human, porcine)

    CAS:
    Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.
    Formula:C77H119N25O14
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1618.95

    Ref: TM-TP1880

  • Adenosine 3'-monophosphate (sodium salt hydrate)
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    Adenosine 3'-monophosphate (sodium salt hydrate)

    <p>Adenosine 3'-monophosphate (sodium salt hydrate) (3'-AMP) is a nucleotide and cAMP-generating agonist that elevates cAMP levels in NG108-15 cells.</p>
    Formula:C10H15N5NaO8P
    Color and Shape:Solid
    Molecular weight:387.22

    Ref: TM-T35571

  • Neuropeptide Y (13-36), amide, human
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    Neuropeptide Y (13-36), amide, human

    CAS:
    <p>Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.</p>
    Formula:C134H207N41O36S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3000.4

    Ref: TM-TP1081

  • 1a,1b-dihomo Prostaglandin E1
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    1a,1b-dihomo Prostaglandin E1

    CAS:
    <p>1a,1b-dihomo Prostaglandin E1 is a class of prostaglandin compounds.</p>
    Formula:C22H38O5
    Color and Shape:Solid
    Molecular weight:382.541

    Ref: TM-T36219

  • CymitQuimica logo
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    Dulaglutide

    CAS:
    <p>Dulaglutide (LY2189265) is a GLP-1 receptor agonist for studying type 2 diabetes mellitus (T2DM).</p>
    Color and Shape:Solid

    Ref: TM-T75718

  • CymitQuimica logo
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    P2Y6R antagonist 1

    <p>P2Y6R antagonist 1 (compound 5ab) is a selective, orally active antagonist of P2Y6R, featuring an IC50 value of 19.6 nM. This compound also exhibits anti-inflammatory properties.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200515

  • Icatibant
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    Icatibant

    CAS:
    <p>Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).</p>
    Formula:C59H89N19O13S
    Purity:98%
    Color and Shape:White Solid
    Molecular weight:1304.52

    Ref: TM-T15547

  • Elabela(19-32)
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    Elabela(19-32)

    CAS:
    <p>APJ receptor agonist with Ki of 0.93 nM, derived from ELA-32, activates Gαi1, β-arrestin-2, lowers rat heart arterial pressure, effective in vivo.</p>
    Formula:C75H119N25O17S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1707.03

    Ref: TM-TP1923

  • Pramlintide
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    Pramlintide

    CAS:
    <p>Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.</p>
    Color and Shape:Solid

    Ref: TM-T38998

  • CymitQuimica logo
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    HDAC6-IN-49

    <p>HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200554

  • ELA-11(human)
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    ELA-11(human)

    CAS:
    <p>Apelin receptor agonist with high affinity (Ki = 14 nM). Blocks cAMP production and promotes β-arrestin activation; derived from ELA-32.</p>
    Formula:C58H90N16O13S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1283.57

    Ref: TM-TP1922

  • CymitQuimica logo
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    TGR5 agonist 1

    <p>Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].</p>
    Formula:C28H48NNaO6S
    Color and Shape:Solid
    Molecular weight:549.74

    Ref: TM-T74824

  • MRS2500 tetraammonium
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    MRS2500 tetraammonium

    CAS:
    <p>Highly potent and selective antagonist of the platelet P2Y1 receptor</p>
    Formula:C13H21IN6O8P2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:578.19

    Ref: TM-T23023

  • Adrenocorticotropic Hormone (ACTH) (1-39), rat
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    Adrenocorticotropic Hormone (ACTH) (1-39), rat

    CAS:
    ACTH (1-39), rat: potent MC2 agonist, forms fragments in vitro, isolated by HPLC, characterized by amino acids and NH2-terminus.
    Formula:C210H315N57O57S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4582.23

    Ref: TM-TP1249

  • Cortistatin 14, human, rat
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    Cortistatin 14, human, rat

    CAS:
    <p>Cortistatin 14: a neuropeptide similar to somatostatin; induces sleep, depresses neuronal activity; found in cortex, hippocampus.</p>
    Formula:C81H113N19O19S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1721.01

    Ref: TM-TP1188

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    Amylin, amide, human TFA

    <p>Amylin, a 37-amino acid human hormone, moderates glucose regulation by reducing glucagon, delaying digestion, and increasing satiety.</p>
    Formula:C167H262F3N51O57S2
    Color and Shape:Solid
    Molecular weight:4017.3

    Ref: TM-T75787

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    CCZ01048 TFA

    CCZ01048 TFA, α-MSH analog, binds MC1R with 0.31 nM affinity, internalizes in melanoma cells, and is stable for melanoma PET imaging.
    Formula:C73H106F3N21O18
    Color and Shape:Solid
    Molecular weight:1622.75

    Ref: TM-T76072L

  • GLP-1R agonist 14
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    GLP-1R agonist 14

    CAS:
    <p>GLP-1R agonist 14, also known as Compound 14, is a potent agonist of the GLP-1 receptor, demonstrating an EC50 range of 0-20 nM against human GLP-1 [1].</p>
    Formula:C45H42F2N10O5
    Color and Shape:Solid
    Molecular weight:840.88

    Ref: TM-T74608

  • PACAP (1-27), human, ovine, rat
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    PACAP (1-27), human, ovine, rat

    CAS:
    PACAP (1-27) (the N-terminal fragment of PACAP-38) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
    Formula:C142H224N40O39S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3147.66

    Ref: TM-TP1070

  • CB1R agonist 1
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    CB1R agonist 1

    <p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>
    Formula:C20H18F3N3O3S
    Color and Shape:Solid
    Molecular weight:437.435

    Ref: TM-T206337

  • Stressin I
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    Stressin I

    <p>Potent CRF1 agonist; Ki: 1.5 nM (CRF1), 224 nM (CRF2). Boosts ACTH, enhances stool frequency after i.p. administration.</p>
    Formula:C203H337N57O56
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4472.24

    Ref: TM-TP2125

  • Cortistatin 14, human, rat acetate
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    Cortistatin 14, human, rat acetate

    Cortistatin 14, human, rat acetate is a neuropeptide having structural similarity to somatostatin-14 and shows anticonvulsive, neuroprotective effects and
    Formula:C80H112N18O19S2
    Purity:97.86%
    Color and Shape:Solid
    Molecular weight:1693.98

    Ref: TM-TP1188L

  • PHM-27 (human)
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    PHM-27 (human)

    CAS:
    <p>Human-derived peptide, VIP/PHM 27 analog, boosts insulin by targeting calcitonin receptor with an EC50 of 11 nM.</p>
    Formula:C135H214N34O40S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2985.44

    Ref: TM-TP1954

  • Mapenterol hydrochloride
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    Mapenterol hydrochloride

    CAS:
    <p>Mapenterol hydrochloride is an agonist of β2-adrenergic receptor.</p>
    Formula:C14H21Cl2F3N2O
    Purity:98.11% - 99.98%
    Color and Shape:Solid
    Molecular weight:361.23

    Ref: TM-T40622

  • CAY10606
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    CAY10606

    CAS:
    <p>CAY10606 has a wide range of applications in life science related research.</p>
    Formula:C22H18ClNO3
    Color and Shape:Solid
    Molecular weight:379.84

    Ref: TM-T37353

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    SAR441255

    SAR441255 is a potent unimolecular peptide that acts as a GLP-1/GIP/GCG receptor triagonist, demonstrating balanced activation across all three target receptors
    Color and Shape:Odour Solid

    Ref: TM-T81214

  • Sar-[D-Phe8]-des-Arg9-Bradykinin
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    Sar-[D-Phe8]-des-Arg9-Bradykinin

    CAS:
    <p>Potent bradykinin B1 agonist, EC50 = 9.02 nM, enzyme resistant, induces hypotension and angiogenesis.</p>
    Formula:C47H66N12O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:975.11

    Ref: TM-TP1917

  • A6770
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    A6770

    CAS:
    <p>A6770 inhibits S1P lyase, causing [3H]dhS1P build-up in IT-79MTNC3 cells (EC50 &lt;0.01 μM); less effective with vitamin B6 (EC50 &lt;100 μM).</p>
    Formula:C6H8N2O2
    Color and Shape:Solid
    Molecular weight:140.142

    Ref: TM-T36833

  • CCR4 antagonist 3
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    CCR4 antagonist 3

    CAS:
    <p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>
    Formula:C24H27Cl2N7O
    Color and Shape:Solid
    Molecular weight:500.43

    Ref: TM-T39661

  • MRS 2365
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    MRS 2365

    CAS:
    <p>Highly potent, selective P2Y1 receptor agonist</p>
    Formula:C13H19N5O9P2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:483.33

    Ref: TM-T23022

  • Substance P (alligator)
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    Substance P (alligator)

    CAS:
    <p>Substance P from alligator: a neuropeptide with structure Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.</p>
    Formula:C63H98N20O13S
    Color and Shape:Solid
    Molecular weight:1375.64

    Ref: TM-T76449