GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5745 products of "GPCR/G-Protein"

Purity (%)

100

products per page.

+ Info
Biotin-NeurokininA
Biotin-NeurokininA: biotinylated peptide, NK-2 receptor agonist, key in human airway and gut function.
Formula:C₆₀H₉₄N₁₆O₁₆S₂
Color and Shape:Solid
Molecular weight:1359.61
Ref: TM-T76435
+ Info
SSTR4 agonist-1
CAS:
- 1638588-92-7
SSTR4agonist-1 (Compound 47) is a selective agonist of the somatostatin receptor 4 (SSTR4), with an EC50 of 4.7 nM. It has a half-life of over 130 minutes in human liver microsomes.
Formula:C₁₆H₂₃N₃O₂
Color and Shape:Solid
Molecular weight:289.37
Ref: TM-T203033
+ Info
Terazosin dimer impurity dihydrochloride
CAS:
- 1486464-41-8
Terazosin dimer impurity dihydrochloride is a chemical byproduct of the α1-antagonist Terazosin, derived from quinazoline.
Formula:C₂₄H₃₀Cl₂N₈O₄
Color and Shape:Solid
Molecular weight:565.46
Ref: TM-T37817
+ Info
(Leu31,Pro34)-Peptide YY (human) (TFA)
"(Leu31,Pro34)-Peptide YY (human) (TFA) is the trifluoroacetic acid (TFA) form of (Leu31,Pro34)-Peptide YY (human), a derivative of Peptide YY that acts as a
Formula:C₁₉₅H₂₉₆N₅₄O₅₆·xC₂HF₃O₂
Purity:98%
Color and Shape:Solid
Molecular weight:4292.75 (free base)
Ref: TM-T80087
+ Info
Galanin (1-15) (porcine, rat)
CAS:
- 112747-70-3
N-terminal galanin fragment used to mediate central cardiovascular effects
Formula:C₇₂H₁₀₅N₁₉O₂₀
Purity:98%
Color and Shape:Solid
Molecular weight:1556.72
Ref: TM-TP2250
+ Info
A3AR agonist 1
A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective
Formula:C₂₈H₃₄N₆O₆
Purity:98%
Color and Shape:Solid
Molecular weight:550.61
Ref: TM-T79372
+ Info
5-HT6R antagonist 6
5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.
Formula:C₂₄H₂₆N₄O₂S
Color and Shape:Solid
Molecular weight:434.55
Ref: TM-T205194
+ Info
CB2 PET Radioligand 1
CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.
Formula:C₂₀H₁₉F₃N₄O
Purity:98%
Color and Shape:Solid
Molecular weight:388.39
Ref: TM-T79577
+ Info
Pancreatic Polypeptide, rat
CAS:
- 90419-12-8
Rat Pancreatic Polypeptide: 36-amino acid peptide, NPYR4 agonist, secreted by islet PP cells.
Formula:C₁₉₅H₂₉₈N₅₈O₅₇S
Purity:98%
Color and Shape:Solid
Molecular weight:4398.87
Ref: TM-TP1044
+ Info
GRK2i
CAS:
- 148505-03-7
GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
Formula:C₁₅₃H₂₅₆N₅₀O₄₁S
Purity:98%
Color and Shape:Solid
Molecular weight:3484.08
Ref: TM-TP2025
+ Info
Amylin (1-37), human acetate
Amylin (1-37), human acetate, a peptide hormone containing 37 amino acids secreted by the pancreas in conjunction with insulin, inhibits glucagon secretion.
Purity:96.21%
Color and Shape:Odour Solid
Ref: TM-T76480L
+ Info
Desglymidodrine
CAS:
- 3600-87-1
Desglymidodrine (ST 1059) is an α1-adrenoceptor agonist and vasoconstrictor, used in cardiovascular research and neurocardiogenic syncope studies.
Formula:C₁₀H₁₅NO₃
Purity:99.56%
Color and Shape:Solid
Molecular weight:197.23
Ref: TM-T31388L
+ Info
Alosetron
CAS:
- 122852-42-0
Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.
Formula:C₁₇H₁₈N₄O
Purity:98%
Color and Shape:Crystalline Powder
Molecular weight:294.36
Ref: TM-T21235
+ Info
11β-Prostaglandin E2
CAS:
- 38310-90-6
11β-PGE2 is the C-11 epimer of PGE2.
Formula:C₂₀H₃₂O₅
Color and Shape:Solid
Molecular weight:352.47
Ref: TM-T36144
+ Info
Vanicoside E
CAS:
- 208707-91-9
Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine and L-DOPA with IC 50 s of 45.23 μM and 189.96 μM, respectively [1] [2] .
Formula:C₅₃H₅₂O₂₂
Color and Shape:Solid
Molecular weight:1040.97
Ref: TM-T75563
+ Info
des-Gln14-Ghrelin TFA
Des-Gln14-Ghrelin TFA, a ligand for GHSR, boosts [Ca2+]i with an EC50 of 2.4 nM in CHO-GHSR62 cells.
Formula:C₁₄₄H₂₃₈F₃N₄₃O₄₂
Color and Shape:Solid
Molecular weight:3300.69
Ref: TM-T75928
+ Info
Neurokinin A(4-10) TFA
Neurokinin A (4-10) TFA is a tachykinin NK 2 receptor agonist [1] .
Formula:C₃₆H₅₅F₃N₈O₁₂S
Color and Shape:Solid
Molecular weight:880.93
Ref: TM-T75742
+ Info
FR167344 free base
CAS:
- 215258-13-2
FR167344 free base: oral, nonpeptide B2 bradykinin receptor antagonist, high-affinity (IC50: 65 nM), no B1 affinity.
Formula:C₃₀H₂₈BrCl₂N₅O₄
Purity:98%
Color and Shape:Solid
Molecular weight:673.38
Ref: TM-T15347
+ Info
Neuropeptide AF (cattle)
CAS:
- 99588-52-0
Neuropeptide AF (cattle) is an RFamide that acts on MrgprA4 (~60 nM), MrgprC11 (~300 nM), NPFF1 (~25-325 nM), NPFF2 (~1-5 nM), and modulates pain.
Formula:C₈₉H₁₃₀N₂₄O₂₄
Color and Shape:Solid
Molecular weight:1920.13
Ref: TM-T76423
+ Info
Tirzepatide TFA
Tirzepatide TFA, a GIP and GLP-1 agonist, targets type 2 diabetes treatment.
Formula:C₂₂₇H₃₄₉F₃N₄₈O₇₀
Color and Shape:Solid
Molecular weight:4927.47
Ref: TM-T76006
+ Info
Iloperidone metabolite P95
CAS:
- 475110-48-6
Iloperidone metabolite P95, a non-brain penetrating compound, binds 5-HT2A, α1-, α2B-, α2C-receptors with Ki of 7.08-83.18 nM.
Formula:C₂₃H₂₅FN₂O₅
Color and Shape:Solid
Molecular weight:428.46
Ref: TM-T36661
+ Info
OXA(17-33) TFA
OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).
Formula:C₈₁H₁₂₆F₃N₂₃O₂₄
Color and Shape:Solid
Molecular weight:1863
Ref: TM-T75922
+ Info
meta-Fluoxetine (hydrochloride)
CAS:
- 79088-29-2
meta-Fluoxetine (hydrochloride) can be used in related research in the field of life sciences. Its product number is T37474 and CAS number is 79088-29-2.
Formula:C₁₇H₁₉ClF₃NO
Color and Shape:Solid
Molecular weight:345.79
Ref: TM-T37474
+ Info
Lys-[Hyp3]-Bradykinin
CAS:
- 113662-39-8
Lys-[Hyp3]-Bradykinin, a human urine-derived kinin and bradykinin agonist, is used for inflammation research.
Formula:C₅₆H₈₅N₁₇O₁₃
Color and Shape:Solid
Molecular weight:1204.38
Ref: TM-T76293
+ Info
(D-Arg8)-Inotocin
CAS:
- 745816-74-4
'(D-Arg8)-Inotocin is a potent, selective, and competitive antagonist of the vasopressin receptor (V 1a R), exhibiting a binding affinity (K i) of 1.3 nM.
Formula:C₃₉H₆₈N₁₄O₁₁S₂
Purity:98%
Color and Shape:Solid
Molecular weight:973.17
Ref: TM-T80138
+ Info
[Deamino-Pen1,Val4,D-Arg8]-vasopressin
CAS:
- 64158-84-5
[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP).
Formula:C₄₈H₆₉N₁₃O₁₁S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1068.27
Ref: TM-T83501
+ Info
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
CAS:
- 129520-65-6
Potent VP V1R antagonist, lowers rat MAP: '(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin'.
Formula:C₅₄H₇₆N₁₄O₁₁
Color and Shape:Solid
Molecular weight:1097.27
Ref: TM-T76633
+ Info
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
CAS:
- 86073-88-3
LH-RH: a hypothalamus-made pituitary hormone, key in reproductive control.
Formula:C₆₀H₇₃N₁₅O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1212.31
Ref: TM-TP1112
+ Info
3-Deoxyglucosone
CAS:
- 4084-27-9
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein
Formula:C₆H₁₀O₅
Purity:95%
Color and Shape:Solid
Molecular weight:162.14
Ref: TM-T19117
+ Info
SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective oral non-peptide NT antagonist, IC50 <4 nM, with brain penetration and potential for psychiatric research.
Formula:C₃₉H₅₃Cl₂N₅O₆
Color and Shape:Solid
Molecular weight:758.77
Ref: TM-T73677
+ Info
Semaglutide TFA
Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels and reduces cardiovascular risk in diabetic patients
Formula:C₁₈₉H₂₉₀F₃N₄₅O₆₁
Purity:99.69%
Color and Shape:Solid
Molecular weight:4225.6482
Ref: TM-T12878
+ Info
FR252384
CAS:
- 447405-11-0
FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM).
Formula:C₁₈H₁₇N₃
Purity:98%
Color and Shape:Solid
Molecular weight:275.35
Ref: TM-T10514
+ Info
Chemerin-9, Mouse
CAS:
- 686324-96-9
Chemokine-like receptor 1 (CMKLR1) agonist (EC50 = 42 nM). Corresponds to C-terminal of full length mouse Chemerin, amino acids 148 - 156.
Formula:C₅₁H₆₈N₁₀O₁₂
Color and Shape:Solid
Molecular weight:1013.163
Ref: TM-T37128
+ Info
N-Desmethyl Pimavanserin
CAS:
- 639863-77-7
N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin and is used in the treatment of insomnia and other sleep disorders.
Formula:C₂₄H₃₂FN₃O₂
Purity:98.02%
Color and Shape:Solid
Molecular weight:413.53
Ref: TM-T37979
+ Info
Spns2-IN-1
Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune
Purity:98%
Color and Shape:Odour Solid
Ref: TM-T81114
+ Info
5-HT6R antagonist 1
Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability
Formula:C₁₇H₂₂F₂N₆O
Purity:98%
Color and Shape:Solid
Molecular weight:364.39
Ref: TM-T79684
+ Info
Protease-Activated Receptor-1, PAR-1 Agonist TFA
PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.
Color and Shape:Liquid
Ref: TM-T36288
+ Info
Pramlintide TFA
Pramlintide TFA, a polypeptide analogue of human amylin and an antidiabetic agent, exhibits antineoplastic properties in colorectal cancer [1].
Formula:C₁₇₃H₂₆₈N₅₁F₃O₅₅S₂
Color and Shape:Solid
Molecular weight:4063.4
Ref: TM-T75709
+ Info
6β-Prostaglandin I1
CAS:
- 62770-50-7
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions.
Formula:C₂₀H₃₄O₅
Color and Shape:Solid
Molecular weight:354.487
Ref: TM-T36239
+ Info
(Trp7,β-Ala8)-Neurokinin A (4-10)
CAS:
- 132041-95-3
(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist [1] .
Formula:C₄₁H₅₇N₉O₁₀S
Color and Shape:Solid
Molecular weight:868.01
Ref: TM-T76635
+ Info
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
CAS:
- 149270-28-0
'[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)' is a selective NK2R agonist with prokinetic activity for smooth muscle studies.
Formula:C₃₉H₆₄N₈O₁₀
Color and Shape:Solid
Molecular weight:804.97
Ref: TM-T76426
+ Info
NR2E3 agonist 1
CAS:
- 911211-69-3
NR2E3 agonist 1 is an NR2E3 agonist with antitumor activity and can be used to study diseases caused by NR2E3 abnormalities.
Formula:C₂₄H₁₉ClN₄O₂
Purity:98.88%
Color and Shape:Soild
Molecular weight:430.89
Ref: TM-T84349
+ Info
Fenoldopam
CAS:
- 67227-56-9
Fenoldopam is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM).
Formula:C₁₆H₁₆ClNO₃
Purity:98%
Color and Shape:Solid
Molecular weight:305.76
Ref: TM-T22779
+ Info
Neuropeptide Y (2-36) (porcine)
CAS:
- 102961-52-4
Porcine Neuropeptide Y (2-36) is 97.14% similar to rat/human, an agonist for Y5, Y2, Y1 receptors, used in obesity research.
Formula:C₁₈₁H₂₇₈N₅₄O₅₅
Color and Shape:Solid
Molecular weight:4090.47
Ref: TM-T76356
+ Info
Cyclosomatostatin TFA
Cyclosomatostatin TFA blocks SST receptor, reduces CRC cell growth, ALDH+ size, and sphere-formation.
Formula:C₄₆H₅₈F₃N₇O₈
Color and Shape:Solid
Molecular weight:893.99
Ref: TM-T75842
+ Info
Adrenomedullin (AM) (22-52), human acetate
Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an
Formula:C₁₆₁H₂₅₆N₄₆O₅₀
Purity:99.42%
Color and Shape:Solid
Molecular weight:3636.09
Ref: TM-TP1257L
+ Info
Sauvagine TFA
Sauvagine TFA: frog-derived, 40-amino-acid CRF agonist; stimulates ACTH release, affects diuresis, cardiovascular system, endocrine glands.
Formula:C₂₀₄H₃₄₇F₃N₅₆O₆₅S₁
Color and Shape:Solid
Molecular weight:4713.33
Ref: TM-T75894
+ Info
CMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-
Color and Shape:Odour Solid
Ref: TM-T82703
+ Info
A6770
CAS:
- 1331754-16-5
A6770 inhibits S1P lyase, causing [3H]dhS1P build-up in IT-79MTNC3 cells (EC50 <0.01 μM); less effective with vitamin B6 (EC50 <100 μM).
Formula:C₆H₈N₂O₂
Color and Shape:Solid
Molecular weight:140.142
Ref: TM-T36833
+ Info
Human follicular gonadotropin releasing peptide
CAS:
- 107873-08-5
Human Follicular Gonadotropin Releasing Peptide (hF-GRP) is a hormonal peptide that, in vitro, can induce the secretion of pituitary luteinizing hormone (LH)
Formula:C₆₈H₉₄N₂₂O₂₇
Molecular weight:1651.61
Ref: TM-T82162