GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(3,031 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5963 products of "GPCR/G-Protein"
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rac Desmethyl Citalopram Hydrochloride
CAS:rac Desmethyl Citalopram Hydrochloride is a 5-hydroxy tryptamine uptake inhibitor with IC50 value of 0.013 μM.Formula:C19H20ClFN2OPurity:99.24%Color and Shape:SolidMolecular weight:346.83MCUF-651
CAS:MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.Formula:C17H22F2N4OSPurity:99.83%Color and Shape:SoildMolecular weight:368.44Ref: TM-T67734
1mg56.00€5mg118.00€10mg178.00€25mg344.00€50mg557.00€100mg790.00€1mL*10mM (DMSO)126.00€LY 344864 racemate
CAS:LY 344864 racemate is a 5-HT1F receptor agonist.Formula:C21H22FN3OPurity:99.75%Color and Shape:SoildMolecular weight:351.42(Ala13)-Apelin-13 acetate
(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.Formula:C65H111N23O18SPurity:98%Color and Shape:SolidMolecular weight:1534.79Ref: TM-T35374L
2mg116.00€5mg166.00€10mg259.00€25mg492.00€50mg740.00€100mg1,110.00€200mg1,668.00€500mg3,167.00€(Phe2,Orn8)-Oxytocin acetate
(Phe2,Orn8)-Oxytocin acetate: V1 agonist with EC50 of 280 nM for rabbit epididymis contractility.Formula:C44H69N13O13S2Color and Shape:SolidMolecular weight:1052.23CART(55-102)(rat) TFA
Rat CART(55-102) TFA suppresses appetite, links to leptin/neuropeptide Y, and may induce anxiety/stress.Formula:C228H368F3N65O67S7Color and Shape:SolidMolecular weight:5373.215(S)-15-methyl Prostaglandin F2α methyl ester
CAS:15(S)-15-methyl Prostaglandin F2α methyl ester can be used in related research in the field of life sciences.Formula:C22H38O5Color and Shape:SolidMolecular weight:382.53Pramlintide
CAS:Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.Color and Shape:SolidAZ7976
CAS:AZ7976 (Compound 42), a potent and highly selective agonist for Relaxin Family Peptide Receptor 1 (RXFP1) with a pEC 50 value greater than 10.5, operates through an allosteric mechanism to enhance RXFP1's cAMP signaling, which physiologically elevates heart rate. This property makes AZ7976 a valuable tool in cardiovascular disease research [1].Formula:C30H33F7N2O6SColor and Shape:SolidMolecular weight:682.65IRL-1620
CAS:IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).Formula:C86H117N17O27Purity:98%Color and Shape:SolidMolecular weight:1820.974ANP [Des18-22] 4-23 amide rat
CAS:ANP [Des18-22] 4-23 amide rat is a peptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds to NPR-C.
Formula:C64H107N25O19S2Color and Shape:SolidMolecular weight:1594.82SAR441255
SAR441255 is a potent unimolecular peptide that acts as a GLP-1/GIP/GCG receptor triagonist, demonstrating balanced activation across all three target receptorsColor and Shape:Odour SolidBMS-193885
CAS:BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.Formula:C33H42N4O6Purity:99.73%Color and Shape:SolidMolecular weight:590.71Benzomalvin B
CAS:Benzomalvin B, a metabolite from Penicillium, blocks 24% NK1 receptor binding at 100 μg/ml.Formula:C24H17N3O2Color and Shape:SolidMolecular weight:379.419{Val1}-Exendin-3/4
{Val1}- exendin-3/4 is the first n-terminal 1-28 residue of exendin-4 peptide.Formula:NAPurity:98%Color and Shape:SolidMolecular weight:3241.7Neurokinin Receptor (393-407), rat
CAS:Rat NK1R fragment (393-407) binds SP, enabling endocytosis and plasma membrane recycling; key in neurogenic inflammation research.Formula:C72H113N17O26S2Color and Shape:SolidMolecular weight:1696.9[His1,Nle27] GHRF (1-32), amide, human
CAS:[His1,Nle27] GHRF (1-32), amide, human is a potent GHRH analog with high GHRHR affinity.
Formula:C159H265N51O46Color and Shape:SolidMolecular weight:3627.12Ro 25-1553
CAS:Ro 25-1553 is a 31-amino acid analog of vasoactive intestinal peptide (VIP) that functions as an agonist for the VIP2 receptor (VPAC2 receptor). In guinea pig models, Ro 25-1553 exhibits bronchodilator effects on tracheal smooth muscle contraction induced by neural stimuli or Carbachol.Formula:C160H258N46O46Color and Shape:SolidMolecular weight:3562.04CRF(6-33)(human)
CAS:CRFBP inhibitor peptide; blocks CRF, reduces weight gain, boosts activity in obese rats.Formula:C141H231N41O43SPurity:98%Color and Shape:SolidMolecular weight:3220.68Setmelanotide Acetate(920014-72-8 free base)
CAS:Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nMFormula:C51H72N18O11S2Purity:99.71%Color and Shape:SolidMolecular weight:1177.35Ref: TM-T12882L
1mg124.00€5mg271.00€10mg408.00€25mg673.00€50mg945.00€100mg1,279.00€1mL*10mM (DMSO)527.00€MM 07
CAS:Biased agonist for apelin/G protein pathway, enhances eNOS and cell growth, reduces apoptosis, improves heart function, and dilates vessels.Formula:C67H106N22O14S3Purity:98%Color and Shape:SolidMolecular weight:1539.9α-Helical CRF(9-41) TFA
α-Helical CRF(9-41) TFA acts as a competitive antagonist for the CRF2 receptor, possessing a binding constant (K B) of approximately 100 nM.Formula:C168H275F3N46O55S2Color and Shape:SolidMolecular weight:3940.42Lanepitant
CAS:Lanepitant (LY303870) is a non-peptide neurokinin-1 (NK-1) antagonist with analgesic activity for the prevention of migraine.Formula:C33H45N5O3Purity:97.71%Color and Shape:SolidMolecular weight:559.74Corazonin
CAS:Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.Formula:C62H83N17O19Color and Shape:SolidMolecular weight:1370.42MrgprX2 antagonist-4
CAS:MrgprX2 antagonist-4, from patent US20210128561A1, inhibits MrgprX2 receptor; useful for skin inflammation studies.Formula:C16H19N3OColor and Shape:SolidMolecular weight:269.348PAMP-12(human, porcine) TFA
PAMP-12(human, porcine) TFA, a significant constituent of immunoreactive (ir)-PAMP, derives from the adrenomedullin precursor and functions as a potentColor and Shape:Odour SoliddCNP
dCNP binds to NPR-B/C receptors (NPR-B/C receptor), initiating the cGMP signaling pathway and regulating vascular function. It exhibits anti-hypoxic effects by downregulating hypoxia-related genes such as HIF1α and HIF2α. Additionally, dCNP inhibits tumor stroma induction, demonstrating antifibrotic properties. It also enhances immune response by upregulating CTL, NK cells, and conventional type 1 dendritic cells in tumors.
Formula:C141H248N38O36S3Color and Shape:SolidMolecular weight:3147.91GRK2i
CAS:GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Formula:C153H256N50O41SPurity:98%Color and Shape:SolidMolecular weight:3484.08Amylin, amide, human TFA
Amylin, a 37-amino acid human hormone, moderates glucose regulation by reducing glucagon, delaying digestion, and increasing satiety.Formula:C167H262F3N51O57S2Color and Shape:SolidMolecular weight:4017.3A 31472
CAS:A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors.Formula:C22H22ClNColor and Shape:SolidMolecular weight:335.87Survodutide
CAS:Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.Formula:C192H289N47O61Purity:99.83%Color and Shape:SolidMolecular weight:4229.0957Tebufelone
CAS:Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).Formula:C20H28O2Purity:99.61%Color and Shape:SolidMolecular weight:300.44Ref: TM-T68155
1mg57.00€5mg120.00€10mg172.00€25mg283.00€50mg434.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)187.00€DOTA-LM3 TFA
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2.Formula:C71H94ClF3N16O21S2Color and Shape:SolidMolecular weight:1664.18Tiflucarbine
CAS:Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of solubleFormula:C16H17FN2SPurity:97.71%Color and Shape:SolidMolecular weight:288.38Galanin (1-15) (porcine, rat)
CAS:N-terminal galanin fragment used to mediate central cardiovascular effectsFormula:C72H105N19O20Purity:98%Color and Shape:SolidMolecular weight:1556.72PD 144418 oxalate
CAS:PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Formula:C20H24N2O5Purity:98.76%Color and Shape:SolidMolecular weight:372.42PAR 4 (1-6)
CAS:PAR 4 (1-6) can be used for relevant research in the life sciences. Its product number is T36293 and CAS number is 225779-44-2.Formula:C28H41N7O9Color and Shape:SolidMolecular weight:619.676FSCPX
CAS:FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency.
Formula:C23H27FN4O6SPurity:98%Color and Shape:SolidMolecular weight:506.55HPP-9
HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BETFormula:C49H52N6O11Color and Shape:SolidMolecular weight:900.97Hemokinin 1, human TFA
Hemokinin-1 is a human TFA and selective NK1 agonist; also activates NK2 & NK3 and induces opioid-independent analgesia.Formula:C56H85F3N14O16SColor and Shape:SolidMolecular weight:1299.42ONO-0300302
CAS:ONO-0300302: LPA1 antagonist, treats Benign Prostatic Hyperplasia, IC50 = 0.16 nM, reduces IUP in rats and dogs for 12h.Formula:C29H35NO5Purity:98%Color and Shape:SolidMolecular weight:477.59Terazosin dimer impurity dihydrochloride
CAS:Terazosin dimer impurity dihydrochloride is a chemical byproduct of the α1-antagonist Terazosin, derived from quinazoline.Formula:C24H30Cl2N8O4Color and Shape:SolidMolecular weight:565.46ACT-1016-0707
CAS:ACT-1016-0707 is a selective, insurmountable LPA1 antagonist with antifibrotic and anti-inflammatory activity in lung fibrosis modelsFormula:C19H23ClN4O4SPurity:99.905%Color and Shape:SolidMolecular weight:438.93α-CGRP(human) TFA
α-CGRP(human) TFA is a 37-amino acid regulatory neuropeptide that is extensively located within the central and peripheral nervous system, functioning as aFormula:C165H268F3N51O51S2Color and Shape:SolidMolecular weight:3903.33EP4 receptor antagonist 3
CAS:EP4 receptor antagonist 3 from patent WO2010019796 A1 targets EP4 for research on pain, arthritis, and cancer.Formula:C26H21F3N2O3SColor and Shape:SolidMolecular weight:498.52Adrenomedullin (AM) (22-52), human acetate
Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and anFormula:C161H256N46O50Purity:99.42%Color and Shape:SolidMolecular weight:3636.09IRL-1038 TFA
IRL-1038 TFA is an ETB receptor antagonist used in the study of cardiovascular disease.Formula:C70H93F3N14O17S2Purity:98.79%Color and Shape:SolidMolecular weight:1523.7Methdilazine
CAS:Methdilazine: oral antibiotic, histamine antagonist, fights mycobacterium (MIC 5-15 μg/mL) for infectious disease research.Formula:C18H20N2SColor and Shape:SolidMolecular weight:296.43Thrombin Receptor Activator for Peptide 5 (TRAP-5)
CAS:Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).Formula:C30H50N8O7Purity:98%Color and Shape:SolidMolecular weight:634.77γ1-MSH
CAS:Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4.Formula:C72H97N21O14SPurity:98%Color and Shape:SolidMolecular weight:1512.76
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