GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5964 products of "GPCR/G-Protein"
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Adenosine 3'-monophosphate (sodium salt hydrate)
Adenosine 3'-monophosphate (sodium salt hydrate) (3'-AMP) is a nucleotide and cAMP-generating agonist that elevates cAMP levels in NG108-15 cells.Formula:C10H15N5NaO8PColor and Shape:SolidMolecular weight:387.22(Iso)-RJW100
CAS:Potent LRH-1/NR5A2 and SF-1/NR5A1 agonist; pEC50: 6.4 (LRH-1), 7.2 (SF-1).Formula:C28H34OPurity:99.79%Color and Shape:SoildMolecular weight:386.57Ref: TM-T64363
1mg109.00€5mg241.00€10mg354.00€25mg532.00€50mg745.00€100mg1,018.00€500mg2,035.00€1mL*10mM (DMSO)259.00€G-Protein antagonist peptide
CAS:Peptide inhibits G protein-receptor binding; competitively blocks M2 and β-adrenoceptor-induced Gs/Gi/Go activation.Formula:C57H64N12O9SPurity:98%Color and Shape:SolidMolecular weight:1093.27(±)5(6)-EET
CAS:5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.Formula:C20H32O3Color and Shape:SolidMolecular weight:320.473SphK1&2-IN-1
CAS:SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
Formula:C14H14N2O3SPurity:99.59%Color and Shape:SolidMolecular weight:290.34Dolcanatide
CAS:Dolcanatide: oral GC-C agonist with laxative, pain-relief, and anti-inflammatory properties for IBD research.Formula:C65H104N18O26S4Color and Shape:SolidMolecular weight:1681.89LUF6096
CAS:LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically whileFormula:C22H21Cl2N3OPurity:99.5%Color and Shape:SolidMolecular weight:414.33Adrenomedullin (11-50), rat
CAS:Adrenomedullin 11-50 rat is a peptide, stimulates CGRP1 receptor for vasodilation, used in bone growth research.Formula:C194H304N58O59S4Purity:98%Color and Shape:SolidMolecular weight:4521.17QWF acetate
QWF acetate is a Substance P antagonist peptide that specifically inhibits the binding to its receptor, NK1, and inhibits the activation of MRGPRX2.
Formula:C40H47N5O10Purity:96.65%Color and Shape:SolidMolecular weight:757.84(±)-PPCC
CAS:(±)-PPCC (oxalate) is a sigma-1 agonist that interacts with sigma-1 receptors (Ki=1.5 nM).Formula:C24H29NO3Color and Shape:SolidMolecular weight:379.49Atriopeptin III (rat)
CAS:Atriopeptin III (rat) (ANP 127-150), a 24-amino acid atrial peptide, functions as a powerful vasodilator and natriuretic/diuretic agent, enhancing renalFormula:C107H165N35O34S2Molecular weight:2549.8MMC(TMZ)-TOC
MMC(TMZ)-TOC exhibits a high binding affinity and selectivity for somatostatin receptor subtype 2 (SSTR2). It is designed to target and deliver TMZ specifically to SSTR2-positive tumor cells. MMC(TMZ)-TOC is applicable for cancer research.Formula:C72H98N20O19S2Molecular weight:1610.67585Tryptamine hydrochloride
CAS:Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1, AHR.
Formula:C10H13ClN2Purity:99.89%Color and Shape:SolidMolecular weight:196.68Vensemaglutide
CAS:Vensemaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, utilized in research related to diabetes or other metabolic disorders.Formula:C214H337N49O67Molecular weight:4668.25Prostaglandin E3
CAS:Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, and shows anti-proliferative effects.Formula:C20H30O5Purity:98%Color and Shape:SolidMolecular weight:350.45Carbocyclic Thromboxane A2
CAS:Carbocyclic Thromboxane A2 can be used in related research in the field of life sciences. Its product number is T36548 and CAS number is 74034-56-3.Formula:C22H36O3Color and Shape:SolidMolecular weight:348.527Big endothelin-1 (rat 1-39)
CAS:Big endothelin-1 (rat 1-39), a 39-residue peptide, induces a diuretic and natriuretic response in conscious Sprague-Dawley rats and elevates blood pressure inColor and Shape:Solid[Asn18] Endothelin-1, human
CAS:[Asn18] Endothelin-1, human, a peptide, represents a predominant isoform of Endothelin, significantly contributing to the regulation of vascular function [1].Formula:C109H164N26O31S5Molecular weight:2494.96Brain Natriuretic Peptide-45, mouse
CAS:Mouse BNP-45, a heart-derived peptide, lowers blood pressure and increases sodium excretion.TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Formula:C22H21ClF2N4OColor and Shape:SolidMolecular weight:430.88Melanostatin, frog TFA
Melanostatin, frog TFA is an α-MSH release inhibitor, a 36 amino acid peptide isolated from the frog brain.Purity:99.23%Color and Shape:Odour SolidSubstance P(1-7) TFA
CAS:Substance P(1-7) TFA is a fragment of neuropeptide P (SP), with anti-harmful effects, used in neurological disease research.Formula:C43H66F3N13O12Purity:98.23%Color and Shape:SolidMolecular weight:1014.06GR231118 TFA
GR231118 TFA: potent Y1 antagonist (pKi 10.4), Y4 agonist (pEC50 8.6, pKi 9.6), weak Y2/Y5 agonist, high affinity for mouse Y6 (pKi 8.8).Formula:C112H171F3N34O26Molecular weight:2466.76Kadsurenin C
CAS:Kadsurenin C (compound 1), a neolignan isolated from the aerial parts of Piper kadsura, exhibits anti-inflammatory properties and significant PAF (Platelet Activating Factor) antagonistic activity, with an IC50 value of 5.1 μM [1].Formula:C21H26O5Molecular weight:358.43[Lys8] Vasopressin Desglycinamide
CAS:[Lys8] Vasopressin Desglycinamide, a vasopressin analog, supports the maintenance of active and passive avoidance behavior and aids in the facilitation ofFormula:C44H63N11O12S2Color and Shape:SolidMolecular weight:1002.17Alkyne-βAG-TOCA
Alkyne-βAG-TOCA is an octreotide derivative that targets somatostatin receptor subtype 2 (SST2). It is utilized in the synthesis and research of radioconjugates (RDC).Formula:C48H65N11O15S2Color and Shape:SolidMolecular weight:1100.22Substance P (1-9)
CAS:Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.Formula:C52H77N15O12Purity:98%Color and Shape:SolidMolecular weight:1104.26Eledoisin
CAS:Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin familyFormula:C54H85N13O15SPurity:98%Color and Shape:SolidMolecular weight:1188.4γ-Glu-Abu TFA
Gamma-Glu-AbuTFA is the TFA salt form of Gamma-Glu-Abu. This compound acts as an agonist for the calcium sensing receptor (CaSR), activating CaSR in HEK-293 cells with an EC50 of 0.21 μM.Formula:C11H17F3N2O7Color and Shape:SolidMolecular weight:346.26Nastorazepide hemicalcium
CAS:Nastorazepide (Z-360) hemicalcium is a selective, orally-administered 1,5-benzodiazepine derivative that functions as a receptor antagonist for gastrin/cholecystokinin 2 (CCK-2), exhibiting potential antitumor activity.Formula:C29H36N4O5CaColor and Shape:SolidMolecular weight:540.66MD01-67
CAS:MD01-67 is a macrocyclic compound selectively targeting the neurotensin 2 receptor (NTS2), with a Ki of 2.9 nM. It exhibits analgesic activity and reduces tactile hypersensitivity in rat models of acute, sustained, and chronic inflammatory pain.Formula:C37H58N8O8Color and Shape:SolidMolecular weight:742.9115(R)-17-phenyl trinor Prostaglandin F2α
CAS:17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocularFormula:C23H32O5Color and Shape:SolidMolecular weight:388.5Neuropeptide Y 13-36 (porcine)
CAS:Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist.Formula:C135H209N41O36Color and Shape:SolidMolecular weight:2982.408PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
PACAP (6-27) is an antagonist for PACAP receptors with varying IC50s; blocks cAMP in neuroblastoma and breast cancer cells.Color and Shape:LiquidCCR6 antagonist 1
CAS:CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.
Formula:C17H12F3NO2Purity:99.83%Color and Shape:SoildMolecular weight:319.28CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.Formula:C31H43ClN4O5Purity:94.05%Color and Shape:SolidMolecular weight:587.15Selepressin acetate
Selepressin acetate is a useful organic compound for research related to life sciences and the catalog number is T73654.Formula:C48H77N13O13S2Color and Shape:SolidMolecular weight:1108.33[Ala2] Endothelin-3, human
CAS:[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.Formula:C120H166N26O32S4Color and Shape:SolidMolecular weight:2613.02Dotanoc
CAS:Dotanoc is a ligand to make gallium Ga 68-DOTANOC, which is a gallium Ga 68-radiolabeled analog of somatostatin.Formula:C69H94N14O17S2Color and Shape:SolidMolecular weight:1455.71Gastrin I, rat
CAS:Gastrin I, rat is a peptide hormone that effectively stimulates gastric acid secretion.Formula:C94H128N22O31S2Color and Shape:SolidMolecular weight:2126.3Neuropeptide Y (3-36) (porcine)
CAS:Neuropeptide Y (3-36) (porcine) is a potent, selective agonist at NPY Y2 receptors, increasing feeding in rats.Formula:C176H271N53O54Color and Shape:SolidMolecular weight:3993.36Ala5-Galanin (2-11)
CAS:Ala5-Galanin (2-11) is a specific agonist for the galanin receptor 2 (GAL2R) with an affinity constant (Ki) of 258 nM [1].Formula:C54H81N13O13Purity:98%Color and Shape:SolidMolecular weight:1120.3Alsactide
CAS:Alsactide, an adrenocorticotropic hormone (ACTH) agonist and a heptadecapeptide analogue, is utilized in the study of the central nervous system [1].Formula:C99H155N29O21SColor and Shape:SolidMolecular weight:2119.53GLP-1(9-36)amide TFA
GLP-1(9-36)amide TFA, a DPP-4 metabolite of GLP-1(7-36) amide, antagonizes human pancreatic GLP-1 receptor.Formula:C142H215F3N36O45Color and Shape:SolidMolecular weight:3203.43Adrenomedullin (16-31), human TFA
Human adrenomedullin (16-31) TFA, fragment 16-31, binds CGRP1 receptor, raises rat blood pressure, not cats’.Formula:C84H130F3N25O23S2Color and Shape:SolidMolecular weight:1979.21Angiopeptin TFA
CAS:Angiopeptin TFA: somatostatin analogue, sst2/sst5 partial agonist (IC50: 0.26/6.92 nM), suppresses GH & IGF-1, for atherosclerosis research.Formula:C58H73F6N11O14S2Color and Shape:SolidMolecular weight:1326.39Amylin (8-37), human
CAS:Human-derived Amylin (8-37) is a vasodilator in rat arteries and forms aggregates linked to type II diabetes.Formula:C138H216N42O45Color and Shape:SolidMolecular weight:3183.495Val9-Oxytocin
CAS:Val9-Oxytocin, an Oxytocin analog where Gly9 is substituted with Val9 [1], functions as a complete antagonist of the vasopressin (V1a) receptor.Formula:C46H72N12O12S2Purity:98%Color and Shape:SolidMolecular weight:1049.27Orexin B, rat, mouse TFA
Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.Formula:C128H216F3N45O36SColor and Shape:SolidMolecular weight:3050.42a-Helical Corticotropin Releasing Factor (12-41)
CAS:α-Helical CRF (12-41), a 30-aa analog, curbs CRF's ACTH-stimulating effect.Formula:C152H251N43O47S2Color and Shape:SolidMolecular weight:3497.01
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