GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5964 products of "GPCR/G-Protein"
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BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2Formula:C96H140N20O25S·xNH3Purity:98%Color and Shape:SolidMolecular weight:2006.32 (free base)TCMCB07 TFA
TCMCB07 TFA is a cyclic nonapeptide and an orally active, brain-penetrating antagonist of the melanocortin receptor 4 (MC4R), playing a significant role inFormula:C63H87N15O11·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:1230.46 (free base)TCMCB07
CAS:TCMCB07, a cyclic nonapeptide, serves as an orally active, brain-penetrant antagonist of the melanocortin receptor 4 (MC4R), with significant implications inFormula:C63H87N15O11Purity:98%Color and Shape:SolidMolecular weight:1230.46Pobilukast
CAS:Pobilukast (SKF 104353) is a cysteinyl leukotriene receptor antagonist that can be used to study limiting myocardial injury in MI/R rats.Formula:C26H34O5SPurity:99.65% - 99.84%Color and Shape:SolidMolecular weight:458.61[Des-His1,Glu9]-Glucagon amide
CAS:Glucagon blocker with pA2 of 7.2; no agonist effect. Boosts insulin; prevents glucagon-driven hyperglycemia in rabbits and diabetic rats.Formula:C148H221N41O47SPurity:98%Color and Shape:SolidMolecular weight:3358.68Galanin-Like Peptide (rat)
CAS:Galanin-Like Peptide (rat), a neuropeptide comprising 60 amino acids, plays a crucial role in regulating feeding, body weight, and energy metabolism [1].Formula:C288H461N87O83SPurity:98%Color and Shape:SolidMolecular weight:6502.34Invopressin
CAS:Invopressin (Compound 42), a vasopressin V1A receptor partial agonist (EC50: 1.0 nM), is utilized in research related to cirrhosis conditions such as bacterialFormula:C110H161N31O27S2Purity:98%Color and Shape:SolidMolecular weight:2413.78S1R agonist 1
CAS:Compound 6b: Selective S1R agonist, K i = 0.93 nM (S1R), 72 nM (S2R); neuroprotective against ROS, NMDA toxicity.Formula:C20H25NOColor and Shape:SolidMolecular weight:295.42(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
CAS:(d(CH2)5[Tyr(Me)2, Dab5]AVP), a vasopressin V1a receptor-specific antagonist, demonstrates a pA2 value of 6.71 [1].Formula:C52H76N14O11S2Purity:98%Color and Shape:SolidMolecular weight:1137.38Luseogliflozin
CAS:Luseogliflozin inhibits SGLT2 for glucose uptake with 1.10 nM potency.Formula:C23H30O6SColor and Shape:SolidMolecular weight:434.55A3AR agonist 1
A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effectiveFormula:C28H34N6O6Purity:98%Color and Shape:SolidMolecular weight:550.61Lys-(Des-Arg9,Leu8)-Bradykinin
CAS:Lys-(Des-Arg9,Leu8)-Bradykinin is a selective antagonist of the bradykinin B1 receptor [1].Formula:C47H75N13O11Purity:98%Color and Shape:SolidMolecular weight:998.18Mibenratide TFA
Mibenratide TFA, a small cyclic peptide, functions as an adrenergic β1 receptor antagonist and has potential applications in heart failure research [1].Purity:98%Color and Shape:Odour Solid(Leu31,Pro34)-Peptide YY (human) (TFA)
"(Leu31,Pro34)-Peptide YY (human) (TFA) is the trifluoroacetic acid (TFA) form of (Leu31,Pro34)-Peptide YY (human), a derivative of Peptide YY that acts as aFormula:C195H296N54O56·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:4292.75 (free base)Galanin-Like Peptide (human)
CAS:Galanin-Like Peptide (human) is a neuropeptide consisting of 60 amino acids, instrumental in regulating feeding, body weight, and energy metabolism [1].Formula:C292H451N83O84SPurity:98%Color and Shape:SolidMolecular weight:6500.28Spantide II
CAS:Spantide II is an antagonist of tachykinin.Formula:C86H104Cl2N18O13Purity:98%Color and Shape:SolidMolecular weight:1668.77Bertilimumab
CAS:Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].
Color and Shape:LiquidDes-Arg9-[Leu8]-Bradykinin acetate
CAS:Des-Arg9-[Leu8]-Bradykinin acetate is a potent antagonist of the bradykinin receptor 1 (B1R), utilized in renal fibrosis research [1].Formula:C43H67N11O12Purity:98%Color and Shape:SolidMolecular weight:930.06KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Formula:C24H32N2O8Purity:98.12%Color and Shape:SolidMolecular weight:476.52Spns2-IN-1
Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immunePurity:98%Color and Shape:Odour Solid[Deamino-Pen1,Val4,D-Arg8]-vasopressin
CAS:[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP).Formula:C48H69N13O11S2Purity:98%Color and Shape:SolidMolecular weight:1068.27(D-Arg8)-Inotocin
CAS:'(D-Arg8)-Inotocin is a potent, selective, and competitive antagonist of the vasopressin receptor (V 1a R), exhibiting a binding affinity (K i) of 1.3 nM.Formula:C39H68N14O11S2Purity:98%Color and Shape:SolidMolecular weight:973.17Bz-Dab(nbd)-awfpp-nle-NH2
CAS:Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2 is a fluorescent NK2 antagonist.Formula:C56H65N13O11Color and Shape:SolidMolecular weight:1096.2Oxmetidine FA
Oxmetidine FA is an orally available specific histamine H2 receptor antagonist with antiulcerogenic properties.Formula:C20H23N5O5SPurity:97.34%Color and Shape:SoildMolecular weight:445.49MLS1082
CAS:MLS1082 is a D1-like dopamine receptor (D1R) orthosteric modulatothat stimulates G-protein signaling upon dopamine activation for neurodegenerative disorders.Formula:C24H23N3O2Purity:99.53%Color and Shape:SolidMolecular weight:385.46Prostaglandin K1
CAS:Prostaglandin K1 (compound 46) is a structurally modified prostanoid analog with an EC50 and Ki of 2800 nM for the EP1 receptor.Formula:C20H32O5Color and Shape:SolidMolecular weight:352.475-HT2A receptor agonist-6
CAS:5-HT2A receptor agonist-6 (compound 47) is a selective agonist of the 5-HT2A receptor with a pEC50 value of 6.58.Formula:C18H19N3O3Color and Shape:SolidMolecular weight:325.36RWJ 676070
CAS:RWJ 676070 is an antagonist of vasopressin V1A/V2 receptor.Formula:C30H26ClFN2O5Color and Shape:SolidMolecular weight:548.994-Hydroxy MPT
CAS:4-Hydroxy MPT (4-OH-MPT) is a serotonin-active compound that acts as an agonist for 5-HT2A and 5-HT2B receptors, with EC50 values of 3.82 nM and 3.4 nM, respectively.Formula:C14H20N2OColor and Shape:SolidMolecular weight:232.32Lys-γ3-MSH(human)
CAS:Pro-opiomelanocortin (POMC) derived peptide that stimulates lipolysisFormula:C128H193N45O39SPurity:98%Color and Shape:SolidMolecular weight:3018.25CCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Formula:C24H27Cl2N7O·xHClColor and Shape:SolidTHX-B
CAS:THX-B, a potent non-peptidic p75 NTR antagonist, aids in researching diabetic kidney disease and neurodegenerative and inflammatory disorders.Formula:C16H24N6O4Color and Shape:SolidMolecular weight:364.4exo-Tetrahydrocannabivarin
CAS:exo-Tetrahydrocannabivarin (Compound 12) is an analog of Δ9,11-THC. It weakly binds to cannabinoid receptors (CB) with an IC50 of 1.4 μM. In mice, exo-Tetrahydrocannabivarin exhibits activity related to both motor function and analgesia.Formula:C19H26O2Color and Shape:SolidMolecular weight:286.41Afubiata
CAS:ADB-FUBIATA is a synthetic cannabinoid studied for its metabolic profile, along with AFUBIATA, CH-FUBIATA, and CH-PIATA. This in vitro analysis by Watanabe S, et al., examines these compounds, as published in "Arch Toxicol," 2023 Dec;97(12):3085-3094.Formula:C27H29FN2OColor and Shape:SolidMolecular weight:416.53Albiglutide fragment TFA
Albiglutide fragment (GLP-1 (7-36) analog) TFA represents a biologically active segment of Albiglutide, resistant to DPP-4 degradation due to its structure as aFormula:C148H224N40O45·xC2HF3O2Color and Shape:SolidBIBP3226
CAS:BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor.Formula:C27H31N5O3Color and Shape:SolidMolecular weight:473.57Bradykinin (1-6)
CAS:Bradykinin (1-6) is a stable, CPY-cleaved metabolite that triggers pain, induces muscle contractions, and activates NO synthetase.Formula:C30H45N9O8Purity:98%Color and Shape:SolidMolecular weight:659.73Pafenolol
CAS:Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.Formula:C18H31N3O3Purity:98.33%Color and Shape:SolidMolecular weight:337.46GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].Formula:C19H16FN5O2Color and Shape:SolidMolecular weight:365.36S1R agonist 2
CAS:S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.Formula:C21H27NOPurity:99.66%Color and Shape:SolidMolecular weight:309.45CAY10509
CAS:CAY10509 is a PGF2α analogue and acts as an FP receptor inhibitor with an IC50 of 30 nM. It shows potential for use in studying the physiological regulatory mechanisms related to prostaglandins.Formula:C23H35FO5SColor and Shape:SolidMolecular weight:442.5815(S)-15-methyl Prostaglandin E2
CAS:15(S)-15-methyl PGE2: A stable PGE2 analog; strong antiulcer with double PGE2 affinity; excels PGE1 in uterine contraction.Formula:C21H34O5Color and Shape:SolidMolecular weight:366.49Tamsolusin Hydrochloride
CAS:Tamsolusin Hydrochloride (YM 12617) is a highly selective alpha-1A adrenergic receptor antagonist used in the treatment of benign prostatic hypertrophy.Formula:C20H29ClN2O5SPurity:99.92%Color and Shape:SoildMolecular weight:444.97Eloralintide
CAS:Eloralintide (LY 3841136) is an AMYR agonist, anticipated for research in type 2 diabetes and obesity.Formula:C201H319N49O65S2Color and Shape:SolidMolecular weight:4526.117-TFM-PGF1α
CAS:17-TFM-PGF1α (Compound 8) is a saturated prostaglandin analog. It exhibits a high affinity and receptor selectivity for the human prostaglandin F receptor (hFP receptor), with an EC50 of 85 nM.Formula:C24H35F3O5Color and Shape:SolidMolecular weight:460.53Sufotidine
CAS:Sufotidine (AH 25352X) is a highly selective competitive H2 receptor antagonist.Formula:C20H31N5O3SPurity:99.03% - 99.92%Color and Shape:SolidMolecular weight:421.56SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Formula:C19H18F2N4OPurity:99.81%Color and Shape:SolidMolecular weight:356.37Tiaspirone hydrochloride
CAS:Tiaspirone hydrochloride (BMY-13859 hydrochloride) exhibits antipsychotic activity and influences the electrophysiological activity of dopaminergic neurons.Formula:C24H33ClN4O2SPurity:99.87%Color and Shape:SoildMolecular weight:477.06LUF6096
CAS:LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically whileFormula:C22H21Cl2N3OPurity:99.5%Color and Shape:SolidMolecular weight:414.33
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