GPCR/G-Protein

Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour

MCI-225 dehydratase is an oral, selective inhibitor of noradrenaline reuptake, and functions as a 5-HT3 antagonist, exhibiting antidepressant effects in vivo .

Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.

Ridazolol HCl (CAS 413) is a novel β-adrenoceptor (β-AR) blocker with α-adrenerolytic activity.

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.

Compound 17, a dopamine D4 receptor ligand, exhibits high potency and selectivity with IC 50 values of 0.057 nM for D4, and >1000, 220, and 270 nM for D2, 5-HT1A, and α1 receptors, respectively [1].

Compound AMTHAMINE DIHYDROBROMIDE is a useful organic compound for research related to life sciences.

Amidephrine hydrochloride is a biochemical.

Amidephrine is an adrenergic agent.

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neuron blockers exhibiting sympathomimetic effects similar to those of bromobenzamine and guanethidine in various animal models, particularly in cats. These compounds inhibit the release of norepinephrine during neural stimulation and enhance the responsiveness of smooth muscle to epinephrine and norepinephrine. Notably, bethanidine sulfate increases the pressor response to tyramine, although this effect diminishes with higher doses. Unlike guanethidine, bethanidine sulfate does not deplete pressor amines in the iris of cats following administration. Additionally, it temporarily suppresses autonomic cholinergic mechanisms and can cause transient neuromuscular paralysis at large doses, contrasting its long-term adrenergic neuron blocking effects.

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.

S 25585 is a neuropeptide Y (NPY) Y5 receptor antagonist.

Proxyfan Oxalate is a potent antagonist of the histamine H3 receptor (histamine H3 receptor), with Ki values of 2.9 nM for rats and 2.7 nM for humans. Its inhibitory effect on H3 receptors is over 1000 times stronger than its effect on other histamine receptors.

Litorin suppresses appetite and stimulates smooth muscle, gastrin, gastric acid, and pancreatic secretion.

Dehydroabiethylamine (NSC-2955) boosts liver CYP2B, blocks PDKs & cholesterol transport, and has anti-tumor effects.

5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.

AR244555 is a bioactive chemical.

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM).

7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.

Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea following

Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic

Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).

LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).

Imnopitant is an antagonist of the NK1 receptor [1].

BMS-192364 is a bio-active chemical.

Compound 18h is a potent A1 adenosine receptor blocker with Ki of 1.49 nM for hA1, 10.2 nM for hA2A, 50.1 nM for hA2B.

JPC-211 is an agonist of dopamine-receptor.

Midodrine D6 hydrochloride is a vasopressor/antihypotensive agent.

Nafadotride is a dopamine D3 receptor antagonist.

Ridazolol is a vasodilating and cardioselective beta adrenergic blocker.

PD168,077 is an agonist of dopamine D4 receptor. It has a facilitatory effect on memory consolidation.

Fluphenazine Decanoate Dihydrochloride: antipsychotic that blocks D2 dopamine receptors in brain regions.

Dopamine D2 autoreceptor agonist

Nexopamil racemate（(Rac)-Nexopamil） is a racemate of Nexopamil. The Nexopamil racemate has potential anti-asthmatic and anti-ulcer activity.

GT 2016 is a H3 receptor antagonist.

CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.

Bavisant (JNJ-310010740) is an oral, selective H3 receptor antagonist enhancing wakefulness and cognition.

Guanoxabenz is an α2 adrenergic receptor agonist.

TSHR antagonist S37a is a selective, orally bioavailable TSHR antagonist that inhibits TSH-induced cAMP in TSHR-expressing HEK 293 cells.

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.

partial agonist of hydroxycarboxylic acid receptor 2 (HCA2)

CB1/2 agonist 4 is a potent CB1 full agonist (EC50: 15.09 nM) and CB2 partial agonist (EC50: 1.16 nM), with anti-pain and TRPV1 activation properties.

Oxetorone fumarate is a non-selective, orally active antagonist of serotonin and 5-HT receptors,used for migraine treatment.

Potent, selective adenosine receptor blocker with strong affinity, especially A2A (Ki 68.5 nM). Promising for cancer, neurodegeneration study.

(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).