GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,997 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(40 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5958 products of "GPCR/G-Protein"
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(E)-Guanabenz
CAS:(E)-Guanabenz is an oral α2-adrenoceptor agonist, antihypertensive, GADD34 inhibitor, and has neuroprotective properties.Formula:C8H8Cl2N4Color and Shape:SolidMolecular weight:231.08SGS518 oxalate
CAS:SGS518 oxalate is a 5-HT6 antagonist.Formula:C23H24F2N2O7SPurity:98%Color and Shape:SolidMolecular weight:510.51PD-156707
CAS:PD-156707 is a selective antagonist of endothelin A receptor.Formula:C28H26NaO9Purity:98%Color and Shape:SolidMolecular weight:529.497Octoclothepin maleate salt
CAS:Octoclothepin maleate salt is a D2 dopamine receptor antagonist and 5-HT2 serotonin receptor antagonist.Formula:C23H25ClN2O4SColor and Shape:SolidMolecular weight:460.97Neladenoson dalanate HCl
CAS:Neladenoson dalanate HCl is a potent, selective, orally active partial agonist of adenosine A1 receptor (EC50: 0.1 nM).Formula:C35H35Cl2N7O4S2Purity:98%Color and Shape:SolidMolecular weight:752.73RTI 336
CAS:RTI 336 is used as a chronic brain dopamine transporter (DAT) inhibitor.Formula:C24H26Cl2N2OPurity:98%Color and Shape:SolidMolecular weight:429.38L-826266
CAS:L-826266 is an antagonist of EP(1) receptor.Formula:C27H21BrClNO4SColor and Shape:SolidMolecular weight:570.88LY314228
CAS:LY314228 is an antagonist of 5-HT2A receptor.Formula:C20H24N4O3Color and Shape:SolidMolecular weight:368.43Methyldopate hydrochloride
CAS:Methyldopate HCl is an agent of antihypertensive.Formula:C12H18ClNO4Color and Shape:SolidMolecular weight:275.73UCSF686
CAS:UCSF686, a UCSF678 analog, lacks 5-HT5A potency but keeps affinity for 5-HT1A, 5-HT2B, 5-HT7, and serves as a control.Formula:C14H19N3O2SColor and Shape:SolidMolecular weight:293.38Zenidolol
CAS:Zenidolol (ICI-118551) is a β2 adrenoceptor blocker with K i values: β2 (0.7 nM), β1 (49.5 nM), β3 (611 nM); used in eye disease research.Formula:C17H27NO2Color and Shape:SolidMolecular weight:277.4SKF-75670 Hydrobromide
CAS:SKF-75670 hydrobromide is an atypical D1DR (dopamine receptor) agonist. It displays agonist activity in vivo and antagonist activity in vitro.Formula:C17H20BrNO2Color and Shape:SolidMolecular weight:350.25Zicronapine
CAS:Zicronapine (LU 31-130), an atypical antipsychotic with monoaminergic action, targets dopamine D1/D2 and serotonin 5HT2A.Formula:C22H27ClN2Color and Shape:SolidMolecular weight:354.92RB-005
CAS:RB-005 is a potent SK1 inhibitor with IC(50) of 3.6 μM, potentially treating proliferative diseases like hypertension and degrades SK1 in human cells.Formula:C21H35NOColor and Shape:SolidMolecular weight:317.51CB1R Allosteric modulator 2
CAS:Compound 18 is a potent CB1R allosteric modulator that acts as a negative modulator (NAM) for CB1R orthosteric ligands.Formula:C19H15ClFN3OColor and Shape:SolidMolecular weight:355.79L 741671
CAS:L 741671 is an antagonist of the neurokinin-1 receptor.Formula:C23H22F6N4O2Color and Shape:SolidMolecular weight:500.44LY 219057
CAS:LY 219057 is a potent, competitive, and specific antagonist of CCK receptor on the exocrine pancreas.Formula:C23H17ClF3N3OSColor and Shape:SolidMolecular weight:475.91CB1R Allosteric modulator 1
CAS:CB1R modulator 1 (compound 11), a potent CB1R inhibitor, decreases activity of orthosteric ligands.Formula:C24H24ClN3OColor and Shape:SolidMolecular weight:405.92INCB38579
CAS:INCB38579: Oral, selective H4 antagonist; crosses brain barrier; IC50s - hH4R: 4.8 nM, mH4R: 42 nM, rH4R: 32 nM; anti-inflammatory and antipruritic.Formula:C25H34N6OColor and Shape:SolidMolecular weight:434.58BAY-u 9773
CAS:BAY-u9773 is a non-selective CysLT receptor antagonist with similar IC50 for CysLT1 and CysLT2, inhibiting LT responses.Formula:C27H36O5SColor and Shape:White OilMolecular weight:472.64Trifluperidol HCl
CAS:Trifluperidol, a dopamine D2-receptor antagonist, is used to treat schizophrenia.Formula:C22H24ClF4NO2Color and Shape:SolidMolecular weight:445.88MAT2A-IN-3
CAS:MAT2A-IN-3: potent MAT2A inhibitor, hinders MTAP-deficient cancer cell growth, potential for cancer research.Formula:C24H16F5N5O3Color and Shape:SolidMolecular weight:517.415-HT2A receptor agonist-2
CAS:Potent 5-HT2A receptor agonist-2 targets 5-HT2A/B/C with EC50 1.7, 0.58, 0.50 nM.Formula:C20H21ClN2O3Color and Shape:SolidMolecular weight:372.85ANEB-001
CAS:ANEB-001 is an orally active CB1 inhibitor that can be used in studies of acute cannabinoid intoxication.Formula:C22H24ClF3N2O2Color and Shape:SolidMolecular weight:440.89R 75317
CAS:R 75317 is a Platelet-activating factor (PAF) antagonist.Formula:C29H50N3O8PSPurity:98%Color and Shape:SolidMolecular weight:631.76SCH-202676 HBr
CAS:SCH-202676 HBr is an allosteric agonist. It also an GPCR antagonist.Formula:C15H13N3SPurity:98%Color and Shape:SolidMolecular weight:267.35Medroxalol
CAS:Medroxalol (RMI81968), an oral α- & β-adrenergic blocker, has antihypertensive and vasodilatory effects.Formula:C20H24N2O5Color and Shape:SolidMolecular weight:372.42JNJ-40255293
CAS:JNJ-40255293 is an antagonist of adenosine A2A/A1.Formula:C23H22N4O3Purity:98%Color and Shape:SolidMolecular weight:402.45MRGPRX1 agonist 2
CAS:MRGPRX1 agonist 2 is a potent modulator with 0.48 μM EC50, potential for neuropathic pain research.Formula:C15H14N2OSColor and Shape:SolidMolecular weight:270.35Loratadine N-oxide
CAS:Loratadine N-oxide is a metabolite of the histamine H1 receptor inverse agonist loratadine.Formula:C22H23ClN2O3Color and Shape:SolidMolecular weight:398.88Mrgx2 antagonist-1
CAS:Mrgx2 antagonist-1 is a potent antagonist of Mrgx2 (Mas-related Gene X2) and can be used to study Mrgx2-mediated diseases and disorders.Formula:C23H26F5N5O3Color and Shape:SolidMolecular weight:515.48Isothipendyl hydrochloride
CAS:Isothipendyl hydrochloride is a 1st generation H1 antagonist.Formula:C16H20ClN3SColor and Shape:SolidMolecular weight:321.87VUF-10497
CAS:VUF-10497: H4 receptor inverse agonist, anti-inflammatory in rats, binds human H1 receptor (pKi=7.57).Formula:C18H20ClN5SPurity:98%Color and Shape:SolidMolecular weight:373.9(R)-V-0219
(R)-V-0219: GLP-1R PAM, orally active, triggers Ca++ flux in HEK-hGLP-1R cells.Formula:C20H25F3N4O2Color and Shape:SolidMolecular weight:410.43SC-41930
CAS:SC-41930 is a potent and selective antagonist of leukotriene B4 receptor.Formula:C28H36O7Color and Shape:SolidMolecular weight:484.58Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Formula:C23H15ClF4N4O2Color and Shape:SolidMolecular weight:490.84RS 79948 hydrochloride
CAS:α2-adrenoreceptor antagonistFormula:C19H29ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:400.96GPR183 antagonist-2
CAS:GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].Formula:C20H18F2N4O5Color and Shape:SolidMolecular weight:432.382-CMDO
CAS:2-CMDO is a Dopamine D2-like receptor antagonist.Formula:C23H23ClN2O5Purity:98%Color and Shape:SolidMolecular weight:442.89Pancopride
CAS:Pancopride（LAS 30451） is a novel, orally available, long-acting, selective 5-HT3 receptor antagonist that blocks nitrogen mustard and dacarbazine-inducedFormula:C18H24ClN3O2Purity:93.64%Color and Shape:SolidMolecular weight:349.86L 641953
CAS:L 641953 is an antagonist of the thromboxane receptor.Formula:C15H9FO3SColor and Shape:SolidMolecular weight:288.29A 987306
CAS:A-987306: Potent, oral histamine H4 antagonist; Ki: 3.4 nM (rat), 5.8 nM (human); reduces inflammation in mouse peritonitis.Formula:C18H25N5OColor and Shape:SolidMolecular weight:327.42SB-221284
CAS:5-HT2C/2B receptor antagonistFormula:C16H14F3N3OSPurity:98%Color and Shape:SolidMolecular weight:353.36SB-226552
CAS:SB-226552 is an aryloxypropanolamine selective beta3AR agonist.Formula:C25H36NO5PColor and Shape:SolidMolecular weight:461.53Alclofenac lysinate
CAS:Alclofenac is an anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also used as an analgesic and an antipyretic.Formula:C17H25ClN2O5Purity:98%Color and Shape:SolidMolecular weight:372.84JHW 007 hydrochloride
CAS:JHW 007 hydrochloride is a Dopamine uptake inhibitor.Formula:C24H30ClF2NOPurity:98%Color and Shape:SolidMolecular weight:421.95(S)-Carvedilol
CAS:(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).Formula:C24H26N2O4Purity:98%Color and Shape:Less Crystalline Solid Colourless Crystalline SolidMolecular weight:406.47Bavisant dihydrochloride
CAS:Bavisant (JNJ-310010740) is an oral, selective H3 receptor antagonist enhancing wakefulness and cognition.Formula:C19H29Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:402.36Roxindole hydrochloride
CAS:Dopamine D2 autoreceptor agonistFormula:C23H27ClN2OPurity:98%Color and Shape:SolidMolecular weight:382.93Nafadotride
CAS:Nafadotride is a dopamine D3 receptor antagonist.Formula:C22H27N3O2Color and Shape:SolidMolecular weight:365.47
