GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5964 products of "GPCR/G-Protein"
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SCH-336
CAS:SCH-336: potent, selective CB2 agonist (Ki=1.8 nM, EC50=2 nM), orally active, 100x CB2 vs. CB1 preference, reduces leukocyte migration and eosinophilia.
Formula:C23H25NO8S3Purity:95.01%Color and Shape:SolidMolecular weight:539.64Fipamezole
CAS:Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.Formula:C14H15FN2Purity:99.32% - 99.97%Color and Shape:SolidMolecular weight:230.28TC LPA5 4
CAS:TC LPA5 4 is a LPA5 receptor antagonist.Formula:C23H23ClN2O3Purity:99.93%Color and Shape:SolidMolecular weight:410.89Ref: TM-T23438
1mg49.00€5mg98.00€10mg157.00€25mg324.00€50mg485.00€100mg713.00€200mg982.00€1mL*10mM (DMSO)107.00€Efletirizine
CAS:Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.Formula:C21H24F2N2O3Purity:99.39%Color and Shape:SolidMolecular weight:390.42Lesopitron
CAS:Lesopitron: anxiolytic, 5-HT1A agonist, treats rodent anxiety, counters benzodiazepine withdrawal, low toxicity, no alcohol/barbiturate interaction.Formula:C15H21ClN6Purity:99.33% - 99.46%Color and Shape:SolidMolecular weight:320.82Ref: TM-T25672
1mg133.00€5mg324.00€10mg477.00€25mg773.00€50mg1,063.00€100mg1,431.00€500mg2,872.00€1mL*10mM (DMSO)323.00€Ensaculin
CAS:Ensaculin, a benzopyrone-piperazine compound, enhances memory, protects neurons, and may treat dementia.Formula:C26H32N2O5Purity:99.56% - 99.81%Color and Shape:SolidMolecular weight:452.54Repinotan
CAS:Repinotan (BAY x 3702 free base) is a 5-HT1A receptor agonist used in acute ischemic stroke studies.Formula:C21H24N2O4SPurity:99%Color and Shape:SolidMolecular weight:400.49Ronacaleret HCl
CAS:Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.Formula:C25H32ClF2NO4Purity:99.97%Color and Shape:SolidMolecular weight:483.98NGD 94-1
CAS:NGD 94-1 is a D4 receptor antagonist that can be used to study psychiatric disorders such as cognitive impairment.Formula:C18H20N6Purity:99.61%Color and Shape:SolidMolecular weight:320.39CL 316243
CAS:CL316243 is a highly potent selective agonist of β3-adrenoceptor.Cost-effective and quality-assured.Formula:C20H18ClNNa2O7Purity:98.00% - 99.68%Color and Shape:SolidMolecular weight:465.79Pipoxazole
CAS:Pipoxazole, an adrenergic receptor antagonist, is used potentially for the treatment of depression.Formula:C14H20N4OPurity:98.58% - 99.53%Color and Shape:SolidMolecular weight:260.33LY-426965
CAS:LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist.Formula:C28H38N2O2Color and Shape:SolidMolecular weight:434.61RXFP1 receptor agonist-2
CAS:RXFP1 Receptor Agonist-2 (Example 124), an EC50 value of 1 nM [1].Formula:C33H32F7N3O5Color and Shape:SolidMolecular weight:683.61Capeserod HCl
CAS:Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.Formula:C23H26Cl2N4O4Purity:98%Color and Shape:SolidMolecular weight:493.38Velagliflozin
CAS:Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.45VU0652925
CAS:VU0652925 is a PAR4 antagonist. VU0652925 has a P-sel IC50 of 39.2 pM (-pIC50±SEM: 10.41±0.04) and a PAC1 IC50 of 43.0 pM (-pIC50±SEM: 10.4±0.04).Formula:C24H18N4O4S2Color and Shape:SolidMolecular weight:490.55Carbidine dihydrochloride
CAS:Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.Formula:C13H20Cl2N2Purity:98.59%Color and Shape:SolidMolecular weight:275.217CaSR antagonist-1
CAS:CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigationFormula:C29H24FN3O2SPurity:98%Color and Shape:SolidMolecular weight:497.58Robotnikinin
CAS:Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.Formula:C25H27ClN2O4Purity:98%Color and Shape:SolidMolecular weight:454.95ATL802
CAS:ATL802 is an adenosine A2B Receptor antagonist.Formula:C24H22F3N7O3Purity:98%Color and Shape:SolidMolecular weight:513.47Ciprostene (calcium salt)
CAS:Ciprostene, a PGI2 stable analog, is less potent, induces hypotension, tachycardia, and inhibits platelet aggregation in monkeys.Formula:C44H74CaO8Color and Shape:SolidMolecular weight:771.146SQ 26655
CAS:SQ 26655 is an antagonist of thromboxane A2/prostaglandin H2.Formula:C21H34O4Purity:98%Color and Shape:SolidMolecular weight:350.4911-keto Fluprostenol
CAS:11-Keto Fluprostenol, a potent analog of prostaglandin F2α (PGF2α), primarily interacts with the FP receptor. It is a structurally modified derivative of prostaglandin D2 (PGD2) designed to enhance its potency and extend its half-life. The compound is produced by oxidizing fluprostenol at the C-11 position, which results in 11-keto fluprostenol. This modification allows 11-keto Fluprostenol to exhibit moderate affinity for the CRTH2/DP2 receptor, though it shows negligible activity at the DP1 receptor, distinguishing its action from that of PGD2.Formula:C23H27F3O6Color and Shape:SolidMolecular weight:456.458Carmoxirole hydrochloride
CAS:Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.Formula:C24H27ClN2O2Purity:99.37% - 99.62%Color and Shape:SolidMolecular weight:410.94Ref: TM-T10683
1mg42.00€5mg86.00€10mg123.00€25mg203.00€50mg299.00€100mg411.00€200mg553.00€1mL*10mM (DMSO)88.00€GSK2263167
CAS:GSK2263167 is an agonist of S1P1 receptor.Formula:C25H26N4O4Color and Shape:SolidMolecular weight:446.5AL 8810 methyl ester
CAS:AL 8810 methyl ester, a prostaglandin F(2α) analog and receptor agonist, competitively antagonizes FP receptor agonist Fluprostenol effects. It lacks significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines [1].Formula:C25H33FO4Color and Shape:SolidMolecular weight:416.53SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formula:C27H28N4O3Purity:98%Color and Shape:SolidMolecular weight:456.54IPG7236
CAS:IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormula:C23H31N3O3SPurity:98%Color and Shape:SolidMolecular weight:429.58Hedgehog IN-2
CAS:Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.46OMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formula:C26H44N2O3Purity:99.73%Color and Shape:SolidMolecular weight:432.64Ref: TM-T12306
1mg93.00€5mg177.00€10mg269.00€25mg429.00€50mg610.00€100mg820.00€200mg1,071.00€1mL*10mM (DMSO)210.00€SC 34301
CAS:SC 34301 (Enisoprost), a strong oral PGE1 analog, decreases bacterial translocation and increases burned mice survival.Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52Orexin receptor antagonist 4
CAS:Orexin antagonist 4: potent, selective for OX2R (IC50=4.27 nM); less for OX1R (IC50=295 nM).Formula:C22H24FN5O2Color and Shape:SolidMolecular weight:409.46Heptadecanoyl ethanolamide
CAS:Heptadecanoyl ethanolamide, an endogenous cannabinoid, serves as a synthetic analog of PEA, featuring an odd-numbered (17-carbon) fatty acid chain [1].Formula:C19H39NO2Color and Shape:SolidMolecular weight:313.52CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formula:C35H47FN4O2Purity:98%Color and Shape:SolidMolecular weight:574.77N-5984
CAS:N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes.
Formula:C20H22ClNO5Purity:98%Color and Shape:SolidMolecular weight:391.85Obestatin(rat) TFA
CAS:Obestatin(rat) TFA, a 23-amino-acid peptide, modulates appetite, gut motility, and body weight; binds GPR39; has anti-inflammatory and antioxidant effects.
Formula:C116H175F3N34O33Color and Shape:SolidMolecular weight:2630.83[D-Ala6]-LH-RH
CAS:[D-Ala6]-LH-RH, a Luteinizing-hormone-releasing hormone (LHRH) analogue, functions as a gonadotropin-releasing hormone (GnRH) receptor agonist [1].Formula:C56H77N17O13Color and Shape:SolidMolecular weight:1196.32GLP-1R agonist 9
CAS:GLP-1R agonist 9 acts as a GLP-1R agonist, demonstrating efficacy with EC50 values of 1.1 nM and 11 nM against CHO GLP-1R Clone H6 and Clone C6, respectively.Formula:C32H30ClF2N3O5Color and Shape:SolidMolecular weight:610.05TGR5 Receptor Agonist 4
CAS:TGR5 Receptor Agonist 4, a selective agonist for the Bile Acid Receptor (TGR5), exhibits potent activity with an EC50 of 2 nM for human TGR5 (hTGR5) and 3 nMFormula:C25H27ClN2O5Color and Shape:SolidMolecular weight:470.954-hydroxy Nebivolol hydrochloride
CAS:4-Hydroxy Nebivolol, a primary metabolite of Nebivolol, results from the enzymatic hydroxylation of Nebivolol by the cytochrome P450 (CYP) isoform CYP2D6.Formula:C22H25F2NO5HClColor and Shape:SolidMolecular weight:457.9NVP-SAA164
CAS:NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.Formula:C36H45N5O5SPurity:98%Color and Shape:SolidMolecular weight:659.84PF-02575799
CAS:PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).Formula:C42H37FN4O4Purity:98%Color and Shape:SolidMolecular weight:680.7715(S)-Fluprostenol
CAS:15(S)-Fluprostenol, an isomer of the FP receptor agonist fluprostenol, serves as a potential active metabolite of 15(S)-fluprostenol isopropyl ester. It can function as an agonist at FP receptors, though with lower potency compared to its 15(R) epimer, fluprostenol.Formula:C23H29F3O6Color and Shape:SolidMolecular weight:458.5CCG-63808
CAS:CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.Formula:C25H15FN4O2SPurity:90%Color and Shape:SolidMolecular weight:454.48TASP 0277308
CAS:NH2-UAMC1110 TFA is an aminobutoxy derivative of UAMC1110 used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activating protein (fap) inhibitor.
Formula:C23H28Cl2N6O3SColor and Shape:SolidMolecular weight:539.484-Chloro-L-phenylalanine
CAS:4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formula:C9H10ClNO2Purity:99.76% - 99.96%Color and Shape:SolidMolecular weight:199.63Prostaglandin E2 serinol amide
CAS:Prostaglandin E2 Serinol Amide acts as a weak inhibitor against the hydrolysis of [3H]2-oleoylglycerol, but it is non-hydrolyzable and cannot produce PGE2. Consequently, it is unable to inhibit leukotriene B4 biosynthesis, superoxide production, migration, and the release of antimicrobial peptides [1].Formula:C23H39NO6Color and Shape:SolidMolecular weight:425.566PSB-1115 potassium salt
CAS:PSB-1115 potassium salt, a selective A2B Adenosine Receptor antagonist, inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) [1].Formula:C14H13KN4O5SColor and Shape:SolidMolecular weight:388.44Dibenamine hydrochloride
CAS:Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.
Formula:C16H19Cl2NPurity:96.43%Color and Shape:Oily Liquid SolidMolecular weight:296.23PF-03550096
CAS:PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].Formula:C19H28N4O4Color and Shape:SolidMolecular weight:376.45
