GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 19 more subcategories

Found 5962 products of "GPCR/G-Protein"

Purity (%)

100

products per page.

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9-Methyl-β-carboline
CAS:
- 2521-07-5
9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.
Formula:C₁₂H₁₀N₂
Color and Shape:Solid
Molecular weight:182.221
Ref: TM-T204669
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ONO-8809
CAS:
- 123288-47-1
ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.
Formula:C₃₀H₄₆BrNO₄S
Purity:98%
Color and Shape:Solid
Molecular weight:596.66
Ref: TM-T28251
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GLP-1R modulator-1
CAS:
- 2978244-71-0
GLP-1R modulator-1 (Compound 384) is a potent and orally active selective agonist of the glucagon-like peptide-1 receptor (GLP-1R). It activates G protein-coupled signaling, leading to increased intracellular cAMP levels, enhanced insulin secretion, delayed gastric emptying, and reduced appetite. GLP-1R modulator-1 holds potential for research in type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
Formula:C₄₁H₃₈ClFN₆O₄
Color and Shape:Solid
Molecular weight:733.23
Ref: TM-T210660
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Ac-Atovaquone
CAS:
- 129700-44-3
Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.
Formula:C₂₄H₂₁ClO₄
Color and Shape:Solid
Molecular weight:408.87
Ref: TM-T201690
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LK 11
CAS:
- 74143-01-4
LK-11, an alkaloid derivative, inhibits the passive uptake of norepinephrine (NA) by synaptic vesicles in the thalamus, similarly to cocaine.
Formula:C₁₅H₂₆N₂O₃
Color and Shape:Solid
Molecular weight:282.38
Ref: TM-T200284
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MK-8318
CAS:
- 1416581-40-2
MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).
Formula:C₂₇H₂₆F₄N₂O₅
Purity:98%
Color and Shape:Solid
Molecular weight:534.5
Ref: TM-T16097
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Fasitibant
CAS:
- 869939-83-3
<p>Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.</p>
Formula:C₃₆H₄₉Cl₂N₆O₆S
Color and Shape:Solid
Molecular weight:764.78
Ref: TM-T68486
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Delmadinone acetate
CAS:
- 13698-49-2
Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.
Formula:C₂₃H₂₇ClO₄
Color and Shape:Solid
Molecular weight:402.911
Ref: TM-T206595
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(±)-Penbutolol
CAS:
- 36507-48-9
(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.
Formula:C₁₈H₂₉NO₂
Color and Shape:Solid
Molecular weight:291.43
Ref: TM-T201472
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FK-3657
CAS:
- 167838-64-4
FK-3657 is a non-peptide antagonist of bradykinin (BK)-B2 receptor.
Formula:C₃₀H₂₇Cl₂N₅O₄
Color and Shape:Solid
Molecular weight:592.47
Ref: TM-T24065
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Tiprenolol hydrochloride
CAS:
- 13379-87-8
Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.
Formula:C₁₃H₂₂ClNO₂S
Color and Shape:Solid
Molecular weight:291.84
Ref: TM-T201760
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1'-Naphthoyl-2-methylindole
CAS:
- 80749-33-3
1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.
Formula:C₂₀H₁₅NO
Color and Shape:Solid
Molecular weight:285.34
Ref: TM-T201477
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Rocavorexant
CAS:
- 2115665-09-1
Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.
Formula:C₁₈H₁₉F₃N₈O
Color and Shape:Solid
Molecular weight:420.392
Ref: TM-T206374
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BIBO3304 diTFA
CAS:
- 2310085-85-7
BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].
Formula:C₃₃H₃₇F₆N₇O₇
Color and Shape:Solid
Molecular weight:757.68
Ref: TM-T84889
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CCR4 antagonist 2
CAS:
- 2206788-99-8
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg
Formula:C₂₆H₂₈Cl₂N₆O
Purity:98%
Color and Shape:Solid
Molecular weight:511.45
Ref: TM-T10713
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Mafoprazine
CAS:
- 80428-29-1
Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.
Formula:C₂₂H₂₈FN₃O₃
Color and Shape:Solid
Molecular weight:401.47
Ref: TM-T200689
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AChE/BChE-IN-21
CAS:
- 2756368-79-1
AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.
Formula:C₃₈H₅₄N₄O₄
Color and Shape:Solid
Molecular weight:630.86
Ref: TM-T200193
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HU-308
CAS:
- 1432056-41-1
<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>
Formula:C₂₇H₄₂O₃
Color and Shape:Solid
Molecular weight:414.62
Ref: TM-T88361
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GnRH antagonist 2
CAS:
- 1709823-61-9
GnRH antagonist 2 is a GnRH receptor antagonist, useful for studying endocrine diseases.
Formula:C₂₈H₂₇F₂N₉O₅
Purity:98.08%
Color and Shape:Solid
Molecular weight:607.57
Ref: TM-T37003
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BAY-899
CAS:
- 2471967-92-5
BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.
Formula:C₂₅H₁₉F₂N₅O₂
Purity:98%
Color and Shape:Solid
Molecular weight:459.45
Ref: TM-T10476