Organometallic Ligands
In this category, you will be able to find a large number of organometallic molecules used as ligands in biomolecules. These organometallic ligands can be used in organic chemistry and synthesis in the laboratory. They play a critical role in forming coordination complexes and catalyzing various chemical reactions. At CymitQuimica, we offer a diverse selection of high-quality organometallic ligands to support your research and industrial needs.
Subcategories of "Organometallic Ligands"
- Buchwald Ligands(22 products)
- DPEN(4 products)
- DPHEN(4 products)
- JOSIPHOS(4 products)
- Phosphine(497 products)
- Porphirines(75 products)
Found 2889 products of "Organometallic Ligands"
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Afatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Formula:C24H25ClFN5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:485.94 g/molCarmustine - Bio-X ™
CAS:Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.Formula:C5H9Cl2N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:214.05 g/molSRT1720 hydrochloride
CAS:SIRT1 activatorFormula:C25H23N7OS·xHClPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:469.56 g/molPNU 159682
CAS:DNA alkylating agent; highly potent metabolite of nemorubicinFormula:C32H35NO13Purity:Min. 90 Area-%Color and Shape:Red PowderMolecular weight:641.62 g/molABTL-0812
CAS:ABTL-0812 is an investigational anticancer compound, which is a synthetic small molecule with a novel mechanism of action. It is derived from the research efforts focused on targeting key metabolic pathways in cancer cells. The mode of action of ABTL-0812 involves the modulation of the Akt/mTOR pathway, leading to the induction of autophagy-mediated cell death, a process that is selectively cytotoxic to cancer cells.Formula:C18H32O3Purity:Min. 95%Color and Shape:PowderMolecular weight:296.4 g/molAR-R 17779 hydrochloride
CAS:AR-R 17779 is a selective agonist for α7 nicotinic acetylcholine receptors (nAChRs) (Ki value = 190 nM for rat α7 receptor). This compound has use as a tool to study the function of α7 nicotinic receptors. One such study revealed a role for α7 nicotinic receptors in nicotine-mediated excitatory effects on hippocampal learning and memory. AR-R17779 reduces formation of atherosclerotic plaques and abdominal aortic aneurysms in apolipoprotein E-deficient mice.Formula:C9H14N2O2•HClPurity:Min. 95%Color and Shape:White PowderMolecular weight:218.68 g/molBIO
CAS:Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Formula:C16H10BrN3O2Purity:Min. 95%Color and Shape:Red To Dark Red SolidMolecular weight:356.17 g/molDapoxetine hydrochloride - Bio-X ™
CAS:Controlled ProductDapoxetine is a drug that belongs to the group of selective serotonin reuptake inhibitors (SSRIs). It is used to treat premature ejaculation. This drug inhibits the serotonin transporter allowing for an increased action of serotonin at the postsynaptic cleft, thus promoting ejaculatory delay.Formula:C21H24ClNOPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:341.87 g/molS26131
CAS:S26131 is an advanced glycation end product (AGE) inhibitor, which is a synthetic compound designed for laboratory research purposes. It is derived from chemical synthesis processes, offering a robust tool for investigating the biochemical pathways associated with glycation. Its mechanism of action involves the inhibition of AGE formation, which is a post-translational modification resulting from the non-enzymatic reaction between sugars and proteins or lipids. This biochemical modulation is vital for studying the implications of glycation in various physiological and pathological contexts.
Formula:C31H34N2O4Purity:Min. 95%Molecular weight:498.6 g/molDCC 2036
CAS:Inhibits multiple tyrosine kinases (Abl1, Src family kinases, Tie-2 and VEGFR-2)Formula:C30H28FN7O3Purity:Min. 95%Color and Shape:PowderMolecular weight:553.59 g/molSGC AAK1 1
CAS:Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Formula:C21H25N5O3SPurity:Min. 95%Color and Shape:SolidMolecular weight:427.52 g/molMotesanib
CAS:Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFormula:C22H23N5OPurity:Min. 95%Molecular weight:373.45 g/mol(R)-ADX 47273
CAS:Positive allosteric modulator of the metabotropic glutamate receptor mGluR5 with EC50 in submicromolar range. The compound is able to increase mGluR5 function in vitro and in vivo. A study showed that ADX-47273 enhanced fear extinction learning as well as improved reversal learning in experimental animals.
Formula:C20H17F2N3O2Purity:Min. 95%Color and Shape:SolidMolecular weight:369.36 g/molSB 239063
CAS:Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormula:C20H21FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:368.4 g/molKenpaullone
CAS:Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.
Formula:C16H11BrN2OPurity:Min. 95%Color and Shape:Yellow To Dark Yellow SolidMolecular weight:326.00548GSK 2606414
CAS:Inhibitor of EIF2AK3/PERK kinasesFormula:C24H20F3N5OPurity:Min. 95%Color and Shape:PowderMolecular weight:451.44 g/molValiglurax
CAS:Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor mGlu4. Valiglurax is orally bioavailable and CNS-penetrant mGlu4 PAM in preclinical development for the Parkinson’s disease therapy and alleviation of the motor symptoms.Formula:C16H10F3N5Purity:Min. 95%Color and Shape:SolidMolecular weight:329.28 g/molBX471 hydrochloride
CAS:BX471 hydrochloride is a selective antagonist of the C-C chemokine receptor type 1 (CCR1), which is synthesized through rigorous chemical processes. It operates by inhibiting the binding of chemokines to the CCR1 receptor, thus interfering with the signaling pathways that lead to inflammation and immune responses. This mechanism is specifically effective in modulating immune system functions and controlling pathophysiological responses in various tissue types.
Formula:C21H25Cl2FN4O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:471.35 g/molSertindole
CAS:Antagonist of cardiac potassium channel HERG; anti-psychoticFormula:C24H26ClFN4OPurity:Min. 95%Color and Shape:PowderMolecular weight:440.94 g/molElacridar
CAS:Inhibitor of ABC transporters; oral bioenhancer for anti-cancer therapyFormula:C34H33N3O5Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:563.64 g/molMCC 950 sodium
CAS:Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.Formula:C20H23N2O5S·NaPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:426.46 g/molSemaglutide
CAS:Anti-diabetic and anti-obesity drug. We also have the heavy labelled material, CRB1301886. Cymit Quimica provides this product solely for uses within the scope of any statute or law providing for an immunity, exemption, or exception to patent infringement (“Exempted Uses”), including but not limited to 35 U.S.C. § 271(e)(1) in the United States, the Bolar type exemption in Europe, and any corresponding exception to patent infringement in any other country. It is the sole responsibility of the purchaser or user of this product, and the purchaser or user of this product agrees to engage only in such Exempted Uses, and to comply with all applicable intellectual property laws and/or regulations. The purchaser of this product agrees to indemnify Cymit Quimica against all claims in connection with the performance of the respective commercial agreement (e.g. supply agreement) and possible infringements of intellectual property rights.Formula:C187H291N45O59Purity:Min. 99.0 Area-%Color and Shape:PowderMolecular weight:4,113.58 g/molGDC 0941
CAS:Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formula:C23H27N7O3S2Purity:Min. 95%Color and Shape:White PowderMolecular weight:513.64 g/molL 838417
CAS:Selective partial GABAA receptor antagonist of subtypes α1, α2, α3, α5 subunits. Non-sedative anxiolytic effects demonstrated in vivo, without compromising motor activity. Anti-nociceptive and anti-inflammatory activities also demonstrated in vivo.Formula:C19H19F2N7OPurity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:399.4 g/molNAcM-OPT
CAS:Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.Formula:C23H29Cl2N3OPurity:Min. 95%Color and Shape:solid.Molecular weight:434.4 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formula:C13H11Cl2N5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:372.16 g/molBosentan - Bio-X ™
CAS:Bosentan is a dual endothelin receptor antagonist that is used to treat hypertension. This drug works by blocking the action of endothelin molecules which prevents the narrowing of blood vessels and decreases blood pressure.
Formula:C27H29N5O6SPurity:Min. 95%Color and Shape:PowderMolecular weight:551.62 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formula:C26H23F2N3O4Purity:Min. 95%Color and Shape:SolidMolecular weight:479.48 g/molDG 172 hydrochloride
CAS:Potent inverse agonist of peroxisome proliferator-activated receptor PPARβ and PPARδ with IC50 value of 27 nM. In mouse myoblasts, DG 172 enhanced recruitment of transcriptional corepressor and down-regulated transcription of PPARβ/δ target gene Angptl4. DG 172 also possess a PPARβ/δ-independent activity on bone marrow cells and promotes dendritic cell differentiation.Formula:C20H20BrN3•HClPurity:Min. 95%Color and Shape:SolidMolecular weight:418.76 g/molBenazepril HCl - Bio-X ™
CAS:Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Formula:C24H28N2O5•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:460.95 g/molt-TUCB
CAS:t-TUCB is a potent soluble epoxide hydrolase (sEH) inhibitor, which is a chemically synthesized compound. The mode of action of t-TUCB involves the inhibition of sEH, an enzyme responsible for the degradation of epoxyeicosatrienoic acids (EETs). By inhibiting sEH, t-TUCB effectively increases the levels of EETs, which are signaling molecules involved in numerous physiological processes, including inflammation, blood pressure regulation, and pain perception.Formula:C21H21F3N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:438.4 g/molVolitinib
CAS:Inhibitor of c-Met kinaseFormula:C17H15N9Purity:Min. 95%Color and Shape:White PowderMolecular weight:345.36 g/molAzumolene
CAS:Azumolene is a muscle relaxant drug, which is a synthetic derivative of dantrolene originating from hydantoin. The mode of action of Azumolene involves the inhibition of calcium ion release from the sarcoplasmic reticulum of skeletal muscle fibers. By impeding this release, Azumolene effectively reduces muscle contraction, thereby acting as a potent muscle relaxant.Formula:C13H9BrN4O3Purity:Min. 95%Color and Shape:PowderMolecular weight:349.14 g/molMianserin HCl - Bio-X ™
CAS:Controlled ProductMianserin is a tetracyclic antidepressant drug that has antihistaminic and hypnosedative properties. It is used to treat depression in adults and children, as well as other disorders such as chronic pain and irritable bowel syndrome. This drug’s mechanism of action is not fully understood but is said to block alpha-adrenergic, histamine H1 and serotonin receptors.Formula:C18H20N2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:300.83 g/molMethotrexate
CAS:Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Formula:C20H22N8O5Color and Shape:Yellow PowderMolecular weight:454.44 g/molNaftopidil - Bio-X ™
CAS:Naftopidil is an alpha adrenergic antagonist drug that is used to treat urinary symptoms and conditions related to benign prostatic hypertrophy. This drug works to relax smooth muscles by inhibiting alpha adrenergic receptors, thus allowing an improvement in urine flow.Formula:C24H28N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:392.49 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/molAMG 9810
CAS:Vanilloid receptor 1 antagonistFormula:C21H23NO3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:337.41 g/molPD 169316
CAS:Inhibitor of p38 kinase
Formula:C20H13FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:360.34 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:431.2 g/molUNC 4203
CAS:Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.Formula:C30H44N6OPurity:Min. 95%Color and Shape:Yellow PowderMolecular weight:504.71 g/molCariprazine
CAS:Partial agonist of D2 and D3 dopamine receptors; anti-psychoticFormula:C21H32Cl2N4OPurity:Min. 95%Color and Shape:White PowderMolecular weight:427.41 g/molLoratadine - Bio-X ™
CAS:Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C22H23ClN2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:382.88 g/molMalotilate - Bio-X ™
CAS:Malotilate is a pharmacological agent that is used to treat symptoms of hepatitis, bowel disease, and collagen diseases. This drug reduces collagen synthesis and cell migration activity of fibroblasts in vitro. It also has been shown to facilitate liver regeneration in rats.Formula:C12H16O4S2Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:288.39 g/molNalmefene hydrochloride
CAS:Controlled ProductOpioid receptor antagonistFormula:C21H25NO3•HClPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:375.89 g/mol(S)-Mephenytoin - Bio-X ™
CAS:(S)-Mephenytoin is a substrate of cytochrome P450 enzyme CYP2C19 (a hydroxylase). It is an effective anticonvulsant that improves control of seizures in patients. According to studies, the drug exhibits a genetic polymorphism in CYP2C19 that results in reduced metabolism in some individuals.Formula:C12H14N2O2Purity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:218.25 g/molBMS 754807
CAS:A reversible inhibitor of IGF-1R kinase and insulin receptor. Has anti-growth effects in mesenchymal, epithelial and hematopoietic tumor types. Synergistic with other cytotoxic, hormonal and targeted anti-cancer therapy.
Formula:C23H24FN9OPurity:Min. 95%Color and Shape:PowderMolecular weight:461.49 g/molN-Trityl candesartan cilexetil
CAS:Angiotensin II receptor antagonist
Formula:C52H48N6O6Purity:Min. 95%Color and Shape:PowderMolecular weight:852.97 g/mol(+)-Muscarine tosylate
CAS:Muscarinic acetylcholine receptor agonistFormula:C9H20NO2·C7H7O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:345.46 g/mol
