Organic Halides

<p>Applications 2-Nitro-5-(trifluoromethyl)aniline is a reagent in the synthesis of benzo[d]imidazole derivatives which has vasorelaxant activity and antihypertensive effects.<br>References Navarrete-Vazquez, G., et al.: Bioorg. Med. Chem., 18, 3985 (2010);<br></p>

<p>Applications 2,2,2-Trifluoroethyl trifluoroacetate is a reagent that is used in the synthesis of Dimethyl Diazomethylphosphonate (D470900).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>

<p>Applications Intermeidate in the preparation of many GABA modulators<br>References Stafford, J., et al.: Bioorg. Med. Chem. Lett., 12, 3215 (2002), Fadeyi, O., et al.: Bioorg. Med. Chem. Lett., 18, 4172 (2008),<br></p>

<p>Applications 1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride is a derivative of 1,1,1-Trichloromethanesulfonic Acid a very strong acid used in protonation reactions, and as a catalyst in esterifications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. et al.: Chem. Rev., 77, 69 (2006);<br></p>

<p>Applications 1-Bromo-2-fluorobenzene is used as a reagent in the synthesis of organic compounds inlcuding that of brominated N-arylated carbazoles which are widely useful in organic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., Synthesis, pages ahead of print, (2015);<br></p>

<p>Applications 2-​Bromo-4-​thiazolesulfonyl chloride is a useful chemical for research.<br></p>

<p>Applications 5-Aminopentanenitrile Hydrochloride is a useful research chemical.<br></p>

<p>Applications Ethyl 2-bromoethanesulfonate is a useful reagent for the esterification of sulfonic acids.<br>References Etienne, A., et al.: Comptes Rendus Acad. Sci., 275, 633 (1972)<br></p>

<p>Applications 2,2,2-Trifluoroethyl Formate acts as a reagent for the preparation of HCV NS5B inhibitor MK-3281, an inhibitor of hepatitis C virus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colarusso, S., et al.: Synlett, 11, 1527 (2011)<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications (S)-(-)-2-Chloropropionic Acid (cas# 29617-66-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.<br>References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);<br></p>

<p>Applications Isobutyryl chloride is a useful intermediate commonly used in synthetic chemistry. Isobutyryl chloride is also a potential inducer of pulmonary adenomas in strain A mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Theiss, J., et al.: Cancer Res., 39, 391 (1979)<br></p>

<p>Applications Nonafluoropentanoic Anhydride is a useful compound in silicon-based energy storage devices.<br>References Ji, L., &amp; Benjamin, Y.: U.S. Pat. Appl. Publ. (2020), US 20200203711 A1<br></p>

<p>Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications o-Tolylhydrazine Hydrochloride is a reagent used in the organic syntheses such as opioid receptor antagonists as well as adenosine receptor antagonists as well as adenosine receptor antagonists.<br>References Colotta, V. et al.: J. Med. Chem., 43, 3118 (2000); Portoghese, P. et al.: J. Med. Chem., 33, 1714 (1990);<br></p>

<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>

<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,​3-​Bis(bromomethyl)​-​5-​methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>

<p>Applications 2,4-Dinitrobenzenesulfenyl Chloride is used in the modification of chlorea toxins and it’s promoters.<br>References De Wolf M. J., et al. : J. Biol. Chem., 256, 5481 (1981)<br></p>

<p>Applications Used for production of peptide thioester. This compound often contains some of the analogous alkyl bromide.<br></p>

<p>Applications 4-(4-Fluorophenyl)benzoic acid<br></p>

<p>Applications 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride is used in the preparation of multifunctional cationized cotton fabric based on TiO2 nanomaterials.<br>References Farouk, A., et la.: Int. J. Biol. Macromolecules, 61, 230 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1,2-bis(Chloromethoxy)ethane is a carcinogenic compound.<br>References Kar, S., Roy, K.: Chemoshpere, 87, 339 (2012)<br></p>

<p>Applications 2-Chloro-4,6-dimethoxyaniline Hydrochloride (cas# 82485-84-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyltriphenylphosphonium Bromide is used as a wittig reagent. Ethyltriphenylphosphonium Bromide and other phosphonium salts show antiviral activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romanov, G.V. et al.: Khim.-Farm. Zhur., 24, 28 (1990);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications A 3-aryl substituted Azetidine (A813000).<br></p>

<p>Applications 2-Chloro-1-(2-((3-chloropropyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethanone is an intermediate used in the synthesis of Ifosfamide Impurity A (I265005), which is an impurity of Ifosfamide (I265000), a cytostatic agent related structurally to cyclophosphamide.<br>References Creaven, P. J., et al.: Cancer Treat. Rep., 60, 445(1976), Schoenike, S. E., Clin. Pharm., 9, 179(1990), Skinner, R., et al.: J. Clin. Oncol., 11, 173 (1993).<br></p>

<p>Applications Bis(Dichloromethyl) Ether an important reagent used in chemical research.<br>References Hsu, F. L., et al.: ACS Med. Chem. Lett., 10, 761-766 (2019)<br></p>

<p>Applications 3,3,3-trifluoro-2-oxopropanoic acid (cas# 431-72-1) is a useful reagent in the biotransformation of pentafluoropropane in rat and humans.<br>References Bayer, T., et al.: Chem. Res. Toxicol., 15, 723 (2002)<br></p>

<p>Applications 2-[[[(9H-Fluoren-9-ylmethoxy)Carbonyl]Amino]Methoxy]-Acetic acid is a useful reagent in organic synthesis.<br></p>

<p>Applications A metabolite of halogenated aniline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cnubben, N.H.P., et al.: Biochem. Pharmacol., 49, 1235 (1995),<br></p>

<p>Applications Oxydiethylene Bis(chloroformate) is a useful research intermediate for organic synthesis.<br>References Qian, W., et al.: Zhejiang Yike Daxue Xuebao, 25, 252 (1996); Alekseev, N. N., et al.: Kinetika i Kataliz, 29, 471 (1988); Alekseev, N. N., et al.: Plast. Massy, 5, 52 (1984)<br></p>

<p>Applications p-Trifluoroacetyltoluene is used as a reagent in the synthesis of 5-methylene-2-(trifluoromethyl)morpholin-3-one derivatives which have fungicidal activity.<br>References Tian, L., et al.: RSC Adv., 5, 100418 (2015)<br></p>

<p>Applications 6-Chloro-2,1,3-benzoselenadiazole (cas# 6343-86-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.<br>References Bensaid, S., et al.: Tetrahedron Lett., 52, 1383 (2011); Lagoja, I., et al.: Eur. J. Pharm. Sci., 43, 386 (2011); Matsubara, K., et al.: J. Organom. Chem., 691, 3693 (2006)<br></p>

<p>Applications (2,3-Dichloro-4-oxyphenyl)-2-thienylmethanone (cas# 40180-03-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Used for preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.<br>References Whitehead, C., et al.: J. Org. Chem., 27 (1962), Phillips, D., et al.: Bioorg. Med. Chem., 10 (2002),<br></p>

<p>Applications 3-Bromo-N-(3-chloropropyl)benzenesulfonamide<br></p>

<p>Applications Trimethylsilylethynyl(phenyl)iodonium Tetrafluoroborate is used in synthesis of 1-Alkynyl(triphenyl)arsonium Tetrafluoroborates by onium transfer reaction of 1-Alkynyl(phenyl)iodonium Tetrafluoroborates with Triphenylarsine. Also, used in preparation of Furan- and Thiophene-substituted alkynes and alkynyl ketones by Copper Iodide-catalyzed coupling and carbonylation of Heterocyclic Boronic Acids with Alkynyliodonium salts.<br>References Nagaoka, T., et al.: Tetrah. Lett., 36, 261-4 (1995); Yu, Chan-Mo, et al.: Synlett, 2631-2634 (2005);<br></p>

<p>Applications 2-AMINOETHANOL HYDROCHLORIDE (cas# 2002-24-6) is a useful research chemical.<br></p>

<p>Applications 5-Fluorobenzofuran-3-one<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Chloroethyl ethyl carbonate (cas# 50893-36-2) is a useful research chemical.<br></p>

<p>Applications Tetrachlorocyclopropene is a useful compound in organic synthesis.<br>References Belding, Lee, et al.: J. of Org. Chem., 83(12), 6489-6497 (2018); Sanchez Garcia, Jessica J., et al.: Pure and App. Chem., 88(12), 1129-1142; (2016)<br></p>

<p>Applications Alpha-(p-toluenesulfonyl)-4-fluorobenzylisonitrile is a useful reagent for the development of DNA-compatible method for novel functionalized imidazoles.<br>References Geigle, S. N., et al.: Org. Lett., 21, 9001 (2019)<br></p>

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Applications (Hydroxymethyl)pentafluorobenzene is a good analogue of Benzyl Alcohol (T536635). Benzyl Alcohol is a good substrate that has been used extensively for kinetic studies and evaluation of quantum mechanical tunneling.<br>References Plapp, B., et al.: 51,Biochemistry, 4035 (2012);<br></p>

<p>Impurity Darifenacin 5 Carboxymethyl Impurity/ Darifenacin Bromo Impurity<br>Applications 5-(2-Bromoethyl)-2,3-dihydrobenzofuran (cas# 127264-14-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-1-(4-trifluoromethoxyphenyl)ethanone Hydrochloride is a reagent for the preparation of 4-phenylimidazole-2-thiones as tyrosinase inhibitors, their pharmaceutical and cosmetics compositions for the treatment or the prevention of the pigmentary disorders.<br>References Boiteau, J. G., et al.: From Fr. Demande (2008), FR 2917087 A1 20081212<br></p>

<p>Impurity Amiodarone EP Impurity H / Amiodarone USP Related Compound H<br>Stability Moisture Sensitive, Hygroscopic<br>Applications 2-Chloro-N,N-diethylethylamine Hydrochloride (Amiodarone EP Impurity H) is a related compound of Amiodarone, a non-selective ion channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)<br></p>

<p>Applications Chloromethanesulfonyl Chloride is a very useful intermediate for organic synthesis. It enhances citric acid production by Aspergillus niger NCIM-1696 and increases the yield of citric acid. It also functions as a useful intermediate for pharmaceutical synthesis.<br>References Mahato, J., et al.: J. Chemtracks, 16, 245 (2014); Shealy, Y. F., et al.: J. Med. Chem., 26, 1168 (1983); Johnson, J. K., et al.: ACS Med. Chem. Lett., 7, 785 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications 1,2,4,5-Tetrabromobenzene is a useful synthetic intermediate. It is used as a building block to prepare various aryl containing compounds such as tetrabenzanthracene, substituted pentacenes [pentacene (P237770)], n-stacking tetracene (N377650) derivatives and so on.<br>References Hilton, C., et al.: J. Am. Chem. Soc., 128, 14824 (2006); Zhao, Y., et al.: J. Org. Chem., 73, 5506 (2008); Chem, Z., et al.: Org. Lett., 8, 273 (2006)<br></p>

<p>Applications 2-Chloro-4-fluoro-1-nitrobenzene<br></p>

<p>Applications (2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors.<br>References Waldschmidt, Helen V, et al.: J. of Med. Chem., 59(8), 3793-3807 (2016).<br></p>

<p>Applications 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a.<br>References Piemontesi, C., et al.: Angew. Chem. Int. Edit., 55, 6556 (2016); Sweis, R., et al.: ACS Med. Chem. Lett., 5, 205 (2014);<br></p>

<p>Applications 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionyl chloride, rech grade<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 2-Bromo-1-bromomethyl-5-chlorobenzene (cas# 66192-24-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-((tert-Butyldiphenylsilyl)oxy)-4-fluorophenyl)boronic Acid is an intermediate used in the synthesis of Bicyclo Risperidone (B382800), which is an impurity of Risperidone (R525000); a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>

<p>Applications Fumaryl Chloride is a reagent used in the synthesis of thermosetting resins which are widely used in industrial fields.<br>References Kudo, K. et al.: J. App. Polym. Sci., 133 (2016);<br></p>

<p>Applications 2-(2-chloroethoxy)benzenesulfonamide (cas# 82097-01-6) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(Trifluoromethylthio)benzoyl Chloride is a reactant in the preparation of anthranilic acids as selective and dual PPAR/FXR ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Merk, D., et. al.: Bioorg. Med. Chem., 23, 499 (2015)<br></p>