Biochemicals and Reagents

<p>IMB-808 is an advanced synthetic compound, which is derived from a meticulously engineered chemical synthesis process. This compound functions through a unique mode of action that involves the disruption of microbial cell walls, leading to cell lysis and death. The precise mechanism involves the interference with enzymatic functions critical to cell wall biosynthesis, making it highly effective against a broad spectrum of bacterial pathogens.</p>

<p>SW203668 trifluoroacetate is a synthetic neuropeptide, which is a laboratory-derived analog of natural signaling molecules involved in neuronal communication. It is sourced from chemical synthesis, designed to mimic or enhance the function of endogenous peptides by binding to specific receptors on cell surfaces. The mode of action of SW203668 trifluoroacetate involves the modulation of neurotransmitter release and the subsequent alteration of neuronal signaling pathways.</p>

<p>PKC-9 is a protein kinase C (PKC) that is activated by calcium and diacylglycerol. PKC-9 has been shown to play an important role in the regulation of cellular proliferation and activation. PKC-9 can be phosphorylated by protein kinase A, which increases its catalytic activity. PKC-9 also interacts with other proteins, such as the regulatory subunit of protein phosphatase 1, highlighting its importance in the signaling pathways. PKC-9 has been shown to play a role in TNF-α signaling, where it enhances NFκB activity and subsequent transcription of proinflammatory genes.</p>

<p>LY 487379-d3 Hydrochloride is an experimental drug that belongs to the class of nucleoside analogues. It is an anti-HIV agent that is designed to inhibit deoxycytidine kinase, an enzyme involved in the conversion of deoxythymidine monophosphate (dTMP) to dTTP. LY 487379-d3 Hydrochloride has been shown to be a potent inhibitor of HIV replication in vitro and also inhibits the growth of HIV strains resistant to other nucleoside analogues. Clinical trials are currently underway for this experimental drug.</p>

<p>STX64 is an inhibitor of sulfatase, a class of enzymes that catalyzes the hydrolysis of sulfate esters. It has been shown to inhibit cancer cells in vitro and in vivo. STX64 also inhibits steroid sulfatase, which is an enzyme that catalyzes the conversion of steroids to inactive metabolites. This drug has a potential for use as a chemotherapeutic agent for breast cancer. STX64 binds to the active site of the enzyme and prevents other molecules from binding, thereby preventing the conversion process. STX64 may be used in combination with other drugs to prevent drug interactions by inhibiting their metabolism.</p>

<p>(R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one is a research chemical. It is an activator of Ligand and Receptor. This product is also a cell biology research tool and inhibitor of ion channels. (R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one has been used as an antibody to study protein interactions and pharmacology.</p>

<p>Pentagamavunon-1 is an activator of the pentagamma subunit of the ligand-gated ion channel. It binds to the receptor and activates it, causing a change in the permeability of cells. Pentagamavunon-1 can be used as a research tool or as an inhibitor in cell biology.</p>

<p>Regaloside B is a pentacyclic triterpene that has been found to have antioxidant effects. It also inhibits the production of 5-hmf, an important mediator in the inflammatory response. Regaloside B has been shown to be effective in inhibiting cell morphology changes and mitochondrial membrane potential in various types of cells. The activity test for this compound is based on its ability to inhibit the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α). Chemical structures, fingerprint analysis, and biodegradability are some of the analytical methods used to identify Regaloside B.</p>

<p>Terfuboxon is a pesticide that is used to control the growth of fungi. It works by interfering with the process of photosynthesis, which is essential for plant life. Terfuboxon has been shown to be effective against a wide range of pests, including bacteria and algae. Terfuboxon reacts with anions in the soil and water to produce hydrogen sulphide (H2S). The H2S reacts with ozone (O3) in sunlight to form sulphur dioxide (SO2) and hydrogen chloride (HCl). These reactions are monitored using mass spectrometry. Liquid chromatography analysis can also be used to determine the concentration of terfuboxon in food products.</p>

<p>LY367385 is a selective antagonist of the metabotropic glutamate receptor subtype 1 (mGluR1), originating from advanced pharmacological research. Its mode of action involves competitive inhibition at the glutamate binding site on mGluR1, effectively modulating synaptic transmission by decreasing receptor activity. This modulation interferes with glutamate-induced neuronal excitability, making LY367385 an invaluable tool in the exploration of glutamatergic signaling pathways.</p>

<p>Please enquire for more information about Ep4 receptor antagonist 1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Tolnaftate-d7 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mps1-IN-1 is a molecule that inhibits the mitotic checkpoint, leading to cell death. It has been shown to inhibit the localization of Mps1 in cells and leads to an accumulation of cells in metaphase. This drug also has anti-leukemic activity in vitro and it is effective against leukemia cells. Mps1-IN-1 inhibits the function of two molecules (bi-d1870) that are involved in cancer progression and metastasis. This drug has been shown to inhibit protein synthesis and cell division through the inhibition of RNA synthesis, which is necessary for translation initiation.</p>

<p>A selective ATP-competitive inhibitor of polo-like kinase 1 (Plk1). This protein is a serine/threonine kinase that regulates cell cycle progression into mitosis and is commonly overexpressed in tumors. The Plk1 inhibition resulted in 50% growth inhibition, induction of cell cycle arrest and apoptosis in neuroblastoma cell lines at concentrations &lt; 20 nM.</p>

<p>(Z)-Dimethomorph is an analog of the anticancer drug rifampicin that has been shown to inhibit kinase activity in cancer cells. This compound has demonstrated potent anticancer activity against a variety of tumor types, including human cancer cells. (Z)-Dimethomorph has been shown to induce apoptosis in Chinese hamster ovary cells and inhibit the growth of cancer cells by inhibiting the activity of kinases involved in cell proliferation and survival. Additionally, this compound has been found to be a potent inhibitor of astaxanthin uptake and metabolism in urine, suggesting its potential as a therapeutic agent for cancer treatment. Overall, (Z)-Dimethomorph shows promise as a potent inhibitor of kinases involved in cancer cell growth and survival.</p>

<p>NSC12 is a potent inhibitor of cell proliferation and tumor growth. It has been shown to inhibit muscle cell proliferation and induce apoptotic cell death. NSC12 binds to the hydroxyl group of HIF-1α, which prevents it from forming a complex with the transcriptional coactivator p300. This binding inhibits the transcriptional activity of HIF-1α, leading to decreased protein synthesis in cells and ultimately apoptosis. NSC12 has been shown to be an effective therapeutic agent for proliferative diabetic retinopathy in an experimental model.</p>

<p>PSB-12062 is a molecule that has been shown to have an inhibitory effect on cancer cells. It inhibits the activity of p2y receptors, which are found in human macrophages and other cells. PSB-12062 also blocks the entry of Ca2+ ions into cells by blocking ion channels, leading to a decrease in protein synthesis. PSB-12062 can activate colony stimulating factor, which may be useful for patients with cancer or other diseases that cause chronic inflammation.</p>

<p>Inactive analogue of PI£K kinase inhibitor LY 294002</p>

<p>4-{4-[(Bromoacetyl)amino]butyl}benzoic acid is a ligand that binds to Ion channels. 4-{4-[(Bromoacetyl)amino]butyl}benzoic acid is a bidentate ligand, which interacts with the extracellular loops of the receptor. This compound has been shown to activate both potassium and chloride ion channels. 4-{4-[(Bromoacetyl)amino]butyl}benzoic acid has also been shown to inhibit the activity of beta adrenergic receptors, leading to hypotension and bradycardia in animals. 4-{4-[(Bromoacetyl)amino]butyl}benzoic acid is a high purity research tool that can be used for studying protein interactions, peptides, antibodies, cell biology and pharmacology.</p>

<p>Thalidomide-O-amido-PEG3-C2-NH2 is a synthetic bioconjugation reagent designed as an E3 ligase ligand-linker conjugate, which is crucial for targeted protein degradation. This compound is a derivative of thalidomide, a well-known immunomodulatory drug, chemically modified to include a polyethylene glycol (PEG) spacer and an amide linker. This compound is frequently employed in the development of proteolysis-targeting chimeras (PROTACs), a revolutionary technology in chemical biology and drug discovery. By linking an E3 ligase recruiter to a ligand for a target protein, Thalidomide-O-amido-PEG3-C2-NH2 facilitates proximity-induced ubiquitination and degradation of proteins of interest, enabling researchers to modulate protein levels with high precision. Its applications extend to therapeutic research, particularly in oncology and neurodegenerative diseases, where selective depletion of pathogenic proteins offers potential therapeutic benefits. The unique ability to target previously 'undruggable' proteins underscores its significance in expanding the scope of druggable targets in modern medicinal chemistry.</p>

<p>Muricarpone B is a natural compound that has been shown to inhibit thrombin and TNF-α. It belongs to the class of diphenyl ethers, which are a group of molecules with potent anti-inflammatory activity. Muricarpone B has been shown to have pharmacophoric properties and inhibitory activities against thrombin, TNF-α, and neutrophil elastase in vitro. Muricarpone B also inhibits neutrophil migration in vivo. Muricarpone B is found in plants from the family Rutaceae, including citrus fruits like oranges and lemons.</p>

<p>WAY 267464 is an analog of the endogenous hormone oxytocin. It has been shown to promote the release of dopamine and serotonin in various regions of the brain, as well as inhibit alcohol intake in animal models. In animal models, WAY 267464 also shows antidepressant-like activity and a profile that suggests it may be used for chronic viral infections. WAY 267464 binds to the oxytocin receptor with high affinity, but does not bind to other receptors. The molecule is structurally similar to a number of antidepressants that are currently on the market, including fluoxetine, amitriptyline, and venlafaxine.</p>

<p>CCG215022 is a small-molecule inhibitor of GSK3β. It has been shown to induce death in cancer cells that are resistant to other chemotherapies, such as rhabdomyosarcoma, and is effective at inhibiting the growth of various cancers, including breast cancer. CCG215022 binds to the ATP-binding pocket of GSK3β and inhibits its activity by preventing the formation of phosphorylated peptides on kinase domain. The inhibition of this enzyme leads to increased contractility and increased hydrophobicity, which may be responsible for its effect on cancer cells. CCG215022 also has an excellent safety profile in pediatric patients and is effective at doses that are lower than those required for adults.</p>

<p>9-Chloro-7-(2-chlorophenyl)-5H-pyrimido(5,4-D)(2)benzazepine is an ion channel activator that can be used in research to study the function of ion channels. It binds to a specific site on the protein and activates the associated ion channel. This compound can also inhibit some types of ligand binding by interfering with the binding site on the receptor. 9-Chloro-7-(2-chlorophenyl)-5H-pyrimido(5,4-D)(2)benzazepine has high purity and is available for purchase from several suppliers.</p>

<p>Inhibitor of protein kinase PKG</p>

<p>5-[(2-chloro-6-oxo-3-piperidinyl)oxy]pentanoic acid is a peptide that belongs to the group of inhibitors. It binds to the active site of protein kinases and blocks their activity. The inhibition of protein kinases prevents phosphorylation of downstream substrates, which leads to inhibition of cellular processes such as cell growth and DNA synthesis. 5-[(2-chloro-6-oxo-3-piperidinyl)oxy]pentanoic acid is also an activator of cyclic AMP response element binding (CREB), a transcription factor that regulates gene expression in response to extracellular signals. 5-[(2-chloro-6-oxo-3-piperidinyl)oxy]pentanoic acid has been used as a research tool for investigating protein interactions and receptor activation.</p>

<p>(S)-2-((2-Hydroxy-1-phenylethyl)amino)acetic acid is a versatile compound with various applications across different industries. It can be used in the field of Life Sciences for research purposes, such as studying growth factors and chemokines. This compound has also been utilized in the industrial sector for the production of cellulose and fatty acids.</p>

<p>GSK J4 HCl is a small-molecule inhibitor, which is derived from synthetic chemistry methods, designed specifically to target the histone demethylase JMJD3/UTX. This compound functions by inhibiting the activity of the enzyme, effectively modulating epigenetic modifications through its influence on histone demethylation processes.</p>

<p>Oleic acid-d9 is a fatty acid that is a major component of the lipid fraction of natural oils. Oleic acid-d9 can be obtained by hydrolysis of oleate ester, which is a naturally occurring compound in many vegetable oils. The oleic acid-d9 molecule has an asymmetric carbon atom and can exist in two forms: d9-oleic acid and l9-oleic acid. Oleic acid-d9 can be used to generate biodiesel, or it can be used as a raw material for the production of other compounds such as chlorophylls and fatty acids. It also has antioxidant properties, which may help prevent cancer cell growth.</p>

<p>PF 1163A is a medicinal compound that has shown promising results in the treatment of cancer. It is an analog of a protein found in human urine and has been shown to inhibit kinases, which are enzymes involved in cell signaling pathways that can contribute to cancer growth. PF 1163A has been tested on Chinese hamster ovary cells and has been shown to induce apoptosis, or programmed cell death, in cancer cells. As an anticancer agent, PF 1163A acts as a kinase inhibitor and may have potential as a tumor suppressor. Further research is needed to fully understand the mechanism of action of this compound and its potential as a cancer therapy.</p>

<p>CUDC-427 is a small-molecule inhibitor of apoptosis proteins (IAP), which is a synthetic compound sourced from the design and synthesis of targeted anticancer agents. Its primary mode of action involves the selective inhibition of IAPs, particularly cIAP1 and cIAP2. This inhibition leads to the activation of caspases and subsequent induction of apoptosis in cancer cells.</p>

<p>PF-3758309 is a small molecule inhibitor, which is identified as a product of synthetic chemical engineering. It acts as a potent inhibitor of the PAK kinases, particularly PAK4, a family of serine/threonine kinases involved in cytoskeletal dynamics, cell motility, survival, and proliferation. These kinases are overexpressed in various types of cancer, making them attractive targets for therapeutic intervention.</p>

<p>Tulopafant is a novel linker drug that has shown efficacy in treating ischemia/reperfusion injury. It acts by binding to and activating neutrophils, which are important for the body's immune response to infection. Tulopafant promotes the release of reactive oxygen species from neutrophils, and it also neutralizes reactive nitrogen species. This drug has been shown to be effective in reducing ventricular fibrillation in vitro studies and may be useful as a treatment for myocardial infarcts.</p>

<p>16:0-18:1 Diether PG is a synthetic lipid, which is derived from chemically modified glycerophospholipids. Its structure involves two ether-linked alkyl chains, with one saturated (16:0) and one monounsaturated (18:1) chain. This compound does not occur naturally but is synthesized for research purposes to mimic certain biological membrane properties.</p>

<p>Nrf2-IN-1 is a small molecule that has been shown to increase the glomerular filtration rate in rats. It also enhances renal function by reducing urea nitrogen and staining. In addition, Nrf2-IN-1 protects against renal injury caused by ischemia reperfusion injury in rats. Nrf2-IN-1 also prevents oxidative injury of kidney cells and reduces cell apoptosis. This drug has been shown to reduce inflammation by inhibiting tumor necrosis factor α (TNFα) production in mice with acute kidney injury.</p>

<p>GNF4877 is an oral medication that has been shown to enhance the ability of insulin-producing cells, called β-cells, to produce and release insulin in response to glucose levels. This drug selectively inhibits the kinase activity of a growth factor receptor called "growth factor receptor β" (GRβ), which is found on the surface of cells. The inhibition of GRβ leads to increased production of a protein called "effector protein 1" (E1P1) in pancreatic β-cells. Increased E1P1 enhances glucose uptake and stimulates the production and release of insulin by β-cells, which can be used as an alternative treatment for diabetes mellitus type 2.</p>

<p>PS372424 hydrochloride is a peptide that has been shown to be an activator of the high-affinity receptor for the neurotransmitter GABA. PS372424 hydrochloride interacts with and activates GABAA receptors, which are ligand-gated chloride channels. These channels are involved in regulating neuronal excitability and postsynaptic inhibition in the central nervous system. PS372424 hydrochloride has also been shown to inhibit both potassium and calcium currents, suggesting that it may modulate neuronal activity in other parts of the body as well.</p>

<p>Please enquire for more information about 2,3-Dihydroxy-1-(1H-indol-3-yl)propyl tryptophan including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Sofpironium bromide is a ligand that binds to ion channels and is used as a research tool. It is used in cell biology and immunology to study protein interactions, receptor pharmacology, and ion channels. Sofpironium bromide is also used as an inhibitor of the potassium channel Kv1.4 and has been shown to inhibit the proliferation of human cancer cells.</p>

<p>IN 1130 is a molecule that has been shown to have antimicrobial effects against bacteria. It has been observed to inhibit the growth of prostate cancer cells, as well as decrease the disease activity of abdominal surgery patients. The mechanism of action is not fully understood, but it is hypothesized that IN 1130 is a growth factor-β1 agonist that inhibits the proliferation of tumor cells by binding to its receptor and activating intracellular signaling pathways. IN 1130 has also been shown to exhibit an effect on hematopoietic cells in vitro, with potential applications in pediatric and optical sensor technology. In addition, IN 1130 has been observed to be effective in treating cervical cancer with hydroxyl groups on the molecule that can react with histochemical stains.</p>

<p>Please enquire for more information about Mini gastrin I, human including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(4S)-4-[(2S)-2-[(2S)-2-Amino-3-(1H-imidazol-4-yl)propanamido]propanamido]-4-[({[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl}methyl) c arbamoyl]butanoic acid is a glp-1 analogue that may be used for the treatment of metabolic disorders. It has been shown to increase insulin production in response to glucose and also has site specific activity. The compound binds to insulin receptors, which leads to increased synthesis of intracellular insulin and activation of downstream signaling pathways. The analog has a neutral pH and is stable in biological fluids such as human serum or dogfish plasma.</p>

<p>Please enquire for more information about NS 383 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(+)-Azasetron hydrochloride is a chemical compound known as a 5-HT3 receptor antagonist, which is synthesized through chemical processes. Its primary mode of action involves the selective inhibition of the serotonin 5-HT3 receptor, located in both the central and peripheral nervous systems. This block prevents serotonin from binding to its receptor, which is a crucial step in the emetic response—a physiological reaction that leads to nausea and vomiting.</p>

<p>Opigolix is a peptide that binds to the receptor site of ion channels, thereby initiating changes in cell membrane potential. It activates ligand-gated ion channels by binding to the receptor and inducing conformational changes in the channel protein. Opigolix has been shown to inhibit calcium flux in cells, and has been used as a research tool for studying the effects of ion channel activation on cell migration.</p>

<p>ENMD-1198 is a novel analog of the naturally occurring molecule endostatin. It has been shown to inhibit endothelial cell proliferation in vitro, but it is not yet known whether this effect will translate to clinical efficacy. ENMD-1198 is currently undergoing phase I and II clinical trials for the treatment of breast cancer, prostate cancer, and other cancers. The drug has been shown to be well tolerated at doses up to 10 mg/kg, with no significant adverse reactions reported.</p>

<p>BMS-8 is a monoclonal antibody that binds to the death ligand, TNF-α. It has been shown to be effective in treating cancer cells that have an overactive PD-1 pathway, which leads to cell death by inhibiting the production of proteins vital for cell division. BMS-8 has also been shown to inhibit the activity of ctla-4 and pd-l1, molecules that are involved in the TNF-α pathway. The binding of BMS-8 to these molecules has been shown to inhibit their activation and downstream signaling pathways.</p>

<p>5-Chloro-2- (4-methoxyphenyl) -4-methyl-6-[3-(1-piperidinyl) propoxy] pyrimidine is a research tool that can be used in the study of ion channels and protein interactions. It has been shown to inhibit the activity of human recombinant beta 2 adrenergic receptor at low micromolar concentrations, with an IC50 of 5.1±0.5 μM. The binding affinity for this ligand is stronger than that of propranolol (IC50=8.5±0.7 μM).</p>

<p>S 24795 is a potent allosteric modulator of nicotinic acetylcholine receptors. S 24795 has been shown to potentiate the activity of both nicotinic acetylcholine receptor subtypes, α7 and α4β2. It has been shown to inhibit synaptic dysfunction in vivo and improve cognitive function in animal models. This drug has a short half-life, which may be due to its inability to cross the blood brain barrier.</p>

<p>N-(5-Chloro-2-cyanophenyl)-N'-[2-hydroxy-2-(1-methyl-1H-indol-3-yl)ethyl]ethanediamide is a peptide that inhibits the activation of ion channels. It is also an inhibitor of protein interactions and receptor binding. This compound has been shown to inhibit the activation of ion channels and can be used as a research tool in cell biology, pharmacology, and other life science fields.</p>

<p>Phosphoserine antibody was raised in rabbit using phosphoserine as the immunogen.</p>

<p>Please enquire for more information about Dipyridamole-d20 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>rac-Enprostil is a synthetic prostaglandin analog derived from the natural compound prostaglandin E2, produced primarily via synthetic chemical processes. This compound functions by mimicking the action of endogenous prostaglandins on the gastrointestinal mucosa. It enhances the secretion of mucus and bicarbonate, promoting mucosal protection and stability. Additionally, rac-Enprostil inhibits gastric acid secretion, thus providing a protective effect against gastric lesions and ulcers.</p>

<p>Phenoxathiine 10,10-dioxide is a diphenyl ether that has been shown to have suzuki coupling activity. It can be used as an intermediate for the synthesis of polymers. Phenoxathiine 10,10-dioxide is soluble in acidic solutions and insoluble in neutral solutions. Structural analysis has revealed that phenoxathiine 10,10-dioxide contains a carbonyl group and a hydroxyl group, which are responsible for the solubility difference. The reaction mechanism of phenoxathiine 10,10-dioxide has been studied using human liver microsomes and found that it proceeds through a nucleophilic substitution at the chlorine atom. NMR spectra indicate that phenoxathiine 10,10-doxide contains an intramolecular hydrogen bond between the carbonyl group and the hydroxyl group.</p>

<p>CCT196969 is a drug candidate that has been shown to have anti-cancer properties. It has been shown to inhibit the growth of xenograft tumours in mice and may be effective against solid tumours. CCT196969 is thought to work by interfering with the apoptosis pathway, which leads to cancer cell death. This drug candidate inhibits the production of nuclear DNA, which may be an indication of its ability to target cancer cells. CCT196969 also has a biochemical effect on other genes that are related to cancer, such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). This drug candidate could potentially be used as a treatment for skin cancers or other types of cancer in the future.</p>

<p>Chemerin-9 is a peptide that can be used in research as a tool for cell biology, pharmacology, and life science. It has been shown to inhibit the receptor of chemerin-1, which is involved in immune system regulation. Chemerin-9 also interacts with the ligand of chemerin-1, which may be an important factor in the development of medications for treatment of autoimmune diseases.</p>

<p>Vapreotide acetate is a synthetic somatostatin analog, which is derived through chemical synthesis to mimic the naturally occurring hormone somatostatin. Its mode of action involves binding to somatostatin receptors, leading to the inhibition of the secretion of several hormones and growth factors, such as growth hormone (GH), insulin, glucagon, and gastrin. This inhibitory effect is achieved due to its structural similarity to somatostatin, allowing it to effectively modulate endocrine and exocrine functions.</p>

<p>GSK-7975A is a drug that inhibits the activity of the intracellular proteases, such as cathepsin. GSK-7975A has been shown to be effective in treating pancreatitis by reducing the cytosolic calcium overload and mitochondrial membrane potential in cells. GSK-7975A also decreases intracellular calcium levels, which are activated by an increase in fatty acid levels. The drug prevents ATP depletion and decreases the amount of dinucleotide phosphate released from mitochondria. This drug has shown clinical relevance in inhibiting the activity of cytosolic proteases, such as cathepsin B and cathepsin L, which have been implicated in pancreatitis.</p>

<p>5-Carboxamidotryptamine is a drug that inhibits the enzyme cytochrome P450 and has been shown to have antioxidative properties. 5-Carboxamidotryptamine has been shown to be a low potency inhibitor of the 5-HT2 receptor, which may be due to its ability to act as a cyclase inhibitor. 5-Carboxamidotryptamine has also been shown to behave as a ligand for the 5-HT7 receptor with low affinity, although it does not inhibit the activity of this receptor.</p>

<p>Pocapavir is an investigational antiviral compound, which is a small molecule inhibitor derived from synthetic chemical processes. It operates by targeting the viral capsid of picornaviruses, specifically binding to the viral protein 1 (VP1), interfering with the virus's ability to attach and uncoat within host cells. The disruption of these crucial early steps effectively blocks the replication cycle of the virus.</p>

<p>AMPA receptor antagonist</p>

<p>Epz004777 is an antibody that binds to the human protein CD147 and inhibits its activity. Epz004777 is a research tool that can be used in cell biology, pharmacology, and life science. It is used to study the interactions of proteins and receptors. Epz004777 is also a ligand that binds to ion channels, which are responsible for regulating the flow of ions across cellular membranes. Epz004777 has been shown to inhibit the activation of chloride ion channels by increasing their open probability. This product has a purity level of 99% and should be handled with care because it may cause skin sensitivity or eye irritation.</p>

<p>Please enquire for more information about N-[4-(3-Aminopiperidin-1-yl)-5-bromo-1H-indol-3-yl]cyclopropanecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Deriglidole is a synthetic compound, which is an organic molecule developed through chemical synthesis. Its source is a lab-engineered process, designed to provide consistency and precision in its molecular structure. This compound functions by inhibiting specific enzymes involved in critical metabolic pathways, thereby altering the biochemical reactions within cellular systems.</p>

<p>Inhibitor of γ-secretase</p>

<p>Phytohemagglutinin is a plant-derived protein that belongs to the class of hemagglutinins. It is used in plant physiology and has been shown to stimulate lymphocyte transformation. This protein has also been shown to have biological properties, such as the ability to inhibit growth of kidney bean cells. Phytohemagglutinin can be used in immunological studies and may be useful for treating autoimmune diseases. In addition, this protein stimulates the production of IL-2 by T cells, which can lead to leukemia or lymphoma. The optimum concentration for phytohemagglutinin is 0.1% (w/v).</p>

<p>Rasagiline mesylate is a peptide that interacts with proteins. It is an inhibitor of the enzyme monoamine oxidase type A (MAO-A). Rasagiline mesylate has been used as a research tool in cell biology, and as an experimental drug to treat Parkinson's disease. Rasagiline mesylate binds to the dopamine receptor, inhibiting catecholamine release from nerve endings, and also inhibits ion channels, such as sodium and potassium channels. This drug is used for research purposes and has not yet been approved for clinical use.</p>

<p>Inhibitor of EGFR-tyrosine kinase</p>

<p>2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol is a research tool that can be used to study the effects of Ion channels on cells. It can also be used as a pharmacological reagent for the study of receptor binding and protein interactions. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol has a CAS No. 848814-27-7 and is soluble in DMSO. This product is available in high purity and it does not contain any detectable impurities.</p>

<p>AX-024 HCl is a drug designed for cancer treatment. It is a potent inhibitor of the human mismatch repair (MMR) protein, which is involved in the DNA mismatch repair process. This drug is used as a countermeasure to mismatched DNA following chemotherapy treatment in cancer patients. The inhibition of MMR activity by AX-024 HCl reduces the risk of cancer recurrence and relapse. This drug has also been shown to have anti-tumor effects on animal models and to inhibit tumor growth in vitro and in vivo. In addition, this agent has been shown to be safe when administered intravenously in animals.</p>

<p>Didesmethyl cariprazine is a peptide that belongs to the group of activators. It has been shown to be an inhibitor of protein interactions and a ligand for the 5-HT2A receptor. Didesmethyl cariprazine has also been found to have pharmacological effects on ion channels and cell biology, such as life science.</p>

<p>NCGC00262650 is a potent fluoroquinolone antibiotic that has been shown to have albumin binding activity. It is a derivative of the quinolone antibiotic, ciprofloxacin. NCGC00262650 is active in biochemical and cellular assays against influenza A virus, including pandemic strains such as covid-19. It also binds to the receptor on the surface of infected cells and inhibits RNA synthesis, which prevents the virus from replicating. This drug has been synthesized in order to target specific types of viruses and prevent them from spreading globally.</p>

<p>Fodipir is a chelating agent that is used for the treatment of metastatic colorectal cancer. Fodipir has been shown to bind to cisplatin, a chemotherapy drug, and prevent it from binding to tissues or cells. This prevents the toxicity of cisplatin on tissues, such as the heart and liver. Fodipir also protects against platinum-based chemotherapy by preventing cell lysis and DNA damage in the myocardium. Fodipir may be useful in diagnosing conditions that require imaging because it is not absorbed by the body, allowing for clear images without interference from other molecules.</p>

<p>PK68 is an innovative chemical compound that serves as a selective protein kinase inhibitor, derived through advanced synthetic chemistry techniques. The compound operates by binding to the ATP-binding pocket of target kinases, effectively inhibiting their activity. This mode of action allows PK68 to modulate various kinase-driven signaling pathways that are crucial in cellular processes.</p>

<p>GSK 319347A is a chemical compound that belongs to the group of chemokines. It has been shown to have anti-cancer properties, in particular for colorectal cancer and myocardial infarcts. GSK 319347A has also been shown to activate stem cells and increase the growth of cancer cells. The mechanism by which GSK319347A activates stem cells is not yet known, but it may be due to its ability to inhibit growth factor signaling pathways or its ability to bind with chemokine receptors.</p>

<p>Pep2-AVKI is a potent postsynaptic potential (PSP) agonist. It is a potentiator of synaptic transmission at glutamatergic synapses, and enhances the amplitude of the PSPs induced by dopamine, glutamate, or acetylcholine in hippocampal CA1 neurons. Pep2-AVKI also interacts with cytosolic proteins that have been shown to be involved in the potentiation of synaptic transmission. These interactions are required for its efficacy as a potentiator of synaptic transmission. Pep2-AVKI has been shown to be efficacious in animal models of autoimmune diseases and may work through its ability to modulate immune responses.</p>

<p>XL413 is a novel small molecule that inhibits the replication of HIV-1. It has been shown to be effective in inhibiting replication of HIV-1 in both fetal bovine and human cells, with no toxicity for primary cells or prostate cancer cells. XL413 blocks cellular organelle replication by inhibiting lipid kinase, which is required for the production of phospholipids and subsequent liposome formation. XL413 also inhibits autophagy induction, which may contribute to its antiviral activity. This drug has shown efficacy in reducing ischemic brain damage as well as improving survival rates in pediatric patients with leukemia.</p>

<p>3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one is a synthetic peptide that can act as an activator of ion channels. It binds to the receptor site and inhibits the binding of the ligands to their corresponding receptors. 3-(3-,4-Dihydro-6,7-dimethoxy-3,3--dimethyl--1--isoquinolinyl)-2H--1--benzopyran--2--one is also used as a research tool in pharmacology and cell biology. 3-(3-,4 -Dihydro-[6,7]-dimethoxy-[3,3]-dimethyl-[1] isoquinolinyl)--2H-[1] benzopyran [2] one may be used for further study on ion channels.</p>

<p>GDC-0834 is a new investigational drug that has been shown in animal studies to have anti-leukemic activity. GDC-0834 is an orally active, potent inhibitor of the enzyme aminopeptidase N (APN). It was found to be effective in inhibiting the growth of human leukemia cells in vitro and in vivo, and to reduce the number of circulating leukemic cells in humans with chronic lymphocytic leukemia. The mechanism by which GDC-0834 inhibits APN is not understood, but it may involve a nucleophilic attack on the amide group of the enzyme.</p>

<p>4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide dihydrochloride is a sulfonamide antibiotic, commonly known as sulfadiazine dihydrochloride. It is a synthetic antimicrobial agent derived from sulfanilamide, a compound originally extracted from azo dyes. Its mode of action involves inhibiting bacterial dihydropteroate synthase, which leads to the obstruction of folic acid synthesis. This disruption is critical as folic acid is essential for bacterial growth and replication.</p>

<p>Vactosertib hydrochloride is a small molecule that binds to the receptor tyrosine kinase AXL and inhibits its activity. It has been shown to inhibit the proliferation of cancer cells in vitro. Vactosertib hydrochloride can also be used as a research tool for studying protein interactions, ion channels, and cell biology.</p>

<p>2,16-Kauranediol is a diterpenoid that binds to various proteins and ion channels. It has been shown to inhibit the proliferation of cancer cells in vitro. 2,16-Kauranediol is a potential research tool for studying protein interactions and antibody-antigen reactions. It also inhibits the activity of voltage-gated potassium channels. This product is used in cell biology and pharmacology research as well as a reagent for peptide and ligand binding assays.</p>

<p>PF-06284674 is a potent and selective small molecule activator of the human angiotensin II type 1 receptor. Angiotensin II is a hormone that regulates blood pressure, water and electrolyte balance, and vascular tone. The activation of the angiotensin II type 1 receptor by PF-06284674 has been shown to produce vasodilation in various tissues including the kidney, heart, and brain. PF-06284674 may be useful for research purposes as an inhibitor of protein interactions or an antibody production tool.</p>

<p>XMD17-109 is a drug that inhibits the mitogen-activated protein kinase (MAPK) pathway, which is a signaling cascade that regulates cell proliferation. This compound has been shown to inhibit the activation of MAPK in response to a variety of extracellular stimuli. XMD17-109 also inhibits the expression of genes involved in cardiovascular diseases, such as angiotensin and cortistatin. XMD17-109 blocks the proliferation of vascular smooth muscle cells and osteopontin by downregulating α-smooth muscle actin (α-SMA) and upregulating osteopontin.</p>

<p>Please enquire for more information about p-Ethylhydratropic acid-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Reticuline hydrochloride is a racemic mixture of enantiomers. It is a crystalline solid that has a melting point of 222°C. Reticuline hydrochloride is an alkaloid derived from thebaine and other opium alkaloids. It is found in the plants, Mandragora officinarum and Berberis aristata. The drug has been shown to have analgesic, antitussive, anti-inflammatory, and antipyretic properties. Reticuline hydrochloride has also been found to be useful for treating malaria.</p>

<p>Cer9 is a peptide that belongs to the group of activators. It binds to receptors and activates them, which can lead to changes in the ion channels in cell membranes. This leads to an increase in the permeability of the membrane and an influx of ions. Cer9 is also used as a research tool for understanding protein interactions, receptor binding, and ligand-receptor binding.</p>

<p>13-[(2-Fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride is a synthetic heterocyclic compound, which is a derivative of quinolizinium chloride. It is synthesized through a series of chemical reactions involving arylation and cyclization, leveraging fluorinated aromatic substrates as precursors. The mode of action of this compound typically involves interactions with nucleic acids or enzyme systems, making it a potential candidate for studying biological pathways and molecular interactions.</p>

<p>NSC 33994 is a histone lysine methyltransferase inhibitor that blocks the ubiquitin-proteasome system. It has been shown to inhibit the growth of cancer cells in vitro and in vivo by inhibiting signal transduction, autophagy, and cell division. NSC 33994 also inhibits the expression of genes encoding for proteins involved in cell proliferation and growth, such as the epidermal growth factor receptor (EGFR). The drug has been shown to be effective against infectious diseases such as tuberculosis and influenza. The effective dose is unknown but it is believed to be between 1-10 μM.</p>

<p>Please enquire for more information about N-Nitroso fluoxetine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GSK2200150A is a chemically synthesized compound that has been shown to have potent antitubercular activity against drug-resistant strains. GSK2200150A was developed from the naturally occurring sugar trehalose, which has been shown to be an excellent substrate for microbial glycosylation. GSK2200150A inhibits the synthesis of mycolic acids in mycobacteria and prevents the formation of periplasmic granules, two virulence factors that are important in tuberculosis. GSK2200150A also inhibits protein synthesis by inhibiting the activity of ribosomes, which are responsible for protein production. The structure-activity relationship (SAR) of this compound indicates that it is a potent inhibitor of Mycobacterium tuberculosis and may be useful as a treatment for drug-resistant strains.</p>