Natural and semi-synthetic antibiotics

<p>Eribulin binds microtubules, halts cancer cell growth, treating metastatic breast cancer.</p>

<p>Applications Labelled Amprenavir, a selective HIV protease inhibitor. An analogue of Ritonavir.<br>References Adkins, J.C., et al.: Drugs, 55, 837 (1998)<br></p>

<p>Stability: Hygroscopic<br>Applications: Posaconazole Succinyl Ester is the derivative of Posaconazole (P689600), which is an orally active triazole antifungal.<br>References Cacciapuoti, A., et al.: Antimicrob. Agents Chemother., 44, 2017 (2000), Herbrecht, R., et al.: Int. J. Clin. Pract., 58, 612 (2004), Panackal, A., et al.: J. Clin. Microbiol., 44, 1740 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Desfuroyl Ceftiofur Dimer is an impurity of the drug Ceftiofur (C244695), a third generation cephalosporin antibiotic used in veterinary medicine.<br>References Donaldson, S.C. et al.: Appl. Environ. Microbiol., 72, 3940 (2006); Yancey, R.J. et al.: Am. J. Vet. Res., 48, 1050 (1987);<br></p>

<p>Impurity Enrofloxacin USP Related Compound Mixture<br>Applications Fluorinated quinolone antibacterial. Enrofloxacin USP Related Compound Mixture.<br>References Altreuther, P., et al.: Vet. Med. Rev., 2, 87 (1987),<br></p>

<p>Impurity Clarithromycin EP Impurity I<br>Applications De(cladinosyl) Clarithromycin (Clarithromycin EP Impurity I) is an impurity of Clarithromycin (C559750). De(cladinosyl) Clarithromycin showed significantly potent antibacterial activity against community acquired respiratory pathogens.<br>References Morimoto, S., et al.: J. Antibiot., 37, 187 (1984), Buxbaum, A., et al.: J. Antimicrob. Chemother., 52, 371 (2003), Westphal, J., et al.: Br. J. Clin. Pharmacol., 50, 285 (2000), Ma, Z., et al.: J. Med. Chem., 44, 4137 (2001),<br></p>

<p>Applications Intermediate in the production of biosynthetic antibiotics<br>References Horton, D., et al.: Anal. Biochem., 59, 452 (1974), Kamenik, Z., et al.: Anal. Bioanal. Chem., 393, 1779 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Delactamimipenem Monosodium is an impurity found in imipenem (I465200).<br>References Ratcliffe, R.W., et. al.: J. Org. Chem., 54, 653 (1989)<br></p>

<p>Stability Hygroscopic<br>Applications Erythromycylamine-d3 is labelled Erythromycylamine (E653400) which is a metabolite of Dirithromycin (D493000). It is also a potent macrolide antibiotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bauldry, S., et al.: J. Biol. Chem., 263, 16787 (1988); Labro, M., et al.: J. Antimicrob. Chemother., 24, 561 (1989); Dumas, R., et al.: Chemother., 36, 381 (1990); Bacci, P., et al.: J. Chemother., 4, 268 (1992); Montenez, J., et al.: Toxicol. Appl. Pharmacol., 156, 129 (1999)<br></p>

<p>Applications An intermediate in the preparation of detoxification inhibitors of the crucifer phytoalexin Brassinin, as potential fungicides against Leptosphaeria maculans.<br>References Gaspari, P., et al.: J. Med. Chem., 49, 684 (2006), Pedras, M., et al.: Bioorg. Med. Chem., 14, 714 (2006),<br></p>

<p>Applications Azithromycin-d5, is the labeled analogue Azithromycin (A927000), a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.<br>References Langtry, H.D., et al.: Drugs, 56, 273 (1998),<br></p>

<p>Applications The major metabolite of Spiramycin I in meat, fish, and milk.<br>References Nakazawa, S., et al.: J. Antibiot., 20, 259 (1967), Rubinstein, E., et al.: J. Antimicrob. Chemother., 42, 572 (1998), Rourick, R., et al.: J. Pharm. Biomed. Anal., 14, 1743 (1996),<br></p>

<p>Impurity Clarithromycin EP Impurity H/ Erythromycin EP Impurity L<br>Applications N-Demethyl-N-formylclarithromycin (Clarithromycin EP Impurity H) is an impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750).<br>References Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Semi-synthetic macrolide antibiotic. Antibacterial.<br>References Malmborg, A.-S., et al.: J. Antimicrob. Chemother., 5, 591 (1979),<br></p>

<p>Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin (C482500).<br>References Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985), Scully, B.E., et al.: Lancet, 1, 819 (1986)<br></p>

<p>Stability Light Sensitive<br>Applications A metabolite of Rifampicin.<br>References Blumenfeld,O.O., et al.: J. Biol. Chem., 236, 2472 (1961), Cowxan, R.A., et al.: Biochem. Biophys. Res. Commun, 23, 799 (1966)<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Impurity Clarithromycin EP Impurity Q<br>Applications Clarithromycin N-oxide (Clarithromycin EP Impurity Q) is an urinary metabolite of Clarithromycin (C559750), a macrolide antibiotic.<br>References Jones, P., et al.: J. Med. Chem., 15, 631 (1972), Watanabe, Y., et al.: J. Antibiot., 46, 647 (1983), Ohmori, S., et al.: Drug Metab. Dispos., 21, 358 (1993),<br></p>

<p>Applications Amoxicillin Closed-loop Dimer is a dimer of Amoxicillin(A634528) which is an antibiotic used in the treatment of various bacterial infections.<br></p>

<p>Applications A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, T.K., et al.: J. Agric. Food Chem., 42, 1786 (1994), Arena, J.P., et al.: J. Parasitol., 81, 286 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Polyether antibiotic. Coccidiostat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Day, et al.: Antimicrob. Agents Chemother., 4, 410 (1973), Buchko, S., et al.: J. Food Prot., 63, 1467 (2000), De Leener, E., et al.: Microb. Drug Resist., 10, 341 (2004), Sanderson, M., et al.: Vet. Microbiol., 110, 125 ( 2005),<br></p>

<p>Impurity Azithromycin EP Impurity L<br>Applications Azithromycin N-Oxide (Azithromycin EP Impurity L) is an Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Applications 4-Nitrobenzaldehyde is a benzaldehyde with a nitro group in the para position. It is used as a reagent in decarboxylative aldol reactions that are catalyzed by lipases and proteases in organic co-solvent mixtures.<br>References Chaurasia, P.K., et al.: Synthetic Commun., 44, 2535 (2014); Ishikawa, F., et al.: Bioorg. Med. Chem., 21, 7011 (2013); Jiang, L., et al.: Biotechnol. Lett., 36, 99 (2014)<br></p>

<p>Applications An impurity of Tobramycin (T524000(P)), which is a single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius; antibacterial.<br>References Brandl, M. et al.: Drug Dev. Ind. Pharm., 18, 1423 (1992); Murase, M. et al.: Prog. Antimicrob. Anticancer Chemother., Proc. Int. Congr. Chemother., 6, 1098 (1970); Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970); Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972); Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996)<br></p>

<p>Applications The first totally synthetic monocyclic β-lactam antibiotic.<br>References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),<br></p>

<p>Applications Spiramycin is a macrolide antibiotics.<br>References Patil, S., et al.: World J. Pharm. Res., 5, 1529 (2016)<br></p>

<p>Impurity Selamectin Impurity B<br>Stability Hygroscopic<br>Applications 22,23-Didehydro Selamectin is an impurity of Selamectin (S247990) which is a topical parasiticide. Selamectin (S247990) is also used as a veterinary antihelminithic agent on animals.<br>References Eshar, D., et al.: J. Am. Veterin. Med. Association., 241, 1056 (2012); Geis-Asteggiante, L., et al.: J. Chromatograph., 1258, 43 (2012);<br></p>

<p>Applications 3”-O-Demethyl Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>

<p>Impurity Cefadroxil EP Impurity B<br>Applications 7-Aminodesacetoxycephalosporanic Acid (Cefadroxil EP Impurity B) is a metabolite of Cephalexin (C256800).<br>References Dantzig, A., et al.: Biochim. Biophys. Acta, 1027, 211 (1990), Shen, H., et al.: J. Biol. Chem., 278, 4786 (2003), Watanabe, C., et al.: Drug Metab. Pharmacokinet., 20, 443 (2005)<br></p>

<p>Applications 25-Deacetyl-21-acetyl Rifampicin is a structural isomer, and impurity, of Rifampicin (R508000), a semisynthetic antibiotic. Antibacerial (tuberculostatic).<br>References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),<br></p>

<p>Applications N-Formyl Erythromycin A is a derivative of Erythromycin (E649950), an antibiotic medication.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Ivermectin B1 Aglycon is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>

<p>Applications Ivermectin B1 Mono-sugar Derivative is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>

<p>Applications Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.<br>References Langtry, H.D., et al.: Drugs, 56, 273 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.<br>References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),<br></p>

<p>Applications Labelled Tylosin (T947650). Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Stability Light Sensitive<br>Applications An intermediate in the synthesis of Terbinafine (T107500).<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications A dimer impurity of the antibacterial Cefpodoxime Proxetil (C243870).<br></p>

<p>Applications Tilmicosin Phosphate Salt is the phosphate salt of the semi-synthetic antibiotic derivative. It can be used in biological study and pharmacological activity of bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica from cattle.<br>References Blondeau, J., et al.: Am J Vet Res, 76, 860 (2015)<br></p>

<p>Applications Nebramine Sulfate is a degradation product on the antibiotic Tobramycin (T524000).<br>References Brandl, M. et al.: Drug Dev. Indust. Pharm., 18, 1423 (1992); Ghinami, C. et al.: J. Chrom. A, 1139, 52 (2007);<br></p>

<p>Impurity Moxidectin EP Impurity K<br>Applications 5-O-(4-nitrobenzoyl)moxidectin is an impurity of moxidectin (M744800), a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.<br>References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);<br></p>

<p>Applications Cefminox is a semisynthetic broad spectrum cephamycin antibiotic. Antibacterial.<br>References Inouye, S., et al.: Antimicrob. Agents Chemother., 26, 722 (1984), Watanabe, T., et al.: Drugs Exp. Clin. Res., 10, 293 (1984), Tsuruoka, T., et al.: Eur. J. Biochem., 151, 209 (1985),<br></p>

<p>Applications Posaconazole intermediate. Antifungal agent.<br>References Ator, M., et al.: J. Med. Chem., 35, 100 (1992), Andriole, V., et al.: J. Antimicrob. Chemother., 44, 151 (1999), Beuchet, P., et al.: Bioorg. Med. Chem., 9, 1599 (1999),<br></p>

<p>Applications Moxidectin EP L is an impurity of Moxidectin (M744800) which is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.<br>References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);<br></p>

<p>Stability Store in Freezer<br>Applications Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).<br>References Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987), Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012), Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012),<br></p>

<p>Applications Cephalosporin 87/359 is an impurity of Cefoxitin (C243190). Cefoxitin is a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial.<br>References Wallick, H., et al.: Antimicrob. Agents Chemother., 5, 25 (1974), Brenner, G.S., et al.: Anal. Profiles Drug Subs., 11, 169 (1982),<br></p>

<p>Impurity Fosfomycin EP Impurity B<br>Stability Very Hygroscopic<br>Applications [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (Fosfomycin EP Impurity B) is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity.<br>References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);<br></p>

<p>Applications 3-Chloro-D-alanine Methyl Ester Hydrochloride is an intermediate in the preparation of antibiotic D-Cycloserine (C988815) which inhibits cell wall biosynthesis in bacteria.<br>References Lamb., J.W., et al.: Anal. Profiles Drug Subs., 1, 53 (1972); Gentry-Weeks, C., et al.: J. Biol. Chem., 268, 7298 (1993); Alexander, F., et al.: Eur. J. Biochem., 219, 953 (1994); Auger, S., et al.: Biochimie, 87, 231 (2005); Chem and Eng. News p. 12, Dec. 7/14 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications The L-diastereomer of the β-lactam antibiotic Cephalexin (C256800). It is transported by PEPT1 (the oligopeptide transporter responsible for absorption of peptide nutrients in the small intestine) with high affinity, but is not metabolized by PEPT1 itself.<br>References Mitsuoka, K. et al.: Biol. Pharmac. Bull., 32, 1459 (2009); Snyder, N.J. et al.: Antimicrob. Agents Chemother., 41, 1649 (1997);<br></p>

<p>Applications Used as an antibacterial agent. LD50 &gt;5000 mg/kg for oral administration to rats.<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971)<br></p>

<p>Applications Terbinafine is used to treat infections caused by a fungus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Mupirocin EP impurity C<br>Stability Hygroscopic<br>Applications An antibiotic isolated from Pseudomonas fluorescens.<br>References Banks, R.M., et al.: J. Antibiot., 41, 609 (1988),<br></p>

<p>Applications Non-absorbable semisynthetic Rifamycin antibiotic.<br>References Brufani, M., et al.: J. Antibiot., 37, 1611 (1984), Gillis, J.C., et al.: Drugs, 49, 467 (1995), Huang, D.B., et al.: J. Infection, 50, 97 (2005),<br></p>

<p>Applications Linezolid (L466500) intermediate.<br></p>

<p>Stability Hygroscopic<br>Applications Mupirocin Lithium is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.<br>References Hughes, J., et al.: J. Antibiot., 31, 330 (1978), Ward, A., et al.: Drugs, 32, 425 (1986), Casewell, M.W., et al.: J. Antimicrob. Chemother., 19, 1 (1987),<br></p>

<p>Applications 7-Amino-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid Hydroiodide, is an impurity of Ceftazidime (C244100). Ceftazidime impurity B.<br>References Miyake, A., et al.: Antimicrob. Agents Chemother., 486, 182 (1989), Seibert, G., et al.: Arzneim.-Forsch., 33, 1084 (1983),<br></p>

<p>Impurity Azithromycin EP Impurity E<br>Applications A metabolite of Azithromycin. Azithromycin Impurity E<br>References Bright, G., et al.: J. Antibiotics., 41, 1029 (1988), Amacher, D., et al.: Antimicrob. Agents Chemother., 35, 1186 (1991), Peters, D., et al.: Drugs, 44, 750 (1992),<br></p>

<p>Impurity Cefalotin EP Impurity B<br>Applications Deacetylcephalothin (Cefalotin EP Impurity B) is an intermediate and the free acid analogue of Deacetylcephalothin Sodium Salt (D198210), which is an impurity in the synthesis of Cefalonium (C236800) and an analog of Cephalothin (C261150) a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows.<br>References Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);<br></p>

<p>Applications Chloramphenicol-d5, is the labeled analogue of Chloramphenicol (C325030), which has a broad spectrum of activity against Gram-positive and gram-negative bacteria. It is also antibacterial, and antirickettsial.<br>References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications The more active Zearalenone (Z270500) metabolite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Olsen, M., et al.: Acta Pharmacol. Toxicol., 48, 15 (1981), Chang, W., et al.: Food Chem. Toxicol., 22, 887 (1984), El Golli, E., et al.: Toxicol Lett., 166, 122 (2006), Hassen, W., et al.: Toxicology, 232, 294 (2007), Benzoni, E., et al.: Reprod. Toxicol., 25, 461 (2008),<br></p>

<p>Applications A key intermediate in the manufacturing of Cephalosporin compounds.<br>References Choi, K., et al.: J. Antibio., 50, 279 (1997),<br></p>

<p>Applications Semisynthetic Erythromycin derivative. Antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications A newly metabolite of Griseofulvin (G787500).<br>References Oda, T., et al.: J. Antibiot., 59, 114 (2006), Rebacz, B., et al.: Cancer Res., 67, 6342 (2007), Uen, Y., et al.: J. Cell Biochem., 101, 1165 (2007),<br></p>

<p>Impurity Ciprofloxacin EP Impurity C/ Enrofloxacin EP impurity G<br>Applications Desethylene Ciprofloxacin Hydrochloride (Ciprofloxacin EP Impurity C) is a metabolite of the fluorinated quinolone antibacterial Ciprofloxacin (C482500(P)).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985), Scully, B.E., et al.: Lancet, 1, 819 (1986)<br></p>

<p>Impurity Lovastatin EP Impurity E; Lovastatin USP Related Compound A<br>Applications 4a,5-Dihydro Lovastatin (Lovastatin EP Impurity E; Lovastatin USP Related Compound A) is an impurity in Lovastatin (L472225) bulk drug.<br>References Bone, E.A., et al.: Bioorg. Med. Chem. Lett., 2, 223 (1992), Houck, A., et al.: Talanta, 40, 491 (1993),<br></p>

<p>Applications Fourth generation cephalosporin antibiotic.<br>References Kavi, J., et al.: J. Antimicrob. Chemother., 22, 911 (1988), Horstmann, G., et al.: Arzneim.-Forsch., 40, 1250 (1990),<br></p>